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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PLEKHM1
Full Name:
Pleckstrin homology domain-containing family M member 1
Alias:
162 kDa adapter protein; AP162; KIAA0356; PKHM1; Pleckstrin homology domain containing, M1; Pleckstriny domain containing, family M (with RUN domain) member 1
Type:
Unknown function
Mass (Da):
117425
Number AA:
1056
UniProt ID:
Q9Y4G2
International Prot ID:
IPI00000764
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0044424
GO:0044464
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0008270
GO:0008289
PhosphoSite+
KinaseNET
Biological Process:
GO:0007154
GO:0007165
GO:0007242
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
I
K
K
K
L
V
G
S
V
K
A
L
Q
K
Q
Site 2
T38
K
Q
Y
V
S
L
D
T
V
V
T
S
E
D
G
Site 3
T49
S
E
D
G
D
A
N
T
M
C
S
A
L
E
A
Site 4
S78
A
G
G
K
R
K
K
S
A
H
Q
K
P
L
P
Site 5
T113
E
H
L
T
F
V
N
T
D
V
G
R
C
R
A
Site 6
Y148
E
Q
A
R
L
H
E
Y
Y
Q
P
T
A
L
L
Site 7
Y149
Q
A
R
L
H
E
Y
Y
Q
P
T
A
L
L
R
Site 8
S175
L
Q
G
L
T
S
L
S
F
E
L
S
Y
K
S
Site 9
Y180
S
L
S
F
E
L
S
Y
K
S
A
I
L
N
E
Site 10
S208
L
S
E
L
D
P
L
S
T
S
G
A
E
L
Q
Site 11
S219
A
E
L
Q
R
K
E
S
L
D
S
I
S
H
S
Site 12
S222
Q
R
K
E
S
L
D
S
I
S
H
S
S
G
S
Site 13
S224
K
E
S
L
D
S
I
S
H
S
S
G
S
E
D
Site 14
S226
S
L
D
S
I
S
H
S
S
G
S
E
D
I
E
Site 15
S229
S
I
S
H
S
S
G
S
E
D
I
E
V
H
H
Site 16
S237
E
D
I
E
V
H
H
S
G
H
K
I
R
R
N
Site 17
T248
I
R
R
N
Q
K
L
T
A
S
S
L
S
L
D
Site 18
S251
N
Q
K
L
T
A
S
S
L
S
L
D
T
A
S
Site 19
S253
K
L
T
A
S
S
L
S
L
D
T
A
S
S
S
Site 20
T256
A
S
S
L
S
L
D
T
A
S
S
S
Q
L
S
Site 21
S258
S
L
S
L
D
T
A
S
S
S
Q
L
S
C
S
Site 22
S260
S
L
D
T
A
S
S
S
Q
L
S
C
S
L
N
Site 23
S263
T
A
S
S
S
Q
L
S
C
S
L
N
S
D
S
Site 24
S265
S
S
S
Q
L
S
C
S
L
N
S
D
S
C
L
Site 25
S268
Q
L
S
C
S
L
N
S
D
S
C
L
L
Q
E
Site 26
S270
S
C
S
L
N
S
D
S
C
L
L
Q
E
N
G
Site 27
S278
C
L
L
Q
E
N
G
S
K
S
P
D
H
C
E
Site 28
S280
L
Q
E
N
G
S
K
S
P
D
H
C
E
E
P
Site 29
S289
D
H
C
E
E
P
M
S
C
D
S
D
L
G
T
Site 30
S292
E
E
P
M
S
C
D
S
D
L
G
T
A
N
A
Site 31
T296
S
C
D
S
D
L
G
T
A
N
A
E
D
S
D
Site 32
S302
G
T
A
N
A
E
D
S
D
R
S
L
Q
E
V
Site 33
S305
N
A
E
D
S
D
R
S
L
Q
E
V
L
L
E
Site 34
S320
F
S
K
A
Q
V
N
S
V
P
T
N
G
L
S
Site 35
S327
S
V
P
T
N
G
L
S
Q
E
T
E
I
P
T
Site 36
T334
S
Q
E
T
E
I
P
T
P
Q
A
S
L
S
L
Site 37
S338
E
I
P
T
P
Q
A
S
L
S
L
H
G
L
N
Site 38
S340
P
T
P
Q
A
S
L
S
L
H
G
L
N
T
S
Site 39
S347
S
L
H
G
L
N
T
S
T
Y
L
H
C
E
A
Site 40
Y349
H
G
L
N
T
S
T
Y
L
H
C
E
A
P
A
Site 41
S382
E
P
R
P
Q
A
P
S
P
L
D
L
Q
Q
P
Site 42
S392
D
L
Q
Q
P
V
E
S
T
S
G
Q
Q
P
S
Site 43
S394
Q
Q
P
V
E
S
T
S
G
Q
Q
P
S
S
T
Site 44
S399
S
T
S
G
Q
Q
P
S
S
T
V
S
E
T
A
Site 45
S400
T
S
G
Q
Q
P
S
S
T
V
S
E
T
A
R
Site 46
T401
S
G
Q
Q
P
S
S
T
V
S
E
T
A
R
E
Site 47
S403
Q
Q
P
S
S
T
V
S
E
T
A
R
E
V
G
Site 48
T405
P
S
S
T
V
S
E
T
A
R
E
V
G
Q
G
Site 49
S431
A
G
L
K
L
V
V
S
S
P
T
S
P
K
N
Site 50
S432
G
L
K
L
V
V
S
S
P
T
S
P
K
N
K
Site 51
T434
K
L
V
V
S
S
P
T
S
P
K
N
K
S
W
Site 52
S435
L
V
V
S
S
P
T
S
P
K
N
K
S
W
I
Site 53
S440
P
T
S
P
K
N
K
S
W
I
S
E
D
D
F
Site 54
S443
P
K
N
K
S
W
I
S
E
D
D
F
Y
R
P
Site 55
Y448
W
I
S
E
D
D
F
Y
R
P
S
R
E
Q
P
Site 56
S451
E
D
D
F
Y
R
P
S
R
E
Q
P
L
E
S
Site 57
S458
S
R
E
Q
P
L
E
S
A
S
D
H
P
I
A
Site 58
S460
E
Q
P
L
E
S
A
S
D
H
P
I
A
S
Y
Site 59
S466
A
S
D
H
P
I
A
S
Y
R
G
T
P
G
S
Site 60
Y467
S
D
H
P
I
A
S
Y
R
G
T
P
G
S
R
Site 61
T470
P
I
A
S
Y
R
G
T
P
G
S
R
P
G
L
Site 62
S473
S
Y
R
G
T
P
G
S
R
P
G
L
H
R
H
Site 63
S482
P
G
L
H
R
H
F
S
Q
E
P
R
K
N
C
Site 64
S490
Q
E
P
R
K
N
C
S
L
G
A
L
D
Q
A
Site 65
S501
L
D
Q
A
C
V
P
S
P
G
R
R
Q
A
Q
Site 66
S512
R
Q
A
Q
A
A
P
S
Q
G
H
K
S
F
R
Site 67
S517
A
P
S
Q
G
H
K
S
F
R
V
V
H
R
R
Site 68
S529
H
R
R
Q
M
G
L
S
N
P
F
R
G
L
M
Site 69
T540
R
G
L
M
K
L
G
T
V
E
R
R
G
A
M
Site 70
S558
K
E
L
F
C
E
L
S
P
L
E
F
R
L
Y
Site 71
Y565
S
P
L
E
F
R
L
Y
L
S
N
E
E
H
T
Site 72
S567
L
E
F
R
L
Y
L
S
N
E
E
H
T
C
V
Site 73
S584
C
S
L
L
R
C
E
S
V
G
P
A
H
S
D
Site 74
S590
E
S
V
G
P
A
H
S
D
G
R
F
E
L
V
Site 75
S599
G
R
F
E
L
V
F
S
G
K
K
L
A
L
R
Site 76
S608
K
K
L
A
L
R
A
S
S
Q
D
E
A
E
D
Site 77
S609
K
L
A
L
R
A
S
S
Q
D
E
A
E
D
W
Site 78
Y640
D
E
W
V
N
V
Q
Y
P
D
Q
P
E
E
P
Site 79
S656
E
A
P
Q
G
C
L
S
P
S
D
L
L
S
E
Site 80
S658
P
Q
G
C
L
S
P
S
D
L
L
S
E
P
A
Site 81
S662
L
S
P
S
D
L
L
S
E
P
A
A
L
Q
G
Site 82
S676
G
T
Q
F
D
W
S
S
A
Q
V
P
E
P
D
Site 83
S688
E
P
D
A
I
K
E
S
L
L
Y
L
Y
M
D
Site 84
Y691
A
I
K
E
S
L
L
Y
L
Y
M
D
R
T
W
Site 85
Y693
K
E
S
L
L
Y
L
Y
M
D
R
T
W
M
P
Site 86
Y701
M
D
R
T
W
M
P
Y
I
F
S
L
S
L
E
Site 87
S723
R
N
N
E
K
M
L
S
D
S
H
G
V
E
T
Site 88
S725
N
E
K
M
L
S
D
S
H
G
V
E
T
I
R
Site 89
T730
S
D
S
H
G
V
E
T
I
R
D
I
L
P
D
Site 90
T738
I
R
D
I
L
P
D
T
S
L
G
G
P
S
F
Site 91
S739
R
D
I
L
P
D
T
S
L
G
G
P
S
F
F
Site 92
T788
E
T
A
E
E
A
V
T
L
G
G
S
L
D
E
Site 93
S826
P
M
E
K
G
L
D
S
Q
G
C
F
C
A
G
Site 94
T891
R
Q
A
L
K
F
L
T
Q
I
R
A
Q
P
L
Site 95
Y909
Q
M
V
N
A
S
L
Y
E
H
V
E
R
M
H
Site 96
S937
D
Y
L
G
L
C
R
S
G
A
L
K
E
L
S
Site 97
S944
S
G
A
L
K
E
L
S
K
R
L
N
H
R
N
Site 98
Y952
K
R
L
N
H
R
N
Y
L
L
E
S
P
H
R
Site 99
S956
H
R
N
Y
L
L
E
S
P
H
R
F
S
V
A
Site 100
S961
L
E
S
P
H
R
F
S
V
A
D
L
Q
Q
I
Site 101
Y989
E
F
A
S
Q
H
V
Y
H
C
D
L
C
T
Q
Site 102
Y1049
R
C
A
R
R
R
K
Y
Q
E
Q
N
I
F
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation