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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZNF451
Full Name:
Zinc finger protein 451
Alias:
Coactivator for steroid receptors
Type:
Mass (Da):
121484
Number AA:
1061
UniProt ID:
Q9Y4E5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
G
D
P
G
S
E
I
I
E
S
V
P
Site 2
S11
P
G
S
E
I
I
E
S
V
P
P
A
G
P
E
Site 3
S20
P
P
A
G
P
E
A
S
E
S
T
T
D
E
N
Site 4
S22
A
G
P
E
A
S
E
S
T
T
D
E
N
E
D
Site 5
T24
P
E
A
S
E
S
T
T
D
E
N
E
D
D
I
Site 6
S50
L
E
Y
I
D
L
V
S
S
D
D
E
E
P
S
Site 7
S51
E
Y
I
D
L
V
S
S
D
D
E
E
P
S
T
Site 8
S57
S
S
D
D
E
E
P
S
T
S
Y
T
D
E
N
Site 9
T58
S
D
D
E
E
P
S
T
S
Y
T
D
E
N
I
Site 10
S59
D
D
E
E
P
S
T
S
Y
T
D
E
N
I
K
Site 11
T61
E
E
P
S
T
S
Y
T
D
E
N
I
K
R
K
Site 12
Y73
K
R
K
D
H
I
D
Y
Q
K
D
K
V
A
L
Site 13
T81
Q
K
D
K
V
A
L
T
L
A
R
L
A
R
H
Site 14
S125
L
E
F
I
R
G
H
S
D
T
E
A
A
R
L
Site 15
T127
F
I
R
G
H
S
D
T
E
A
A
R
L
C
V
Site 16
T152
T
G
T
I
N
C
G
T
K
S
S
F
R
R
G
Site 17
S154
T
I
N
C
G
T
K
S
S
F
R
R
G
G
H
Site 18
S155
I
N
C
G
T
K
S
S
F
R
R
G
G
H
T
Site 19
T162
S
F
R
R
G
G
H
T
W
V
S
G
K
P
I
Site 20
S196
H
L
K
R
F
D
H
S
P
C
D
P
T
I
T
Site 21
T201
D
H
S
P
C
D
P
T
I
T
L
H
G
P
F
Site 22
T203
S
P
C
D
P
T
I
T
L
H
G
P
F
F
S
Site 23
S269
F
S
R
K
E
E
C
S
K
H
M
S
G
K
N
Site 24
S295
K
G
I
A
H
P
I
S
F
P
S
F
A
K
K
Site 25
T331
L
R
S
H
M
E
L
T
A
H
F
R
V
H
C
Site 26
S350
P
V
A
V
A
E
K
S
I
T
Q
V
A
E
K
Site 27
Y363
E
K
F
I
L
R
G
Y
C
P
D
C
N
Q
V
Site 28
Y401
V
E
E
S
V
L
L
Y
C
H
S
S
E
G
N
Site 29
S404
S
V
L
L
Y
C
H
S
S
E
G
N
K
D
P
Site 30
S405
V
L
L
Y
C
H
S
S
E
G
N
K
D
P
S
Site 31
S412
S
E
G
N
K
D
P
S
S
D
L
H
L
L
L
Site 32
S413
E
G
N
K
D
P
S
S
D
L
H
L
L
L
D
Site 33
S422
L
H
L
L
L
D
Q
S
K
F
S
S
L
K
R
Site 34
S426
L
D
Q
S
K
F
S
S
L
K
R
T
M
S
I
Site 35
T430
K
F
S
S
L
K
R
T
M
S
I
K
E
S
S
Site 36
S432
S
S
L
K
R
T
M
S
I
K
E
S
S
S
L
Site 37
S436
R
T
M
S
I
K
E
S
S
S
L
E
C
I
A
Site 38
S455
K
M
N
L
K
D
K
S
H
E
G
V
A
C
V
Site 39
S482
E
C
N
Q
R
F
P
S
E
D
A
V
E
K
H
Site 40
T545
K
E
L
T
R
K
D
T
I
M
A
H
V
T
E
Site 41
Y559
E
F
H
N
G
H
R
Y
F
Y
E
M
D
E
V
Site 42
Y561
H
N
G
H
R
Y
F
Y
E
M
D
E
V
E
G
Site 43
T570
M
D
E
V
E
G
E
T
L
P
S
S
S
T
T
Site 44
S573
V
E
G
E
T
L
P
S
S
S
T
T
L
D
N
Site 45
S574
E
G
E
T
L
P
S
S
S
T
T
L
D
N
L
Site 46
T577
T
L
P
S
S
S
T
T
L
D
N
L
T
A
N
Site 47
T582
S
T
T
L
D
N
L
T
A
N
K
P
S
S
A
Site 48
S588
L
T
A
N
K
P
S
S
A
I
T
V
I
D
H
Site 49
T591
N
K
P
S
S
A
I
T
V
I
D
H
S
P
A
Site 50
S596
A
I
T
V
I
D
H
S
P
A
N
S
S
P
R
Site 51
S600
I
D
H
S
P
A
N
S
S
P
R
G
K
W
Q
Site 52
S601
D
H
S
P
A
N
S
S
P
R
G
K
W
Q
C
Site 53
Y620
D
M
F
D
S
Q
E
Y
V
K
Q
H
C
M
S
Site 54
Y636
A
S
H
K
F
H
R
Y
S
C
A
H
C
R
K
Site 55
Y652
F
H
K
I
E
T
L
Y
R
H
C
Q
D
E
H
Site 56
S684
N
V
E
E
A
F
L
S
H
Y
E
E
H
H
S
Site 57
Y686
E
E
A
F
L
S
H
Y
E
E
H
H
S
I
D
Site 58
Y694
E
E
H
H
S
I
D
Y
V
F
V
S
E
K
T
Site 59
S698
S
I
D
Y
V
F
V
S
E
K
T
E
T
S
I
Site 60
T707
K
T
E
T
S
I
K
T
E
D
D
F
P
V
I
Site 61
T721
I
E
T
S
N
Q
L
T
C
G
C
R
E
S
Y
Site 62
Y728
T
C
G
C
R
E
S
Y
I
C
K
V
N
R
K
Site 63
Y738
K
V
N
R
K
E
D
Y
S
R
C
L
Q
I
M
Site 64
S780
H
Q
V
H
K
E
K
S
D
E
E
E
Q
Q
Y
Site 65
Y787
S
D
E
E
E
Q
Q
Y
V
I
K
C
G
T
C
Site 66
S819
H
C
F
L
Q
K
P
S
V
A
H
F
G
S
E
Site 67
S825
P
S
V
A
H
F
G
S
E
K
S
N
L
Y
K
Site 68
S828
A
H
F
G
S
E
K
S
N
L
Y
K
F
T
A
Site 69
Y831
G
S
E
K
S
N
L
Y
K
F
T
A
S
A
S
Site 70
T834
K
S
N
L
Y
K
F
T
A
S
A
S
H
T
E
Site 71
T840
F
T
A
S
A
S
H
T
E
R
K
L
K
Q
A
Site 72
S851
L
K
Q
A
I
N
Y
S
K
S
L
D
M
E
K
Site 73
S853
Q
A
I
N
Y
S
K
S
L
D
M
E
K
G
V
Site 74
S865
K
G
V
E
N
D
L
S
Y
Q
N
I
E
E
E
Site 75
Y866
G
V
E
N
D
L
S
Y
Q
N
I
E
E
E
I
Site 76
Y881
V
E
L
P
D
L
D
Y
L
R
T
M
T
H
I
Site 77
Y932
P
P
L
N
C
K
I
Y
N
Y
L
N
R
I
G
Site 78
S948
F
F
L
H
P
R
C
S
K
R
K
D
A
A
D
Site 79
T976
L
P
K
Q
I
P
F
T
I
L
S
G
D
Q
G
Site 80
T994
L
E
N
Q
F
K
K
T
Q
R
P
A
H
I
L
Site 81
S1019
C
A
L
L
N
S
I
S
D
T
T
K
E
C
D
Site 82
T1021
L
L
N
S
I
S
D
T
T
K
E
C
D
S
D
Site 83
S1027
D
T
T
K
E
C
D
S
D
D
N
M
G
A
K
Site 84
S1044
S
I
G
E
E
F
I
S
T
E
D
V
E
L
E
Site 85
T1045
I
G
E
E
F
I
S
T
E
D
V
E
L
E
E
Site 86
S1057
L
E
E
A
I
R
R
S
L
E
E
M
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation