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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Neu2
Full Name:
Sialidase-2
Alias:
Cytosolic sialidase; EC 3.2.1.18; N-acetyl-alpha-neuraminidase 2; Sialidase 2
Type:
Enzyme - Hydrolase
Mass (Da):
42254
Number AA:
380
UniProt ID:
Q9Y3R4
International Prot ID:
IPI00022482
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0004308
PhosphoSite+
KinaseNET
Biological Process:
GO:0008152
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
L
P
V
L
Q
K
E
S
V
F
Q
S
G
A
H
Site 2
S15
Q
K
E
S
V
F
Q
S
G
A
H
A
Y
R
I
Site 3
S43
A
F
A
E
Q
R
A
S
K
K
D
E
H
A
E
Site 4
Y59
I
V
L
R
R
G
D
Y
D
A
P
T
H
Q
V
Site 5
S84
A
R
L
D
G
H
R
S
M
N
P
C
P
L
Y
Site 6
Y91
S
M
N
P
C
P
L
Y
D
A
Q
T
G
T
L
Site 7
T128
V
T
R
L
C
Q
V
T
S
T
D
H
G
R
T
Site 8
T130
R
L
C
Q
V
T
S
T
D
H
G
R
T
W
S
Site 9
S137
T
D
H
G
R
T
W
S
S
P
R
D
L
T
D
Site 10
S138
D
H
G
R
T
W
S
S
P
R
D
L
T
D
A
Site 11
T143
W
S
S
P
R
D
L
T
D
A
A
I
G
P
A
Site 12
Y151
D
A
A
I
G
P
A
Y
R
E
W
S
T
F
A
Site 13
S155
G
P
A
Y
R
E
W
S
T
F
A
V
G
P
G
Site 14
T156
P
A
Y
R
E
W
S
T
F
A
V
G
P
G
H
Site 15
S173
Q
L
H
D
R
A
R
S
L
V
V
P
A
Y
A
Site 16
Y179
R
S
L
V
V
P
A
Y
A
Y
R
K
L
H
P
Site 17
T216
G
H
F
V
A
Q
D
T
L
E
C
Q
V
A
E
Site 18
T233
T
G
E
Q
R
V
V
T
L
N
A
R
S
H
L
Site 19
S248
R
A
R
V
Q
A
Q
S
T
N
D
G
L
D
F
Site 20
T249
A
R
V
Q
A
Q
S
T
N
D
G
L
D
F
Q
Site 21
S258
D
G
L
D
F
Q
E
S
Q
L
V
K
K
L
V
Site 22
S275
P
P
Q
G
C
Q
G
S
V
I
S
F
P
S
P
Site 23
S278
G
C
Q
G
S
V
I
S
F
P
S
P
R
S
G
Site 24
S281
G
S
V
I
S
F
P
S
P
R
S
G
P
G
S
Site 25
S284
I
S
F
P
S
P
R
S
G
P
G
S
P
A
Q
Site 26
S288
S
P
R
S
G
P
G
S
P
A
Q
W
L
L
Y
Site 27
Y295
S
P
A
Q
W
L
L
Y
T
H
P
T
H
S
W
Site 28
Y310
Q
R
A
D
L
G
A
Y
L
N
P
R
P
P
A
Site 29
S322
P
P
A
P
E
A
W
S
E
P
V
L
L
A
K
Site 30
S335
A
K
G
S
C
A
Y
S
D
L
Q
S
M
G
T
Site 31
S339
C
A
Y
S
D
L
Q
S
M
G
T
G
P
D
G
Site 32
T342
S
D
L
Q
S
M
G
T
G
P
D
G
S
P
L
Site 33
Y354
S
P
L
F
G
C
L
Y
E
A
N
D
Y
E
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation