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Updated November 2019
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Protein Info
Short Name:
DMXL1
Full Name:
DmX-like protein 1
Alias:
Dmx-like 1; XL1; X-like 1
Type:
Unknown function
Mass (Da):
337853
Number AA:
3027
UniProt ID:
Q9Y485
International Prot ID:
IPI00294728
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
N
L
H
Q
V
L
T
G
A
V
N
P
G
D
Site 2
S19
N
P
G
D
H
C
F
S
V
G
S
I
G
D
Q
Site 3
T29
S
I
G
D
Q
R
F
T
A
Y
A
S
G
C
D
Site 4
Y31
G
D
Q
R
F
T
A
Y
A
S
G
C
D
I
V
Site 5
Y98
Q
K
K
N
L
E
L
Y
S
Q
W
Q
K
S
G
Site 6
S99
K
K
N
L
E
L
Y
S
Q
W
Q
K
S
G
Q
Site 7
S104
L
Y
S
Q
W
Q
K
S
G
Q
F
F
L
E
S
Site 8
T117
E
S
I
A
H
N
I
T
W
D
P
T
G
S
R
Site 9
T121
H
N
I
T
W
D
P
T
G
S
R
L
L
T
G
Site 10
S123
I
T
W
D
P
T
G
S
R
L
L
T
G
S
S
Site 11
T127
P
T
G
S
R
L
L
T
G
S
S
Y
L
Q
L
Site 12
S129
G
S
R
L
L
T
G
S
S
Y
L
Q
L
W
S
Site 13
S130
S
R
L
L
T
G
S
S
Y
L
Q
L
W
S
N
Site 14
Y131
R
L
L
T
G
S
S
Y
L
Q
L
W
S
N
T
Site 15
S177
Q
V
H
L
M
K
F
S
P
D
G
E
F
F
A
Site 16
T185
P
D
G
E
F
F
A
T
A
G
K
D
D
C
L
Site 17
T204
Y
N
V
E
N
W
R
T
A
V
T
S
P
D
G
Site 18
S208
N
W
R
T
A
V
T
S
P
D
G
S
S
E
K
Site 19
S212
A
V
T
S
P
D
G
S
S
E
K
Q
S
Q
G
Site 20
S213
V
T
S
P
D
G
S
S
E
K
Q
S
Q
G
E
Site 21
S217
D
G
S
S
E
K
Q
S
Q
G
E
I
D
F
S
Site 22
S224
S
Q
G
E
I
D
F
S
F
V
Y
L
A
H
P
Site 23
S238
P
R
A
V
N
G
F
S
W
R
K
T
S
K
Y
Site 24
T242
N
G
F
S
W
R
K
T
S
K
Y
M
P
R
A
Site 25
S243
G
F
S
W
R
K
T
S
K
Y
M
P
R
A
S
Site 26
Y245
S
W
R
K
T
S
K
Y
M
P
R
A
S
V
C
Site 27
Y279
L
P
N
D
C
L
L
Y
G
G
D
C
S
H
W
Site 28
S301
N
N
F
K
R
N
A
S
S
K
E
R
V
Q
N
Site 29
S302
N
F
K
R
N
A
S
S
K
E
R
V
Q
N
A
Site 30
S324
F
R
R
G
R
R
R
S
L
A
L
V
A
H
T
Site 31
T347
P
H
H
V
H
R
N
T
P
L
H
A
N
A
L
Site 32
S377
P
L
L
P
S
I
T
S
L
S
L
N
E
N
E
Site 33
S379
L
P
S
I
T
S
L
S
L
N
E
N
E
E
K
Site 34
T403
N
N
K
E
L
H
F
T
L
S
M
E
V
F
L
Site 35
S405
K
E
L
H
F
T
L
S
M
E
V
F
L
Q
Q
Site 36
S416
F
L
Q
Q
L
R
K
S
F
E
Q
P
S
S
E
Site 37
S421
R
K
S
F
E
Q
P
S
S
E
A
S
V
E
D
Site 38
S422
K
S
F
E
Q
P
S
S
E
A
S
V
E
D
S
Site 39
S425
E
Q
P
S
S
E
A
S
V
E
D
S
N
Q
A
Site 40
S429
S
E
A
S
V
E
D
S
N
Q
A
D
V
K
S
Site 41
S436
S
N
Q
A
D
V
K
S
D
E
E
T
D
D
G
Site 42
T440
D
V
K
S
D
E
E
T
D
D
G
V
D
D
L
Site 43
S465
C
D
K
M
V
P
N
S
S
F
T
S
L
S
S
Site 44
S466
D
K
M
V
P
N
S
S
F
T
S
L
S
S
A
Site 45
S471
N
S
S
F
T
S
L
S
S
A
A
I
D
H
Q
Site 46
S472
S
S
F
T
S
L
S
S
A
A
I
D
H
Q
I
Site 47
S484
H
Q
I
E
V
L
L
S
E
W
S
K
N
A
D
Site 48
S487
E
V
L
L
S
E
W
S
K
N
A
D
M
L
F
Site 49
Y514
H
V
D
W
L
D
E
Y
Q
P
G
M
F
R
Q
Site 50
T552
S
I
M
M
Y
A
C
T
K
N
V
D
L
A
I
Site 51
S572
K
P
S
G
L
T
R
S
T
S
M
L
I
S
S
Site 52
T573
P
S
G
L
T
R
S
T
S
M
L
I
S
S
G
Site 53
S574
S
G
L
T
R
S
T
S
M
L
I
S
S
G
H
Site 54
S578
R
S
T
S
M
L
I
S
S
G
H
N
K
S
S
Site 55
S579
S
T
S
M
L
I
S
S
G
H
N
K
S
S
N
Site 56
S584
I
S
S
G
H
N
K
S
S
N
S
L
K
L
S
Site 57
S585
S
S
G
H
N
K
S
S
N
S
L
K
L
S
I
Site 58
S587
G
H
N
K
S
S
N
S
L
K
L
S
I
F
T
Site 59
S607
I
S
K
H
A
D
G
S
L
N
Q
W
L
V
S
Site 60
T623
A
E
E
S
A
F
S
T
V
L
S
I
S
H
K
Site 61
S626
S
A
F
S
T
V
L
S
I
S
H
K
S
R
Y
Site 62
S628
F
S
T
V
L
S
I
S
H
K
S
R
Y
C
G
Site 63
Y633
S
I
S
H
K
S
R
Y
C
G
H
R
F
H
L
Site 64
T663
S
H
H
N
A
L
R
T
P
D
V
D
N
P
E
Site 65
T684
N
I
E
E
C
S
L
T
Q
Q
N
K
S
T
V
Site 66
S689
S
L
T
Q
Q
N
K
S
T
V
D
V
A
F
Q
Site 67
T690
L
T
Q
Q
N
K
S
T
V
D
V
A
F
Q
D
Site 68
Y702
F
Q
D
P
S
A
V
Y
S
E
L
I
L
W
R
Site 69
S703
Q
D
P
S
A
V
Y
S
E
L
I
L
W
R
V
Site 70
S717
V
D
P
V
G
P
L
S
F
S
G
G
V
S
E
Site 71
S719
P
V
G
P
L
S
F
S
G
G
V
S
E
L
A
Site 72
Y754
P
S
Y
C
L
G
A
Y
C
N
S
P
S
A
C
Site 73
Y773
D
G
Q
Y
L
R
L
Y
E
A
V
I
D
A
K
Site 74
S784
I
D
A
K
K
L
L
S
E
L
S
N
P
E
I
Site 75
S787
K
K
L
L
S
E
L
S
N
P
E
I
S
K
Y
Site 76
Y794
S
N
P
E
I
S
K
Y
V
G
E
V
F
N
I
Site 77
S803
G
E
V
F
N
I
V
S
Q
Q
S
T
A
R
P
Site 78
T820
I
I
A
L
D
P
I
T
K
L
H
G
R
K
T
Site 79
T827
T
K
L
H
G
R
K
T
Q
L
L
H
V
F
E
Site 80
S846
L
N
N
L
E
K
K
S
L
G
K
D
S
I
L
Site 81
S854
L
G
K
D
S
I
L
S
N
A
G
S
S
P
N
Site 82
S858
S
I
L
S
N
A
G
S
S
P
N
G
F
S
E
Site 83
S859
I
L
S
N
A
G
S
S
P
N
G
F
S
E
K
Site 84
S864
G
S
S
P
N
G
F
S
E
K
F
Y
L
I
V
Site 85
S891
M
W
N
L
H
L
K
S
I
P
V
S
L
D
E
Site 86
S895
H
L
K
S
I
P
V
S
L
D
E
K
V
D
T
Site 87
T902
S
L
D
E
K
V
D
T
K
L
S
E
A
V
W
Site 88
S905
E
K
V
D
T
K
L
S
E
A
V
W
Q
P
E
Site 89
Y915
V
W
Q
P
E
E
H
Y
S
S
S
P
E
K
I
Site 90
S916
W
Q
P
E
E
H
Y
S
S
S
P
E
K
I
L
Site 91
S917
Q
P
E
E
H
Y
S
S
S
P
E
K
I
L
S
Site 92
S918
P
E
E
H
Y
S
S
S
P
E
K
I
L
S
P
Site 93
S924
S
S
P
E
K
I
L
S
P
F
S
Q
K
Y
Q
Site 94
S927
E
K
I
L
S
P
F
S
Q
K
Y
Q
A
C
R
Site 95
Y930
L
S
P
F
S
Q
K
Y
Q
A
C
R
A
N
L
Site 96
S939
A
C
R
A
N
L
Q
S
T
S
R
L
T
L
F
Site 97
S947
T
S
R
L
T
L
F
S
E
M
V
Y
S
Q
E
Site 98
S952
L
F
S
E
M
V
Y
S
Q
E
L
H
L
P
E
Site 99
S965
P
E
G
V
E
I
I
S
I
K
P
S
A
G
H
Site 100
S969
E
I
I
S
I
K
P
S
A
G
H
L
S
S
S
Site 101
S974
K
P
S
A
G
H
L
S
S
S
S
I
Y
P
A
Site 102
S975
P
S
A
G
H
L
S
S
S
S
I
Y
P
A
C
Site 103
S976
S
A
G
H
L
S
S
S
S
I
Y
P
A
C
S
Site 104
Y979
H
L
S
S
S
S
I
Y
P
A
C
S
A
P
Y
Site 105
S991
A
P
Y
L
L
A
T
S
C
S
D
E
K
V
R
Site 106
S993
Y
L
L
A
T
S
C
S
D
E
K
V
R
F
W
Site 107
T1005
R
F
W
R
C
R
V
T
D
G
E
S
A
T
S
Site 108
S1012
T
D
G
E
S
A
T
S
K
N
G
K
I
D
L
Site 109
Y1021
N
G
K
I
D
L
A
Y
I
W
E
E
W
P
L
Site 110
S1036
L
I
E
D
G
L
Q
S
N
S
S
I
T
V
P
Site 111
S1038
E
D
G
L
Q
S
N
S
S
I
T
V
P
G
R
Site 112
S1039
D
G
L
Q
S
N
S
S
I
T
V
P
G
R
P
Site 113
T1041
L
Q
S
N
S
S
I
T
V
P
G
R
P
V
E
Site 114
S1050
P
G
R
P
V
E
V
S
C
A
H
T
N
R
L
Site 115
Y1061
T
N
R
L
A
V
A
Y
K
Q
P
A
S
N
S
Site 116
S1066
V
A
Y
K
Q
P
A
S
N
S
R
S
S
Q
D
Site 117
S1068
Y
K
Q
P
A
S
N
S
R
S
S
Q
D
F
V
Site 118
S1070
Q
P
A
S
N
S
R
S
S
Q
D
F
V
M
H
Site 119
S1071
P
A
S
N
S
R
S
S
Q
D
F
V
M
H
V
Site 120
S1089
E
C
E
S
T
G
G
S
C
W
V
L
E
Q
T
Site 121
S1108
E
L
S
T
V
L
D
S
G
I
S
V
D
S
N
Site 122
S1114
D
S
G
I
S
V
D
S
N
L
V
A
Y
N
K
Site 123
Y1125
A
Y
N
K
Q
D
M
Y
L
S
S
K
E
N
I
Site 124
S1128
K
Q
D
M
Y
L
S
S
K
E
N
I
T
S
N
Site 125
S1134
S
S
K
E
N
I
T
S
N
T
K
H
L
V
H
Site 126
S1151
W
M
S
R
E
D
G
S
H
I
L
T
V
G
I
Site 127
T1176
A
G
K
V
Q
D
Q
T
G
K
E
T
L
A
F
Site 128
S1207
L
R
S
V
D
L
V
S
S
V
D
G
S
P
P
Site 129
S1208
R
S
V
D
L
V
S
S
V
D
G
S
P
P
F
Site 130
S1218
G
S
P
P
F
P
V
S
L
S
W
V
R
D
G
Site 131
T1252
S
K
Q
E
P
V
I
T
D
S
Y
S
G
S
T
Site 132
S1254
Q
E
P
V
I
T
D
S
Y
S
G
S
T
P
S
Site 133
Y1255
E
P
V
I
T
D
S
Y
S
G
S
T
P
S
I
Site 134
S1256
P
V
I
T
D
S
Y
S
G
S
T
P
S
I
T
Site 135
S1258
I
T
D
S
Y
S
G
S
T
P
S
I
T
S
L
Site 136
T1259
T
D
S
Y
S
G
S
T
P
S
I
T
S
L
I
Site 137
S1261
S
Y
S
G
S
T
P
S
I
T
S
L
I
K
Q
Site 138
T1263
S
G
S
T
P
S
I
T
S
L
I
K
Q
S
N
Site 139
S1264
G
S
T
P
S
I
T
S
L
I
K
Q
S
N
S
Site 140
S1269
I
T
S
L
I
K
Q
S
N
S
S
S
G
L
H
Site 141
S1271
S
L
I
K
Q
S
N
S
S
S
G
L
H
P
P
Site 142
S1273
I
K
Q
S
N
S
S
S
G
L
H
P
P
K
K
Site 143
T1281
G
L
H
P
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T
N
T
P
F
K
S
K
H
H
L
A
L
S
Site 296
S2590
S
K
H
H
L
A
L
S
V
K
R
L
W
Q
Y
Site 297
Y2597
S
V
K
R
L
W
Q
Y
L
V
K
Q
E
E
I
Site 298
T2607
K
Q
E
E
I
Q
E
T
F
I
K
N
I
F
T
Site 299
Y2628
E
I
E
A
D
L
G
Y
P
G
G
K
A
R
I
Site 300
T2644
H
K
E
S
D
I
I
T
A
F
A
V
N
K
A
Site 301
S2661
N
C
I
A
I
A
S
S
H
D
V
Q
E
L
D
Site 302
S2692
I
E
V
E
T
K
G
S
E
D
F
L
V
I
H
Site 303
T2705
I
H
A
R
D
D
L
T
A
V
Q
G
T
T
P
Site 304
T2711
L
T
A
V
Q
G
T
T
P
Y
T
H
S
N
P
Site 305
Y2713
A
V
Q
G
T
T
P
Y
T
H
S
N
P
G
T
Site 306
T2714
V
Q
G
T
T
P
Y
T
H
S
N
P
G
T
P
Site 307
S2716
G
T
T
P
Y
T
H
S
N
P
G
T
P
I
N
Site 308
T2720
Y
T
H
S
N
P
G
T
P
I
N
M
P
W
L
Site 309
T2732
P
W
L
G
S
T
Q
T
G
R
G
A
S
V
M
Site 310
S2737
T
Q
T
G
R
G
A
S
V
M
I
K
K
A
I
Site 311
T2751
I
N
N
V
R
R
M
T
S
H
P
T
L
P
Y
Site 312
S2752
N
N
V
R
R
M
T
S
H
P
T
L
P
Y
Y
Site 313
T2755
R
R
M
T
S
H
P
T
L
P
Y
Y
L
T
G
Site 314
Y2759
S
H
P
T
L
P
Y
Y
L
T
G
A
Q
D
G
Site 315
T2761
P
T
L
P
Y
Y
L
T
G
A
Q
D
G
S
V
Site 316
S2767
L
T
G
A
Q
D
G
S
V
R
M
F
E
W
G
Site 317
S2788
C
F
R
S
G
G
N
S
R
V
T
R
M
R
F
Site 318
T2791
S
G
G
N
S
R
V
T
R
M
R
F
N
Y
Q
Site 319
Y2797
V
T
R
M
R
F
N
Y
Q
G
N
K
F
G
I
Site 320
Y2810
G
I
V
D
A
D
G
Y
L
S
L
Y
Q
T
N
Site 321
Y2814
A
D
G
Y
L
S
L
Y
Q
T
N
W
K
C
C
Site 322
S2826
K
C
C
P
V
T
G
S
M
P
K
P
Y
L
T
Site 323
T2883
D
S
L
V
H
A
F
T
C
H
D
S
G
A
T
Site 324
S2903
P
K
H
Q
L
L
I
S
G
G
R
K
G
F
T
Site 325
T2910
S
G
G
R
K
G
F
T
Y
V
F
D
L
C
Q
Site 326
Y2911
G
G
R
K
G
F
T
Y
V
F
D
L
C
Q
R
Site 327
S2926
Q
Q
R
Q
L
F
Q
S
H
D
S
P
V
K
A
Site 328
S2929
Q
L
F
Q
S
H
D
S
P
V
K
A
V
A
V
Site 329
T2939
K
A
V
A
V
D
P
T
E
E
Y
F
V
T
G
Site 330
Y2942
A
V
D
P
T
E
E
Y
F
V
T
G
S
A
E
Site 331
T2945
P
T
E
E
Y
F
V
T
G
S
A
E
G
N
I
Site 332
S2947
E
E
Y
F
V
T
G
S
A
E
G
N
I
K
I
Site 333
T2965
S
T
F
G
L
L
H
T
F
V
S
E
H
A
R
Site 334
S2968
G
L
L
H
T
F
V
S
E
H
A
R
Q
S
I
Site 335
S2974
V
S
E
H
A
R
Q
S
I
F
R
N
I
G
T
Site 336
S3013
R
I
L
P
D
Q
F
S
P
L
N
E
V
L
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation