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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TLN1
Full Name:
Talin-1
Alias:
ILWEQ; Talin 1; TLN
Type:
Cytoskeletal protein
Mass (Da):
269767
Number AA:
2541
UniProt ID:
Q9Y490
International Prot ID:
IPI00784273
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005911
GO:0005856
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0030274
GO:0003779
GO:0005200
PhosphoSite+
KinaseNET
Biological Process:
GO:0007043
GO:0006928
GO:0007016
Phosida
TranscriptoNet
STRING
Kinexus Products
Talin 1 Y70 phosphosite-specific antibody AB-PN542#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN542#Talin-1 (Y270-H283), peptide - Powder PE-01AML95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01AML95#Talin 1 (A67-L73, human) pY70 phosphopeptide - Powder PE-04ADP85#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ADP85
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T16
S
I
G
N
V
V
K
T
M
Q
F
E
P
S
T
Site 2
S22
K
T
M
Q
F
E
P
S
T
M
V
Y
D
A
C
Site 3
T23
T
M
Q
F
E
P
S
T
M
V
Y
D
A
C
R
Site 4
Y26
F
E
P
S
T
M
V
Y
D
A
C
R
I
I
R
Site 5
S52
S
D
F
G
L
F
L
S
D
D
D
P
K
K
G
Site 6
Y70
E
A
G
K
A
L
D
Y
Y
M
L
R
N
G
D
Talin 1 Y70 phosphosite-specific antibody AB-PN542#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN542#Talin 1 (A67-L73, human) pY70 phosphopeptide - Powder PE-04ADP85#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ADP85
Site 7
Y71
A
G
K
A
L
D
Y
Y
M
L
R
N
G
D
T
Site 8
T78
Y
M
L
R
N
G
D
T
M
E
Y
R
K
K
Q
Site 9
Y81
R
N
G
D
T
M
E
Y
R
K
K
Q
R
P
L
Site 10
S105
K
T
I
M
V
D
D
S
K
T
V
T
D
M
L
Site 11
T122
I
C
A
R
I
G
I
T
N
H
D
E
Y
S
L
Site 12
Y127
G
I
T
N
H
D
E
Y
S
L
V
R
E
L
M
Site 13
S128
I
T
N
H
D
E
Y
S
L
V
R
E
L
M
E
Site 14
T142
E
E
K
K
E
E
I
T
G
T
L
R
K
D
K
Site 15
T144
K
K
E
E
I
T
G
T
L
R
K
D
K
T
L
Site 16
T150
G
T
L
R
K
D
K
T
L
L
R
D
E
K
K
Site 17
T167
K
L
K
Q
K
L
H
T
D
D
E
L
N
W
L
Site 18
T179
N
W
L
D
H
G
R
T
L
R
E
Q
G
V
E
Site 19
T190
Q
G
V
E
E
H
E
T
L
L
L
R
R
K
F
Site 20
Y199
L
L
R
R
K
F
F
Y
S
D
Q
N
V
D
S
Site 21
S200
L
R
R
K
F
F
Y
S
D
Q
N
V
D
S
R
Site 22
S206
Y
S
D
Q
N
V
D
S
R
D
P
V
Q
L
N
Site 23
S227
R
D
D
I
L
N
G
S
H
P
V
S
F
D
K
Site 24
S231
L
N
G
S
H
P
V
S
F
D
K
A
C
E
F
Site 25
Y270
K
D
F
L
P
K
E
Y
V
K
Q
K
G
E
R
Site 26
Y298
E
I
E
A
K
V
R
Y
V
K
L
A
R
S
L
Site 27
T344
V
M
R
V
D
E
K
T
K
E
V
I
Q
E
W
Site 28
S362
N
I
K
R
W
A
A
S
P
K
S
F
T
L
D
Site 29
S365
R
W
A
A
S
P
K
S
F
T
L
D
F
G
D
Site 30
Y373
F
T
L
D
F
G
D
Y
Q
D
G
Y
Y
S
V
Site 31
Y377
F
G
D
Y
Q
D
G
Y
Y
S
V
Q
T
T
E
Site 32
Y378
G
D
Y
Q
D
G
Y
Y
S
V
Q
T
T
E
G
Site 33
S379
D
Y
Q
D
G
Y
Y
S
V
Q
T
T
E
G
E
Site 34
T383
G
Y
Y
S
V
Q
T
T
E
G
E
Q
I
A
Q
Site 35
S405
I
I
L
K
K
K
K
S
K
D
H
F
G
L
E
Site 36
S417
G
L
E
G
D
E
E
S
T
M
L
E
D
S
V
Site 37
T418
L
E
G
D
E
E
S
T
M
L
E
D
S
V
S
Site 38
S423
E
S
T
M
L
E
D
S
V
S
P
K
K
S
T
Site 39
S425
T
M
L
E
D
S
V
S
P
K
K
S
T
V
L
Site 40
S429
D
S
V
S
P
K
K
S
T
V
L
Q
Q
Q
Y
Site 41
Y436
S
T
V
L
Q
Q
Q
Y
N
R
V
G
K
V
E
Site 42
S455
A
L
P
A
I
M
R
S
G
A
S
G
P
E
N
Site 43
T489
R
G
H
M
P
P
L
T
S
A
Q
Q
A
L
T
Site 44
T496
T
S
A
Q
Q
A
L
T
G
T
I
N
S
S
M
Site 45
T498
A
Q
Q
A
L
T
G
T
I
N
S
S
M
Q
A
Site 46
T518
A
T
L
D
D
F
D
T
L
P
P
L
G
Q
D
Site 47
S528
P
L
G
Q
D
A
A
S
K
A
W
R
K
N
K
Site 48
S539
R
K
N
K
M
D
E
S
K
H
E
I
H
S
Q
Site 49
S545
E
S
K
H
E
I
H
S
Q
V
D
A
I
T
A
Site 50
Y570
G
D
P
A
E
T
D
Y
T
A
V
G
C
A
V
Site 51
T571
D
P
A
E
T
D
Y
T
A
V
G
C
A
V
T
Site 52
T579
A
V
G
C
A
V
T
T
I
S
S
N
L
T
E
Site 53
T585
T
T
I
S
S
N
L
T
E
M
S
R
G
V
K
Site 54
S588
S
S
N
L
T
E
M
S
R
G
V
K
L
L
A
Site 55
S625
A
V
S
E
L
L
R
S
A
Q
P
A
S
A
E
Site 56
S630
L
R
S
A
Q
P
A
S
A
E
P
R
Q
N
L
Site 57
T660
Q
Q
I
G
E
S
D
T
D
P
H
F
Q
D
A
Site 58
S688
A
L
V
L
K
A
K
S
V
A
Q
R
T
E
D
Site 59
T700
T
E
D
S
G
L
Q
T
Q
V
I
A
A
A
T
Site 60
S752
K
A
V
E
G
C
V
S
A
S
Q
A
A
T
E
Site 61
S754
V
E
G
C
V
S
A
S
Q
A
A
T
E
D
G
Site 62
T758
V
S
A
S
Q
A
A
T
E
D
G
Q
L
L
R
Site 63
T802
A
G
R
Y
D
Q
A
T
D
T
I
L
T
V
T
Site 64
T804
R
Y
D
Q
A
T
D
T
I
L
T
V
T
E
N
Site 65
S815
V
T
E
N
I
F
S
S
M
G
D
A
G
E
M
Site 66
S858
E
N
S
R
K
L
L
S
A
A
K
I
L
A
D
Site 67
S883
G
A
A
A
H
P
D
S
E
E
Q
Q
Q
R
L
Site 68
T901
A
E
G
L
R
M
A
T
N
A
A
A
Q
N
A
Site 69
S940
A
A
A
Q
H
A
A
S
T
P
K
A
S
A
G
Site 70
T941
A
A
Q
H
A
A
S
T
P
K
A
S
A
G
P
Site 71
S945
A
A
S
T
P
K
A
S
A
G
P
Q
P
L
L
Site 72
S955
P
Q
P
L
L
V
Q
S
C
K
A
V
A
E
Q
Site 73
S973
L
V
Q
G
V
R
G
S
Q
A
Q
P
D
S
P
Site 74
S979
G
S
Q
A
Q
P
D
S
P
S
A
Q
L
A
L
Site 75
S1016
P
T
I
Q
D
Q
A
S
A
M
Q
L
S
Q
C
Site 76
S1021
Q
A
S
A
M
Q
L
S
Q
C
A
K
N
L
G
Site 77
S1055
L
E
M
D
S
A
L
S
V
V
Q
N
L
E
K
Site 78
T1095
T
Q
D
L
G
N
S
T
K
A
V
S
S
A
I
Site 79
Y1116
V
A
Q
G
N
E
N
Y
A
G
I
A
A
R
D
Site 80
S1130
D
V
A
G
G
L
R
S
L
A
Q
A
A
R
G
Site 81
S1163
S
D
V
L
D
K
A
S
S
L
I
E
E
A
K
Site 82
S1164
D
V
L
D
K
A
S
S
L
I
E
E
A
K
K
Site 83
S1181
G
H
P
G
D
P
E
S
Q
Q
R
L
A
Q
V
Site 84
S1201
Q
A
L
N
R
C
V
S
C
L
P
G
Q
R
D
Site 85
S1220
L
R
A
V
G
D
A
S
K
R
L
L
S
D
S
Site 86
S1225
D
A
S
K
R
L
L
S
D
S
L
P
P
S
T
Site 87
S1227
S
K
R
L
L
S
D
S
L
P
P
S
T
G
T
Site 88
S1231
L
S
D
S
L
P
P
S
T
G
T
F
Q
E
A
Site 89
T1234
S
L
P
P
S
T
G
T
F
Q
E
A
Q
S
R
Site 90
T1254
A
G
L
N
Q
A
A
T
E
L
V
Q
A
S
R
Site 91
T1263
L
V
Q
A
S
R
G
T
P
Q
D
L
A
R
A
Site 92
S1271
P
Q
D
L
A
R
A
S
G
R
F
G
Q
D
F
Site 93
S1279
G
R
F
G
Q
D
F
S
T
F
L
E
A
G
V
Site 94
T1280
R
F
G
Q
D
F
S
T
F
L
E
A
G
V
E
Site 95
S1294
E
M
A
G
Q
A
P
S
Q
E
D
R
A
Q
V
Site 96
S1303
E
D
R
A
Q
V
V
S
N
L
K
G
I
S
M
Site 97
S1323
L
L
A
A
K
A
L
S
T
D
P
A
A
P
N
Site 98
T1324
L
A
A
K
A
L
S
T
D
P
A
A
P
N
L
Site 99
S1333
P
A
A
P
N
L
K
S
Q
L
A
A
A
A
R
Site 100
T1372
N
A
L
R
E
L
E
T
V
R
E
L
L
E
N
Site 101
Y1389
Q
P
I
N
D
M
S
Y
F
G
C
L
D
S
V
Site 102
S1395
S
Y
F
G
C
L
D
S
V
M
E
N
S
K
V
Site 103
S1400
L
D
S
V
M
E
N
S
K
V
L
G
E
A
M
Site 104
S1411
G
E
A
M
T
G
I
S
Q
N
A
K
N
G
N
Site 105
S1450
A
A
Y
L
V
G
V
S
D
P
N
S
Q
A
G
Site 106
S1454
V
G
V
S
D
P
N
S
Q
A
G
Q
Q
G
L
Site 107
S1508
H
T
S
A
L
C
N
S
C
R
L
A
S
A
R
Site 108
S1513
C
N
S
C
R
L
A
S
A
R
T
T
N
P
T
Site 109
T1517
R
L
A
S
A
R
T
T
N
P
T
A
K
R
Q
Site 110
T1520
S
A
R
T
T
N
P
T
A
K
R
Q
F
V
Q
Site 111
S1528
A
K
R
Q
F
V
Q
S
A
K
E
V
A
N
S
Site 112
S1573
L
E
A
V
D
N
L
S
A
F
A
S
N
P
E
Site 113
S1577
D
N
L
S
A
F
A
S
N
P
E
F
S
S
I
Site 114
S1583
A
S
N
P
E
F
S
S
I
P
A
Q
I
S
P
Site 115
S1589
S
S
I
P
A
Q
I
S
P
E
G
R
A
A
M
Site 116
T1616
S
A
G
G
L
I
Q
T
A
R
A
L
A
V
N
Site 117
S1629
V
N
P
R
D
P
P
S
W
S
V
L
A
G
H
Site 118
S1631
P
R
D
P
P
S
W
S
V
L
A
G
H
S
R
Site 119
S1637
W
S
V
L
A
G
H
S
R
T
V
S
D
S
I
Site 120
T1639
V
L
A
G
H
S
R
T
V
S
D
S
I
K
K
Site 121
S1641
A
G
H
S
R
T
V
S
D
S
I
K
K
L
I
Site 122
S1643
H
S
R
T
V
S
D
S
I
K
K
L
I
T
S
Site 123
S1650
S
I
K
K
L
I
T
S
M
R
D
K
A
P
G
Site 124
T1663
P
G
Q
L
E
C
E
T
A
I
A
A
L
N
S
Site 125
S1679
L
R
D
L
D
Q
A
S
L
A
A
V
S
Q
Q
Site 126
S1694
L
A
P
R
E
G
I
S
Q
E
A
L
H
T
Q
Site 127
S1732
S
Q
L
G
H
K
V
S
Q
M
A
Q
Y
F
E
Site 128
Y1737
K
V
S
Q
M
A
Q
Y
F
E
P
L
T
L
A
Site 129
T1742
A
Q
Y
F
E
P
L
T
L
A
A
V
G
A
A
Site 130
T1752
A
V
G
A
A
S
K
T
L
S
H
P
Q
Q
M
Site 131
S1754
G
A
A
S
K
T
L
S
H
P
Q
Q
M
A
L
Site 132
T1767
A
L
L
D
Q
T
K
T
L
A
E
S
A
L
Q
Site 133
Y1777
E
S
A
L
Q
L
L
Y
T
A
K
E
A
G
G
Site 134
T1778
S
A
L
Q
L
L
Y
T
A
K
E
A
G
G
N
Site 135
T1811
T
E
A
V
E
D
L
T
T
T
L
N
E
A
A
Site 136
T1812
E
A
V
E
D
L
T
T
T
L
N
E
A
A
S
Site 137
T1832
G
G
M
V
D
S
I
T
Q
A
I
N
Q
L
D
Site 138
S1849
P
M
G
E
P
E
G
S
F
V
D
Y
Q
T
T
Site 139
Y1853
P
E
G
S
F
V
D
Y
Q
T
T
M
V
R
T
Site 140
T1855
G
S
F
V
D
Y
Q
T
T
M
V
R
T
A
K
Site 141
S1875
V
Q
E
M
V
T
K
S
N
T
S
P
E
E
L
Site 142
S1878
M
V
T
K
S
N
T
S
P
E
E
L
G
P
L
Site 143
S1891
P
L
A
N
Q
L
T
S
D
Y
G
R
L
A
S
Site 144
Y1893
A
N
Q
L
T
S
D
Y
G
R
L
A
S
E
A
Site 145
S1898
S
D
Y
G
R
L
A
S
E
A
K
P
A
A
V
Site 146
S1940
K
A
G
A
L
Q
C
S
P
S
D
A
Y
T
K
Site 147
S1942
G
A
L
Q
C
S
P
S
D
A
Y
T
K
K
E
Site 148
Y1945
Q
C
S
P
S
D
A
Y
T
K
K
E
L
I
E
Site 149
T1946
C
S
P
S
D
A
Y
T
K
K
E
L
I
E
C
Site 150
S1958
I
E
C
A
R
R
V
S
E
K
V
S
H
V
L
Site 151
S1962
R
R
V
S
E
K
V
S
H
V
L
A
A
L
Q
Site 152
T2009
G
T
L
N
R
E
G
T
E
T
F
A
D
H
R
Site 153
T2011
L
N
R
E
G
T
E
T
F
A
D
H
R
E
G
Site 154
T2030
A
K
V
L
V
E
D
T
K
V
L
V
Q
N
A
Site 155
S2040
L
V
Q
N
A
A
G
S
Q
E
K
L
A
Q
A
Site 156
T2131
N
V
T
S
L
L
K
T
V
K
A
V
E
D
E
Site 157
T2140
K
A
V
E
D
E
A
T
K
G
T
R
A
L
E
Site 158
T2149
G
T
R
A
L
E
A
T
T
E
H
I
R
Q
E
Site 159
S2162
Q
E
L
A
V
F
C
S
P
E
P
P
A
K
T
Site 160
T2171
E
P
P
A
K
T
S
T
P
E
D
F
I
R
M
Site 161
T2179
P
E
D
F
I
R
M
T
K
G
I
T
M
A
T
Site 162
S2195
K
A
V
A
A
G
N
S
C
R
Q
E
D
V
I
Site 163
Y2224
R
A
C
K
E
A
A
Y
H
P
E
V
A
P
D
Site 164
Y2239
V
R
L
R
A
L
H
Y
G
R
E
C
A
N
G
Site 165
Y2247
G
R
E
C
A
N
G
Y
L
E
L
L
D
H
V
Site 166
T2257
L
L
D
H
V
L
L
T
L
Q
K
P
S
P
E
Site 167
S2262
L
L
T
L
Q
K
P
S
P
E
L
K
Q
Q
L
Site 168
T2270
P
E
L
K
Q
Q
L
T
G
H
S
K
R
V
A
Site 169
S2273
K
Q
Q
L
T
G
H
S
K
R
V
A
G
S
V
Site 170
S2279
H
S
K
R
V
A
G
S
V
T
E
L
I
Q
A
Site 171
T2302
W
V
D
P
E
D
P
T
V
I
A
E
N
E
L
Site 172
S2338
K
P
K
E
A
D
E
S
L
N
F
E
E
Q
I
Site 173
S2390
A
L
D
D
G
Q
W
S
Q
G
L
I
S
A
A
Site 174
S2420
A
A
V
Q
G
H
A
S
Q
E
K
L
I
S
S
Site 175
S2426
A
S
Q
E
K
L
I
S
S
A
K
Q
V
A
A
Site 176
S2450
K
V
K
A
D
Q
D
S
E
A
M
K
R
L
Q
Site 177
S2467
G
N
A
V
K
R
A
S
D
N
L
V
K
A
A
Site 178
T2487
F
E
E
Q
E
N
E
T
V
V
V
K
E
K
M
Site 179
Y2530
A
Q
I
R
Q
Q
Q
Y
K
F
L
P
S
E
L
Site 180
S2535
Q
Q
Y
K
F
L
P
S
E
L
R
D
E
H
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation