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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FARP1
Full Name:
FERM, RhoGEF and pleckstrin domain-containing protein 1
Alias:
CDEP; Chondrocyte- derived ezrin-like; Chondrocyte-derived ezrin-like protein; FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived); MGC87400; PLEKHC2
Type:
Guanine nucleotide exchange factor, Rac/Rho
Mass (Da):
118633
Number AA:
1045
UniProt ID:
Q9Y4F1
International Prot ID:
IPI00024773
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0005089
GO:0008092
PhosphoSite+
KinaseNET
Biological Process:
GO:0035023
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
G
E
I
E
Q
R
P
T
P
G
S
R
L
G
A
Site 2
S12
E
Q
R
P
T
P
G
S
R
L
G
A
P
E
N
Site 3
S20
R
L
G
A
P
E
N
S
G
I
S
T
L
E
R
Site 4
S23
A
P
E
N
S
G
I
S
T
L
E
R
G
Q
K
Site 5
T24
P
E
N
S
G
I
S
T
L
E
R
G
Q
K
P
Site 6
T34
R
G
Q
K
P
P
P
T
P
S
G
K
L
V
S
Site 7
S36
Q
K
P
P
P
T
P
S
G
K
L
V
S
I
K
Site 8
T50
K
I
Q
M
L
D
D
T
Q
E
A
F
E
V
P
Site 9
Y80
L
N
L
V
E
G
D
Y
F
G
L
E
F
P
D
Site 10
T92
F
P
D
H
K
K
I
T
V
W
L
D
L
L
K
Site 11
T125
K
F
F
P
P
D
H
T
Q
L
Q
E
E
L
T
Site 12
Y134
L
Q
E
E
L
T
R
Y
L
F
A
L
Q
V
K
Site 13
T150
D
L
A
Q
G
R
L
T
C
N
D
T
S
A
A
Site 14
Y185
E
H
L
A
K
N
K
Y
I
P
Q
Q
D
A
L
Site 15
T207
H
H
N
H
I
G
Q
T
P
A
E
S
D
F
Q
Site 16
S211
I
G
Q
T
P
A
E
S
D
F
Q
L
L
E
I
Site 17
Y225
I
A
R
R
L
E
M
Y
G
I
R
L
H
P
A
Site 18
T238
P
A
K
D
R
E
G
T
K
I
N
L
A
V
A
Site 19
S270
W
A
K
V
R
K
L
S
F
K
R
K
R
F
L
Site 20
S286
K
L
R
P
D
A
N
S
A
Y
Q
D
T
L
E
Site 21
Y288
R
P
D
A
N
S
A
Y
Q
D
T
L
E
F
L
Site 22
T291
A
N
S
A
Y
Q
D
T
L
E
F
L
M
A
S
Site 23
S332
K
P
K
P
V
L
F
S
R
G
S
S
F
R
F
Site 24
S335
P
V
L
F
S
R
G
S
S
F
R
F
S
G
R
Site 25
S336
V
L
F
S
R
G
S
S
F
R
F
S
G
R
T
Site 26
S340
R
G
S
S
F
R
F
S
G
R
T
Q
K
Q
V
Site 27
T343
S
F
R
F
S
G
R
T
Q
K
Q
V
L
D
Y
Site 28
Y350
T
Q
K
Q
V
L
D
Y
V
K
E
G
G
H
K
Site 29
S366
V
Q
F
E
R
K
H
S
K
I
H
S
I
R
S
Site 30
S370
R
K
H
S
K
I
H
S
I
R
S
L
A
S
Q
Site 31
S373
S
K
I
H
S
I
R
S
L
A
S
Q
P
T
E
Site 32
S376
H
S
I
R
S
L
A
S
Q
P
T
E
L
N
S
Site 33
S383
S
Q
P
T
E
L
N
S
E
V
L
E
Q
S
Q
Site 34
S389
N
S
E
V
L
E
Q
S
Q
Q
S
T
S
L
T
Site 35
T393
L
E
Q
S
Q
Q
S
T
S
L
T
F
G
E
G
Site 36
S394
E
Q
S
Q
Q
S
T
S
L
T
F
G
E
G
A
Site 37
T396
S
Q
Q
S
T
S
L
T
F
G
E
G
A
E
S
Site 38
S403
T
F
G
E
G
A
E
S
P
G
G
Q
S
C
R
Site 39
S408
A
E
S
P
G
G
Q
S
C
R
R
G
K
E
P
Site 40
S418
R
G
K
E
P
K
V
S
A
G
E
P
G
S
H
Site 41
S424
V
S
A
G
E
P
G
S
H
P
S
P
A
P
R
Site 42
S427
G
E
P
G
S
H
P
S
P
A
P
R
R
S
P
Site 43
S433
P
S
P
A
P
R
R
S
P
A
G
N
K
Q
A
Site 44
T459
E
E
V
V
K
D
R
T
Q
Q
S
K
P
Q
P
Site 45
S462
V
K
D
R
T
Q
Q
S
K
P
Q
P
P
Q
P
Site 46
S470
K
P
Q
P
P
Q
P
S
T
G
S
L
T
G
S
Site 47
T471
P
Q
P
P
Q
P
S
T
G
S
L
T
G
S
P
Site 48
S473
P
P
Q
P
S
T
G
S
L
T
G
S
P
H
L
Site 49
T475
Q
P
S
T
G
S
L
T
G
S
P
H
L
S
E
Site 50
S477
S
T
G
S
L
T
G
S
P
H
L
S
E
L
S
Site 51
S481
L
T
G
S
P
H
L
S
E
L
S
V
N
S
Q
Site 52
S484
S
P
H
L
S
E
L
S
V
N
S
Q
G
G
V
Site 53
S487
L
S
E
L
S
V
N
S
Q
G
G
V
A
P
A
Site 54
S499
A
P
A
N
V
T
L
S
P
N
L
S
P
D
T
Site 55
S503
V
T
L
S
P
N
L
S
P
D
T
K
Q
A
S
Site 56
T506
S
P
N
L
S
P
D
T
K
Q
A
S
P
L
I
Site 57
S510
S
P
D
T
K
Q
A
S
P
L
I
S
P
L
L
Site 58
S514
K
Q
A
S
P
L
I
S
P
L
L
N
D
Q
A
Site 59
T525
N
D
Q
A
C
P
R
T
D
D
E
D
E
G
R
Site 60
T538
G
R
R
K
R
F
P
T
D
K
A
Y
F
I
A
Site 61
Y542
R
F
P
T
D
K
A
Y
F
I
A
K
E
V
S
Site 62
T551
I
A
K
E
V
S
T
T
E
R
T
Y
L
K
D
Site 63
Y555
V
S
T
T
E
R
T
Y
L
K
D
L
E
V
I
Site 64
S564
K
D
L
E
V
I
T
S
W
F
Q
S
T
V
S
Site 65
S568
V
I
T
S
W
F
Q
S
T
V
S
K
E
D
A
Site 66
T569
I
T
S
W
F
Q
S
T
V
S
K
E
D
A
M
Site 67
S613
L
A
L
W
E
G
R
S
N
A
Q
I
R
D
Y
Site 68
Y620
S
N
A
Q
I
R
D
Y
Q
R
I
G
D
V
M
Site 69
S657
A
L
E
N
G
I
K
S
S
R
R
L
E
N
F
Site 70
S658
L
E
N
G
I
K
S
S
R
R
L
E
N
F
C
Site 71
Y692
P
L
H
R
L
M
H
Y
K
Q
V
L
E
R
L
Site 72
S765
R
E
F
I
R
L
G
S
L
S
K
L
S
G
K
Site 73
S790
N
D
V
L
L
Y
T
S
R
G
L
T
A
S
N
Site 74
T794
L
Y
T
S
R
G
L
T
A
S
N
Q
F
K
V
Site 75
S796
T
S
R
G
L
T
A
S
N
Q
F
K
V
H
G
Site 76
Y808
V
H
G
Q
L
P
L
Y
G
M
T
I
E
E
S
Site 77
S815
Y
G
M
T
I
E
E
S
E
D
E
W
G
V
P
Site 78
T826
W
G
V
P
H
C
L
T
L
R
G
Q
R
Q
S
Site 79
S833
T
L
R
G
Q
R
Q
S
I
I
V
A
A
S
S
Site 80
S839
Q
S
I
I
V
A
A
S
S
R
S
E
M
E
K
Site 81
S840
S
I
I
V
A
A
S
S
R
S
E
M
E
K
W
Site 82
S861
A
I
D
L
A
E
K
S
S
S
P
A
P
E
F
Site 83
S863
D
L
A
E
K
S
S
S
P
A
P
E
F
L
A
Site 84
S871
P
A
P
E
F
L
A
S
S
P
P
D
N
K
S
Site 85
S872
A
P
E
F
L
A
S
S
P
P
D
N
K
S
P
Site 86
S878
S
S
P
P
D
N
K
S
P
D
E
A
T
A
A
Site 87
S889
A
T
A
A
D
Q
E
S
E
D
D
L
S
A
S
Site 88
S894
Q
E
S
E
D
D
L
S
A
S
R
T
S
L
E
Site 89
S896
S
E
D
D
L
S
A
S
R
T
S
L
E
R
Q
Site 90
T898
D
D
L
S
A
S
R
T
S
L
E
R
Q
A
P
Site 91
S899
D
L
S
A
S
R
T
S
L
E
R
Q
A
P
H
Site 92
S975
Q
D
N
H
P
L
A
S
L
P
L
L
G
Y
S
Site 93
T984
P
L
L
G
Y
S
L
T
I
P
S
E
S
E
N
Site 94
S989
S
L
T
I
P
S
E
S
E
N
I
Q
K
D
Y
Site 95
Y996
S
E
N
I
Q
K
D
Y
V
F
K
L
H
F
K
Site 96
Y1007
L
H
F
K
S
H
V
Y
Y
F
R
A
E
S
E
Site 97
Y1008
H
F
K
S
H
V
Y
Y
F
R
A
E
S
E
Y
Site 98
Y1015
Y
F
R
A
E
S
E
Y
T
F
E
R
W
M
E
Site 99
T1016
F
R
A
E
S
E
Y
T
F
E
R
W
M
E
V
Site 100
S1026
R
W
M
E
V
I
R
S
A
T
S
S
A
S
R
Site 101
T1028
M
E
V
I
R
S
A
T
S
S
A
S
R
P
H
Site 102
S1029
E
V
I
R
S
A
T
S
S
A
S
R
P
H
V
Site 103
S1030
V
I
R
S
A
T
S
S
A
S
R
P
H
V
L
Site 104
S1032
R
S
A
T
S
S
A
S
R
P
H
V
L
S
H
Site 105
S1038
A
S
R
P
H
V
L
S
H
K
E
S
L
V
Y
Site 106
S1042
H
V
L
S
H
K
E
S
L
V
Y
_
_
_
_
Site 107
Y1045
S
H
K
E
S
L
V
Y
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation