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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SIT
Full Name:
Signaling threshold-regulating transmembrane adapter 1
Alias:
SHP2 interacting transmembrane adaptor; Signaling threshold regulating transmembrane adaptor 1; SIT protein precursor; SIT1
Type:
Adapter/scaffold protein
Mass (Da):
21126
Number AA:
196
UniProt ID:
Q9Y3P8
International Prot ID:
IPI00004407
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0042169
GO:0019900
PhosphoSite+
KinaseNET
Biological Process:
GO:0006955
GO:0050863
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Signaling threshold-regulating transmembrane adapter 1 Y90 phosphosite-specific antibody AB-PN535#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN535#Signaling threshold-regulating transmembrane adapter 1 Y95 phosphosite-specific antibody AB-PN536#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN536#Signaling threshold-regulating transmembrane adapter 1 (V87-L93, human) pY90 phosphopeptide - Powder PE-04AEL99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AEL99#Signaling threshold-regulating transmembrane adapter 1 (N92-T98, human) pY95 phosphopeptide - Powder PE-04AHF95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AHF95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
T
L
T
S
A
A
M
S
R
G
D
N
C
T
D
Site 2
S64
I
S
L
A
A
H
L
S
Q
W
T
R
G
R
S
Site 3
S71
S
Q
W
T
R
G
R
S
R
S
H
P
G
Q
G
Site 4
S73
W
T
R
G
R
S
R
S
H
P
G
Q
G
R
S
Site 5
S80
S
H
P
G
Q
G
R
S
G
E
S
V
E
E
V
Site 6
S83
G
Q
G
R
S
G
E
S
V
E
E
V
P
L
Y
Site 7
Y90
S
V
E
E
V
P
L
Y
G
N
L
H
Y
L
Q
Signaling threshold-regulating transmembrane adapter 1 Y90 phosphosite-specific antibody AB-PN535#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN535#Signaling threshold-regulating transmembrane adapter 1 (V87-L93, human) pY90 phosphopeptide - Powder PE-04AEL99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AEL99
Site 8
Y95
P
L
Y
G
N
L
H
Y
L
Q
T
G
R
L
S
Signaling threshold-regulating transmembrane adapter 1 Y95 phosphosite-specific antibody AB-PN536#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN536#Signaling threshold-regulating transmembrane adapter 1 (N92-T98, human) pY95 phosphopeptide - Powder PE-04AHF95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AHF95
Site 9
T98
G
N
L
H
Y
L
Q
T
G
R
L
S
Q
D
P
Site 10
S102
Y
L
Q
T
G
R
L
S
Q
D
P
E
P
D
Q
Site 11
T113
E
P
D
Q
Q
D
P
T
L
G
G
P
A
R
A
Site 12
Y127
A
A
E
E
V
M
C
Y
T
S
L
Q
L
R
P
Site 13
T128
A
E
E
V
M
C
Y
T
S
L
Q
L
R
P
P
Site 14
S129
E
E
V
M
C
Y
T
S
L
Q
L
R
P
P
Q
Site 15
T144
G
R
I
P
G
P
G
T
P
V
K
Y
S
E
V
Site 16
Y148
G
P
G
T
P
V
K
Y
S
E
V
V
L
D
S
Site 17
S149
P
G
T
P
V
K
Y
S
E
V
V
L
D
S
E
Site 18
S155
Y
S
E
V
V
L
D
S
E
P
K
S
Q
A
S
Site 19
S159
V
L
D
S
E
P
K
S
Q
A
S
G
P
E
P
Site 20
S162
S
E
P
K
S
Q
A
S
G
P
E
P
E
L
Y
Site 21
Y169
S
G
P
E
P
E
L
Y
A
S
V
C
A
Q
T
Site 22
S171
P
E
P
E
L
Y
A
S
V
C
A
Q
T
R
R
Site 23
S182
Q
T
R
R
A
R
A
S
F
P
D
Q
A
Y
A
Site 24
Y188
A
S
F
P
D
Q
A
Y
A
N
S
Q
P
A
A
Site 25
S191
P
D
Q
A
Y
A
N
S
Q
P
A
A
S
_
_
Site 26
S196
A
N
S
Q
P
A
A
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation