KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
SH3BP1
Full Name:
SH3 domain-binding protein 1
Alias:
3BP1; dJ37E16.2; SH3 domain binding protein 1; SH3-domain binding protein 1
Type:
Adaptor/scaffold
Mass (Da):
75713
Number AA:
701
UniProt ID:
Q9Y3L3
International Prot ID:
IPI00456744
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005096
GO:0017124
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T15
R
M
R
Q
L
A
Q
T
G
S
L
G
R
T
P
Site 2
S17
R
Q
L
A
Q
T
G
S
L
G
R
T
P
E
T
Site 3
T21
Q
T
G
S
L
G
R
T
P
E
T
A
E
F
L
Site 4
S78
K
L
P
L
M
A
L
S
T
T
M
A
E
S
F
Site 5
S84
L
S
T
T
M
A
E
S
F
K
E
L
D
P
D
Site 6
S92
F
K
E
L
D
P
D
S
S
M
G
K
A
L
E
Site 7
S93
K
E
L
D
P
D
S
S
M
G
K
A
L
E
M
Site 8
S128
R
D
V
L
Q
P
L
S
R
L
S
E
E
E
L
Site 9
S131
L
Q
P
L
S
R
L
S
E
E
E
L
P
A
I
Site 10
S144
A
I
L
K
H
K
K
S
L
Q
K
L
V
S
D
Site 11
S150
K
S
L
Q
K
L
V
S
D
W
N
T
L
K
S
Site 12
T154
K
L
V
S
D
W
N
T
L
K
S
R
L
S
Q
Site 13
S157
S
D
W
N
T
L
K
S
R
L
S
Q
A
T
K
Site 14
S160
N
T
L
K
S
R
L
S
Q
A
T
K
N
S
G
Site 15
T163
K
S
R
L
S
Q
A
T
K
N
S
G
S
S
Q
Site 16
S166
L
S
Q
A
T
K
N
S
G
S
S
Q
G
L
G
Site 17
S168
Q
A
T
K
N
S
G
S
S
Q
G
L
G
G
S
Site 18
S175
S
S
Q
G
L
G
G
S
P
G
S
H
S
H
T
Site 19
S178
G
L
G
G
S
P
G
S
H
S
H
T
T
M
A
Site 20
S180
G
G
S
P
G
S
H
S
H
T
T
M
A
N
K
Site 21
T182
S
P
G
S
H
S
H
T
T
M
A
N
K
V
E
Site 22
Y209
V
E
Q
C
R
D
E
Y
L
A
D
L
Y
H
F
Site 23
Y214
D
E
Y
L
A
D
L
Y
H
F
V
T
K
E
D
Site 24
T218
A
D
L
Y
H
F
V
T
K
E
D
S
Y
A
N
Site 25
Y223
F
V
T
K
E
D
S
Y
A
N
Y
F
I
R
L
Site 26
Y226
K
E
D
S
Y
A
N
Y
F
I
R
L
L
E
I
Site 27
Y237
L
L
E
I
Q
A
D
Y
H
R
R
S
L
S
S
Site 28
S241
Q
A
D
Y
H
R
R
S
L
S
S
L
D
T
A
Site 29
S243
D
Y
H
R
R
S
L
S
S
L
D
T
A
L
A
Site 30
S244
Y
H
R
R
S
L
S
S
L
D
T
A
L
A
E
Site 31
T247
R
S
L
S
S
L
D
T
A
L
A
E
L
R
E
Site 32
S262
N
H
G
Q
A
D
H
S
P
S
M
T
A
T
H
Site 33
S264
G
Q
A
D
H
S
P
S
M
T
A
T
H
F
P
Site 34
T266
A
D
H
S
P
S
M
T
A
T
H
F
P
R
V
Site 35
T268
H
S
P
S
M
T
A
T
H
F
P
R
V
Y
G
Site 36
S277
F
P
R
V
Y
G
V
S
L
A
T
H
L
Q
E
Site 37
T326
V
L
K
R
L
K
Q
T
M
A
S
D
P
H
S
Site 38
S329
R
L
K
Q
T
M
A
S
D
P
H
S
L
E
E
Site 39
S333
T
M
A
S
D
P
H
S
L
E
E
F
C
S
D
Site 40
S339
H
S
L
E
E
F
C
S
D
P
H
A
V
A
G
Site 41
Y351
V
A
G
A
L
K
S
Y
L
R
E
L
P
E
P
Site 42
T361
E
L
P
E
P
L
M
T
F
D
L
Y
D
D
W
Site 43
Y365
P
L
M
T
F
D
L
Y
D
D
W
M
R
A
A
Site 44
S373
D
D
W
M
R
A
A
S
L
K
E
P
G
A
R
Site 45
S389
Q
A
L
Q
E
V
C
S
R
L
P
P
E
N
L
Site 46
S397
R
L
P
P
E
N
L
S
N
L
R
Y
L
M
K
Site 47
Y401
E
N
L
S
N
L
R
Y
L
M
K
F
L
A
R
Site 48
T419
E
Q
E
V
N
K
M
T
P
S
N
I
A
I
V
Site 49
T489
S
A
V
T
L
Q
D
T
V
S
D
R
L
A
S
Site 50
S491
V
T
L
Q
D
T
V
S
D
R
L
A
S
E
E
Site 51
S496
T
V
S
D
R
L
A
S
E
E
L
P
S
T
A
Site 52
T502
A
S
E
E
L
P
S
T
A
V
P
T
P
A
T
Site 53
T534
S
A
A
T
K
E
R
T
E
S
E
V
P
P
R
Site 54
S536
A
T
K
E
R
T
E
S
E
V
P
P
R
P
A
Site 55
S544
E
V
P
P
R
P
A
S
P
K
V
T
R
S
P
Site 56
T548
R
P
A
S
P
K
V
T
R
S
P
P
E
T
A
Site 57
S550
A
S
P
K
V
T
R
S
P
P
E
T
A
A
P
Site 58
T554
V
T
R
S
P
P
E
T
A
A
P
V
E
D
M
Site 59
T565
V
E
D
M
A
R
R
T
K
R
P
A
P
A
R
Site 60
T574
R
P
A
P
A
R
P
T
M
P
P
P
Q
V
S
Site 61
S581
T
M
P
P
P
Q
V
S
G
S
R
S
S
P
P
Site 62
S583
P
P
P
Q
V
S
G
S
R
S
S
P
P
A
P
Site 63
S585
P
Q
V
S
G
S
R
S
S
P
P
A
P
P
L
Site 64
S586
Q
V
S
G
S
R
S
S
P
P
A
P
P
L
P
Site 65
S596
A
P
P
L
P
P
G
S
G
S
P
G
T
P
Q
Site 66
S598
P
L
P
P
G
S
G
S
P
G
T
P
Q
A
L
Site 67
T601
P
G
S
G
S
P
G
T
P
Q
A
L
P
R
R
Site 68
S613
P
R
R
L
V
G
S
S
L
R
A
P
T
V
P
Site 69
T618
G
S
S
L
R
A
P
T
V
P
P
P
L
P
P
Site 70
T626
V
P
P
P
L
P
P
T
P
P
Q
P
A
R
R
Site 71
S635
P
Q
P
A
R
R
Q
S
R
R
S
P
A
S
P
Site 72
S638
A
R
R
Q
S
R
R
S
P
A
S
P
S
P
A
Site 73
S641
Q
S
R
R
S
P
A
S
P
S
P
A
S
P
G
Site 74
S643
R
R
S
P
A
S
P
S
P
A
S
P
G
P
A
Site 75
S646
P
A
S
P
S
P
A
S
P
G
P
A
S
P
S
Site 76
S651
P
A
S
P
G
P
A
S
P
S
P
V
S
L
S
Site 77
S653
S
P
G
P
A
S
P
S
P
V
S
L
S
N
P
Site 78
S656
P
A
S
P
S
P
V
S
L
S
N
P
A
Q
V
Site 79
S658
S
P
S
P
V
S
L
S
N
P
A
Q
V
D
L
Site 80
T683
E
A
I
S
G
V
P
T
P
P
A
I
P
P
Q
Site 81
S695
P
P
Q
P
R
P
R
S
L
A
S
E
T
N
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation