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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DAAM1
Full Name:
Disheveled-associated activator of morphogenesis 1
Alias:
Dishevelled associated activator of morphogenesis 1; KIAA0666
Type:
Adaptor/scaffold
Mass (Da):
123473
Number AA:
1078
UniProt ID:
Q9Y4D1
International Prot ID:
IPI00337800
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0017048
GO:0003779
PhosphoSite+
KinaseNET
Biological Process:
GO:0030036
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S34
T
Y
R
L
R
N
D
S
N
F
A
L
Q
T
M
Site 2
T40
D
S
N
F
A
L
Q
T
M
E
P
A
L
P
M
Site 3
T67
L
V
D
E
L
D
L
T
D
K
H
R
E
A
M
Site 4
Y86
A
E
K
K
W
Q
I
Y
C
S
K
K
K
D
Q
Site 5
S101
E
E
N
K
G
A
T
S
W
P
E
F
Y
I
D
Site 6
S118
N
S
M
A
A
R
K
S
L
L
A
L
E
K
E
Site 7
S131
K
E
E
E
E
E
R
S
K
T
I
E
S
L
K
Site 8
T133
E
E
E
E
R
S
K
T
I
E
S
L
K
T
A
Site 9
S136
E
R
S
K
T
I
E
S
L
K
T
A
L
R
T
Site 10
T139
K
T
I
E
S
L
K
T
A
L
R
T
K
P
M
Site 11
T150
T
K
P
M
R
F
V
T
R
F
I
D
L
D
G
Site 12
T167
C
I
L
N
F
L
K
T
M
D
Y
E
T
S
E
Site 13
Y170
N
F
L
K
T
M
D
Y
E
T
S
E
S
R
I
Site 14
T172
L
K
T
M
D
Y
E
T
S
E
S
R
I
H
T
Site 15
S173
K
T
M
D
Y
E
T
S
E
S
R
I
H
T
S
Site 16
S175
M
D
Y
E
T
S
E
S
R
I
H
T
S
L
I
Site 17
T179
T
S
E
S
R
I
H
T
S
L
I
G
C
I
K
Site 18
S192
I
K
A
L
M
N
N
S
Q
G
R
A
H
V
L
Site 19
S211
S
I
N
V
I
A
Q
S
L
S
T
E
N
I
K
Site 20
S213
N
V
I
A
Q
S
L
S
T
E
N
I
K
T
K
Site 21
Y247
V
L
Q
A
M
L
H
Y
Q
K
Y
A
S
E
R
Site 22
Y250
A
M
L
H
Y
Q
K
Y
A
S
E
R
T
R
F
Site 23
S252
L
H
Y
Q
K
Y
A
S
E
R
T
R
F
Q
T
Site 24
T255
Q
K
Y
A
S
E
R
T
R
F
Q
T
L
I
N
Site 25
T259
S
E
R
T
R
F
Q
T
L
I
N
D
L
D
K
Site 26
S267
L
I
N
D
L
D
K
S
T
G
R
Y
R
D
E
Site 27
T268
I
N
D
L
D
K
S
T
G
R
Y
R
D
E
V
Site 28
S276
G
R
Y
R
D
E
V
S
L
K
T
A
I
M
S
Site 29
S297
S
Q
G
A
G
V
E
S
L
D
F
R
L
H
L
Site 30
S326
K
L
R
E
H
E
N
S
T
L
D
R
H
L
D
Site 31
T327
L
R
E
H
E
N
S
T
L
D
R
H
L
D
F
Site 32
T361
H
I
D
T
K
S
A
T
Q
M
F
E
L
T
R
Site 33
T367
A
T
Q
M
F
E
L
T
R
K
R
L
T
H
S
Site 34
T372
E
L
T
R
K
R
L
T
H
S
E
A
Y
P
H
Site 35
S374
T
R
K
R
L
T
H
S
E
A
Y
P
H
F
M
Site 36
Y377
R
L
T
H
S
E
A
Y
P
H
F
M
S
I
L
Site 37
Y392
H
H
C
L
Q
M
P
Y
K
R
S
G
N
T
V
Site 38
Y401
R
S
G
N
T
V
Q
Y
W
L
L
L
D
R
I
Site 39
S424
D
K
G
Q
D
P
D
S
T
P
L
E
N
F
N
Site 40
T425
K
G
Q
D
P
D
S
T
P
L
E
N
F
N
I
Site 41
T477
E
R
E
C
D
A
K
T
Q
E
K
E
E
M
M
Site 42
T486
E
K
E
E
M
M
Q
T
L
N
K
M
K
E
K
Site 43
T499
E
K
L
E
K
E
T
T
E
H
K
Q
V
K
Q
Site 44
T512
K
Q
Q
V
A
D
L
T
A
Q
L
H
E
L
S
Site 45
S519
T
A
Q
L
H
E
L
S
R
R
A
V
C
A
S
Site 46
S526
S
R
R
A
V
C
A
S
I
P
G
G
P
S
P
Site 47
S532
A
S
I
P
G
G
P
S
P
G
A
P
G
G
P
Site 48
S547
F
P
S
S
V
P
G
S
L
L
P
P
P
P
P
Site 49
S602
G
L
A
L
K
K
K
S
I
P
Q
P
T
N
A
Site 50
S612
Q
P
T
N
A
L
K
S
F
N
W
S
K
L
P
Site 51
S616
A
L
K
S
F
N
W
S
K
L
P
E
N
K
L
Site 52
T626
P
E
N
K
L
E
G
T
V
W
T
E
I
D
D
Site 53
T648
D
L
E
D
L
E
R
T
F
S
A
Y
Q
R
Q
Site 54
S650
E
D
L
E
R
T
F
S
A
Y
Q
R
Q
Q
D
Site 55
Y652
L
E
R
T
F
S
A
Y
Q
R
Q
Q
D
F
F
Site 56
T675
E
A
D
A
I
D
D
T
L
S
S
K
L
K
V
Site 57
S677
D
A
I
D
D
T
L
S
S
K
L
K
V
K
E
Site 58
S678
A
I
D
D
T
L
S
S
K
L
K
V
K
E
L
Site 59
S686
K
L
K
V
K
E
L
S
V
I
D
G
R
R
A
Site 60
S701
Q
N
C
N
I
L
L
S
R
L
K
L
S
N
D
Site 61
S706
L
L
S
R
L
K
L
S
N
D
E
I
K
R
A
Site 62
S739
L
K
F
V
P
E
K
S
D
I
D
L
L
E
E
Site 63
Y770
E
M
S
R
I
N
H
Y
Q
Q
R
L
Q
S
L
Site 64
Y778
Q
Q
R
L
Q
S
L
Y
F
K
K
K
F
A
E
Site 65
S799
P
K
V
E
A
I
R
S
G
S
E
E
V
F
R
Site 66
S801
V
E
A
I
R
S
G
S
E
E
V
F
R
S
G
Site 67
S807
G
S
E
E
V
F
R
S
G
A
L
K
Q
L
L
Site 68
Y823
V
V
L
A
F
G
N
Y
M
N
K
G
Q
R
G
Site 69
Y833
K
G
Q
R
G
N
A
Y
G
F
K
I
S
S
L
Site 70
S839
A
Y
G
F
K
I
S
S
L
N
K
I
A
D
T
Site 71
T846
S
L
N
K
I
A
D
T
K
S
S
I
D
K
N
Site 72
S848
N
K
I
A
D
T
K
S
S
I
D
K
N
I
T
Site 73
S897
T
E
L
D
K
E
I
S
T
L
R
S
G
L
K
Site 74
T898
E
L
D
K
E
I
S
T
L
R
S
G
L
K
A
Site 75
S901
K
E
I
S
T
L
R
S
G
L
K
A
V
E
T
Site 76
T908
S
G
L
K
A
V
E
T
E
L
E
Y
Q
K
S
Site 77
Y912
A
V
E
T
E
L
E
Y
Q
K
S
Q
P
P
Q
Site 78
S915
T
E
L
E
Y
Q
K
S
Q
P
P
Q
P
G
D
Site 79
T954
A
E
A
K
D
L
F
T
K
A
V
K
H
F
G
Site 80
S1038
G
E
F
D
D
L
V
S
A
L
R
S
G
E
V
Site 81
S1042
D
L
V
S
A
L
R
S
G
E
V
F
D
K
D
Site 82
S1051
E
V
F
D
K
D
L
S
K
L
K
R
N
R
K
Site 83
T1061
K
R
N
R
K
R
I
T
N
Q
M
T
D
S
S
Site 84
S1067
I
T
N
Q
M
T
D
S
S
R
E
R
P
I
T
Site 85
S1068
T
N
Q
M
T
D
S
S
R
E
R
P
I
T
K
Site 86
T1074
S
S
R
E
R
P
I
T
K
L
N
F
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation