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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NSDDR
Full Name:
Sn1-specific diacylglycerol lipase alpha
Alias:
C11orf11; DAGLALPHA; DGLA; DGL-alpha; Diacylglycerol lipase, alpha; KIAA0659; Neural stem cell-derived dendrite regulator
Type:
Hydrolase; EC 3.1.1.-
Mass (Da):
114952
Number AA:
1042
UniProt ID:
Q9Y4D2
International Prot ID:
IPI00000706
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0004806
PhosphoSite+
KinaseNET
Biological Process:
GO:0016042
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
V
V
F
R
R
R
W
S
V
G
S
D
D
L
V
Site 2
S15
R
R
R
W
S
V
G
S
D
D
L
V
L
P
A
Site 3
Y62
L
V
D
H
G
R
G
Y
L
G
I
L
L
S
C
Site 4
Y87
S
M
R
G
G
I
L
Y
T
E
P
R
D
S
M
Site 5
T88
M
R
G
G
I
L
Y
T
E
P
R
D
S
M
Q
Site 6
S93
L
Y
T
E
P
R
D
S
M
Q
Y
V
L
Y
V
Site 7
Y96
E
P
R
D
S
M
Q
Y
V
L
Y
V
R
L
A
Site 8
T130
Y
T
S
C
N
D
L
T
A
K
N
V
T
L
G
Site 9
T163
V
F
D
P
T
G
R
T
F
V
K
L
R
A
T
Site 10
T170
T
F
V
K
L
R
A
T
K
R
R
Q
R
N
L
Site 11
Y180
R
Q
R
N
L
R
T
Y
N
L
R
H
R
L
E
Site 12
T192
R
L
E
E
G
Q
A
T
S
W
S
R
R
L
K
Site 13
S193
L
E
E
G
Q
A
T
S
W
S
R
R
L
K
V
Site 14
S195
E
G
Q
A
T
S
W
S
R
R
L
K
V
F
L
Site 15
T207
V
F
L
C
C
T
R
T
K
D
S
Q
S
D
A
Site 16
S210
C
C
T
R
T
K
D
S
Q
S
D
A
Y
S
E
Site 17
S212
T
R
T
K
D
S
Q
S
D
A
Y
S
E
I
A
Site 18
Y215
K
D
S
Q
S
D
A
Y
S
E
I
A
Y
L
F
Site 19
S216
D
S
Q
S
D
A
Y
S
E
I
A
Y
L
F
A
Site 20
T275
G
M
P
V
T
R
N
T
K
Y
L
D
L
K
N
Site 21
Y277
P
V
T
R
N
T
K
Y
L
D
L
K
N
S
Q
Site 22
S283
K
Y
L
D
L
K
N
S
Q
E
M
L
R
Y
K
Site 23
Y289
N
S
Q
E
M
L
R
Y
K
E
V
C
Y
Y
M
Site 24
Y308
A
A
Y
G
W
P
M
Y
L
M
R
K
P
A
C
Site 25
Y370
M
T
A
V
D
I
V
Y
T
S
C
H
D
A
V
Site 26
Y378
T
S
C
H
D
A
V
Y
E
T
P
F
Y
V
A
Site 27
Y383
A
V
Y
E
T
P
F
Y
V
A
V
D
H
D
K
Site 28
S396
D
K
K
K
V
V
I
S
I
R
G
T
L
S
P
Site 29
S402
I
S
I
R
G
T
L
S
P
K
D
A
L
T
D
Site 30
T408
L
S
P
K
D
A
L
T
D
L
T
G
D
A
E
Site 31
T411
K
D
A
L
T
D
L
T
G
D
A
E
R
L
P
Site 32
S435
G
H
K
G
M
V
L
S
A
E
Y
I
K
K
K
Site 33
S450
L
E
Q
E
M
V
L
S
Q
A
F
G
R
D
L
Site 34
T461
G
R
D
L
G
R
G
T
K
H
Y
G
L
I
V
Site 35
T491
L
L
R
P
Q
Y
P
T
L
K
C
F
A
Y
S
Site 36
S505
S
P
P
G
G
L
L
S
E
D
A
M
E
Y
S
Site 37
S532
L
V
P
R
I
G
L
S
Q
L
E
G
F
R
R
Site 38
T549
L
D
V
L
Q
R
S
T
K
P
K
W
R
I
I
Site 39
T560
W
R
I
I
V
G
A
T
K
C
I
P
K
S
E
Site 40
S566
A
T
K
C
I
P
K
S
E
L
P
E
E
V
E
Site 41
S579
V
E
V
T
T
L
A
S
T
R
L
W
T
H
P
Site 42
T584
L
A
S
T
R
L
W
T
H
P
S
D
L
T
I
Site 43
S587
T
R
L
W
T
H
P
S
D
L
T
I
A
L
S
Site 44
T590
W
T
H
P
S
D
L
T
I
A
L
S
A
S
T
Site 45
T597
T
I
A
L
S
A
S
T
P
L
Y
P
P
G
R
Site 46
Y600
L
S
A
S
T
P
L
Y
P
P
G
R
I
I
H
Site 47
Y627
C
E
Q
E
E
P
T
Y
F
A
I
W
G
D
N
Site 48
T689
S
P
T
E
V
D
L
T
P
E
L
I
F
Q
Q
Site 49
T701
F
Q
Q
Q
P
L
P
T
G
P
P
M
P
T
G
Site 50
S721
P
T
A
D
H
R
N
S
S
V
R
S
K
S
Q
Site 51
S722
T
A
D
H
R
N
S
S
V
R
S
K
S
Q
S
Site 52
S725
H
R
N
S
S
V
R
S
K
S
Q
S
E
M
S
Site 53
S727
N
S
S
V
R
S
K
S
Q
S
E
M
S
L
E
Site 54
S729
S
V
R
S
K
S
Q
S
E
M
S
L
E
G
F
Site 55
S732
S
K
S
Q
S
E
M
S
L
E
G
F
S
E
G
Site 56
S737
E
M
S
L
E
G
F
S
E
G
R
L
L
S
P
Site 57
S743
F
S
E
G
R
L
L
S
P
V
V
A
A
A
A
Site 58
T762
V
E
L
L
L
L
S
T
Q
E
R
L
A
A
E
Site 59
T779
A
R
R
A
P
L
A
T
M
E
S
L
S
D
T
Site 60
S782
A
P
L
A
T
M
E
S
L
S
D
T
E
S
L
Site 61
S784
L
A
T
M
E
S
L
S
D
T
E
S
L
Y
S
Site 62
T786
T
M
E
S
L
S
D
T
E
S
L
Y
S
F
D
Site 63
S788
E
S
L
S
D
T
E
S
L
Y
S
F
D
S
R
Site 64
Y790
L
S
D
T
E
S
L
Y
S
F
D
S
R
R
S
Site 65
S791
S
D
T
E
S
L
Y
S
F
D
S
R
R
S
S
Site 66
S794
E
S
L
Y
S
F
D
S
R
R
S
S
G
F
R
Site 67
S797
Y
S
F
D
S
R
R
S
S
G
F
R
S
I
R
Site 68
S798
S
F
D
S
R
R
S
S
G
F
R
S
I
R
G
Site 69
S802
R
R
S
S
G
F
R
S
I
R
G
S
P
S
L
Site 70
S806
G
F
R
S
I
R
G
S
P
S
L
H
A
V
L
Site 71
S808
R
S
I
R
G
S
P
S
L
H
A
V
L
E
R
Site 72
Y822
R
D
E
G
H
L
F
Y
I
D
P
A
I
P
E
Site 73
S833
A
I
P
E
E
N
P
S
L
S
S
R
T
E
L
Site 74
S835
P
E
E
N
P
S
L
S
S
R
T
E
L
L
A
Site 75
S845
T
E
L
L
A
A
D
S
L
S
K
H
S
Q
D
Site 76
S847
L
L
A
A
D
S
L
S
K
H
S
Q
D
T
Q
Site 77
S862
P
L
E
A
A
L
G
S
G
G
V
T
P
E
R
Site 78
T866
A
L
G
S
G
G
V
T
P
E
R
P
P
S
A
Site 79
S872
V
T
P
E
R
P
P
S
A
A
A
N
D
E
E
Site 80
S891
G
G
G
G
G
P
A
S
R
G
E
L
A
L
H
Site 81
S905
H
N
G
R
L
G
D
S
P
S
P
Q
V
L
E
Site 82
S907
G
R
L
G
D
S
P
S
P
Q
V
L
E
F
A
Site 83
S919
E
F
A
E
F
I
D
S
L
F
N
L
D
S
K
Site 84
S925
D
S
L
F
N
L
D
S
K
S
S
S
F
Q
D
Site 85
S927
L
F
N
L
D
S
K
S
S
S
F
Q
D
L
Y
Site 86
S928
F
N
L
D
S
K
S
S
S
F
Q
D
L
Y
C
Site 87
S929
N
L
D
S
K
S
S
S
F
Q
D
L
Y
C
M
Site 88
Y934
S
S
S
F
Q
D
L
Y
C
M
V
V
P
E
S
Site 89
S941
Y
C
M
V
V
P
E
S
P
T
S
D
Y
A
E
Site 90
S944
V
V
P
E
S
P
T
S
D
Y
A
E
G
P
K
Site 91
Y946
P
E
S
P
T
S
D
Y
A
E
G
P
K
S
P
Site 92
S952
D
Y
A
E
G
P
K
S
P
S
Q
Q
E
I
L
Site 93
S954
A
E
G
P
K
S
P
S
Q
Q
E
I
L
L
R
Site 94
S979
P
P
R
L
F
A
G
S
A
D
P
S
S
G
I
Site 95
S983
F
A
G
S
A
D
P
S
S
G
I
S
L
S
P
Site 96
S984
A
G
S
A
D
P
S
S
G
I
S
L
S
P
S
Site 97
S987
A
D
P
S
S
G
I
S
L
S
P
S
F
P
L
Site 98
S989
P
S
S
G
I
S
L
S
P
S
F
P
L
S
S
Site 99
S991
S
G
I
S
L
S
P
S
F
P
L
S
S
S
G
Site 100
S995
L
S
P
S
F
P
L
S
S
S
G
E
L
M
D
Site 101
S997
P
S
F
P
L
S
S
S
G
E
L
M
D
L
T
Site 102
T1004
S
G
E
L
M
D
L
T
P
T
G
L
S
S
Q
Site 103
T1006
E
L
M
D
L
T
P
T
G
L
S
S
Q
E
C
Site 104
S1010
L
T
P
T
G
L
S
S
Q
E
C
L
A
A
D
Site 105
T1021
L
A
A
D
K
I
R
T
S
T
P
T
G
H
G
Site 106
S1022
A
A
D
K
I
R
T
S
T
P
T
G
H
G
A
Site 107
T1023
A
D
K
I
R
T
S
T
P
T
G
H
G
A
S
Site 108
T1025
K
I
R
T
S
T
P
T
G
H
G
A
S
P
A
Site 109
S1030
T
P
T
G
H
G
A
S
P
A
K
Q
D
E
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation