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Updated November 2019
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Protein Info
Short Name:
DOPEY2
Full Name:
Protein dopey-2
Alias:
C21orf5; DOP2; dopey family member 2; dopey-2; KIAA0933
Type:
Unknown function
Mass (Da):
258184
Number AA:
2298
UniProt ID:
Q9Y3R5
International Prot ID:
IPI00294653
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000139
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0006895
GO:0007029
GO:0007275
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y12
E
Q
E
L
L
N
D
Y
R
Y
R
S
Y
S
S
Site 2
Y14
E
L
L
N
D
Y
R
Y
R
S
Y
S
S
V
I
Site 3
S16
L
N
D
Y
R
Y
R
S
Y
S
S
V
I
E
K
Site 4
Y17
N
D
Y
R
Y
R
S
Y
S
S
V
I
E
K
A
Site 5
S18
D
Y
R
Y
R
S
Y
S
S
V
I
E
K
A
L
Site 6
S30
K
A
L
R
N
F
E
S
S
S
E
W
A
D
L
Site 7
S31
A
L
R
N
F
E
S
S
S
E
W
A
D
L
I
Site 8
S32
L
R
N
F
E
S
S
S
E
W
A
D
L
I
S
Site 9
S39
S
E
W
A
D
L
I
S
S
L
G
K
L
N
K
Site 10
S50
K
L
N
K
A
L
Q
S
N
L
R
Y
S
L
L
Site 11
S55
L
Q
S
N
L
R
Y
S
L
L
P
R
R
L
L
Site 12
S162
L
E
E
G
S
E
I
S
D
R
T
D
A
L
L
Site 13
T165
G
S
E
I
S
D
R
T
D
A
L
L
L
R
L
Site 14
Y218
A
P
G
R
E
Q
K
Y
M
L
G
T
N
H
Q
Site 15
T227
L
G
T
N
H
Q
L
T
V
K
S
L
R
A
S
Site 16
S230
N
H
Q
L
T
V
K
S
L
R
A
S
L
L
D
Site 17
S234
T
V
K
S
L
R
A
S
L
L
D
S
N
V
L
Site 18
S238
L
R
A
S
L
L
D
S
N
V
L
V
Q
R
N
Site 19
S262
P
F
Y
T
C
L
D
S
N
E
R
A
I
P
L
Site 20
T284
I
L
S
A
A
T
Q
T
L
L
R
R
D
M
S
Site 21
S291
T
L
L
R
R
D
M
S
L
N
R
R
L
Y
A
Site 22
Y297
M
S
L
N
R
R
L
Y
A
W
L
L
G
S
D
Site 23
T309
G
S
D
I
K
G
N
T
V
V
P
E
S
E
I
Site 24
S314
G
N
T
V
V
P
E
S
E
I
S
N
S
Y
E
Site 25
S317
V
V
P
E
S
E
I
S
N
S
Y
E
D
Q
S
Site 26
S319
P
E
S
E
I
S
N
S
Y
E
D
Q
S
S
Y
Site 27
Y320
E
S
E
I
S
N
S
Y
E
D
Q
S
S
Y
F
Site 28
S324
S
N
S
Y
E
D
Q
S
S
Y
F
F
E
K
Y
Site 29
S325
N
S
Y
E
D
Q
S
S
Y
F
F
E
K
Y
S
Site 30
Y326
S
Y
E
D
Q
S
S
Y
F
F
E
K
Y
S
K
Site 31
Y331
S
S
Y
F
F
E
K
Y
S
K
D
L
L
V
E
Site 32
Y360
V
E
E
R
H
H
A
Y
L
K
P
F
R
V
L
Site 33
S402
Y
C
R
D
A
L
G
S
D
L
K
L
S
Y
T
Site 34
S407
L
G
S
D
L
K
L
S
Y
T
Q
S
G
N
S
Site 35
Y408
G
S
D
L
K
L
S
Y
T
Q
S
G
N
S
L
Site 36
T409
S
D
L
K
L
S
Y
T
Q
S
G
N
S
L
I
Site 37
S411
L
K
L
S
Y
T
Q
S
G
N
S
L
I
S
A
Site 38
S414
S
Y
T
Q
S
G
N
S
L
I
S
A
I
K
E
Site 39
S426
I
K
E
N
R
N
A
S
E
I
V
K
T
V
N
Site 40
Y447
S
T
D
F
L
W
D
Y
M
T
R
C
F
E
E
Site 41
S464
R
P
V
K
Q
R
Y
S
V
R
N
S
V
S
P
Site 42
S468
Q
R
Y
S
V
R
N
S
V
S
P
P
P
T
V
Site 43
S470
Y
S
V
R
N
S
V
S
P
P
P
T
V
S
E
Site 44
Y494
D
V
I
P
L
E
L
Y
S
E
V
Q
T
Q
Y
Site 45
Y501
Y
S
E
V
Q
T
Q
Y
L
P
Q
V
L
G
C
Site 46
S521
A
E
D
M
E
A
L
S
L
P
E
L
T
H
A
Site 47
S537
K
T
C
F
K
V
L
S
K
V
Q
M
P
P
S
Site 48
S544
S
K
V
Q
M
P
P
S
Y
L
D
T
E
S
T
Site 49
Y545
K
V
Q
M
P
P
S
Y
L
D
T
E
S
T
S
Site 50
T548
M
P
P
S
Y
L
D
T
E
S
T
S
G
T
S
Site 51
S550
P
S
Y
L
D
T
E
S
T
S
G
T
S
S
P
Site 52
T551
S
Y
L
D
T
E
S
T
S
G
T
S
S
P
V
Site 53
S552
Y
L
D
T
E
S
T
S
G
T
S
S
P
V
K
Site 54
T554
D
T
E
S
T
S
G
T
S
S
P
V
K
G
E
Site 55
S556
E
S
T
S
G
T
S
S
P
V
K
G
E
N
G
Site 56
S580
I
P
G
D
E
D
A
S
F
P
P
L
K
S
E
Site 57
S586
A
S
F
P
P
L
K
S
E
D
S
G
I
G
L
Site 58
S589
P
P
L
K
S
E
D
S
G
I
G
L
S
A
S
Site 59
S594
E
D
S
G
I
G
L
S
A
S
S
P
E
L
S
Site 60
S596
S
G
I
G
L
S
A
S
S
P
E
L
S
E
H
Site 61
S597
G
I
G
L
S
A
S
S
P
E
L
S
E
H
L
Site 62
S601
S
A
S
S
P
E
L
S
E
H
L
R
V
P
R
Site 63
S610
H
L
R
V
P
R
V
S
L
E
R
D
D
V
W
Site 64
T626
K
G
G
S
M
Q
R
T
F
L
C
I
Q
E
L
Site 65
T648
N
I
F
G
V
Q
L
T
A
S
G
E
E
S
K
Site 66
S650
F
G
V
Q
L
T
A
S
G
E
E
S
K
S
E
Site 67
S654
L
T
A
S
G
E
E
S
K
S
E
E
P
A
G
Site 68
S656
A
S
G
E
E
S
K
S
E
E
P
A
G
K
R
Site 69
T668
G
K
R
D
R
D
G
T
Q
S
L
A
A
N
D
Site 70
S670
R
D
R
D
G
T
Q
S
L
A
A
N
D
S
S
Site 71
S676
Q
S
L
A
A
N
D
S
S
R
K
N
S
W
E
Site 72
S677
S
L
A
A
N
D
S
S
R
K
N
S
W
E
P
Site 73
S681
N
D
S
S
R
K
N
S
W
E
P
K
P
I
T
Site 74
T688
S
W
E
P
K
P
I
T
V
P
Q
F
K
Q
M
Site 75
T701
Q
M
L
S
D
L
F
T
A
R
G
S
P
F
K
Site 76
S705
D
L
F
T
A
R
G
S
P
F
K
T
K
S
S
Site 77
T709
A
R
G
S
P
F
K
T
K
S
S
E
S
P
S
Site 78
S711
G
S
P
F
K
T
K
S
S
E
S
P
S
S
S
Site 79
S712
S
P
F
K
T
K
S
S
E
S
P
S
S
S
P
Site 80
S714
F
K
T
K
S
S
E
S
P
S
S
S
P
S
S
Site 81
S716
T
K
S
S
E
S
P
S
S
S
P
S
S
P
A
Site 82
S717
K
S
S
E
S
P
S
S
S
P
S
S
P
A
R
Site 83
S718
S
S
E
S
P
S
S
S
P
S
S
P
A
R
K
Site 84
S720
E
S
P
S
S
S
P
S
S
P
A
R
K
N
G
Site 85
S721
S
P
S
S
S
P
S
S
P
A
R
K
N
G
G
Site 86
Y766
D
C
A
T
F
P
V
Y
L
S
E
E
E
T
E
Site 87
S768
A
T
F
P
V
Y
L
S
E
E
E
T
E
Q
L
Site 88
T772
V
Y
L
S
E
E
E
T
E
Q
L
C
A
T
L
Site 89
S788
Q
L
P
G
A
G
D
S
S
F
P
S
W
L
K
Site 90
S789
L
P
G
A
G
D
S
S
F
P
S
W
L
K
S
Site 91
S792
A
G
D
S
S
F
P
S
W
L
K
S
L
M
T
Site 92
Y838
I
E
D
K
M
K
R
Y
K
S
S
G
H
N
P
Site 93
S840
D
K
M
K
R
Y
K
S
S
G
H
N
P
F
F
Site 94
Y873
I
A
E
K
T
D
F
Y
Q
R
V
A
R
V
L
Site 95
T894
E
T
R
E
H
H
V
T
C
V
E
L
F
Y
R
Site 96
S936
L
E
A
L
F
R
F
S
V
I
W
H
L
T
R
Site 97
T942
F
S
V
I
W
H
L
T
R
E
I
Q
G
S
R
Site 98
S948
L
T
R
E
I
Q
G
S
R
V
T
S
H
N
R
Site 99
T951
E
I
Q
G
S
R
V
T
S
H
N
R
S
F
D
Site 100
S952
I
Q
G
S
R
V
T
S
H
N
R
S
F
D
R
Site 101
S956
R
V
T
S
H
N
R
S
F
D
R
S
L
F
V
Site 102
S960
H
N
R
S
F
D
R
S
L
F
V
V
L
D
S
Site 103
T1008
L
L
L
L
Q
P
K
T
Q
R
T
S
I
H
C
Site 104
S1012
Q
P
K
T
Q
R
T
S
I
H
C
L
K
Q
E
Site 105
S1021
H
C
L
K
Q
E
N
S
A
D
D
L
H
R
W
Site 106
T1034
R
W
F
N
R
K
K
T
S
F
R
E
A
C
A
Site 107
S1035
W
F
N
R
K
K
T
S
F
R
E
A
C
A
V
Site 108
S1048
A
V
P
E
P
Q
E
S
G
S
E
E
H
L
P
Site 109
S1050
P
E
P
Q
E
S
G
S
E
E
H
L
P
L
S
Site 110
S1057
S
E
E
H
L
P
L
S
Q
F
T
T
V
D
R
Site 111
T1061
L
P
L
S
Q
F
T
T
V
D
R
E
A
I
W
Site 112
Y1078
V
E
K
E
P
E
K
Y
P
L
R
G
E
L
S
Site 113
S1085
Y
P
L
R
G
E
L
S
E
E
E
L
P
Y
Y
Site 114
Y1091
L
S
E
E
E
L
P
Y
Y
V
E
L
P
D
R
Site 115
Y1092
S
E
E
E
L
P
Y
Y
V
E
L
P
D
R
T
Site 116
S1106
T
A
H
G
A
P
D
S
S
E
H
T
E
S
A
Site 117
S1107
A
H
G
A
P
D
S
S
E
H
T
E
S
A
D
Site 118
T1110
A
P
D
S
S
E
H
T
E
S
A
D
T
S
S
Site 119
S1112
D
S
S
E
H
T
E
S
A
D
T
S
S
G
H
Site 120
T1115
E
H
T
E
S
A
D
T
S
S
G
H
T
D
S
Site 121
S1116
H
T
E
S
A
D
T
S
S
G
H
T
D
S
E
Site 122
S1117
T
E
S
A
D
T
S
S
G
H
T
D
S
E
N
Site 123
T1120
A
D
T
S
S
G
H
T
D
S
E
N
T
S
S
Site 124
S1122
T
S
S
G
H
T
D
S
E
N
T
S
S
F
S
Site 125
T1125
G
H
T
D
S
E
N
T
S
S
F
S
S
P
S
Site 126
S1126
H
T
D
S
E
N
T
S
S
F
S
S
P
S
H
Site 127
S1127
T
D
S
E
N
T
S
S
F
S
S
P
S
H
D
Site 128
S1129
S
E
N
T
S
S
F
S
S
P
S
H
D
L
Q
Site 129
S1130
E
N
T
S
S
F
S
S
P
S
H
D
L
Q
E
Site 130
S1132
T
S
S
F
S
S
P
S
H
D
L
Q
E
L
S
Site 131
S1139
S
H
D
L
Q
E
L
S
N
E
E
N
C
C
A
Site 132
Y1155
I
P
M
G
G
R
A
Y
P
K
R
S
A
L
L
Site 133
S1169
L
A
A
F
Q
S
E
S
F
K
A
G
A
K
L
Site 134
S1177
F
K
A
G
A
K
L
S
L
V
R
V
D
S
D
Site 135
S1183
L
S
L
V
R
V
D
S
D
K
T
Q
A
S
E
Site 136
T1186
V
R
V
D
S
D
K
T
Q
A
S
E
S
F
S
Site 137
S1189
D
S
D
K
T
Q
A
S
E
S
F
S
S
D
E
Site 138
S1191
D
K
T
Q
A
S
E
S
F
S
S
D
E
E
A
Site 139
S1193
T
Q
A
S
E
S
F
S
S
D
E
E
A
D
L
Site 140
S1194
Q
A
S
E
S
F
S
S
D
E
E
A
D
L
E
Site 141
T1206
D
L
E
L
Q
A
L
T
T
S
R
L
L
K
Q
Site 142
Y1231
L
F
K
H
I
L
L
Y
L
Q
P
Y
D
S
R
Site 143
S1237
L
Y
L
Q
P
Y
D
S
R
R
V
L
Y
A
F
Site 144
S1263
K
E
F
I
E
A
V
S
R
T
S
M
D
T
S
Site 145
S1266
I
E
A
V
S
R
T
S
M
D
T
S
S
T
A
Site 146
T1269
V
S
R
T
S
M
D
T
S
S
T
A
H
L
N
Site 147
S1270
S
R
T
S
M
D
T
S
S
T
A
H
L
N
L
Site 148
S1293
Q
E
A
L
I
G
Q
S
F
Y
G
K
L
Q
T
Site 149
Y1295
A
L
I
G
Q
S
F
Y
G
K
L
Q
T
Q
V
Site 150
T1300
S
F
Y
G
K
L
Q
T
Q
V
P
N
V
C
P
Site 151
Y1330
L
R
S
Y
Y
P
C
Y
L
K
V
S
H
R
D
Site 152
S1361
R
I
M
M
Q
L
V
S
V
A
K
S
S
E
G
Site 153
S1365
Q
L
V
S
V
A
K
S
S
E
G
K
N
V
E
Site 154
S1376
K
N
V
E
F
I
H
S
L
L
Q
R
C
K
V
Site 155
S1394
V
L
L
S
L
S
A
S
M
Y
T
S
Q
K
R
Site 156
Y1396
L
S
L
S
A
S
M
Y
T
S
Q
K
R
Y
G
Site 157
S1398
L
S
A
S
M
Y
T
S
Q
K
R
Y
G
L
A
Site 158
T1406
Q
K
R
Y
G
L
A
T
A
H
H
G
R
A
L
Site 159
S1417
G
R
A
L
P
E
D
S
L
F
E
E
S
L
I
Site 160
S1422
E
D
S
L
F
E
E
S
L
I
N
L
G
Q
D
Site 161
Y1487
Q
A
I
S
A
L
Q
Y
V
Q
P
H
P
L
T
Site 162
Y1511
V
R
G
L
Q
P
A
Y
G
Y
G
M
H
P
A
Site 163
S1533
S
L
P
Y
F
G
K
S
L
G
W
T
V
T
P
Site 164
Y1556
L
D
D
L
V
K
Q
Y
E
S
E
S
V
K
L
Site 165
S1558
D
L
V
K
Q
Y
E
S
E
S
V
K
L
S
V
Site 166
S1560
V
K
Q
Y
E
S
E
S
V
K
L
S
V
S
T
Site 167
S1564
E
S
E
S
V
K
L
S
V
S
T
T
S
K
R
Site 168
S1566
E
S
V
K
L
S
V
S
T
T
S
K
R
E
N
Site 169
T1568
V
K
L
S
V
S
T
T
S
K
R
E
N
I
S
Site 170
S1569
K
L
S
V
S
T
T
S
K
R
E
N
I
S
P
Site 171
S1575
T
S
K
R
E
N
I
S
P
D
Y
P
L
T
L
Site 172
Y1578
R
E
N
I
S
P
D
Y
P
L
T
L
L
E
G
Site 173
S1658
L
G
A
T
K
G
S
S
S
V
Y
F
K
T
T
Site 174
S1659
G
A
T
K
G
S
S
S
V
Y
F
K
T
T
K
Site 175
Y1661
T
K
G
S
S
S
V
Y
F
K
T
T
K
T
I
Site 176
T1664
S
S
S
V
Y
F
K
T
T
K
T
I
R
Q
K
Site 177
T1665
S
S
V
Y
F
K
T
T
K
T
I
R
Q
K
I
Site 178
T1667
V
Y
F
K
T
T
K
T
I
R
Q
K
I
L
D
Site 179
S1704
R
K
K
A
Q
R
H
S
K
M
K
I
I
P
T
Site 180
T1711
S
K
M
K
I
I
P
T
A
S
A
S
Q
L
T
Site 181
S1755
V
K
G
G
D
E
K
S
P
L
V
D
I
P
V
Site 182
T1814
S
M
L
N
D
F
V
T
R
T
P
N
L
E
N
Site 183
T1816
L
N
D
F
V
T
R
T
P
N
L
E
N
K
K
Site 184
S1846
V
G
N
I
A
G
S
S
L
E
Q
T
S
W
L
Site 185
T1850
A
G
S
S
L
E
Q
T
S
W
L
S
R
N
L
Site 186
S1851
G
S
S
L
E
Q
T
S
W
L
S
R
N
L
E
Site 187
S1866
V
K
A
Q
P
Q
A
S
L
E
E
S
D
A
E
Site 188
S1870
P
Q
A
S
L
E
E
S
D
A
E
E
D
L
Y
Site 189
Y1877
S
D
A
E
E
D
L
Y
D
A
A
A
A
S
A
Site 190
Y1914
A
S
L
L
D
M
V
Y
R
S
D
E
K
E
K
Site 191
S1916
L
L
D
M
V
Y
R
S
D
E
K
E
K
A
V
Site 192
Y1932
L
I
S
R
L
L
Y
Y
V
F
P
Y
L
R
N
Site 193
S1941
F
P
Y
L
R
N
H
S
A
Y
N
A
P
S
F
Site 194
Y1943
Y
L
R
N
H
S
A
Y
N
A
P
S
F
R
A
Site 195
S1947
H
S
A
Y
N
A
P
S
F
R
A
G
A
Q
L
Site 196
S1959
A
Q
L
L
S
S
L
S
G
Y
A
Y
T
K
R
Site 197
Y1961
L
L
S
S
L
S
G
Y
A
Y
T
K
R
A
W
Site 198
Y1963
S
S
L
S
G
Y
A
Y
T
K
R
A
W
R
K
Site 199
T2000
S
I
I
D
H
L
L
T
H
E
K
T
M
F
K
Site 200
T2004
H
L
L
T
H
E
K
T
M
F
K
D
L
M
N
Site 201
S2014
K
D
L
M
N
M
Q
S
S
S
L
K
L
F
S
Site 202
S2021
S
S
S
L
K
L
F
S
S
F
E
Q
K
A
M
Site 203
S2022
S
S
L
K
L
F
S
S
F
E
Q
K
A
M
L
Site 204
Y2048
E
L
D
Q
Y
H
L
Y
L
P
L
I
Q
E
R
Site 205
T2057
P
L
I
Q
E
R
L
T
D
N
L
R
V
G
Q
Site 206
T2065
D
N
L
R
V
G
Q
T
S
I
V
A
A
Q
M
Site 207
S2066
N
L
R
V
G
Q
T
S
I
V
A
A
Q
M
F
Site 208
T2102
M
V
S
E
L
I
Q
T
F
T
Q
L
E
E
D
Site 209
S2116
D
L
K
D
E
D
E
S
L
R
S
T
N
K
V
Site 210
T2120
E
D
E
S
L
R
S
T
N
K
V
N
R
T
K
Site 211
S2137
V
P
D
A
N
G
P
S
V
G
E
I
P
Q
S
Site 212
S2161
K
F
L
D
T
A
L
S
F
P
P
D
K
M
P
Site 213
S2190
T
E
G
P
A
F
L
S
D
V
E
E
N
H
Q
Site 214
T2203
H
Q
E
C
K
P
H
T
V
R
I
L
E
L
L
Site 215
S2218
K
L
K
F
G
E
I
S
S
S
D
E
I
T
M
Site 216
S2219
L
K
F
G
E
I
S
S
S
D
E
I
T
M
K
Site 217
S2220
K
F
G
E
I
S
S
S
D
E
I
T
M
K
S
Site 218
T2224
I
S
S
S
D
E
I
T
M
K
S
E
F
P
L
Site 219
S2227
S
D
E
I
T
M
K
S
E
F
P
L
L
R
Q
Site 220
S2236
F
P
L
L
R
Q
H
S
V
S
S
I
R
Q
L
Site 221
S2238
L
L
R
Q
H
S
V
S
S
I
R
Q
L
M
P
Site 222
S2239
L
R
Q
H
S
V
S
S
I
R
Q
L
M
P
F
Site 223
T2256
T
L
N
G
A
F
K
T
Q
R
Q
L
P
A
D
Site 224
S2264
Q
R
Q
L
P
A
D
S
P
G
T
P
F
L
D
Site 225
T2275
P
F
L
D
F
P
V
T
D
S
P
R
I
L
K
Site 226
S2277
L
D
F
P
V
T
D
S
P
R
I
L
K
Q
L
Site 227
Y2290
Q
L
E
E
C
I
E
Y
D
F
L
E
H
P
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation