KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
FLJ30092
Full Name:
Probable E3 ubiquitin-protein ligase C12orf51
Alias:
AF-1 specific protein phosphatase; Chromosome 12 open reading frame 51; FLJ34154; KIAA0614
Type:
Ligase; EC 6.3.2.-
Mass (Da):
327982
Number AA:
3000
UniProt ID:
Q9Y4D8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0016881
PhosphoSite+
KinaseNET
Biological Process:
GO:0019941
GO:0006464
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
K
E
L
E
L
L
C
S
M
K
E
V
S
F
D
Site 2
S14
L
C
S
M
K
E
V
S
F
D
G
N
D
L
E
Site 3
S26
D
L
E
N
M
V
L
S
L
R
E
K
F
L
Q
Site 4
S37
K
F
L
Q
E
V
N
S
L
I
Q
K
P
S
H
Site 5
S43
N
S
L
I
Q
K
P
S
H
P
L
A
K
T
K
Site 6
T49
P
S
H
P
L
A
K
T
K
T
L
V
K
S
L
Site 7
T51
H
P
L
A
K
T
K
T
L
V
K
S
L
M
N
Site 8
S55
K
T
K
T
L
V
K
S
L
M
N
R
A
E
L
Site 9
S77
A
Q
S
G
L
T
R
S
I
S
G
T
P
A
E
Site 10
S79
S
G
L
T
R
S
I
S
G
T
P
A
E
T
P
Site 11
T81
L
T
R
S
I
S
G
T
P
A
E
T
P
A
C
Site 12
T85
I
S
G
T
P
A
E
T
P
A
C
K
S
A
S
Site 13
S92
T
P
A
C
K
S
A
S
E
T
K
V
I
S
H
Site 14
S98
A
S
E
T
K
V
I
S
H
A
V
R
Q
P
V
Site 15
S109
R
Q
P
V
F
L
R
S
M
S
A
P
S
D
L
Site 16
S111
P
V
F
L
R
S
M
S
A
P
S
D
L
E
M
Site 17
S114
L
R
S
M
S
A
P
S
D
L
E
M
I
G
N
Site 18
T137
N
Q
R
R
R
H
V
T
S
H
R
S
S
S
F
Site 19
S138
Q
R
R
R
H
V
T
S
H
R
S
S
S
F
T
Site 20
S141
R
H
V
T
S
H
R
S
S
S
F
T
L
L
Q
Site 21
S142
H
V
T
S
H
R
S
S
S
F
T
L
L
Q
S
Site 22
S143
V
T
S
H
R
S
S
S
F
T
L
L
Q
S
L
Site 23
S149
S
S
F
T
L
L
Q
S
L
A
I
E
D
S
R
Site 24
S155
Q
S
L
A
I
E
D
S
R
D
K
P
T
Y
S
Site 25
T160
E
D
S
R
D
K
P
T
Y
S
V
L
L
G
Q
Site 26
Y161
D
S
R
D
K
P
T
Y
S
V
L
L
G
Q
L
Site 27
S162
S
R
D
K
P
T
Y
S
V
L
L
G
Q
L
F
Site 28
S181
T
N
P
D
Q
A
V
S
S
S
S
F
L
L
A
Site 29
T191
S
F
L
L
A
A
Q
T
R
W
R
R
G
N
T
Site 30
T198
T
R
W
R
R
G
N
T
R
K
Q
A
L
V
H
Site 31
T240
G
P
R
I
E
E
L
T
C
G
G
M
V
E
Q
Site 32
Y282
G
L
L
C
T
I
P
Y
T
R
S
E
E
K
C
Site 33
S304
Q
L
M
D
R
L
C
S
L
S
N
Q
T
E
S
Site 34
S306
M
D
R
L
C
S
L
S
N
Q
T
E
S
S
S
Site 35
T309
L
C
S
L
S
N
Q
T
E
S
S
S
S
E
K
Site 36
S311
S
L
S
N
Q
T
E
S
S
S
S
E
K
Q
T
Site 37
S313
S
N
Q
T
E
S
S
S
S
E
K
Q
T
K
K
Site 38
S314
N
Q
T
E
S
S
S
S
E
K
Q
T
K
K
Q
Site 39
T318
S
S
S
S
E
K
Q
T
K
K
Q
K
V
A
T
Site 40
S348
W
E
K
E
E
G
G
S
T
E
A
V
H
S
G
Site 41
T349
E
K
E
E
G
G
S
T
E
A
V
H
S
G
L
Site 42
T365
R
Q
V
S
S
L
L
T
N
H
L
A
R
A
T
Site 43
T372
T
N
H
L
A
R
A
T
E
C
C
G
N
Q
A
Site 44
S390
D
A
L
Q
D
V
L
S
L
L
N
D
L
S
R
Site 45
S396
L
S
L
L
N
D
L
S
R
S
H
I
G
K
A
Site 46
S456
N
V
E
L
P
P
W
S
Y
S
V
P
S
L
N
Site 47
Y457
V
E
L
P
P
W
S
Y
S
V
P
S
L
N
S
Site 48
S458
E
L
P
P
W
S
Y
S
V
P
S
L
N
S
E
Site 49
S461
P
W
S
Y
S
V
P
S
L
N
S
E
Q
E
D
Site 50
S464
Y
S
V
P
S
L
N
S
E
Q
E
D
P
S
D
Site 51
S470
N
S
E
Q
E
D
P
S
D
P
A
S
K
I
A
Site 52
S474
E
D
P
S
D
P
A
S
K
I
A
S
L
L
L
Site 53
S497
P
G
C
Q
T
V
L
S
P
T
A
S
E
P
D
Site 54
S501
T
V
L
S
P
T
A
S
E
P
D
T
T
L
T
Site 55
T505
P
T
A
S
E
P
D
T
T
L
T
K
T
S
P
Site 56
T506
T
A
S
E
P
D
T
T
L
T
K
T
S
P
K
Site 57
T508
S
E
P
D
T
T
L
T
K
T
S
P
K
N
S
Site 58
T510
P
D
T
T
L
T
K
T
S
P
K
N
S
L
K
Site 59
S511
D
T
T
L
T
K
T
S
P
K
N
S
L
K
G
Site 60
S515
T
K
T
S
P
K
N
S
L
K
G
D
K
D
P
Site 61
S526
D
K
D
P
G
E
E
S
E
A
V
D
G
K
L
Site 62
S545
H
K
R
E
D
Q
S
S
H
E
V
L
Q
P
L
Site 63
S554
E
V
L
Q
P
L
L
S
S
S
E
G
R
P
F
Site 64
S555
V
L
Q
P
L
L
S
S
S
E
G
R
P
F
R
Site 65
S556
L
Q
P
L
L
S
S
S
E
G
R
P
F
R
L
Site 66
T565
G
R
P
F
R
L
G
T
G
A
N
M
E
K
V
Site 67
T600
A
A
A
L
R
K
A
T
K
W
A
Q
S
G
L
Site 68
S617
S
I
G
P
P
V
E
S
I
N
P
E
T
V
S
Site 69
T622
V
E
S
I
N
P
E
T
V
S
G
L
S
T
G
Site 70
S624
S
I
N
P
E
T
V
S
G
L
S
T
G
D
K
Site 71
T628
E
T
V
S
G
L
S
T
G
D
K
K
K
T
A
Site 72
T634
S
T
G
D
K
K
K
T
A
Q
T
S
I
C
R
Site 73
S638
K
K
K
T
A
Q
T
S
I
C
R
E
R
N
S
Site 74
S645
S
I
C
R
E
R
N
S
E
L
A
R
T
D
P
Site 75
T650
R
N
S
E
L
A
R
T
D
P
V
R
P
F
I
Site 76
S658
D
P
V
R
P
F
I
S
G
H
V
A
N
S
M
Site 77
Y709
Y
I
P
Q
L
G
K
Y
A
E
S
I
L
E
N
Site 78
S719
S
I
L
E
N
G
S
S
S
G
R
K
L
A
K
Site 79
S720
I
L
E
N
G
S
S
S
G
R
K
L
A
K
L
Site 80
S752
K
E
T
I
K
I
G
S
E
V
Q
V
L
G
R
Site 81
T779
N
E
Q
E
G
I
A
T
V
R
F
P
P
I
D
Site 82
T790
P
P
I
D
C
R
K
T
S
Q
A
S
D
T
L
Site 83
S791
P
I
D
C
R
K
T
S
Q
A
S
D
T
L
T
Site 84
S794
C
R
K
T
S
Q
A
S
D
T
L
T
I
P
L
Site 85
T796
K
T
S
Q
A
S
D
T
L
T
I
P
L
S
R
Site 86
T798
S
Q
A
S
D
T
L
T
I
P
L
S
R
L
C
Site 87
S809
S
R
L
C
V
P
R
S
E
A
L
P
L
H
K
Site 88
S839
L
P
Q
E
G
S
L
S
I
H
T
S
L
P
A
Site 89
T842
E
G
S
L
S
I
H
T
S
L
P
A
T
G
D
Site 90
S843
G
S
L
S
I
H
T
S
L
P
A
T
G
D
G
Site 91
Y923
C
E
R
L
R
M
L
Y
R
D
C
A
R
P
P
Site 92
T945
R
R
Q
P
K
E
I
T
W
S
P
S
R
V
F
Site 93
S947
Q
P
K
E
I
T
W
S
P
S
R
V
F
P
P
Site 94
S949
K
E
I
T
W
S
P
S
R
V
F
P
P
V
R
Site 95
T983
G
G
G
L
P
R
G
T
F
I
Y
A
T
S
P
Site 96
Y1007
W
E
I
E
I
V
S
Y
G
D
T
D
D
D
T
Site 97
T1010
E
I
V
S
Y
G
D
T
D
D
D
T
G
P
I
Site 98
T1014
Y
G
D
T
D
D
D
T
G
P
I
V
S
F
G
Site 99
S1019
D
D
T
G
P
I
V
S
F
G
F
T
T
E
A
Site 100
T1023
P
I
V
S
F
G
F
T
T
E
A
E
K
R
D
Site 101
T1034
E
K
R
D
G
A
W
T
N
P
V
G
T
C
L
Site 102
Y1051
N
N
G
R
A
V
H
Y
N
G
S
S
L
L
Q
Site 103
T1084
G
W
E
R
T
E
G
T
P
P
P
P
G
Q
P
Site 104
Y1097
Q
P
A
K
G
R
V
Y
F
T
Y
C
G
Q
R
Site 105
T1099
A
K
G
R
V
Y
F
T
Y
C
G
Q
R
L
S
Site 106
Y1100
K
G
R
V
Y
F
T
Y
C
G
Q
R
L
S
P
Site 107
S1106
T
Y
C
G
Q
R
L
S
P
Y
L
E
D
V
S
Site 108
Y1108
C
G
Q
R
L
S
P
Y
L
E
D
V
S
G
G
Site 109
T1129
I
Q
K
K
N
T
K
T
R
A
N
F
G
S
R
Site 110
S1135
K
T
R
A
N
F
G
S
R
P
F
A
Y
A
E
Site 111
Y1140
F
G
S
R
P
F
A
Y
A
E
G
Q
A
H
R
Site 112
S1173
A
L
P
F
A
M
A
S
D
S
D
N
D
A
G
Site 113
S1175
P
F
A
M
A
S
D
S
D
N
D
A
G
T
S
Site 114
T1181
D
S
D
N
D
A
G
T
S
I
A
S
D
P
G
Site 115
S1185
D
A
G
T
S
I
A
S
D
P
G
T
H
G
P
Site 116
T1189
S
I
A
S
D
P
G
T
H
G
P
P
C
R
I
Site 117
Y1206
V
A
T
A
Q
Q
Q
Y
D
S
D
T
S
C
H
Site 118
Y1220
H
Y
K
V
E
L
S
Y
E
N
F
I
T
S
G
Site 119
T1225
L
S
Y
E
N
F
I
T
S
G
P
D
P
H
P
Site 120
S1240
P
P
I
A
D
D
E
S
D
D
D
D
D
D
D
Site 121
Y1254
D
I
P
Q
E
D
H
Y
A
L
L
V
K
A
W
Site 122
T1268
W
E
T
K
V
F
P
T
I
R
R
R
F
R
N
Site 123
S1281
R
N
E
A
E
R
K
S
G
L
D
Q
I
K
G
Site 124
T1301
M
V
D
I
A
R
Q
T
V
E
F
L
Y
E
E
Site 125
Y1306
R
Q
T
V
E
F
L
Y
E
E
N
G
G
I
P
Site 126
Y1317
G
G
I
P
R
D
L
Y
L
P
T
I
E
D
I
Site 127
T1341
D
K
V
R
K
G
L
T
V
V
T
R
S
P
D
Site 128
T1344
R
K
G
L
T
V
V
T
R
S
P
D
S
N
N
Site 129
S1346
G
L
T
V
V
T
R
S
P
D
S
N
N
V
A
Site 130
S1349
V
V
T
R
S
P
D
S
N
N
V
A
S
S
A
Site 131
S1355
D
S
N
N
V
A
S
S
A
V
G
T
A
L
P
Site 132
T1359
V
A
S
S
A
V
G
T
A
L
P
K
F
A
I
Site 133
Y1418
L
E
R
P
P
A
G
Y
R
R
T
A
T
N
G
Site 134
T1421
P
P
A
G
Y
R
R
T
A
T
N
G
L
V
T
Site 135
T1423
A
G
Y
R
R
T
A
T
N
G
L
V
T
L
D
Site 136
Y1529
C
S
A
T
D
L
F
Y
Q
G
N
S
Q
T
V
Site 137
S1564
E
L
T
K
Q
I
C
S
F
L
Q
T
A
P
E
Site 138
T1568
Q
I
C
S
F
L
Q
T
A
P
E
Q
F
P
S
Site 139
S1575
T
A
P
E
Q
F
P
S
E
E
F
P
I
S
E
Site 140
S1581
P
S
E
E
F
P
I
S
E
S
K
V
N
M
D
Site 141
S1604
V
V
V
S
C
K
E
S
Q
S
G
F
R
K
D
Site 142
S1606
V
S
C
K
E
S
Q
S
G
F
R
K
D
S
S
Site 143
S1612
Q
S
G
F
R
K
D
S
S
L
Y
K
A
P
W
Site 144
S1613
S
G
F
R
K
D
S
S
L
Y
K
A
P
W
A
Site 145
Y1615
F
R
K
D
S
S
L
Y
K
A
P
W
A
R
V
Site 146
Y1645
N
L
I
E
A
A
C
Y
P
R
D
A
S
P
A
Site 147
S1650
A
C
Y
P
R
D
A
S
P
A
N
T
G
L
A
Site 148
T1654
R
D
A
S
P
A
N
T
G
L
A
P
P
P
T
Site 149
T1661
T
G
L
A
P
P
P
T
A
D
Q
Y
P
S
V
Site 150
Y1665
P
P
P
T
A
D
Q
Y
P
S
V
V
L
S
T
Site 151
S1667
P
T
A
D
Q
Y
P
S
V
V
L
S
T
D
R
Site 152
S1671
Q
Y
P
S
V
V
L
S
T
D
R
V
H
I
K
Site 153
S1710
A
F
A
E
Q
L
L
S
W
K
S
E
D
S
E
Site 154
S1713
E
Q
L
L
S
W
K
S
E
D
S
E
G
K
S
Site 155
S1716
L
S
W
K
S
E
D
S
E
G
K
S
E
D
E
Site 156
S1720
S
E
D
S
E
G
K
S
E
D
E
P
D
T
I
Site 157
T1726
K
S
E
D
E
P
D
T
I
P
T
S
V
L
L
Site 158
T1769
E
L
L
R
T
V
H
T
L
E
Q
R
R
H
P
Site 159
S1780
R
R
H
P
A
G
L
S
S
S
I
A
L
Q
L
Site 160
Y1805
Q
S
E
L
H
K
L
Y
D
E
E
T
Q
N
W
Site 161
T1809
H
K
L
Y
D
E
E
T
Q
N
W
V
S
G
G
Site 162
S1814
E
E
T
Q
N
W
V
S
G
G
A
C
G
G
S
Site 163
S1821
S
G
G
A
C
G
G
S
G
G
A
A
A
G
D
Site 164
T1834
G
D
Q
G
R
F
S
T
Y
F
H
A
L
M
E
Site 165
Y1835
D
Q
G
R
F
S
T
Y
F
H
A
L
M
E
G
Site 166
S1871
S
A
T
A
P
N
L
S
D
S
S
S
S
S
S
Site 167
S1873
T
A
P
N
L
S
D
S
S
S
S
S
S
S
S
Site 168
S1874
A
P
N
L
S
D
S
S
S
S
S
S
S
S
P
Site 169
S1875
P
N
L
S
D
S
S
S
S
S
S
S
S
P
G
Site 170
S1876
N
L
S
D
S
S
S
S
S
S
S
S
P
G
Q
Site 171
S1877
L
S
D
S
S
S
S
S
S
S
S
P
G
Q
T
Site 172
S1878
S
D
S
S
S
S
S
S
S
S
P
G
Q
T
P
Site 173
S1879
D
S
S
S
S
S
S
S
S
P
G
Q
T
P
Q
Site 174
S1880
S
S
S
S
S
S
S
S
P
G
Q
T
P
Q
S
Site 175
T1884
S
S
S
S
P
G
Q
T
P
Q
S
P
S
L
L
Site 176
S1887
S
P
G
Q
T
P
Q
S
P
S
L
L
S
K
R
Site 177
S1889
G
Q
T
P
Q
S
P
S
L
L
S
K
R
K
K
Site 178
S1892
P
Q
S
P
S
L
L
S
K
R
K
K
V
K
M
Site 179
S1905
K
M
K
R
E
K
A
S
S
S
G
K
R
Q
S
Site 180
S1906
M
K
R
E
K
A
S
S
S
G
K
R
Q
S
S
Site 181
S1907
K
R
E
K
A
S
S
S
G
K
R
Q
S
S
R
Site 182
S1912
S
S
S
G
K
R
Q
S
S
R
T
V
D
S
D
Site 183
S1913
S
S
G
K
R
Q
S
S
R
T
V
D
S
D
P
Site 184
T1915
G
K
R
Q
S
S
R
T
V
D
S
D
P
T
V
Site 185
S1918
Q
S
S
R
T
V
D
S
D
P
T
V
L
S
I
Site 186
T1921
R
T
V
D
S
D
P
T
V
L
S
I
G
G
S
Site 187
S1924
D
S
D
P
T
V
L
S
I
G
G
S
K
P
E
Site 188
S1928
T
V
L
S
I
G
G
S
K
P
E
D
M
L
W
Site 189
T1941
L
W
F
H
R
A
L
T
L
L
I
I
L
R
H
Site 190
T1950
L
I
I
L
R
H
L
T
R
K
D
P
Q
G
L
Site 191
Y2015
G
V
F
K
D
E
I
Y
I
P
L
Q
E
E
D
Site 192
T2023
I
P
L
Q
E
E
D
T
K
K
P
K
D
K
A
Site 193
T2042
G
K
V
E
P
E
K
T
L
A
F
P
G
T
D
Site 194
T2048
K
T
L
A
F
P
G
T
D
S
M
E
V
S
T
Site 195
S2050
L
A
F
P
G
T
D
S
M
E
V
S
T
S
S
Site 196
S2054
G
T
D
S
M
E
V
S
T
S
S
S
L
T
P
Site 197
S2056
D
S
M
E
V
S
T
S
S
S
L
T
P
A
M
Site 198
S2068
P
A
M
S
I
S
A
S
A
S
T
S
Q
A
S
Site 199
S2075
S
A
S
T
S
Q
A
S
I
C
S
S
Q
G
I
Site 200
S2078
T
S
Q
A
S
I
C
S
S
Q
G
I
S
Q
T
Site 201
S2079
S
Q
A
S
I
C
S
S
Q
G
I
S
Q
T
V
Site 202
S2083
I
C
S
S
Q
G
I
S
Q
T
V
S
D
L
S
Site 203
T2085
S
S
Q
G
I
S
Q
T
V
S
D
L
S
V
D
Site 204
S2087
Q
G
I
S
Q
T
V
S
D
L
S
V
D
P
L
Site 205
S2090
S
Q
T
V
S
D
L
S
V
D
P
L
P
A
G
Site 206
S2113
L
L
E
P
H
A
V
S
S
Q
E
S
L
D
I
Site 207
S2114
L
E
P
H
A
V
S
S
Q
E
S
L
D
I
S
Site 208
S2117
H
A
V
S
S
Q
E
S
L
D
I
S
L
C
S
Site 209
S2121
S
Q
E
S
L
D
I
S
L
C
S
T
G
S
L
Site 210
S2130
C
S
T
G
S
L
G
S
L
G
S
L
G
E
P
Site 211
S2133
G
S
L
G
S
L
G
S
L
G
E
P
L
D
N
Site 212
T2143
E
P
L
D
N
A
E
T
A
S
V
S
D
M
G
Site 213
S2145
L
D
N
A
E
T
A
S
V
S
D
M
G
S
M
Site 214
S2147
N
A
E
T
A
S
V
S
D
M
G
S
M
Y
T
Site 215
Y2153
V
S
D
M
G
S
M
Y
T
V
T
S
L
D
N
Site 216
T2154
S
D
M
G
S
M
Y
T
V
T
S
L
D
N
Q
Site 217
S2157
G
S
M
Y
T
V
T
S
L
D
N
Q
P
L
A
Site 218
S2188
K
I
E
K
I
R
A
S
L
F
N
N
N
D
L
Site 219
S2200
N
D
L
I
G
L
S
S
L
D
G
E
D
E
L
Site 220
S2211
E
D
E
L
M
E
M
S
T
E
E
I
L
T
V
Site 221
S2224
T
V
S
V
V
N
Q
S
L
F
D
T
Q
G
S
Site 222
T2228
V
N
Q
S
L
F
D
T
Q
G
S
P
G
L
E
Site 223
S2231
S
L
F
D
T
Q
G
S
P
G
L
E
D
Y
F
Site 224
Y2237
G
S
P
G
L
E
D
Y
F
N
D
K
S
I
K
Site 225
S2242
E
D
Y
F
N
D
K
S
I
K
G
E
K
L
V
Site 226
S2262
V
L
T
E
I
F
K
S
C
A
H
S
E
Q
T
Site 227
S2266
I
F
K
S
C
A
H
S
E
Q
T
L
S
L
T
Site 228
T2269
S
C
A
H
S
E
Q
T
L
S
L
T
P
A
K
Site 229
S2271
A
H
S
E
Q
T
L
S
L
T
P
A
K
P
I
Site 230
T2273
S
E
Q
T
L
S
L
T
P
A
K
P
I
R
V
Site 231
S2281
P
A
K
P
I
R
V
S
D
I
Y
L
S
K
E
Site 232
Y2284
P
I
R
V
S
D
I
Y
L
S
K
E
Q
I
N
Site 233
S2286
R
V
S
D
I
Y
L
S
K
E
Q
I
N
S
Q
Site 234
S2292
L
S
K
E
Q
I
N
S
Q
T
P
G
N
L
L
Site 235
T2294
K
E
Q
I
N
S
Q
T
P
G
N
L
L
H
L
Site 236
T2304
N
L
L
H
L
F
F
T
N
V
R
P
P
K
K
Site 237
T2318
K
V
L
E
D
Q
L
T
Q
I
L
R
K
Y
G
Site 238
Y2324
L
T
Q
I
L
R
K
Y
G
V
P
K
P
K
F
Site 239
S2334
P
K
P
K
F
D
K
S
K
Y
S
K
A
G
K
Site 240
Y2336
P
K
F
D
K
S
K
Y
S
K
A
G
K
E
Q
Site 241
S2350
Q
H
P
V
K
V
V
S
T
K
R
P
I
T
K
Site 242
T2351
H
P
V
K
V
V
S
T
K
R
P
I
T
K
P
Site 243
T2356
V
S
T
K
R
P
I
T
K
P
P
A
K
D
K
Site 244
S2368
K
D
K
A
V
L
N
S
V
S
R
T
A
L
S
Site 245
S2370
K
A
V
L
N
S
V
S
R
T
A
L
S
E
K
Site 246
T2372
V
L
N
S
V
S
R
T
A
L
S
E
K
K
P
Site 247
S2375
S
V
S
R
T
A
L
S
E
K
K
P
T
V
K
Site 248
T2380
A
L
S
E
K
K
P
T
V
K
P
K
S
P
E
Site 249
S2385
K
P
T
V
K
P
K
S
P
E
K
S
K
P
D
Site 250
S2389
K
P
K
S
P
E
K
S
K
P
D
E
K
D
P
Site 251
S2399
D
E
K
D
P
E
K
S
P
T
K
K
Q
E
V
Site 252
T2401
K
D
P
E
K
S
P
T
K
K
Q
E
V
P
E
Site 253
Y2411
Q
E
V
P
E
E
K
Y
L
T
L
E
G
F
H
Site 254
T2413
V
P
E
E
K
Y
L
T
L
E
G
F
H
K
F
Site 255
S2431
R
A
R
Q
D
I
R
S
V
W
R
A
I
L
S
Site 256
Y2441
R
A
I
L
S
C
G
Y
D
L
H
F
E
R
C
Site 257
T2464
Q
K
A
S
R
K
W
T
L
E
M
D
V
A
L
Site 258
T2485
L
C
R
H
L
A
I
T
P
A
R
L
H
P
H
Site 259
Y2495
R
L
H
P
H
E
V
Y
L
D
P
A
D
A
A
Site 260
T2544
P
L
V
E
L
R
Q
T
P
M
Y
T
H
S
I
Site 261
Y2547
E
L
R
Q
T
P
M
Y
T
H
S
I
A
A
L
Site 262
S2550
Q
T
P
M
Y
T
H
S
I
A
A
L
L
K
E
Site 263
T2566
K
G
L
I
F
Y
D
T
K
V
T
V
M
N
R
Site 264
T2578
M
N
R
V
L
N
A
T
V
Q
R
T
A
D
H
Site 265
S2605
V
G
G
E
I
R
A
S
E
N
S
Y
F
C
Q
Site 266
S2608
E
I
R
A
S
E
N
S
Y
F
C
Q
A
A
R
Site 267
Y2609
I
R
A
S
E
N
S
Y
F
C
Q
A
A
R
Q
Site 268
S2619
Q
A
A
R
Q
L
A
S
V
P
S
S
Q
L
C
Site 269
Y2637
A
S
G
G
D
P
T
Y
A
F
N
I
R
F
T
Site 270
T2644
Y
A
F
N
I
R
F
T
G
E
E
V
H
G
T
Site 271
T2651
T
G
E
E
V
H
G
T
S
G
S
F
R
H
F
Site 272
S2654
E
V
H
G
T
S
G
S
F
R
H
F
L
W
Q
Site 273
T2692
N
K
G
K
Y
I
L
T
P
S
P
I
T
Y
G
Site 274
S2694
G
K
Y
I
L
T
P
S
P
I
T
Y
G
E
E
Site 275
Y2698
L
T
P
S
P
I
T
Y
G
E
E
Q
L
L
H
Site 276
T2751
L
Q
E
A
D
I
L
T
Y
N
Y
V
K
K
F
Site 277
Y2754
A
D
I
L
T
Y
N
Y
V
K
K
F
E
S
I
Site 278
T2781
I
A
S
Q
H
L
A
T
E
S
P
D
S
P
N
Site 279
S2783
S
Q
H
L
A
T
E
S
P
D
S
P
N
K
P
Site 280
S2786
L
A
T
E
S
P
D
S
P
N
K
P
C
C
R
Site 281
Y2796
K
P
C
C
R
F
T
Y
L
T
M
T
G
E
E
Site 282
Y2823
A
W
E
N
K
D
I
Y
A
A
A
I
R
S
L
Site 283
T2938
C
K
D
G
G
P
D
T
A
H
V
P
P
Y
P
Site 284
Y2944
D
T
A
H
V
P
P
Y
P
M
K
I
A
P
P
Site 285
T2954
K
I
A
P
P
D
G
T
A
G
S
P
D
S
R
Site 286
S2957
P
P
D
G
T
A
G
S
P
D
S
R
Y
I
R
Site 287
S2960
G
T
A
G
S
P
D
S
R
Y
I
R
V
E
T
Site 288
Y2962
A
G
S
P
D
S
R
Y
I
R
V
E
T
C
M
Site 289
S2979
I
K
L
P
Q
Y
S
S
L
E
I
M
L
E
K
Site 290
Y2993
K
L
R
C
A
I
H
Y
R
E
D
P
L
S
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation