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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
VPRBP
Full Name:
Protein VPRBP
Alias:
DCAF1; DDB1 and CUL4 associated factor 1; DDB1- and CUL4-associated factor 1; HIV-1 Vpr-binding protein; KIAA0800; MGC102804; Vpr (HIV-1) binding protein
Type:
Ubiquitin conjugating system
Mass (Da):
169007
Number AA:
1507
UniProt ID:
Q9Y4B6
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0044424
GO:0044464
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005488
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0044419
GO:0019941
GO:0008152
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S39
V
P
I
L
T
R
M
S
Q
L
I
E
K
E
T
Site 2
Y49
I
E
K
E
T
E
E
Y
R
K
G
D
P
D
P
Site 3
Y92
M
N
A
L
V
N
A
Y
V
M
T
S
R
E
P
Site 4
T145
E
A
D
Q
P
L
R
T
Y
S
T
G
L
L
G
Site 5
Y146
A
D
Q
P
L
R
T
Y
S
T
G
L
L
G
G
Site 6
S147
D
Q
P
L
R
T
Y
S
T
G
L
L
G
G
A
Site 7
S169
A
N
Y
R
D
E
N
S
Q
L
V
A
I
V
L
Site 8
S197
R
Q
E
N
K
R
P
S
P
R
K
L
S
S
E
Site 9
S202
R
P
S
P
R
K
L
S
S
E
P
L
L
P
L
Site 10
S203
P
S
P
R
K
L
S
S
E
P
L
L
P
L
D
Site 11
Y218
E
E
A
V
D
M
D
Y
G
D
M
A
V
D
V
Site 12
S234
D
G
D
Q
E
E
A
S
G
D
M
E
I
S
F
Site 13
S240
A
S
G
D
M
E
I
S
F
H
L
D
S
G
H
Site 14
S245
E
I
S
F
H
L
D
S
G
H
K
T
S
S
R
Site 15
T249
H
L
D
S
G
H
K
T
S
S
R
V
N
S
T
Site 16
S250
L
D
S
G
H
K
T
S
S
R
V
N
S
T
T
Site 17
S251
D
S
G
H
K
T
S
S
R
V
N
S
T
T
K
Site 18
S255
K
T
S
S
R
V
N
S
T
T
K
P
E
D
G
Site 19
T256
T
S
S
R
V
N
S
T
T
K
P
E
D
G
G
Site 20
T257
S
S
R
V
N
S
T
T
K
P
E
D
G
G
L
Site 21
S269
G
G
L
K
K
N
K
S
A
K
Q
G
D
R
E
Site 22
S288
A
K
Q
K
L
G
F
S
S
S
D
P
D
R
M
Site 23
S289
K
Q
K
L
G
F
S
S
S
D
P
D
R
M
F
Site 24
S290
Q
K
L
G
F
S
S
S
D
P
D
R
M
F
V
Site 25
S300
D
R
M
F
V
E
L
S
N
S
S
W
S
E
M
Site 26
S302
M
F
V
E
L
S
N
S
S
W
S
E
M
S
P
Site 27
S303
F
V
E
L
S
N
S
S
W
S
E
M
S
P
W
Site 28
S305
E
L
S
N
S
S
W
S
E
M
S
P
W
V
I
Site 29
S308
N
S
S
W
S
E
M
S
P
W
V
I
G
T
N
Site 30
T322
N
Y
T
L
Y
P
M
T
P
A
I
E
Q
R
L
Site 31
Y333
E
Q
R
L
I
L
Q
Y
L
T
P
L
G
E
Y
Site 32
T335
R
L
I
L
Q
Y
L
T
P
L
G
E
Y
Q
E
Site 33
Y359
S
R
E
L
M
M
F
Y
I
D
L
K
Q
T
N
Site 34
Y418
T
G
V
S
M
C
L
Y
Y
L
S
Y
N
Q
D
Site 35
Y419
G
V
S
M
C
L
Y
Y
L
S
Y
N
Q
D
A
Site 36
S506
E
D
Q
G
A
L
L
S
D
D
E
I
F
A
S
Site 37
S513
S
D
D
E
I
F
A
S
R
Q
T
G
K
H
T
Site 38
T516
E
I
F
A
S
R
Q
T
G
K
H
T
C
M
A
Site 39
S542
K
L
E
Q
V
K
Q
S
L
Q
R
T
E
G
G
Site 40
T546
V
K
Q
S
L
Q
R
T
E
G
G
I
L
V
H
Site 41
Y558
L
V
H
P
Q
P
P
Y
K
A
C
S
Y
T
H
Site 42
Y584
E
Y
G
P
A
Q
L
Y
W
E
P
A
E
V
F
Site 43
T619
T
Y
Y
A
R
N
D
T
V
R
F
A
L
D
V
Site 44
S697
C
G
P
D
N
R
I
S
S
I
G
K
F
I
S
Site 45
S698
G
P
D
N
R
I
S
S
I
G
K
F
I
S
G
Site 46
S704
S
S
I
G
K
F
I
S
G
T
P
R
R
K
L
Site 47
T706
I
G
K
F
I
S
G
T
P
R
R
K
L
P
Q
Site 48
S717
K
L
P
Q
N
P
K
S
S
E
H
T
L
A
K
Site 49
T721
N
P
K
S
S
E
H
T
L
A
K
M
W
N
V
Site 50
S740
N
G
I
K
V
L
L
S
L
L
S
I
K
M
P
Site 51
S743
K
V
L
L
S
L
L
S
I
K
M
P
I
T
D
Site 52
T749
L
S
I
K
M
P
I
T
D
A
D
Q
I
R
A
Site 53
S766
C
K
A
L
V
G
L
S
R
S
S
T
V
R
Q
Site 54
S768
A
L
V
G
L
S
R
S
S
T
V
R
Q
I
I
Site 55
S769
L
V
G
L
S
R
S
S
T
V
R
Q
I
I
S
Site 56
T770
V
G
L
S
R
S
S
T
V
R
Q
I
I
S
K
Site 57
S800
P
V
L
Q
D
K
R
S
D
H
V
K
F
C
K
Site 58
Y808
D
H
V
K
F
C
K
Y
A
A
E
L
I
E
R
Site 59
S817
A
E
L
I
E
R
V
S
G
K
P
L
L
I
G
Site 60
T825
G
K
P
L
L
I
G
T
D
V
S
L
A
R
L
Site 61
S841
K
A
D
V
V
A
Q
S
R
I
S
F
P
E
K
Site 62
S860
L
I
R
N
H
L
I
S
K
G
L
G
E
T
A
Site 63
T868
K
G
L
G
E
T
A
T
V
L
T
K
E
A
D
Site 64
T879
K
E
A
D
L
P
M
T
A
A
S
H
S
S
A
Site 65
S882
D
L
P
M
T
A
A
S
H
S
S
A
F
T
P
Site 66
T888
A
S
H
S
S
A
F
T
P
V
T
A
A
A
S
Site 67
S895
T
P
V
T
A
A
A
S
P
V
S
L
P
R
T
Site 68
S898
T
A
A
A
S
P
V
S
L
P
R
T
P
R
I
Site 69
T902
S
P
V
S
L
P
R
T
P
R
I
A
N
G
I
Site 70
S946
P
L
A
L
P
G
P
S
Y
A
G
N
S
P
L
Site 71
S951
G
P
S
Y
A
G
N
S
P
L
I
G
R
I
S
Site 72
S958
S
P
L
I
G
R
I
S
F
I
R
E
R
P
S
Site 73
S965
S
F
I
R
E
R
P
S
P
C
N
G
R
K
I
Site 74
S979
I
R
V
L
R
Q
K
S
D
H
G
A
Y
S
Q
Site 75
S985
K
S
D
H
G
A
Y
S
Q
S
P
A
I
K
K
Site 76
S987
D
H
G
A
Y
S
Q
S
P
A
I
K
K
Q
L
Site 77
S1000
Q
L
D
R
H
L
P
S
P
P
T
L
D
S
I
Site 78
T1003
R
H
L
P
S
P
P
T
L
D
S
I
I
T
E
Site 79
S1006
P
S
P
P
T
L
D
S
I
I
T
E
Y
L
R
Site 80
Y1011
L
D
S
I
I
T
E
Y
L
R
E
Q
H
A
R
Site 81
T1033
C
P
P
F
S
L
F
T
P
H
Q
C
P
E
P
Site 82
S1059
S
R
L
N
R
R
A
S
F
P
K
Y
G
G
V
Site 83
Y1063
R
R
A
S
F
P
K
Y
G
G
V
D
G
G
C
Site 84
S1078
F
D
R
H
L
I
F
S
R
F
R
P
I
S
V
Site 85
S1084
F
S
R
F
R
P
I
S
V
F
R
E
A
N
E
Site 86
T1097
N
E
D
E
S
G
F
T
C
C
A
F
S
A
R
Site 87
Y1120
C
T
G
Q
L
K
L
Y
N
V
F
S
G
Q
E
Site 88
S1124
L
K
L
Y
N
V
F
S
G
Q
E
E
A
S
Y
Site 89
S1130
F
S
G
Q
E
E
A
S
Y
N
C
H
N
S
A
Site 90
Y1131
S
G
Q
E
E
A
S
Y
N
C
H
N
S
A
I
Site 91
S1148
L
E
P
S
R
D
G
S
L
L
L
T
S
A
T
Site 92
T1152
R
D
G
S
L
L
L
T
S
A
T
W
S
Q
P
Site 93
S1161
A
T
W
S
Q
P
L
S
A
L
W
G
M
K
S
Site 94
S1175
S
V
F
D
M
K
H
S
F
T
E
D
H
Y
V
Site 95
T1177
F
D
M
K
H
S
F
T
E
D
H
Y
V
E
F
Site 96
Y1181
H
S
F
T
E
D
H
Y
V
E
F
S
K
H
S
Site 97
S1185
E
D
H
Y
V
E
F
S
K
H
S
Q
D
R
V
Site 98
S1188
Y
V
E
F
S
K
H
S
Q
D
R
V
I
G
T
Site 99
Y1203
K
G
D
I
A
H
I
Y
D
I
Q
T
G
N
K
Site 100
T1207
A
H
I
Y
D
I
Q
T
G
N
K
L
L
T
L
Site 101
Y1223
N
P
D
L
A
N
N
Y
K
R
N
C
A
T
F
Site 102
T1229
N
Y
K
R
N
C
A
T
F
N
P
T
D
D
L
Site 103
S1328
L
M
E
E
R
M
K
S
P
F
G
S
S
F
R
Site 104
S1332
R
M
K
S
P
F
G
S
S
F
R
T
F
N
A
Site 105
S1333
M
K
S
P
F
G
S
S
F
R
T
F
N
A
T
Site 106
T1336
P
F
G
S
S
F
R
T
F
N
A
T
D
Y
K
Site 107
T1340
S
F
R
T
F
N
A
T
D
Y
K
P
I
A
T
Site 108
Y1342
R
T
F
N
A
T
D
Y
K
P
I
A
T
I
D
Site 109
Y1365
C
T
D
T
K
D
C
Y
L
A
V
I
E
N
Q
Site 110
S1374
A
V
I
E
N
Q
G
S
M
D
A
L
N
M
D
Site 111
Y1387
M
D
T
V
C
R
L
Y
E
V
G
R
Q
R
L
Site 112
T1421
D
D
E
D
D
D
D
T
D
D
L
D
E
L
D
Site 113
S1455
E
D
G
D
N
D
F
S
P
S
D
E
E
L
A
Site 114
S1457
G
D
N
D
F
S
P
S
D
E
E
L
A
N
L
Site 115
S1476
E
D
G
E
D
E
D
S
D
A
D
E
E
V
E
Site 116
T1489
V
E
L
I
L
G
D
T
D
S
S
D
N
S
D
Site 117
S1491
L
I
L
G
D
T
D
S
S
D
N
S
D
L
E
Site 118
S1492
I
L
G
D
T
D
S
S
D
N
S
D
L
E
D
Site 119
S1495
D
T
D
S
S
D
N
S
D
L
E
D
D
I
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation