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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LKAP
Full Name:
Limkain-b1
Alias:
KIAA0430; Limkain b1
Type:
Vesicle protein
Mass (Da):
192728
Number AA:
1741
UniProt ID:
Q9Y4F3
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005777
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0000166
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
E
G
N
G
T
E
N
S
C
S
R
T
R
G
W
Site 2
S11
N
G
T
E
N
S
C
S
R
T
R
G
W
L
Q
Site 3
T13
T
E
N
S
C
S
R
T
R
G
W
L
Q
Q
D
Site 4
S35
W
K
F
S
N
C
F
S
R
P
E
Q
T
L
P
Site 5
T40
C
F
S
R
P
E
Q
T
L
P
H
S
P
Q
T
Site 6
S44
P
E
Q
T
L
P
H
S
P
Q
T
K
E
Y
M
Site 7
S65
V
E
L
K
D
V
P
S
P
L
H
A
G
S
K
Site 8
S84
V
P
L
P
D
I
R
S
L
Q
Q
P
K
I
Q
Site 9
S93
Q
Q
P
K
I
Q
L
S
S
V
P
K
V
S
C
Site 10
S94
Q
P
K
I
Q
L
S
S
V
P
K
V
S
C
C
Site 11
S109
A
H
C
P
N
E
P
S
T
S
P
M
R
F
G
Site 12
S111
C
P
N
E
P
S
T
S
P
M
R
F
G
G
G
Site 13
S126
G
G
G
S
G
G
T
S
S
L
I
H
P
G
A
Site 14
S137
H
P
G
A
L
L
D
S
Q
S
T
R
T
I
T
Site 15
S139
G
A
L
L
D
S
Q
S
T
R
T
I
T
C
Q
Site 16
T144
S
Q
S
T
R
T
I
T
C
Q
V
G
S
G
F
Site 17
S155
G
S
G
F
A
F
Q
S
A
S
S
L
Q
N
A
Site 18
S157
G
F
A
F
Q
S
A
S
S
L
Q
N
A
S
A
Site 19
S158
F
A
F
Q
S
A
S
S
L
Q
N
A
S
A
R
Site 20
S163
A
S
S
L
Q
N
A
S
A
R
N
N
L
A
G
Site 21
S182
F
P
S
M
C
L
E
S
N
L
S
S
C
K
H
Site 22
S213
H
K
L
H
Q
F
P
S
L
Q
G
C
T
S
A
Site 23
S219
P
S
L
Q
G
C
T
S
A
G
Y
F
P
C
S
Site 24
Y222
Q
G
C
T
S
A
G
Y
F
P
C
S
D
F
T
Site 25
S226
S
A
G
Y
F
P
C
S
D
F
T
S
G
A
P
Site 26
T229
Y
F
P
C
S
D
F
T
S
G
A
P
G
H
L
Site 27
S230
F
P
C
S
D
F
T
S
G
A
P
G
H
L
E
Site 28
S241
G
H
L
E
E
H
I
S
Q
S
E
L
T
P
H
Site 29
S243
L
E
E
H
I
S
Q
S
E
L
T
P
H
L
C
Site 30
T246
H
I
S
Q
S
E
L
T
P
H
L
C
T
N
S
Site 31
S281
L
N
K
P
A
R
N
S
I
I
D
A
A
K
V
Site 32
T297
P
N
I
P
P
P
N
T
Q
P
A
P
L
A
V
Site 33
S332
T
S
L
G
K
A
A
S
K
F
G
S
P
E
V
Site 34
S362
F
W
D
I
E
N
C
S
V
P
S
G
R
S
A
Site 35
S365
I
E
N
C
S
V
P
S
G
R
S
A
T
A
V
Site 36
T370
V
P
S
G
R
S
A
T
A
V
V
Q
R
I
R
Site 37
S431
A
D
D
K
L
R
Q
S
L
R
R
F
A
N
T
Site 38
T438
S
L
R
R
F
A
N
T
H
T
A
P
A
T
V
Site 39
S459
V
N
F
A
L
E
L
S
D
L
R
H
R
H
G
Site 40
S496
I
R
F
E
E
F
I
S
D
L
P
P
R
L
P
Site 41
Y514
P
Q
C
H
T
L
L
Y
V
Y
N
L
P
A
N
Site 42
Y516
C
H
T
L
L
Y
V
Y
N
L
P
A
N
K
D
Site 43
S526
P
A
N
K
D
G
K
S
V
S
N
R
L
R
R
Site 44
S528
N
K
D
G
K
S
V
S
N
R
L
R
R
L
S
Site 45
S535
S
N
R
L
R
R
L
S
D
N
C
G
G
K
V
Site 46
S559
L
R
F
I
N
Q
D
S
A
E
R
A
Q
K
R
Site 47
S580
F
G
N
R
I
I
V
S
F
T
P
K
N
R
E
Site 48
T582
N
R
I
I
V
S
F
T
P
K
N
R
E
L
C
Site 49
T591
K
N
R
E
L
C
E
T
K
S
S
N
A
I
A
Site 50
S593
R
E
L
C
E
T
K
S
S
N
A
I
A
D
K
Site 51
S603
A
I
A
D
K
V
K
S
P
K
K
L
K
N
P
Site 52
S619
L
C
L
I
K
D
A
S
E
Q
S
S
S
A
K
Site 53
S623
K
D
A
S
E
Q
S
S
S
A
K
A
T
P
G
Site 54
S624
D
A
S
E
Q
S
S
S
A
K
A
T
P
G
K
Site 55
T628
Q
S
S
S
A
K
A
T
P
G
K
G
S
Q
A
Site 56
S633
K
A
T
P
G
K
G
S
Q
A
N
S
G
S
A
Site 57
S637
G
K
G
S
Q
A
N
S
G
S
A
T
K
N
T
Site 58
T641
Q
A
N
S
G
S
A
T
K
N
T
N
V
K
S
Site 59
T644
S
G
S
A
T
K
N
T
N
V
K
S
L
Q
E
Site 60
S648
T
K
N
T
N
V
K
S
L
Q
E
L
C
R
M
Site 61
S657
Q
E
L
C
R
M
E
S
K
T
G
H
R
N
S
Site 62
T659
L
C
R
M
E
S
K
T
G
H
R
N
S
E
H
Site 63
S664
S
K
T
G
H
R
N
S
E
H
Q
Q
G
H
L
Site 64
T677
H
L
R
L
V
V
P
T
H
G
N
S
S
A
A
Site 65
S681
V
V
P
T
H
G
N
S
S
A
A
V
S
T
P
Site 66
S682
V
P
T
H
G
N
S
S
A
A
V
S
T
P
K
Site 67
S686
G
N
S
S
A
A
V
S
T
P
K
N
S
G
V
Site 68
T687
N
S
S
A
A
V
S
T
P
K
N
S
G
V
A
Site 69
Y698
S
G
V
A
E
P
V
Y
K
T
S
Q
K
K
E
Site 70
S701
A
E
P
V
Y
K
T
S
Q
K
K
E
N
L
S
Site 71
S708
S
Q
K
K
E
N
L
S
A
R
S
V
T
S
S
Site 72
S711
K
E
N
L
S
A
R
S
V
T
S
S
P
V
E
Site 73
T713
N
L
S
A
R
S
V
T
S
S
P
V
E
K
K
Site 74
S715
S
A
R
S
V
T
S
S
P
V
E
K
K
D
K
Site 75
T725
E
K
K
D
K
E
E
T
V
F
Q
V
S
Y
P
Site 76
S730
E
E
T
V
F
Q
V
S
Y
P
S
A
F
S
K
Site 77
Y731
E
T
V
F
Q
V
S
Y
P
S
A
F
S
K
L
Site 78
S736
V
S
Y
P
S
A
F
S
K
L
V
A
S
R
Q
Site 79
S750
Q
V
S
P
L
L
A
S
Q
S
W
S
S
R
S
Site 80
S752
S
P
L
L
A
S
Q
S
W
S
S
R
S
M
S
Site 81
S754
L
L
A
S
Q
S
W
S
S
R
S
M
S
P
N
Site 82
S755
L
A
S
Q
S
W
S
S
R
S
M
S
P
N
L
Site 83
S757
S
Q
S
W
S
S
R
S
M
S
P
N
L
L
N
Site 84
S759
S
W
S
S
R
S
M
S
P
N
L
L
N
R
A
Site 85
S778
F
N
I
A
N
S
S
S
E
A
D
C
P
D
P
Site 86
Y799
V
Q
V
S
N
I
D
Y
R
L
S
R
K
E
L
Site 87
S802
S
N
I
D
Y
R
L
S
R
K
E
L
Q
Q
L
Site 88
S822
A
R
H
G
K
V
K
S
V
E
L
S
P
H
T
Site 89
S826
K
V
K
S
V
E
L
S
P
H
T
D
Y
Q
L
Site 90
Y831
E
L
S
P
H
T
D
Y
Q
L
K
A
V
V
Q
Site 91
S851
D
A
I
G
A
V
N
S
L
H
R
Y
K
I
G
Site 92
Y855
A
V
N
S
L
H
R
Y
K
I
G
S
K
K
I
Site 93
S859
L
H
R
Y
K
I
G
S
K
K
I
L
V
S
L
Site 94
S872
S
L
A
T
G
A
A
S
K
S
L
S
L
L
S
Site 95
Y903
L
F
K
F
T
D
I
Y
E
K
K
F
G
H
K
Site 96
S914
F
G
H
K
L
N
V
S
D
L
Y
K
L
T
D
Site 97
Y917
K
L
N
V
S
D
L
Y
K
L
T
D
T
V
A
Site 98
T922
D
L
Y
K
L
T
D
T
V
A
I
R
E
Q
G
Site 99
S945
P
S
S
Q
A
R
Q
S
P
L
G
S
S
Q
S
Site 100
S949
A
R
Q
S
P
L
G
S
S
Q
S
H
D
G
S
Site 101
S950
R
Q
S
P
L
G
S
S
Q
S
H
D
G
S
S
Site 102
S952
S
P
L
G
S
S
Q
S
H
D
G
S
S
T
N
Site 103
S956
S
S
Q
S
H
D
G
S
S
T
N
C
S
P
I
Site 104
S957
S
Q
S
H
D
G
S
S
T
N
C
S
P
I
I
Site 105
T958
Q
S
H
D
G
S
S
T
N
C
S
P
I
I
F
Site 106
S961
D
G
S
S
T
N
C
S
P
I
I
F
E
E
L
Site 107
Y970
I
I
F
E
E
L
E
Y
H
E
P
V
C
R
Q
Site 108
Y994
H
E
F
D
P
D
S
Y
K
I
P
F
V
I
L
Site 109
S1012
T
F
A
P
Q
V
H
S
L
L
Q
T
H
E
G
Site 110
T1016
Q
V
H
S
L
L
Q
T
H
E
G
T
V
P
L
Site 111
T1083
N
K
P
P
P
P
N
T
D
P
W
L
L
R
S
Site 112
S1090
T
D
P
W
L
L
R
S
K
S
P
V
G
N
P
Site 113
S1092
P
W
L
L
R
S
K
S
P
V
G
N
P
Q
L
Site 114
S1138
F
A
K
Q
C
R
V
S
D
Y
G
Y
S
K
L
Site 115
Y1140
K
Q
C
R
V
S
D
Y
G
Y
S
K
L
I
E
Site 116
T1168
M
G
S
K
R
L
L
T
L
T
H
R
A
Q
V
Site 117
T1170
S
K
R
L
L
T
L
T
H
R
A
Q
V
K
R
Site 118
T1179
R
A
Q
V
K
R
F
T
Q
D
L
L
K
L
L
Site 119
S1188
D
L
L
K
L
L
K
S
Q
A
S
K
Q
V
I
Site 120
Y1203
V
R
E
F
S
Q
A
Y
H
W
C
F
S
K
D
Site 121
Y1216
K
D
W
D
V
T
E
Y
G
V
C
E
L
I
D
Site 122
T1232
V
S
E
I
P
D
T
T
I
C
L
S
Q
Q
D
Site 123
S1236
P
D
T
T
I
C
L
S
Q
Q
D
N
E
M
V
Site 124
T1252
C
I
P
K
R
E
R
T
Q
D
E
I
E
R
T
Site 125
T1259
T
Q
D
E
I
E
R
T
K
Q
F
S
K
D
V
Site 126
S1263
I
E
R
T
K
Q
F
S
K
D
V
V
D
L
L
Site 127
Y1300
R
Q
C
K
L
A
Y
Y
G
F
T
K
L
L
E
Site 128
T1328
C
G
E
E
K
I
L
T
L
T
E
V
E
R
F
Site 129
S1348
Q
F
V
K
L
L
R
S
Q
K
D
N
C
L
M
Site 130
Y1363
M
T
D
L
L
T
E
Y
A
K
T
F
G
Y
T
Site 131
Y1369
E
Y
A
K
T
F
G
Y
T
F
R
L
Q
D
Y
Site 132
Y1376
Y
T
F
R
L
Q
D
Y
D
V
S
S
I
S
A
Site 133
S1379
R
L
Q
D
Y
D
V
S
S
I
S
A
L
T
Q
Site 134
S1380
L
Q
D
Y
D
V
S
S
I
S
A
L
T
Q
K
Site 135
S1410
I
Q
L
I
N
R
K
S
L
R
S
L
T
A
Q
Site 136
T1428
L
L
M
S
W
E
G
T
T
H
L
S
V
E
E
Site 137
S1432
W
E
G
T
T
H
L
S
V
E
E
L
K
R
H
Site 138
Y1440
V
E
E
L
K
R
H
Y
E
S
T
H
N
T
P
Site 139
T1443
L
K
R
H
Y
E
S
T
H
N
T
P
L
N
P
Site 140
T1446
H
Y
E
S
T
H
N
T
P
L
N
P
C
E
Y
Site 141
T1499
N
V
R
S
L
L
H
T
Y
H
Y
Q
Q
I
F
Site 142
Y1500
V
R
S
L
L
H
T
Y
H
Y
Q
Q
I
F
L
Site 143
Y1502
S
L
L
H
T
Y
H
Y
Q
Q
I
F
L
H
E
Site 144
Y1514
L
H
E
F
S
M
A
Y
T
K
Y
V
G
E
T
Site 145
T1515
H
E
F
S
M
A
Y
T
K
Y
V
G
E
T
L
Site 146
Y1517
F
S
M
A
Y
T
K
Y
V
G
E
T
L
Q
P
Site 147
T1521
Y
T
K
Y
V
G
E
T
L
Q
P
K
T
Y
G
Site 148
T1526
G
E
T
L
Q
P
K
T
Y
G
H
S
S
V
E
Site 149
Y1527
E
T
L
Q
P
K
T
Y
G
H
S
S
V
E
E
Site 150
S1531
P
K
T
Y
G
H
S
S
V
E
E
L
L
G
A
Site 151
S1562
V
L
K
N
D
M
K
S
R
L
S
S
L
S
L
Site 152
S1565
N
D
M
K
S
R
L
S
S
L
S
L
S
P
A
Site 153
S1566
D
M
K
S
R
L
S
S
L
S
L
S
P
A
N
Site 154
S1568
K
S
R
L
S
S
L
S
L
S
P
A
N
H
E
Site 155
S1570
R
L
S
S
L
S
L
S
P
A
N
H
E
N
Q
Site 156
S1579
A
N
H
E
N
Q
P
S
E
G
E
R
I
L
E
Site 157
S1590
R
I
L
E
V
P
E
S
H
T
A
S
E
L
K
Site 158
S1594
V
P
E
S
H
T
A
S
E
L
K
L
G
A
D
Site 159
S1603
L
K
L
G
A
D
G
S
G
P
S
H
T
E
Q
Site 160
T1616
E
Q
E
L
L
R
L
T
D
D
S
P
V
D
L
Site 161
S1634
P
V
P
S
C
L
P
S
P
Q
L
R
P
D
P
Site 162
S1660
E
E
R
P
Q
E
P
S
E
I
M
I
L
N
Q
Site 163
S1679
E
I
P
I
P
G
K
S
K
T
L
T
S
D
S
Site 164
T1681
P
I
P
G
K
S
K
T
L
T
S
D
S
S
S
Site 165
T1683
P
G
K
S
K
T
L
T
S
D
S
S
S
S
C
Site 166
S1684
G
K
S
K
T
L
T
S
D
S
S
S
S
C
I
Site 167
S1686
S
K
T
L
T
S
D
S
S
S
S
C
I
S
A
Site 168
S1687
K
T
L
T
S
D
S
S
S
S
C
I
S
A
A
Site 169
S1702
V
P
V
P
P
C
P
S
S
E
T
S
E
S
L
Site 170
S1703
P
V
P
P
C
P
S
S
E
T
S
E
S
L
L
Site 171
S1706
P
C
P
S
S
E
T
S
E
S
L
L
S
K
D
Site 172
S1708
P
S
S
E
T
S
E
S
L
L
S
K
D
P
V
Site 173
S1711
E
T
S
E
S
L
L
S
K
D
P
V
E
S
P
Site 174
S1717
L
S
K
D
P
V
E
S
P
A
K
K
Q
P
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation