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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ADAM18
Full Name:
Disintegrin and metalloproteinase domain-containing protein 18
Alias:
AD18; ADA18; ADAM metallopeptidase domain 18; ADAM27; TMDC III; TMDC3; TMDCIII; Transmembrane metalloproteinase-like, disintegrin-like, and cysteine- rich protein III; UNQ858/PRO1867
Type:
Adhesion
Mass (Da):
82856
Number AA:
739
UniProt ID:
Q9Y3Q7
International Prot ID:
IPI00003365
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005624
Uniprot
OncoNet
Molecular Function:
GO:0004222
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0030154
GO:0007275
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
R
L
Q
A
H
E
G
S
E
G
I
F
L
H
V
Site 2
S35
T
V
P
R
K
I
K
S
N
D
S
E
V
S
E
Site 3
S38
R
K
I
K
S
N
D
S
E
V
S
E
R
K
M
Site 4
S41
K
S
N
D
S
E
V
S
E
R
K
M
I
Y
I
Site 5
Y47
V
S
E
R
K
M
I
Y
I
I
T
I
D
G
Q
Site 6
T50
R
K
M
I
Y
I
I
T
I
D
G
Q
P
Y
T
Site 7
Y56
I
T
I
D
G
Q
P
Y
T
L
H
L
G
K
Q
Site 8
T57
T
I
D
G
Q
P
Y
T
L
H
L
G
K
Q
S
Site 9
S64
T
L
H
L
G
K
Q
S
F
L
P
Q
N
F
L
Site 10
Y73
L
P
Q
N
F
L
V
Y
T
Y
N
E
T
G
S
Site 11
T74
P
Q
N
F
L
V
Y
T
Y
N
E
T
G
S
L
Site 12
Y75
Q
N
F
L
V
Y
T
Y
N
E
T
G
S
L
H
Site 13
S80
Y
T
Y
N
E
T
G
S
L
H
S
V
S
P
Y
Site 14
S83
N
E
T
G
S
L
H
S
V
S
P
Y
F
M
M
Site 15
Y125
L
Q
F
E
N
I
S
Y
G
I
E
P
V
E
S
Site 16
S132
Y
G
I
E
P
V
E
S
S
A
R
F
E
H
I
Site 17
S133
G
I
E
P
V
E
S
S
A
R
F
E
H
I
I
Site 18
Y141
A
R
F
E
H
I
I
Y
Q
M
K
N
N
D
P
Site 19
Y167
I
W
Q
K
D
Q
P
Y
K
V
P
L
N
S
Q
Site 20
S173
P
Y
K
V
P
L
N
S
Q
I
K
N
L
S
K
Site 21
Y197
I
I
V
E
K
A
L
Y
D
Y
M
G
S
E
M
Site 22
S714
I
F
K
R
N
E
I
S
K
S
C
N
R
E
N
Site 23
S716
K
R
N
E
I
S
K
S
C
N
R
E
N
A
E
Site 24
Y724
C
N
R
E
N
A
E
Y
N
R
N
S
S
V
V
Site 25
S728
N
A
E
Y
N
R
N
S
S
V
V
S
E
S
D
Site 26
S729
A
E
Y
N
R
N
S
S
V
V
S
E
S
D
D
Site 27
S732
N
R
N
S
S
V
V
S
E
S
D
D
V
G
H
Site 28
S734
N
S
S
V
V
S
E
S
D
D
V
G
H
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation