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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RABGAP1
Full Name:
Rab GTPase-activating protein 1
Alias:
GAP and centrosome-associated protein; GAPCENA; HSPC094; RAB GTPase activating protein 1; Rab6 GTPase activating protein (GAP and centrosome-associated); Rab6 GTPase-activating protein GAPCenA; RBGP1; TBC1 domain family, member 11; TBC1D11
Type:
Mass (Da):
121737
Number AA:
1069
UniProt ID:
Q9Y3P9
International Prot ID:
IPI00016702
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
GO:0005737
GO:0005813
Uniprot
OncoNet
Molecular Function:
GO:0005083
GO:0005096
GO:0005097
PhosphoSite+
KinaseNET
Biological Process:
GO:0007049
GO:0009987
GO:0032313
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
D
D
K
A
S
V
G
K
I
S
V
S
Site 2
S11
K
A
S
V
G
K
I
S
V
S
S
D
S
V
S
Site 3
S16
K
I
S
V
S
S
D
S
V
S
T
L
N
S
E
Site 4
S18
S
V
S
S
D
S
V
S
T
L
N
S
E
D
F
Site 5
S29
S
E
D
F
V
L
V
S
R
Q
G
D
E
T
P
Site 6
T35
V
S
R
Q
G
D
E
T
P
S
T
N
N
G
S
Site 7
S37
R
Q
G
D
E
T
P
S
T
N
N
G
S
D
D
Site 8
T38
Q
G
D
E
T
P
S
T
N
N
G
S
D
D
E
Site 9
S42
T
P
S
T
N
N
G
S
D
D
E
K
T
G
L
Site 10
T47
N
G
S
D
D
E
K
T
G
L
K
I
V
G
N
Site 11
S86
E
K
E
L
V
K
R
S
Q
L
D
G
E
G
D
Site 12
S97
G
E
G
D
G
P
L
S
N
Q
L
S
A
S
S
Site 13
S101
G
P
L
S
N
Q
L
S
A
S
S
T
I
N
P
Site 14
S120
G
L
Q
K
P
E
M
S
L
P
V
K
P
G
Q
Site 15
S130
V
K
P
G
Q
G
D
S
E
A
S
S
P
F
T
Site 16
S133
G
Q
G
D
S
E
A
S
S
P
F
T
P
V
A
Site 17
S134
Q
G
D
S
E
A
S
S
P
F
T
P
V
A
D
Site 18
T137
S
E
A
S
S
P
F
T
P
V
A
D
E
D
S
Site 19
S144
T
P
V
A
D
E
D
S
V
V
F
S
K
L
T
Site 20
S157
L
T
Y
L
G
C
A
S
V
N
A
P
R
S
E
Site 21
S163
A
S
V
N
A
P
R
S
E
V
E
A
L
R
M
Site 22
S176
R
M
M
S
I
L
R
S
Q
C
Q
I
S
L
D
Site 23
T203
V
R
L
L
D
P
Q
T
N
T
E
I
A
N
Y
Site 24
T225
C
V
R
G
H
D
G
T
P
E
S
D
C
F
A
Site 25
S228
G
H
D
G
T
P
E
S
D
C
F
A
F
T
E
Site 26
T265
R
I
L
Y
S
F
A
T
A
F
R
R
S
A
K
Site 27
S270
F
A
T
A
F
R
R
S
A
K
Q
T
P
L
S
Site 28
T274
F
R
R
S
A
K
Q
T
P
L
S
A
T
A
A
Site 29
S277
S
A
K
Q
T
P
L
S
A
T
A
A
P
Q
T
Site 30
T279
K
Q
T
P
L
S
A
T
A
A
P
Q
T
P
D
Site 31
T284
S
A
T
A
A
P
Q
T
P
D
S
D
I
F
T
Site 32
S287
A
A
P
Q
T
P
D
S
D
I
F
T
F
S
V
Site 33
S293
D
S
D
I
F
T
F
S
V
S
L
E
I
K
E
Site 34
S295
D
I
F
T
F
S
V
S
L
E
I
K
E
D
D
Site 35
Y306
K
E
D
D
G
K
G
Y
F
S
A
V
P
K
D
Site 36
Y332
I
D
K
K
I
V
I
Y
V
Q
Q
T
T
N
K
Site 37
S352
R
C
F
G
L
L
L
S
P
G
K
D
V
R
N
Site 38
S360
P
G
K
D
V
R
N
S
D
M
H
L
L
D
L
Site 39
S369
M
H
L
L
D
L
E
S
M
G
K
S
S
D
G
Site 40
S373
D
L
E
S
M
G
K
S
S
D
G
K
S
Y
V
Site 41
S374
L
E
S
M
G
K
S
S
D
G
K
S
Y
V
I
Site 42
S378
G
K
S
S
D
G
K
S
Y
V
I
T
G
S
W
Site 43
Y379
K
S
S
D
G
K
S
Y
V
I
T
G
S
W
N
Site 44
T382
D
G
K
S
Y
V
I
T
G
S
W
N
P
K
S
Site 45
S384
K
S
Y
V
I
T
G
S
W
N
P
K
S
P
H
Site 46
S389
T
G
S
W
N
P
K
S
P
H
F
Q
V
V
N
Site 47
T399
F
Q
V
V
N
E
E
T
P
K
D
K
V
L
F
Site 48
T416
T
A
V
D
L
V
I
T
E
V
Q
E
P
V
R
Site 49
T428
P
V
R
F
L
L
E
T
K
V
R
V
C
S
P
Site 50
S434
E
T
K
V
R
V
C
S
P
N
E
R
L
F
W
Site 51
S444
E
R
L
F
W
P
F
S
K
R
S
T
T
E
N
Site 52
S447
F
W
P
F
S
K
R
S
T
T
E
N
F
F
L
Site 53
T448
W
P
F
S
K
R
S
T
T
E
N
F
F
L
K
Site 54
T449
P
F
S
K
R
S
T
T
E
N
F
F
L
K
L
Site 55
T470
E
R
K
N
N
T
D
T
L
Y
E
V
V
C
L
Site 56
Y472
K
N
N
T
D
T
L
Y
E
V
V
C
L
E
S
Site 57
S481
V
V
C
L
E
S
E
S
E
R
E
R
R
K
T
Site 58
T488
S
E
R
E
R
R
K
T
T
A
S
P
S
V
R
Site 59
T489
E
R
E
R
R
K
T
T
A
S
P
S
V
R
L
Site 60
S491
E
R
R
K
T
T
A
S
P
S
V
R
L
P
Q
Site 61
S493
R
K
T
T
A
S
P
S
V
R
L
P
Q
S
G
Site 62
S499
P
S
V
R
L
P
Q
S
G
S
Q
S
S
V
I
Site 63
S501
V
R
L
P
Q
S
G
S
Q
S
S
V
I
P
S
Site 64
S503
L
P
Q
S
G
S
Q
S
S
V
I
P
S
P
P
Site 65
S504
P
Q
S
G
S
Q
S
S
V
I
P
S
P
P
E
Site 66
S508
S
Q
S
S
V
I
P
S
P
P
E
D
D
E
E
Site 67
S524
D
N
D
E
P
L
L
S
G
S
G
D
V
S
K
Site 68
S526
D
E
P
L
L
S
G
S
G
D
V
S
K
E
C
Site 69
S530
L
S
G
S
G
D
V
S
K
E
C
A
E
K
I
Site 70
S560
N
V
R
P
K
Q
L
S
S
L
V
R
N
G
V
Site 71
S561
V
R
P
K
Q
L
S
S
L
V
R
N
G
V
P
Site 72
Y592
N
D
H
L
V
E
K
Y
R
I
L
I
T
K
E
Site 73
S600
R
I
L
I
T
K
E
S
P
Q
D
S
A
I
T
Site 74
S604
T
K
E
S
P
Q
D
S
A
I
T
R
D
I
N
Site 75
Y619
R
T
F
P
A
H
D
Y
F
K
D
T
G
G
D
Site 76
S630
T
G
G
D
G
Q
D
S
L
Y
K
I
C
K
A
Site 77
Y632
G
D
G
Q
D
S
L
Y
K
I
C
K
A
Y
S
Site 78
Y641
I
C
K
A
Y
S
V
Y
D
E
E
I
G
Y
C
Site 79
Y647
V
Y
D
E
E
I
G
Y
C
Q
G
Q
S
F
L
Site 80
Y696
E
D
L
H
C
K
F
Y
Q
L
E
R
L
M
Q
Site 81
Y705
L
E
R
L
M
Q
E
Y
I
P
D
L
Y
N
H
Site 82
Y710
Q
E
Y
I
P
D
L
Y
N
H
F
L
D
I
S
Site 83
T774
S
K
D
D
L
L
L
T
D
F
E
G
A
L
K
Site 84
S793
Q
L
P
K
R
Y
R
S
E
E
N
A
K
K
L
Site 85
S810
L
A
C
N
M
K
I
S
Q
K
K
L
K
K
Y
Site 86
Y817
S
Q
K
K
L
K
K
Y
E
K
E
Y
H
T
M
Site 87
S866
L
A
H
E
L
V
T
S
K
I
A
L
R
K
D
Site 88
S909
K
R
R
L
E
E
E
S
A
Q
L
K
E
M
C
Site 89
S925
R
E
L
D
K
A
E
S
E
I
K
K
N
S
S
Site 90
Y937
N
S
S
I
I
G
D
Y
K
Q
I
C
S
Q
L
Site 91
S942
G
D
Y
K
Q
I
C
S
Q
L
S
E
R
L
E
Site 92
S945
K
Q
I
C
S
Q
L
S
E
R
L
E
K
Q
Q
Site 93
T953
E
R
L
E
K
Q
Q
T
A
N
K
V
E
I
E
Site 94
S986
E
G
R
V
K
G
I
S
S
T
K
E
V
L
D
Site 95
T996
K
E
V
L
D
E
D
T
D
E
E
K
E
T
L
Site 96
T1002
D
T
D
E
E
K
E
T
L
K
N
Q
L
R
E
Site 97
T1053
K
K
T
W
F
N
R
T
L
S
S
I
K
T
A
Site 98
S1055
T
W
F
N
R
T
L
S
S
I
K
T
A
T
G
Site 99
S1056
W
F
N
R
T
L
S
S
I
K
T
A
T
G
V
Site 100
T1059
R
T
L
S
S
I
K
T
A
T
G
V
Q
G
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation