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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GRIP1
Full Name:
Glutamate receptor-interacting protein 1
Alias:
glutamate receptor interacting protein 1
Type:
Mass (Da):
122423
Number AA:
1128
UniProt ID:
Q9Y3R0
International Prot ID:
IPI00409578
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0016023
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0050681
GO:0030159
GO:0003713
PhosphoSite+
KinaseNET
Biological Process:
GO:0030521
GO:0045893
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T17
C
Q
I
L
R
R
L
T
K
D
E
S
P
Y
T
Site 2
S21
R
R
L
T
K
D
E
S
P
Y
T
K
S
A
S
Site 3
T24
T
K
D
E
S
P
Y
T
K
S
A
S
Q
T
K
Site 4
S26
D
E
S
P
Y
T
K
S
A
S
Q
T
K
P
P
Site 5
S28
S
P
Y
T
K
S
A
S
Q
T
K
P
P
D
G
Site 6
T30
Y
T
K
S
A
S
Q
T
K
P
P
D
G
A
L
Site 7
S43
A
L
A
V
R
R
Q
S
I
P
E
E
F
K
G
Site 8
S51
I
P
E
E
F
K
G
S
T
V
V
E
L
M
K
Site 9
T67
E
G
T
T
L
G
L
T
V
S
G
G
I
D
K
Site 10
S69
T
T
L
G
L
T
V
S
G
G
I
D
K
D
G
Site 11
S81
K
D
G
K
P
R
V
S
N
L
R
Q
G
G
I
Site 12
S92
Q
G
G
I
A
A
R
S
D
Q
L
D
V
G
D
Site 13
Y100
D
Q
L
D
V
G
D
Y
I
K
A
V
N
G
I
Site 14
T154
I
F
R
T
V
E
V
T
L
H
K
E
G
N
T
Site 15
S177
A
H
D
D
R
N
K
S
R
P
V
V
I
T
C
Site 16
T183
K
S
R
P
V
V
I
T
C
V
R
P
G
G
P
Site 17
T196
G
P
A
D
R
E
G
T
I
K
P
G
D
R
L
Site 18
S205
K
P
G
D
R
L
L
S
V
D
G
I
R
L
L
Site 19
S285
I
V
I
D
K
I
K
S
A
S
I
A
D
R
C
Site 20
S287
I
D
K
I
K
S
A
S
I
A
D
R
C
G
A
Site 21
S303
H
V
G
D
H
I
L
S
I
D
G
T
S
M
E
Site 22
S308
I
L
S
I
D
G
T
S
M
E
Y
C
T
L
A
Site 23
S353
D
H
V
K
I
Q
R
S
D
R
Q
L
T
W
D
Site 24
T358
Q
R
S
D
R
Q
L
T
W
D
S
W
A
S
N
Site 25
S361
D
R
Q
L
T
W
D
S
W
A
S
N
H
S
S
Site 26
T371
S
N
H
S
S
L
H
T
N
H
H
Y
N
T
Y
Site 27
T389
H
C
R
V
P
A
L
T
F
P
K
A
P
P
P
Site 28
S398
P
K
A
P
P
P
N
S
P
P
A
L
V
S
S
Site 29
S404
N
S
P
P
A
L
V
S
S
S
F
S
P
T
S
Site 30
S405
S
P
P
A
L
V
S
S
S
F
S
P
T
S
M
Site 31
S406
P
P
A
L
V
S
S
S
F
S
P
T
S
M
S
Site 32
T410
V
S
S
S
F
S
P
T
S
M
S
A
Y
S
L
Site 33
S411
S
S
S
F
S
P
T
S
M
S
A
Y
S
L
S
Site 34
S413
S
F
S
P
T
S
M
S
A
Y
S
L
S
S
L
Site 35
Y415
S
P
T
S
M
S
A
Y
S
L
S
S
L
N
M
Site 36
S416
P
T
S
M
S
A
Y
S
L
S
S
L
N
M
G
Site 37
T424
L
S
S
L
N
M
G
T
L
P
R
S
L
Y
S
Site 38
S428
N
M
G
T
L
P
R
S
L
Y
S
T
S
P
R
Site 39
Y430
G
T
L
P
R
S
L
Y
S
T
S
P
R
G
T
Site 40
S431
T
L
P
R
S
L
Y
S
T
S
P
R
G
T
M
Site 41
T432
L
P
R
S
L
Y
S
T
S
P
R
G
T
M
M
Site 42
S433
P
R
S
L
Y
S
T
S
P
R
G
T
M
M
R
Site 43
T437
Y
S
T
S
P
R
G
T
M
M
R
R
R
L
K
Site 44
S450
L
K
K
K
D
F
K
S
S
L
S
L
A
S
S
Site 45
S451
K
K
K
D
F
K
S
S
L
S
L
A
S
S
T
Site 46
S453
K
D
F
K
S
S
L
S
L
A
S
S
T
V
G
Site 47
T494
L
Q
G
S
V
F
A
T
E
T
L
S
S
P
P
Site 48
S504
L
S
S
P
P
L
I
S
Y
I
E
A
D
S
P
Site 49
Y505
S
S
P
P
L
I
S
Y
I
E
A
D
S
P
A
Site 50
S510
I
S
Y
I
E
A
D
S
P
A
E
R
C
G
V
Site 51
T532
M
A
I
N
G
I
P
T
E
D
S
T
F
E
E
Site 52
S535
N
G
I
P
T
E
D
S
T
F
E
E
A
S
Q
Site 53
T536
G
I
P
T
E
D
S
T
F
E
E
A
S
Q
L
Site 54
S541
D
S
T
F
E
E
A
S
Q
L
L
R
D
S
S
Site 55
S547
A
S
Q
L
L
R
D
S
S
I
T
S
K
V
T
Site 56
S548
S
Q
L
L
R
D
S
S
I
T
S
K
V
T
L
Site 57
S551
L
R
D
S
S
I
T
S
K
V
T
L
E
I
E
Site 58
T571
S
V
I
P
S
S
G
T
F
H
V
K
L
P
K
Site 59
T587
H
N
V
E
L
G
I
T
I
S
S
P
S
S
R
Site 60
S589
V
E
L
G
I
T
I
S
S
P
S
S
R
K
P
Site 61
S590
E
L
G
I
T
I
S
S
P
S
S
R
K
P
G
Site 62
S592
G
I
T
I
S
S
P
S
S
R
K
P
G
D
P
Site 63
S593
I
T
I
S
S
P
S
S
R
K
P
G
D
P
L
Site 64
S603
P
G
D
P
L
V
I
S
D
I
K
K
G
S
V
Site 65
S609
I
S
D
I
K
K
G
S
V
A
H
R
T
G
T
Site 66
T614
K
G
S
V
A
H
R
T
G
T
L
E
L
G
D
Site 67
T616
S
V
A
H
R
T
G
T
L
E
L
G
D
K
L
Site 68
S661
I
R
K
D
E
D
N
S
D
E
Q
E
S
S
G
Site 69
S667
N
S
D
E
Q
E
S
S
G
A
I
I
Y
T
V
Site 70
T673
S
S
G
A
I
I
Y
T
V
E
L
K
R
Y
G
Site 71
Y679
Y
T
V
E
L
K
R
Y
G
G
P
L
G
I
T
Site 72
T686
Y
G
G
P
L
G
I
T
I
S
G
T
E
E
P
Site 73
S688
G
P
L
G
I
T
I
S
G
T
E
E
P
F
D
Site 74
T711
K
G
G
L
A
E
R
T
G
A
I
H
I
G
D
Site 75
S725
D
R
I
L
A
I
N
S
S
S
L
K
G
K
P
Site 76
S726
R
I
L
A
I
N
S
S
S
L
K
G
K
P
L
Site 77
S727
I
L
A
I
N
S
S
S
L
K
G
K
P
L
S
Site 78
S734
S
L
K
G
K
P
L
S
E
A
I
H
L
L
Q
Site 79
S759
K
K
Q
T
D
A
Q
S
A
S
S
P
K
K
F
Site 80
S761
Q
T
D
A
Q
S
A
S
S
P
K
K
F
P
I
Site 81
S762
T
D
A
Q
S
A
S
S
P
K
K
F
P
I
S
Site 82
S769
S
P
K
K
F
P
I
S
S
H
L
S
D
L
G
Site 83
S770
P
K
K
F
P
I
S
S
H
L
S
D
L
G
D
Site 84
S773
F
P
I
S
S
H
L
S
D
L
G
D
V
E
E
Site 85
S782
L
G
D
V
E
E
D
S
S
P
A
Q
K
P
G
Site 86
S783
G
D
V
E
E
D
S
S
P
A
Q
K
P
G
K
Site 87
S792
A
Q
K
P
G
K
L
S
D
M
Y
P
S
T
V
Site 88
Y795
P
G
K
L
S
D
M
Y
P
S
T
V
P
S
V
Site 89
S797
K
L
S
D
M
Y
P
S
T
V
P
S
V
D
S
Site 90
T798
L
S
D
M
Y
P
S
T
V
P
S
V
D
S
A
Site 91
S801
M
Y
P
S
T
V
P
S
V
D
S
A
V
D
S
Site 92
S804
S
T
V
P
S
V
D
S
A
V
D
S
W
D
G
Site 93
S808
S
V
D
S
A
V
D
S
W
D
G
S
A
I
D
Site 94
S812
A
V
D
S
W
D
G
S
A
I
D
T
S
Y
G
Site 95
T816
W
D
G
S
A
I
D
T
S
Y
G
T
E
G
T
Site 96
S817
D
G
S
A
I
D
T
S
Y
G
T
E
G
T
S
Site 97
Y818
G
S
A
I
D
T
S
Y
G
T
E
G
T
S
F
Site 98
S824
S
Y
G
T
E
G
T
S
F
Q
A
S
G
Y
N
Site 99
S828
E
G
T
S
F
Q
A
S
G
Y
N
F
N
T
Y
Site 100
Y835
S
G
Y
N
F
N
T
Y
D
W
R
S
P
K
Q
Site 101
S839
F
N
T
Y
D
W
R
S
P
K
Q
R
G
S
L
Site 102
S845
R
S
P
K
Q
R
G
S
L
S
P
V
T
K
P
Site 103
S847
P
K
Q
R
G
S
L
S
P
V
T
K
P
R
S
Site 104
T850
R
G
S
L
S
P
V
T
K
P
R
S
Q
T
Y
Site 105
S854
S
P
V
T
K
P
R
S
Q
T
Y
P
D
V
G
Site 106
T856
V
T
K
P
R
S
Q
T
Y
P
D
V
G
L
S
Site 107
Y857
T
K
P
R
S
Q
T
Y
P
D
V
G
L
S
Y
Site 108
S863
T
Y
P
D
V
G
L
S
Y
E
D
W
D
R
S
Site 109
S870
S
Y
E
D
W
D
R
S
T
A
S
G
F
A
G
Site 110
T871
Y
E
D
W
D
R
S
T
A
S
G
F
A
G
A
Site 111
S881
G
F
A
G
A
A
D
S
A
E
T
E
Q
E
E
Site 112
S892
E
Q
E
E
N
F
W
S
Q
A
L
E
D
L
E
Site 113
T900
Q
A
L
E
D
L
E
T
C
G
Q
S
G
I
L
Site 114
S919
E
K
A
D
R
R
V
S
L
R
N
M
T
L
L
Site 115
S933
L
A
T
I
M
S
G
S
T
M
S
L
N
H
E
Site 116
S936
I
M
S
G
S
T
M
S
L
N
H
E
A
P
T
Site 117
T943
S
L
N
H
E
A
P
T
P
R
S
Q
L
G
R
Site 118
S946
H
E
A
P
T
P
R
S
Q
L
G
R
Q
A
S
Site 119
S953
S
Q
L
G
R
Q
A
S
F
Q
E
R
S
S
S
Site 120
S958
Q
A
S
F
Q
E
R
S
S
S
R
P
H
Y
S
Site 121
S959
A
S
F
Q
E
R
S
S
S
R
P
H
Y
S
Q
Site 122
S960
S
F
Q
E
R
S
S
S
R
P
H
Y
S
Q
T
Site 123
Y964
R
S
S
S
R
P
H
Y
S
Q
T
T
R
S
N
Site 124
S965
S
S
S
R
P
H
Y
S
Q
T
T
R
S
N
T
Site 125
T967
S
R
P
H
Y
S
Q
T
T
R
S
N
T
L
P
Site 126
S970
H
Y
S
Q
T
T
R
S
N
T
L
P
S
D
V
Site 127
T972
S
Q
T
T
R
S
N
T
L
P
S
D
V
G
R
Site 128
S975
T
R
S
N
T
L
P
S
D
V
G
R
K
S
V
Site 129
S981
P
S
D
V
G
R
K
S
V
T
L
R
K
M
K
Site 130
T983
D
V
G
R
K
S
V
T
L
R
K
M
K
Q
E
Site 131
S996
Q
E
I
K
E
I
M
S
P
T
P
V
E
L
H
Site 132
T998
I
K
E
I
M
S
P
T
P
V
E
L
H
K
V
Site 133
Y1008
E
L
H
K
V
T
L
Y
K
D
S
D
M
E
D
Site 134
S1011
K
V
T
L
Y
K
D
S
D
M
E
D
F
G
F
Site 135
Y1030
G
L
L
E
K
G
V
Y
V
K
N
I
R
P
A
Site 136
Y1048
D
L
G
G
L
K
P
Y
D
R
L
L
Q
V
N
Site 137
S1083
N
K
L
D
L
V
I
S
R
N
P
L
A
S
Q
Site 138
S1089
I
S
R
N
P
L
A
S
Q
K
S
I
D
Q
Q
Site 139
S1092
N
P
L
A
S
Q
K
S
I
D
Q
Q
S
L
P
Site 140
S1097
Q
K
S
I
D
Q
Q
S
L
P
G
D
W
S
E
Site 141
S1103
Q
S
L
P
G
D
W
S
E
Q
N
S
A
F
F
Site 142
S1107
G
D
W
S
E
Q
N
S
A
F
F
Q
Q
P
S
Site 143
T1121
S
H
G
G
N
L
E
T
R
E
P
T
N
T
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation