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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FAM21C
Full Name:
WASH complex subunit FAM21C
Alias:
KIAA0592; Protein FAM21C; WASH complex subunit FAM21C
Type:
Unknown function
Mass (Da):
144668
Number AA:
1318
UniProt ID:
Q9Y4E1
International Prot ID:
IPI00514705
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
M
N
R
T
T
P
D
Q
E
L
V
P
Site 2
S15
D
Q
E
L
V
P
A
S
E
P
V
W
E
R
P
Site 3
S24
P
V
W
E
R
P
W
S
V
E
E
I
R
R
S
Site 4
S31
S
V
E
E
I
R
R
S
S
Q
S
W
S
L
A
Site 5
S32
V
E
E
I
R
R
S
S
Q
S
W
S
L
A
A
Site 6
S34
E
I
R
R
S
S
Q
S
W
S
L
A
A
D
A
Site 7
S36
R
R
S
S
Q
S
W
S
L
A
A
D
A
G
L
Site 8
S51
L
Q
F
L
Q
E
F
S
Q
Q
T
I
S
R
T
Site 9
S56
E
F
S
Q
Q
T
I
S
R
T
H
E
I
K
K
Site 10
T72
V
D
G
L
I
R
E
T
K
A
T
D
C
R
L
Site 11
T75
L
I
R
E
T
K
A
T
D
C
R
L
H
N
V
Site 12
T92
D
F
L
M
L
S
N
T
Q
F
I
E
N
R
V
Site 13
Y100
Q
F
I
E
N
R
V
Y
D
E
E
V
E
E
P
Site 14
T116
L
K
A
E
A
E
K
T
E
Q
E
K
T
R
E
Site 15
T121
E
K
T
E
Q
E
K
T
R
E
Q
K
E
V
D
Site 16
Y139
K
V
Q
E
A
V
N
Y
G
L
Q
V
L
D
S
Site 17
S158
L
D
I
K
A
G
N
S
D
S
E
E
D
D
A
Site 18
S160
I
K
A
G
N
S
D
S
E
E
D
D
A
N
G
Site 19
Y179
I
L
E
P
K
D
L
Y
I
D
R
P
L
P
Y
Site 20
S205
D
V
G
L
G
E
L
S
S
E
E
G
S
V
G
Site 21
S206
V
G
L
G
E
L
S
S
E
E
G
S
V
G
S
Site 22
S210
E
L
S
S
E
E
G
S
V
G
S
D
R
G
S
Site 23
S213
S
E
E
G
S
V
G
S
D
R
G
S
I
V
D
Site 24
S217
S
V
G
S
D
R
G
S
I
V
D
T
E
E
E
Site 25
T221
D
R
G
S
I
V
D
T
E
E
E
K
E
E
E
Site 26
S230
E
E
K
E
E
E
E
S
D
E
D
F
A
H
H
Site 27
S265
G
C
D
L
F
A
D
S
E
K
E
E
E
D
I
Site 28
S284
E
N
T
R
P
K
R
S
R
P
T
S
F
A
D
Site 29
T287
R
P
K
R
S
R
P
T
S
F
A
D
E
L
A
Site 30
S288
P
K
R
S
R
P
T
S
F
A
D
E
L
A
A
Site 31
T310
G
R
V
D
E
E
P
T
T
L
P
S
G
E
A
Site 32
T311
R
V
D
E
E
P
T
T
L
P
S
G
E
A
K
Site 33
S314
E
E
P
T
T
L
P
S
G
E
A
K
P
R
K
Site 34
T322
G
E
A
K
P
R
K
T
L
K
E
K
K
E
R
Site 35
T331
K
E
K
K
E
R
R
T
P
S
D
D
E
E
D
Site 36
S333
K
K
E
R
R
T
P
S
D
D
E
E
D
N
L
Site 37
T347
L
F
A
P
P
K
L
T
D
E
D
F
S
P
F
Site 38
S352
K
L
T
D
E
D
F
S
P
F
G
S
G
G
G
Site 39
S356
E
D
F
S
P
F
G
S
G
G
G
L
F
S
G
Site 40
S362
G
S
G
G
G
L
F
S
G
G
K
G
L
F
D
Site 41
S375
F
D
D
E
D
E
E
S
D
L
F
T
E
A
S
Site 42
T379
D
E
E
S
D
L
F
T
E
A
S
Q
D
R
Q
Site 43
S382
S
D
L
F
T
E
A
S
Q
D
R
Q
A
G
A
Site 44
S390
Q
D
R
Q
A
G
A
S
V
K
E
E
S
S
S
Site 45
S395
G
A
S
V
K
E
E
S
S
S
S
K
P
G
K
Site 46
S396
A
S
V
K
E
E
S
S
S
S
K
P
G
K
K
Site 47
S397
S
V
K
E
E
S
S
S
S
K
P
G
K
K
I
Site 48
S398
V
K
E
E
S
S
S
S
K
P
G
K
K
I
P
Site 49
S423
T
D
V
F
G
A
A
S
V
P
S
L
K
E
P
Site 50
S426
F
G
A
A
S
V
P
S
L
K
E
P
Q
K
P
Site 51
T437
P
Q
K
P
E
Q
P
T
P
R
K
S
P
Y
G
Site 52
S441
E
Q
P
T
P
R
K
S
P
Y
G
P
P
P
T
Site 53
Y443
P
T
P
R
K
S
P
Y
G
P
P
P
T
G
L
Site 54
T448
S
P
Y
G
P
P
P
T
G
L
F
D
D
D
D
Site 55
S464
D
D
D
D
D
F
F
S
A
P
H
S
K
P
S
Site 56
S468
D
F
F
S
A
P
H
S
K
P
S
K
T
R
K
Site 57
S471
S
A
P
H
S
K
P
S
K
T
R
K
V
Q
S
Site 58
T473
P
H
S
K
P
S
K
T
R
K
V
Q
S
T
A
Site 59
S478
S
K
T
R
K
V
Q
S
T
A
D
I
F
G
D
Site 60
T479
K
T
R
K
V
Q
S
T
A
D
I
F
G
D
E
Site 61
S498
F
K
E
K
A
V
A
S
P
E
A
T
V
S
Q
Site 62
T502
A
V
A
S
P
E
A
T
V
S
Q
T
D
E
N
Site 63
S504
A
S
P
E
A
T
V
S
Q
T
D
E
N
K
A
Site 64
T518
A
R
A
E
K
K
V
T
L
S
Y
S
K
N
L
Site 65
S520
A
E
K
K
V
T
L
S
Y
S
K
N
L
K
P
Site 66
Y521
E
K
K
V
T
L
S
Y
S
K
N
L
K
P
S
Site 67
S522
K
K
V
T
L
S
Y
S
K
N
L
K
P
S
S
Site 68
S529
S
K
N
L
K
P
S
S
E
T
K
T
Q
K
G
Site 69
T531
N
L
K
P
S
S
E
T
K
T
Q
K
G
L
F
Site 70
T533
K
P
S
S
E
T
K
T
Q
K
G
L
F
S
D
Site 71
S539
K
T
Q
K
G
L
F
S
D
E
E
D
S
E
D
Site 72
S544
L
F
S
D
E
E
D
S
E
D
L
F
S
S
Q
Site 73
S549
E
D
S
E
D
L
F
S
S
Q
S
A
S
N
L
Site 74
S550
D
S
E
D
L
F
S
S
Q
S
A
S
N
L
K
Site 75
S552
E
D
L
F
S
S
Q
S
A
S
N
L
K
G
A
Site 76
S554
L
F
S
S
Q
S
A
S
N
L
K
G
A
S
L
Site 77
S560
A
S
N
L
K
G
A
S
L
L
P
G
K
L
P
Site 78
S569
L
P
G
K
L
P
T
S
V
S
L
F
D
D
E
Site 79
S571
G
K
L
P
T
S
V
S
L
F
D
D
E
D
E
Site 80
S594
A
A
K
K
Q
T
L
S
L
Q
A
Q
R
E
E
Site 81
S614
E
L
S
K
K
K
A
S
A
L
L
F
S
S
D
Site 82
S619
K
A
S
A
L
L
F
S
S
D
E
E
D
Q
W
Site 83
S620
A
S
A
L
L
F
S
S
D
E
E
D
Q
W
N
Site 84
S631
D
Q
W
N
I
P
A
S
Q
T
H
L
A
S
D
Site 85
S637
A
S
Q
T
H
L
A
S
D
S
R
S
K
G
E
Site 86
S639
Q
T
H
L
A
S
D
S
R
S
K
G
E
P
R
Site 87
S784
V
K
H
S
D
L
F
S
S
S
S
P
W
D
K
Site 88
S785
K
H
S
D
L
F
S
S
S
S
P
W
D
K
G
Site 89
T797
D
K
G
T
K
P
R
T
K
T
V
L
S
L
F
Site 90
T1117
D
S
G
D
I
F
S
T
G
T
G
S
Q
S
V
Site 91
S1121
I
F
S
T
G
T
G
S
Q
S
V
E
R
T
K
Site 92
S1200
V
K
K
N
E
T
K
S
S
S
Q
Q
D
V
I
Site 93
S1291
A
K
T
T
K
P
K
S
R
S
A
Q
A
A
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation