KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
PYGO1
Full Name:
Pygopus homolog 1
Alias:
DKFZp547g0910; Pygo1; Pygopus homologue 1 (drosophila)
Type:
Mass (Da):
45116
Number AA:
419
UniProt ID:
Q9Y3Y4
International Prot ID:
IPI00163904
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0016055
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
P
A
E
N
S
P
A
P
A
Y
K
V
Site 2
Y11
E
N
S
P
A
P
A
Y
K
V
S
S
H
G
G
Site 3
S14
P
A
P
A
Y
K
V
S
S
H
G
G
D
S
G
Site 4
S15
A
P
A
Y
K
V
S
S
H
G
G
D
S
G
L
Site 5
S20
V
S
S
H
G
G
D
S
G
L
D
G
L
G
G
Site 6
S34
G
P
G
V
Q
L
G
S
P
D
K
K
K
R
K
Site 7
T44
K
K
K
R
K
A
N
T
Q
G
P
S
F
P
P
Site 8
S48
K
A
N
T
Q
G
P
S
F
P
P
L
S
E
Y
Site 9
S53
G
P
S
F
P
P
L
S
E
Y
A
P
P
P
N
Site 10
Y55
S
F
P
P
L
S
E
Y
A
P
P
P
N
P
N
Site 11
S63
A
P
P
P
N
P
N
S
D
H
L
V
A
A
N
Site 12
Y76
A
N
P
F
D
D
N
Y
N
T
I
S
Y
K
P
Site 13
T78
P
F
D
D
N
Y
N
T
I
S
Y
K
P
L
P
Site 14
S80
D
D
N
Y
N
T
I
S
Y
K
P
L
P
S
S
Site 15
S86
I
S
Y
K
P
L
P
S
S
N
P
Y
L
G
P
Site 16
S87
S
Y
K
P
L
P
S
S
N
P
Y
L
G
P
G
Site 17
Y90
P
L
P
S
S
N
P
Y
L
G
P
G
Y
P
G
Site 18
Y95
N
P
Y
L
G
P
G
Y
P
G
F
G
G
Y
S
Site 19
T103
P
G
F
G
G
Y
S
T
F
R
M
P
P
H
V
Site 20
S115
P
H
V
P
P
R
M
S
S
P
Y
C
G
P
Y
Site 21
S116
H
V
P
P
R
M
S
S
P
Y
C
G
P
Y
S
Site 22
Y118
P
P
R
M
S
S
P
Y
C
G
P
Y
S
L
R
Site 23
S123
S
P
Y
C
G
P
Y
S
L
R
N
Q
P
H
P
Site 24
S154
N
F
G
P
H
D
N
S
S
F
G
N
P
S
Y
Site 25
S155
F
G
P
H
D
N
S
S
F
G
N
P
S
Y
N
Site 26
S160
N
S
S
F
G
N
P
S
Y
N
N
A
L
S
Q
Site 27
Y161
S
S
F
G
N
P
S
Y
N
N
A
L
S
Q
N
Site 28
S166
P
S
Y
N
N
A
L
S
Q
N
V
N
M
P
N
Site 29
S185
Q
N
P
A
E
N
F
S
Q
I
P
P
Q
N
A
Site 30
S193
Q
I
P
P
Q
N
A
S
Q
V
S
N
P
D
L
Site 31
S196
P
Q
N
A
S
Q
V
S
N
P
D
L
A
S
N
Site 32
S202
V
S
N
P
D
L
A
S
N
F
V
P
G
N
N
Site 33
S210
N
F
V
P
G
N
N
S
N
F
T
S
P
L
E
Site 34
S214
G
N
N
S
N
F
T
S
P
L
E
S
N
H
S
Site 35
S218
N
F
T
S
P
L
E
S
N
H
S
F
I
P
P
Site 36
S221
S
P
L
E
S
N
H
S
F
I
P
P
P
N
T
Site 37
T228
S
F
I
P
P
P
N
T
F
G
Q
A
K
A
P
Site 38
T242
P
P
P
K
Q
D
F
T
Q
G
A
T
K
N
T
Site 39
T249
T
Q
G
A
T
K
N
T
N
Q
N
S
S
A
H
Site 40
S253
T
K
N
T
N
Q
N
S
S
A
H
P
P
H
L
Site 41
T265
P
H
L
N
M
D
D
T
V
N
Q
S
N
I
E
Site 42
S287
N
A
V
N
Q
E
N
S
R
S
S
S
T
E
A
Site 43
S289
V
N
Q
E
N
S
R
S
S
S
T
E
A
T
N
Site 44
S290
N
Q
E
N
S
R
S
S
S
T
E
A
T
N
N
Site 45
S291
Q
E
N
S
R
S
S
S
T
E
A
T
N
N
N
Site 46
T295
R
S
S
S
T
E
A
T
N
N
N
P
A
N
G
Site 47
T318
R
G
A
A
D
A
C
T
T
E
K
S
N
K
S
Site 48
S322
D
A
C
T
T
E
K
S
N
K
S
S
L
H
P
Site 49
S326
T
E
K
S
N
K
S
S
L
H
P
N
R
H
G
Site 50
S335
H
P
N
R
H
G
H
S
S
S
D
P
V
Y
P
Site 51
S336
P
N
R
H
G
H
S
S
S
D
P
V
Y
P
C
Site 52
S337
N
R
H
G
H
S
S
S
D
P
V
Y
P
C
G
Site 53
Y341
H
S
S
S
D
P
V
Y
P
C
G
I
C
T
N
Site 54
T409
Q
L
M
R
T
R
E
T
F
G
P
S
A
V
G
Site 55
S413
T
R
E
T
F
G
P
S
A
V
G
S
D
A
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation