KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
PKP3
Full Name:
Plakophilin-3
Alias:
Plakophilin 3
Type:
Adhesion protein
Mass (Da):
87082
Number AA:
797
UniProt ID:
Q9Y446
International Prot ID:
IPI00026952
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030057
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007155
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
Q
D
G
N
F
L
L
S
A
L
Q
P
E
A
G
Site 2
T75
E
P
E
P
E
A
E
T
A
R
G
T
S
R
G
Site 3
T79
E
A
E
T
A
R
G
T
S
R
G
Q
Y
H
T
Site 4
S80
A
E
T
A
R
G
T
S
R
G
Q
Y
H
T
L
Site 5
Y84
R
G
T
S
R
G
Q
Y
H
T
L
Q
A
G
F
Site 6
T86
T
S
R
G
Q
Y
H
T
L
Q
A
G
F
S
S
Site 7
S92
H
T
L
Q
A
G
F
S
S
R
S
Q
G
L
S
Site 8
S93
T
L
Q
A
G
F
S
S
R
S
Q
G
L
S
G
Site 9
S95
Q
A
G
F
S
S
R
S
Q
G
L
S
G
D
K
Site 10
S99
S
S
R
S
Q
G
L
S
G
D
K
T
S
G
F
Site 11
T103
Q
G
L
S
G
D
K
T
S
G
F
R
P
I
A
Site 12
S104
G
L
S
G
D
K
T
S
G
F
R
P
I
A
K
Site 13
Y114
R
P
I
A
K
P
A
Y
S
P
A
S
W
S
S
Site 14
S115
P
I
A
K
P
A
Y
S
P
A
S
W
S
S
R
Site 15
S118
K
P
A
Y
S
P
A
S
W
S
S
R
S
A
V
Site 16
S120
A
Y
S
P
A
S
W
S
S
R
S
A
V
D
L
Site 17
S121
Y
S
P
A
S
W
S
S
R
S
A
V
D
L
S
Site 18
S123
P
A
S
W
S
S
R
S
A
V
D
L
S
C
S
Site 19
S128
S
R
S
A
V
D
L
S
C
S
R
R
L
S
S
Site 20
S130
S
A
V
D
L
S
C
S
R
R
L
S
S
A
H
Site 21
S134
L
S
C
S
R
R
L
S
S
A
H
N
G
G
S
Site 22
S135
S
C
S
R
R
L
S
S
A
H
N
G
G
S
A
Site 23
S141
S
S
A
H
N
G
G
S
A
F
G
A
A
G
Y
Site 24
Y148
S
A
F
G
A
A
G
Y
G
G
A
Q
P
T
P
Site 25
T154
G
Y
G
G
A
Q
P
T
P
P
M
P
T
R
P
Site 26
T159
Q
P
T
P
P
M
P
T
R
P
V
S
F
H
E
Site 27
S163
P
M
P
T
R
P
V
S
F
H
E
R
G
G
V
Site 28
S172
H
E
R
G
G
V
G
S
R
A
D
Y
D
T
L
Site 29
Y176
G
V
G
S
R
A
D
Y
D
T
L
S
L
R
S
Site 30
T178
G
S
R
A
D
Y
D
T
L
S
L
R
S
L
R
Site 31
S180
R
A
D
Y
D
T
L
S
L
R
S
L
R
L
G
Site 32
S183
Y
D
T
L
S
L
R
S
L
R
L
G
P
G
G
Site 33
Y195
P
G
G
L
D
D
R
Y
S
L
V
S
E
Q
L
Site 34
S196
G
G
L
D
D
R
Y
S
L
V
S
E
Q
L
E
Site 35
S199
D
D
R
Y
S
L
V
S
E
Q
L
E
P
A
A
Site 36
T207
E
Q
L
E
P
A
A
T
S
T
Y
R
A
F
A
Site 37
S208
Q
L
E
P
A
A
T
S
T
Y
R
A
F
A
Y
Site 38
T209
L
E
P
A
A
T
S
T
Y
R
A
F
A
Y
E
Site 39
Y210
E
P
A
A
T
S
T
Y
R
A
F
A
Y
E
R
Site 40
Y215
S
T
Y
R
A
F
A
Y
E
R
Q
A
S
S
S
Site 41
S220
F
A
Y
E
R
Q
A
S
S
S
S
S
R
A
G
Site 42
S221
A
Y
E
R
Q
A
S
S
S
S
S
R
A
G
G
Site 43
S222
Y
E
R
Q
A
S
S
S
S
S
R
A
G
G
L
Site 44
S223
E
R
Q
A
S
S
S
S
S
R
A
G
G
L
D
Site 45
S224
R
Q
A
S
S
S
S
S
R
A
G
G
L
D
W
Site 46
T235
G
L
D
W
P
E
A
T
E
V
S
P
S
R
T
Site 47
S238
W
P
E
A
T
E
V
S
P
S
R
T
I
R
A
Site 48
S240
E
A
T
E
V
S
P
S
R
T
I
R
A
P
A
Site 49
T242
T
E
V
S
P
S
R
T
I
R
A
P
A
V
R
Site 50
T250
I
R
A
P
A
V
R
T
L
Q
R
F
Q
S
S
Site 51
S256
R
T
L
Q
R
F
Q
S
S
H
R
S
R
G
V
Site 52
S257
T
L
Q
R
F
Q
S
S
H
R
S
R
G
V
G
Site 53
S260
R
F
Q
S
S
H
R
S
R
G
V
G
G
A
V
Site 54
S280
E
P
V
A
R
A
P
S
V
R
S
L
S
L
S
Site 55
S283
A
R
A
P
S
V
R
S
L
S
L
S
L
A
D
Site 56
S302
P
D
V
H
G
F
N
S
Y
G
S
H
R
T
L
Site 57
Y303
D
V
H
G
F
N
S
Y
G
S
H
R
T
L
Q
Site 58
S305
H
G
F
N
S
Y
G
S
H
R
T
L
Q
R
L
Site 59
T308
N
S
Y
G
S
H
R
T
L
Q
R
L
S
S
G
Site 60
S313
H
R
T
L
Q
R
L
S
S
G
F
D
D
I
D
Site 61
S314
R
T
L
Q
R
L
S
S
G
F
D
D
I
D
L
Site 62
S323
F
D
D
I
D
L
P
S
A
V
K
Y
L
M
A
Site 63
Y327
D
L
P
S
A
V
K
Y
L
M
A
S
D
P
N
Site 64
S331
A
V
K
Y
L
M
A
S
D
P
N
L
Q
V
L
Site 65
Y342
L
Q
V
L
G
A
A
Y
I
Q
H
K
C
Y
S
Site 66
S359
A
A
K
K
Q
A
R
S
L
Q
A
V
P
R
L
Site 67
T382
Q
E
V
Q
R
H
A
T
G
A
M
R
N
L
I
Site 68
Y390
G
A
M
R
N
L
I
Y
D
N
A
D
N
K
L
Site 69
T411
G
I
F
E
L
L
R
T
L
R
E
Q
D
D
E
Site 70
S431
T
G
I
L
W
N
L
S
S
S
D
H
L
K
D
Site 71
S432
G
I
L
W
N
L
S
S
S
D
H
L
K
D
R
Site 72
S433
I
L
W
N
L
S
S
S
D
H
L
K
D
R
L
Site 73
T444
K
D
R
L
A
R
D
T
L
E
Q
L
T
D
L
Site 74
T449
R
D
T
L
E
Q
L
T
D
L
V
L
S
P
L
Site 75
Y476
A
S
E
A
E
I
F
Y
N
A
T
G
F
L
R
Site 76
S486
T
G
F
L
R
N
L
S
S
A
S
Q
A
T
R
Site 77
S487
G
F
L
R
N
L
S
S
A
S
Q
A
T
R
Q
Site 78
S489
L
R
N
L
S
S
A
S
Q
A
T
R
Q
K
M
Site 79
S523
A
G
K
C
E
D
K
S
V
E
N
A
V
C
V
Site 80
S535
V
C
V
L
R
N
L
S
Y
R
L
Y
D
E
M
Site 81
Y536
C
V
L
R
N
L
S
Y
R
L
Y
D
E
M
P
Site 82
Y539
R
N
L
S
Y
R
L
Y
D
E
M
P
P
S
A
Site 83
S545
L
Y
D
E
M
P
P
S
A
L
Q
R
L
E
G
Site 84
T571
G
E
V
V
G
C
F
T
P
Q
S
R
R
L
R
Site 85
S574
V
G
C
F
T
P
Q
S
R
R
L
R
E
L
P
Site 86
Y611
S
P
Q
I
V
G
L
Y
N
R
L
L
Q
R
C
Site 87
T624
R
C
E
L
N
R
H
T
T
E
A
A
A
G
A
Site 88
T625
C
E
L
N
R
H
T
T
E
A
A
A
G
A
L
Site 89
T666
P
L
L
D
R
V
R
T
A
D
H
H
Q
L
R
Site 90
S674
A
D
H
H
Q
L
R
S
L
T
G
L
I
R
N
Site 91
T676
H
H
Q
L
R
S
L
T
G
L
I
R
N
L
S
Site 92
S683
T
G
L
I
R
N
L
S
R
N
A
R
N
K
D
Site 93
S693
A
R
N
K
D
E
M
S
T
K
V
V
S
H
L
Site 94
S707
L
I
E
K
L
P
G
S
V
G
E
K
S
P
P
Site 95
S712
P
G
S
V
G
E
K
S
P
P
A
E
V
L
V
Site 96
S757
F
I
K
K
K
R
D
S
P
D
S
E
K
S
S
Site 97
S760
K
K
R
D
S
P
D
S
E
K
S
S
R
A
A
Site 98
S763
D
S
P
D
S
E
K
S
S
R
A
A
S
S
L
Site 99
S764
S
P
D
S
E
K
S
S
R
A
A
S
S
L
L
Site 100
S768
E
K
S
S
R
A
A
S
S
L
L
A
N
L
W
Site 101
S769
K
S
S
R
A
A
S
S
L
L
A
N
L
W
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation