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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
USP15
Full Name:
Ubiquitin carboxyl-terminal hydrolase 15
Alias:
Deubiquitinating enzyme; Deubiquitinating enzyme 15; KIAA0529; Ubiquitin carboxyl-terminal hydrolase 15; Ubiquitin specific peptidase 15; Ubiquitin specific protease 15; Ubiquitin thioesterase 15; Ubiquitin thiolesterase 15; Ubiquitin-specific-processing protease 15; UBP15; Unph-2; Unph4
Type:
Ubiquitin conjugating system; Protease; EC 3.1.2.15
Mass (Da):
112419
Number AA:
981
UniProt ID:
Q9Y4E8
International Prot ID:
IPI00000728
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005730
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0004175
GO:0004197
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
GO:0006511
GO:0008152
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T11
G
G
A
A
D
L
D
T
Q
R
S
D
I
A
T
Site 2
S14
A
D
L
D
T
Q
R
S
D
I
A
T
L
L
K
Site 3
T18
T
Q
R
S
D
I
A
T
L
L
K
T
S
L
R
Site 4
S23
I
A
T
L
L
K
T
S
L
R
K
G
D
T
W
Site 5
T29
T
S
L
R
K
G
D
T
W
Y
L
V
D
S
R
Site 6
Y31
L
R
K
G
D
T
W
Y
L
V
D
S
R
W
F
Site 7
Y53
G
F
D
S
W
D
K
Y
Q
M
G
D
Q
N
V
Site 8
Y61
Q
M
G
D
Q
N
V
Y
P
G
P
I
D
N
S
Site 9
S78
L
K
D
G
D
A
Q
S
L
K
E
H
L
I
D
Site 10
S102
E
G
W
N
K
L
V
S
W
Y
T
L
M
E
G
Site 11
Y104
W
N
K
L
V
S
W
Y
T
L
M
E
G
Q
E
Site 12
T149
G
N
M
N
N
V
V
T
R
R
F
S
K
A
D
Site 13
S153
N
V
V
T
R
R
F
S
K
A
D
T
I
D
T
Site 14
T157
R
R
F
S
K
A
D
T
I
D
T
I
E
K
E
Site 15
T160
S
K
A
D
T
I
D
T
I
E
K
E
I
R
K
Site 16
S170
K
E
I
R
K
I
F
S
I
P
D
E
K
E
T
Site 17
Y183
E
T
R
L
W
N
K
Y
M
S
N
T
F
E
P
Site 18
T187
W
N
K
Y
M
S
N
T
F
E
P
L
N
K
P
Site 19
S196
E
P
L
N
K
P
D
S
T
I
Q
D
A
G
L
Site 20
T197
P
L
N
K
P
D
S
T
I
Q
D
A
G
L
Y
Site 21
T219
E
Q
K
N
E
D
G
T
W
P
R
G
P
S
T
Site 22
S225
G
T
W
P
R
G
P
S
T
P
K
S
P
G
A
Site 23
T226
T
W
P
R
G
P
S
T
P
K
S
P
G
A
S
Site 24
S229
R
G
P
S
T
P
K
S
P
G
A
S
N
F
S
Site 25
S233
T
P
K
S
P
G
A
S
N
F
S
T
L
P
K
Site 26
S236
S
P
G
A
S
N
F
S
T
L
P
K
I
S
P
Site 27
T237
P
G
A
S
N
F
S
T
L
P
K
I
S
P
S
Site 28
S242
F
S
T
L
P
K
I
S
P
S
S
L
S
N
N
Site 29
S244
T
L
P
K
I
S
P
S
S
L
S
N
N
Y
N
Site 30
S245
L
P
K
I
S
P
S
S
L
S
N
N
Y
N
N
Site 31
S247
K
I
S
P
S
S
L
S
N
N
Y
N
N
M
N
Site 32
Y263
R
N
V
K
N
S
N
Y
C
L
P
S
Y
T
A
Site 33
Y268
S
N
Y
C
L
P
S
Y
T
A
Y
K
N
Y
D
Site 34
T269
N
Y
C
L
P
S
Y
T
A
Y
K
N
Y
D
Y
Site 35
Y271
C
L
P
S
Y
T
A
Y
K
N
Y
D
Y
S
E
Site 36
Y274
S
Y
T
A
Y
K
N
Y
D
Y
S
E
P
G
R
Site 37
Y276
T
A
Y
K
N
Y
D
Y
S
E
P
G
R
N
N
Site 38
S277
A
Y
K
N
Y
D
Y
S
E
P
G
R
N
N
E
Site 39
S308
N
S
A
I
Q
C
L
S
N
T
P
P
L
T
E
Site 40
T314
L
S
N
T
P
P
L
T
E
Y
F
L
N
D
K
Site 41
Y316
N
T
P
P
L
T
E
Y
F
L
N
D
K
Y
Q
Site 42
Y322
E
Y
F
L
N
D
K
Y
Q
E
E
L
N
F
D
Site 43
S341
M
R
G
E
I
A
K
S
Y
A
E
L
I
K
Q
Site 44
Y342
R
G
E
I
A
K
S
Y
A
E
L
I
K
Q
M
Site 45
Y356
M
W
S
G
K
F
S
Y
V
T
P
R
A
F
K
Site 46
T358
S
G
K
F
S
Y
V
T
P
R
A
F
K
T
Q
Site 47
T364
V
T
P
R
A
F
K
T
Q
V
G
R
F
A
P
Site 48
Y376
F
A
P
Q
F
S
G
Y
Q
Q
Q
D
C
Q
E
Site 49
Y463
V
T
F
D
P
F
C
Y
L
T
L
P
L
P
M
Site 50
T475
L
P
M
K
K
E
R
T
L
E
V
Y
L
V
R
Site 51
Y479
K
E
R
T
L
E
V
Y
L
V
R
M
D
P
L
Site 52
T487
L
V
R
M
D
P
L
T
K
P
M
Q
Y
K
V
Site 53
Y526
K
M
I
V
T
D
I
Y
N
H
R
F
H
R
I
Site 54
S542
A
M
D
E
N
L
S
S
I
M
E
R
D
D
I
Site 55
Y550
I
M
E
R
D
D
I
Y
V
F
E
I
N
I
N
Site 56
T562
N
I
N
R
T
E
D
T
E
H
V
I
I
P
V
Site 57
S578
L
R
E
K
F
R
H
S
S
Y
T
H
H
T
G
Site 58
S579
R
E
K
F
R
H
S
S
Y
T
H
H
T
G
S
Site 59
Y580
E
K
F
R
H
S
S
Y
T
H
H
T
G
S
S
Site 60
T581
K
F
R
H
S
S
Y
T
H
H
T
G
S
S
L
Site 61
S586
S
Y
T
H
H
T
G
S
S
L
F
G
Q
P
F
Site 62
S587
Y
T
H
H
T
G
S
S
L
F
G
Q
P
F
L
Site 63
T602
M
A
V
P
R
N
N
T
E
D
K
L
Y
N
L
Site 64
Y607
N
N
T
E
D
K
L
Y
N
L
L
L
L
R
M
Site 65
S621
M
C
R
Y
V
K
I
S
T
E
T
E
E
T
E
Site 66
T627
I
S
T
E
T
E
E
T
E
G
S
L
H
C
C
Site 67
S630
E
T
E
E
T
E
G
S
L
H
C
C
K
D
Q
Site 68
S652
N
G
I
H
E
E
G
S
P
S
E
M
E
T
D
Site 69
S654
I
H
E
E
G
S
P
S
E
M
E
T
D
E
P
Site 70
T658
G
S
P
S
E
M
E
T
D
E
P
D
D
E
S
Site 71
S665
T
D
E
P
D
D
E
S
S
Q
D
Q
E
L
P
Site 72
S666
D
E
P
D
D
E
S
S
Q
D
Q
E
L
P
S
Site 73
S673
S
Q
D
Q
E
L
P
S
E
N
E
N
S
Q
S
Site 74
S678
L
P
S
E
N
E
N
S
Q
S
E
D
S
V
G
Site 75
S680
S
E
N
E
N
S
Q
S
E
D
S
V
G
G
D
Site 76
S683
E
N
S
Q
S
E
D
S
V
G
G
D
N
D
S
Site 77
S690
S
V
G
G
D
N
D
S
E
N
G
L
C
T
E
Site 78
T699
N
G
L
C
T
E
D
T
C
K
G
Q
L
T
G
Site 79
T713
G
H
K
K
R
L
F
T
F
Q
F
N
N
L
G
Site 80
Y726
L
G
N
T
D
I
N
Y
I
K
D
D
T
R
H
Site 81
S747
Q
L
R
L
D
E
R
S
F
L
A
L
D
W
D
Site 82
S775
E
D
F
E
K
H
E
S
V
E
Y
K
P
P
K
Site 83
Y778
E
K
H
E
S
V
E
Y
K
P
P
K
K
P
F
Site 84
T797
D
C
I
E
L
F
T
T
K
E
K
L
G
A
E
Site 85
Y808
L
G
A
E
D
P
W
Y
C
P
N
C
K
E
H
Site 86
S826
T
K
K
L
D
L
W
S
L
P
P
V
L
V
V
Site 87
S839
V
V
H
L
K
R
F
S
Y
S
R
Y
M
R
D
Site 88
Y840
V
H
L
K
R
F
S
Y
S
R
Y
M
R
D
K
Site 89
Y843
K
R
F
S
Y
S
R
Y
M
R
D
K
L
D
T
Site 90
T850
Y
M
R
D
K
L
D
T
L
V
D
F
P
I
N
Site 91
S862
P
I
N
D
L
D
M
S
E
F
L
I
N
P
N
Site 92
Y875
P
N
A
G
P
C
R
Y
N
L
I
A
V
S
N
Site 93
S881
R
Y
N
L
I
A
V
S
N
H
Y
G
G
M
G
Site 94
Y892
G
G
M
G
G
G
H
Y
T
A
F
A
K
N
K
Site 95
Y905
N
K
D
D
G
K
W
Y
Y
F
D
D
S
S
V
Site 96
Y906
K
D
D
G
K
W
Y
Y
F
D
D
S
S
V
S
Site 97
S910
K
W
Y
Y
F
D
D
S
S
V
S
T
A
S
E
Site 98
S911
W
Y
Y
F
D
D
S
S
V
S
T
A
S
E
D
Site 99
T914
F
D
D
S
S
V
S
T
A
S
E
D
Q
I
V
Site 100
S916
D
S
S
V
S
T
A
S
E
D
Q
I
V
S
K
Site 101
Y926
Q
I
V
S
K
A
A
Y
V
L
F
Y
Q
R
Q
Site 102
Y930
K
A
A
Y
V
L
F
Y
Q
R
Q
D
T
F
S
Site 103
T935
L
F
Y
Q
R
Q
D
T
F
S
G
T
G
F
F
Site 104
S937
Y
Q
R
Q
D
T
F
S
G
T
G
F
F
P
L
Site 105
T948
F
F
P
L
D
R
E
T
K
G
A
S
A
A
T
Site 106
S952
D
R
E
T
K
G
A
S
A
A
T
G
I
P
L
Site 107
T955
T
K
G
A
S
A
A
T
G
I
P
L
E
S
D
Site 108
S961
A
T
G
I
P
L
E
S
D
E
D
S
N
D
N
Site 109
S965
P
L
E
S
D
E
D
S
N
D
N
D
N
D
I
Site 110
T980
E
N
E
N
C
M
H
T
N
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation