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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FAM65B
Full Name:
Protein FAM65B
Alias:
C6orf32; DIFF40; DIFF48; FA65B; KIAA0386; LOC9750; PL48
Type:
Cytoskeletal protein
Mass (Da):
118544
Number AA:
1068
UniProt ID:
Q9Y4F9
International Prot ID:
IPI00016800
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005856
GO:0030175
GO:0005739
Uniprot
OncoNet
Molecular Function:
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0030154
GO:0007517
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
L
V
G
S
Q
S
F
S
P
G
G
P
N
Site 2
S9
L
V
G
S
Q
S
F
S
P
G
G
P
N
G
I
Site 3
S19
G
P
N
G
I
I
R
S
Q
S
F
A
G
F
S
Site 4
S21
N
G
I
I
R
S
Q
S
F
A
G
F
S
G
L
Site 5
S26
S
Q
S
F
A
G
F
S
G
L
Q
E
R
R
S
Site 6
S33
S
G
L
Q
E
R
R
S
R
Q
N
S
F
I
E
Site 7
S37
E
R
R
S
R
Q
N
S
F
I
E
N
S
S
A
Site 8
S43
N
S
F
I
E
N
S
S
A
L
K
K
P
Q
A
Site 9
Y78
P
K
R
V
E
E
V
Y
R
A
L
K
N
G
L
Site 10
Y88
L
K
N
G
L
D
E
Y
L
E
V
H
Q
T
E
Site 11
T94
E
Y
L
E
V
H
Q
T
E
L
D
K
L
T
A
Site 12
S110
L
K
D
M
K
R
N
S
R
L
G
V
L
Y
D
Site 13
Y116
N
S
R
L
G
V
L
Y
D
L
D
K
Q
I
K
Site 14
T124
D
L
D
K
Q
I
K
T
I
E
R
Y
M
R
R
Site 15
Y128
Q
I
K
T
I
E
R
Y
M
R
R
L
E
F
H
Site 16
S137
R
R
L
E
F
H
I
S
K
V
D
E
L
Y
E
Site 17
Y143
I
S
K
V
D
E
L
Y
E
A
Y
C
I
Q
R
Site 18
S157
R
R
L
Q
D
G
A
S
K
M
K
Q
A
F
A
Site 19
S166
M
K
Q
A
F
A
T
S
P
A
S
K
A
A
R
Site 20
S169
A
F
A
T
S
P
A
S
K
A
A
R
E
S
L
Site 21
S175
A
S
K
A
A
R
E
S
L
T
E
I
N
R
S
Site 22
T177
K
A
A
R
E
S
L
T
E
I
N
R
S
F
K
Site 23
S182
S
L
T
E
I
N
R
S
F
K
E
Y
T
E
N
Site 24
Y186
I
N
R
S
F
K
E
Y
T
E
N
M
C
T
I
Site 25
T192
E
Y
T
E
N
M
C
T
I
E
V
E
L
E
N
Site 26
Y223
R
L
C
P
G
D
Q
Y
E
I
F
M
K
Y
G
Site 27
Y229
Q
Y
E
I
F
M
K
Y
G
R
Q
R
W
K
L
Site 28
Y316
L
N
L
E
I
T
W
Y
P
F
D
V
E
D
M
Site 29
T324
P
F
D
V
E
D
M
T
A
S
S
G
A
G
N
Site 30
S341
A
A
L
Q
R
R
M
S
M
Y
S
Q
G
T
P
Site 31
Y343
L
Q
R
R
M
S
M
Y
S
Q
G
T
P
E
T
Site 32
S344
Q
R
R
M
S
M
Y
S
Q
G
T
P
E
T
P
Site 33
T347
M
S
M
Y
S
Q
G
T
P
E
T
P
T
F
K
Site 34
T350
Y
S
Q
G
T
P
E
T
P
T
F
K
D
H
S
Site 35
T352
Q
G
T
P
E
T
P
T
F
K
D
H
S
F
F
Site 36
S365
F
F
R
W
L
H
P
S
P
D
K
P
R
R
L
Site 37
S373
P
D
K
P
R
R
L
S
V
L
S
A
L
Q
D
Site 38
S389
F
F
A
K
L
H
R
S
R
S
F
S
D
L
P
Site 39
S391
A
K
L
H
R
S
R
S
F
S
D
L
P
S
L
Site 40
S393
L
H
R
S
R
S
F
S
D
L
P
S
L
R
P
Site 41
S397
R
S
F
S
D
L
P
S
L
R
P
S
P
K
A
Site 42
S401
D
L
P
S
L
R
P
S
P
K
A
V
L
E
L
Site 43
S430
A
E
E
K
M
P
L
S
L
S
F
S
D
L
P
Site 44
S432
E
K
M
P
L
S
L
S
F
S
D
L
P
N
G
Site 45
S434
M
P
L
S
L
S
F
S
D
L
P
N
G
D
C
Site 46
T444
P
N
G
D
C
A
L
T
S
H
S
T
G
S
P
Site 47
S445
N
G
D
C
A
L
T
S
H
S
T
G
S
P
S
Site 48
S447
D
C
A
L
T
S
H
S
T
G
S
P
S
N
S
Site 49
T448
C
A
L
T
S
H
S
T
G
S
P
S
N
S
T
Site 50
S450
L
T
S
H
S
T
G
S
P
S
N
S
T
N
P
Site 51
S452
S
H
S
T
G
S
P
S
N
S
T
N
P
E
I
Site 52
S454
S
T
G
S
P
S
N
S
T
N
P
E
I
T
I
Site 53
T462
T
N
P
E
I
T
I
T
P
A
E
F
N
L
S
Site 54
S469
T
P
A
E
F
N
L
S
S
L
A
S
Q
N
E
Site 55
S470
P
A
E
F
N
L
S
S
L
A
S
Q
N
E
G
Site 56
S473
F
N
L
S
S
L
A
S
Q
N
E
G
M
D
D
Site 57
T481
Q
N
E
G
M
D
D
T
S
S
A
S
S
R
N
Site 58
S482
N
E
G
M
D
D
T
S
S
A
S
S
R
N
S
Site 59
S483
E
G
M
D
D
T
S
S
A
S
S
R
N
S
L
Site 60
S485
M
D
D
T
S
S
A
S
S
R
N
S
L
G
E
Site 61
S486
D
D
T
S
S
A
S
S
R
N
S
L
G
E
G
Site 62
S489
S
S
A
S
S
R
N
S
L
G
E
G
Q
E
P
Site 63
S498
G
E
G
Q
E
P
K
S
H
L
K
E
E
D
P
Site 64
S513
E
E
P
R
K
P
A
S
A
P
S
E
A
C
R
Site 65
S523
S
E
A
C
R
R
Q
S
S
G
A
G
A
E
H
Site 66
S524
E
A
C
R
R
Q
S
S
G
A
G
A
E
H
L
Site 67
S545
A
E
A
L
L
Q
E
S
E
E
A
S
E
L
K
Site 68
S549
L
Q
E
S
E
E
A
S
E
L
K
P
V
E
L
Site 69
S559
K
P
V
E
L
D
T
S
E
G
N
I
T
K
Q
Site 70
T572
K
Q
L
V
K
R
L
T
S
A
E
V
P
M
A
Site 71
S573
Q
L
V
K
R
L
T
S
A
E
V
P
M
A
T
Site 72
T580
S
A
E
V
P
M
A
T
D
R
L
L
S
E
G
Site 73
S585
M
A
T
D
R
L
L
S
E
G
S
V
G
G
E
Site 74
S588
D
R
L
L
S
E
G
S
V
G
G
E
S
E
G
Site 75
S593
E
G
S
V
G
G
E
S
E
G
C
R
S
F
L
Site 76
S598
G
E
S
E
G
C
R
S
F
L
D
G
S
L
E
Site 77
S603
C
R
S
F
L
D
G
S
L
E
D
A
F
N
G
Site 78
S646
L
K
C
K
P
A
V
S
R
S
R
S
S
S
L
Site 79
S648
C
K
P
A
V
S
R
S
R
S
S
S
L
S
L
Site 80
S650
P
A
V
S
R
S
R
S
S
S
L
S
L
T
V
Site 81
S651
A
V
S
R
S
R
S
S
S
L
S
L
T
V
E
Site 82
S652
V
S
R
S
R
S
S
S
L
S
L
T
V
E
S
Site 83
S654
R
S
R
S
S
S
L
S
L
T
V
E
S
A
L
Site 84
T656
R
S
S
S
L
S
L
T
V
E
S
A
L
E
S
Site 85
S663
T
V
E
S
A
L
E
S
F
D
F
L
N
T
S
Site 86
S670
S
F
D
F
L
N
T
S
D
F
D
E
E
E
D
Site 87
S690
N
V
G
G
G
A
D
S
V
F
S
D
T
E
T
Site 88
S693
G
G
A
D
S
V
F
S
D
T
E
T
E
K
H
Site 89
T695
A
D
S
V
F
S
D
T
E
T
E
K
H
S
Y
Site 90
T697
S
V
F
S
D
T
E
T
E
K
H
S
Y
R
S
Site 91
Y702
T
E
T
E
K
H
S
Y
R
S
V
H
P
E
A
Site 92
S704
T
E
K
H
S
Y
R
S
V
H
P
E
A
R
G
Site 93
T718
G
H
L
S
E
A
L
T
E
D
T
G
V
G
T
Site 94
T721
S
E
A
L
T
E
D
T
G
V
G
T
S
V
A
Site 95
S726
E
D
T
G
V
G
T
S
V
A
G
S
P
L
P
Site 96
T735
A
G
S
P
L
P
L
T
T
G
N
E
S
L
D
Site 97
T736
G
S
P
L
P
L
T
T
G
N
E
S
L
D
I
Site 98
T744
G
N
E
S
L
D
I
T
I
V
R
H
L
Q
Y
Site 99
S771
K
T
P
F
V
A
R
S
L
L
E
K
L
S
R
Site 100
S777
R
S
L
L
E
K
L
S
R
Q
I
Q
V
M
E
Site 101
S798
D
E
N
I
G
N
I
S
S
V
V
E
A
I
P
Site 102
S812
P
E
F
H
K
K
L
S
L
L
S
F
W
T
K
Site 103
Y827
C
C
S
P
V
G
V
Y
H
S
P
A
D
R
V
Site 104
S829
S
P
V
G
V
Y
H
S
P
A
D
R
V
M
K
Site 105
S841
V
M
K
Q
L
E
A
S
F
A
R
T
V
N
K
Site 106
T845
L
E
A
S
F
A
R
T
V
N
K
E
Y
P
G
Site 107
Y850
A
R
T
V
N
K
E
Y
P
G
L
A
D
P
V
Site 108
S874
D
R
A
E
P
L
L
S
S
S
L
S
S
E
V
Site 109
S875
R
A
E
P
L
L
S
S
S
L
S
S
E
V
V
Site 110
S878
P
L
L
S
S
S
L
S
S
E
V
V
T
V
F
Site 111
Y887
E
V
V
T
V
F
Q
Y
Y
S
Y
F
T
S
H
Site 112
Y890
T
V
F
Q
Y
Y
S
Y
F
T
S
H
G
V
S
Site 113
S893
Q
Y
Y
S
Y
F
T
S
H
G
V
S
D
L
E
Site 114
S897
Y
F
T
S
H
G
V
S
D
L
E
S
Y
L
S
Site 115
S901
H
G
V
S
D
L
E
S
Y
L
S
Q
L
A
R
Site 116
Y902
G
V
S
D
L
E
S
Y
L
S
Q
L
A
R
Q
Site 117
S904
S
D
L
E
S
Y
L
S
Q
L
A
R
Q
V
S
Site 118
S911
S
Q
L
A
R
Q
V
S
M
V
Q
T
L
Q
S
Site 119
T915
R
Q
V
S
M
V
Q
T
L
Q
S
L
R
D
E
Site 120
S918
S
M
V
Q
T
L
Q
S
L
R
D
E
K
L
L
Site 121
S929
E
K
L
L
Q
T
M
S
D
L
A
P
S
N
L
Site 122
T945
A
Q
Q
E
V
L
R
T
L
A
L
L
L
T
R
Site 123
T951
R
T
L
A
L
L
L
T
R
E
D
N
E
V
S
Site 124
S958
T
R
E
D
N
E
V
S
E
A
V
T
L
Y
L
Site 125
Y981
F
R
E
K
A
L
L
Y
Y
C
E
A
L
T
K
Site 126
Y982
R
E
K
A
L
L
Y
Y
C
E
A
L
T
K
T
Site 127
T1015
E
S
I
K
M
L
V
T
L
C
Q
S
D
T
E
Site 128
T1021
V
T
L
C
Q
S
D
T
E
E
I
R
N
V
A
Site 129
S1029
E
E
I
R
N
V
A
S
E
T
L
L
S
L
G
Site 130
Y1043
G
E
D
G
R
L
A
Y
E
Q
L
D
K
F
P
Site 131
T1062
K
V
G
G
R
H
G
T
E
V
A
T
A
F
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation