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Updated November 2019
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Protein Info
Short Name:
RAPGEF2
Full Name:
Rap guanine nucleotide exchange factor 2
Alias:
DKFZP586O1422; KIAA0313; Neural RAP guanine nucleotide exchange protein; NRap GEP; PDZ domain-containing guanine nucleotide exchange factor 1; PDZGEF1; PDZ-GEF1; RA-GEF; Rap GEP; Rap guanine nucleotide exchange factor (GEF) 2; RPGF2
Type:
Guanine nucleotide exchange factor, misc.
Mass (Da):
167417
Number AA:
1499
UniProt ID:
Q9Y4G8
International Prot ID:
IPI00738628
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0046582
GO:0017034
GO:0005509
PhosphoSite+
KinaseNET
Biological Process:
GO:0000165
GO:0019933
GO:0051056
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T31
D
F
T
K
L
H
L
T
D
S
L
H
P
Q
V
Site 2
S33
T
K
L
H
L
T
D
S
L
H
P
Q
V
T
H
Site 3
T39
D
S
L
H
P
Q
V
T
H
V
S
S
S
H
S
Site 4
S42
H
P
Q
V
T
H
V
S
S
S
H
S
G
C
S
Site 5
S44
Q
V
T
H
V
S
S
S
H
S
G
C
S
I
T
Site 6
S46
T
H
V
S
S
S
H
S
G
C
S
I
T
S
D
Site 7
S49
S
S
S
H
S
G
C
S
I
T
S
D
S
G
S
Site 8
T51
S
H
S
G
C
S
I
T
S
D
S
G
S
S
S
Site 9
S52
H
S
G
C
S
I
T
S
D
S
G
S
S
S
L
Site 10
S54
G
C
S
I
T
S
D
S
G
S
S
S
L
S
D
Site 11
S56
S
I
T
S
D
S
G
S
S
S
L
S
D
I
Y
Site 12
S58
T
S
D
S
G
S
S
S
L
S
D
I
Y
Q
A
Site 13
S60
D
S
G
S
S
S
L
S
D
I
Y
Q
A
T
E
Site 14
Y63
S
S
S
L
S
D
I
Y
Q
A
T
E
S
E
A
Site 15
S76
E
A
G
D
M
D
L
S
G
L
P
E
T
A
V
Site 16
T81
D
L
S
G
L
P
E
T
A
V
D
S
E
D
D
Site 17
S85
L
P
E
T
A
V
D
S
E
D
D
D
D
E
E
Site 18
S98
E
E
D
I
E
R
A
S
D
P
L
M
S
R
D
Site 19
T119
E
K
D
P
I
D
R
T
D
D
D
I
E
Q
L
Site 20
S172
N
D
G
E
E
L
D
S
W
S
V
I
L
N
G
Site 21
S174
G
E
E
L
D
S
W
S
V
I
L
N
G
S
V
Site 22
T184
L
N
G
S
V
E
V
T
Y
P
D
G
K
A
E
Site 23
Y185
N
G
S
V
E
V
T
Y
P
D
G
K
A
E
I
Site 24
S202
M
G
N
S
F
G
V
S
P
T
M
D
K
E
Y
Site 25
Y209
S
P
T
M
D
K
E
Y
M
K
G
V
M
R
T
Site 26
T263
E
H
R
E
L
D
R
T
G
T
R
K
G
H
I
Site 27
T265
R
E
L
D
R
T
G
T
R
K
G
H
I
V
I
Site 28
T275
G
H
I
V
I
K
G
T
S
E
R
L
T
M
H
Site 29
S276
H
I
V
I
K
G
T
S
E
R
L
T
M
H
L
Site 30
T280
K
G
T
S
E
R
L
T
M
H
L
V
E
E
H
Site 31
T304
D
F
L
L
T
Y
R
T
F
L
S
S
P
M
E
Site 32
S308
T
Y
R
T
F
L
S
S
P
M
E
V
G
K
K
Site 33
S324
L
E
W
F
N
D
P
S
L
R
D
K
V
T
R
Site 34
T351
F
E
G
D
P
A
M
T
R
F
L
E
E
F
E
Site 35
T387
K
A
K
R
R
L
M
T
L
T
K
P
S
R
E
Site 36
T389
K
R
R
L
M
T
L
T
K
P
S
R
E
A
P
Site 37
S418
I
F
V
D
S
V
D
S
G
S
K
A
T
E
A
Site 38
S420
V
D
S
V
D
S
G
S
K
A
T
E
A
G
L
Site 39
S447
N
F
E
N
I
Q
L
S
K
A
M
E
I
L
R
Site 40
T457
M
E
I
L
R
N
N
T
H
L
S
I
T
V
K
Site 41
S460
L
R
N
N
T
H
L
S
I
T
V
K
T
N
L
Site 42
S478
K
E
L
L
T
R
L
S
E
E
K
R
N
G
A
Site 43
Y500
D
I
K
K
A
S
R
Y
S
I
P
D
L
A
V
Site 44
S501
I
K
K
A
S
R
Y
S
I
P
D
L
A
V
D
Site 45
S522
L
E
K
V
N
K
K
S
K
A
N
T
V
G
G
Site 46
T526
N
K
K
S
K
A
N
T
V
G
G
R
N
K
L
Site 47
T540
L
K
K
I
L
D
K
T
R
I
S
I
L
P
Q
Site 48
S543
I
L
D
K
T
R
I
S
I
L
P
Q
K
P
Y
Site 49
Y550
S
I
L
P
Q
K
P
Y
N
D
I
G
I
G
Q
Site 50
S558
N
D
I
G
I
G
Q
S
Q
D
D
S
I
V
G
Site 51
S562
I
G
Q
S
Q
D
D
S
I
V
G
L
R
Q
T
Site 52
T574
R
Q
T
K
H
I
P
T
A
L
P
V
S
G
T
Site 53
T581
T
A
L
P
V
S
G
T
L
S
S
S
N
P
D
Site 54
S583
L
P
V
S
G
T
L
S
S
S
N
P
D
L
L
Site 55
S584
P
V
S
G
T
L
S
S
S
N
P
D
L
L
Q
Site 56
S585
V
S
G
T
L
S
S
S
N
P
D
L
L
Q
S
Site 57
S592
S
N
P
D
L
L
Q
S
H
H
R
I
L
D
F
Site 58
S600
H
H
R
I
L
D
F
S
A
T
P
D
L
P
D
Site 59
T602
R
I
L
D
F
S
A
T
P
D
L
P
D
Q
V
Site 60
Y621
K
A
D
Q
Q
S
R
Y
I
M
I
S
K
D
T
Site 61
S625
Q
S
R
Y
I
M
I
S
K
D
T
T
A
K
E
Site 62
T644
A
I
R
E
F
A
V
T
A
T
P
D
Q
Y
S
Site 63
T646
R
E
F
A
V
T
A
T
P
D
Q
Y
S
L
C
Site 64
S651
T
A
T
P
D
Q
Y
S
L
C
E
V
S
V
T
Site 65
S673
R
R
L
P
D
Q
L
S
K
L
A
D
R
I
Q
Site 66
S682
L
A
D
R
I
Q
L
S
G
R
Y
Y
L
K
N
Site 67
Y686
I
Q
L
S
G
R
Y
Y
L
K
N
N
M
E
T
Site 68
S698
M
E
T
E
T
L
C
S
D
E
D
A
Q
E
L
Site 69
S709
A
Q
E
L
L
R
E
S
Q
I
S
L
L
Q
L
Site 70
T739
L
F
R
N
I
E
P
T
E
Y
I
D
D
L
F
Site 71
Y741
R
N
I
E
P
T
E
Y
I
D
D
L
F
K
L
Site 72
S750
D
D
L
F
K
L
R
S
K
T
S
C
A
N
L
Site 73
T752
L
F
K
L
R
S
K
T
S
C
A
N
L
K
R
Site 74
S753
F
K
L
R
S
K
T
S
C
A
N
L
K
R
F
Site 75
T768
E
E
V
I
N
Q
E
T
F
W
V
A
S
E
I
Site 76
T779
A
S
E
I
L
R
E
T
N
Q
L
K
R
M
K
Site 77
T824
A
P
V
A
R
L
R
T
T
W
E
K
L
P
N
Site 78
T825
P
V
A
R
L
R
T
T
W
E
K
L
P
N
K
Site 79
Y853
P
S
R
N
M
A
K
Y
R
N
V
L
N
S
Q
Site 80
S859
K
Y
R
N
V
L
N
S
Q
N
L
Q
P
P
I
Site 81
T878
P
V
I
K
K
D
L
T
F
L
H
E
G
N
D
Site 82
S886
F
L
H
E
G
N
D
S
K
V
D
G
L
V
N
Site 83
S912
R
H
V
G
R
M
A
S
V
N
M
D
P
A
L
Site 84
S930
T
R
K
K
K
W
R
S
L
G
S
L
S
Q
G
Site 85
S933
K
K
W
R
S
L
G
S
L
S
Q
G
S
T
N
Site 86
S935
W
R
S
L
G
S
L
S
Q
G
S
T
N
A
T
Site 87
S938
L
G
S
L
S
Q
G
S
T
N
A
T
V
L
D
Site 88
T939
G
S
L
S
Q
G
S
T
N
A
T
V
L
D
V
Site 89
T942
S
Q
G
S
T
N
A
T
V
L
D
V
A
Q
T
Site 90
S959
H
K
K
R
V
R
R
S
S
F
L
N
A
K
K
Site 91
S960
K
K
R
V
R
R
S
S
F
L
N
A
K
K
L
Site 92
Y980
M
A
R
K
V
K
Q
Y
L
S
N
L
E
L
E
Site 93
S982
R
K
V
K
Q
Y
L
S
N
L
E
L
E
M
D
Site 94
S992
E
L
E
M
D
E
E
S
L
Q
T
L
S
L
Q
Site 95
T995
M
D
E
E
S
L
Q
T
L
S
L
Q
C
E
P
Site 96
S997
E
E
S
L
Q
T
L
S
L
Q
C
E
P
A
T
Site 97
T1006
Q
C
E
P
A
T
N
T
L
P
K
N
P
G
D
Site 98
S1019
G
D
K
K
P
V
K
S
E
T
S
P
V
A
P
Site 99
S1022
K
P
V
K
S
E
T
S
P
V
A
P
R
A
G
Site 100
S1030
P
V
A
P
R
A
G
S
Q
Q
K
A
Q
S
L
Site 101
S1036
G
S
Q
Q
K
A
Q
S
L
P
Q
P
Q
Q
Q
Site 102
S1060
G
L
Q
V
P
A
V
S
L
Y
P
S
R
K
K
Site 103
Y1062
Q
V
P
A
V
S
L
Y
P
S
R
K
K
V
P
Site 104
S1064
P
A
V
S
L
Y
P
S
R
K
K
V
P
V
K
Site 105
S1080
L
P
P
F
G
I
N
S
P
Q
A
L
K
K
I
Site 106
S1089
Q
A
L
K
K
I
L
S
L
S
E
E
G
S
L
Site 107
S1091
L
K
K
I
L
S
L
S
E
E
G
S
L
E
R
Site 108
S1095
L
S
L
S
E
E
G
S
L
E
R
H
K
K
Q
Site 109
T1106
H
K
K
Q
A
E
D
T
I
S
N
A
S
S
Q
Site 110
S1108
K
Q
A
E
D
T
I
S
N
A
S
S
Q
L
S
Site 111
S1111
E
D
T
I
S
N
A
S
S
Q
L
S
S
P
P
Site 112
S1112
D
T
I
S
N
A
S
S
Q
L
S
S
P
P
T
Site 113
S1115
S
N
A
S
S
Q
L
S
S
P
P
T
S
P
Q
Site 114
S1116
N
A
S
S
Q
L
S
S
P
P
T
S
P
Q
S
Site 115
T1119
S
Q
L
S
S
P
P
T
S
P
Q
S
S
P
R
Site 116
S1120
Q
L
S
S
P
P
T
S
P
Q
S
S
P
R
K
Site 117
S1123
S
P
P
T
S
P
Q
S
S
P
R
K
G
Y
T
Site 118
S1124
P
P
T
S
P
Q
S
S
P
R
K
G
Y
T
L
Site 119
Y1129
Q
S
S
P
R
K
G
Y
T
L
A
P
S
G
T
Site 120
T1130
S
S
P
R
K
G
Y
T
L
A
P
S
G
T
V
Site 121
T1136
Y
T
L
A
P
S
G
T
V
D
N
F
S
D
S
Site 122
S1141
S
G
T
V
D
N
F
S
D
S
G
H
S
E
I
Site 123
S1143
T
V
D
N
F
S
D
S
G
H
S
E
I
S
S
Site 124
S1146
N
F
S
D
S
G
H
S
E
I
S
S
R
S
S
Site 125
S1149
D
S
G
H
S
E
I
S
S
R
S
S
I
V
S
Site 126
S1150
S
G
H
S
E
I
S
S
R
S
S
I
V
S
N
Site 127
S1152
H
S
E
I
S
S
R
S
S
I
V
S
N
S
S
Site 128
S1153
S
E
I
S
S
R
S
S
I
V
S
N
S
S
F
Site 129
S1156
S
S
R
S
S
I
V
S
N
S
S
F
D
S
V
Site 130
S1158
R
S
S
I
V
S
N
S
S
F
D
S
V
P
V
Site 131
S1159
S
S
I
V
S
N
S
S
F
D
S
V
P
V
S
Site 132
S1162
V
S
N
S
S
F
D
S
V
P
V
S
L
H
D
Site 133
S1166
S
F
D
S
V
P
V
S
L
H
D
E
R
R
Q
Site 134
S1176
D
E
R
R
Q
R
H
S
V
S
I
V
E
T
N
Site 135
S1178
R
R
Q
R
H
S
V
S
I
V
E
T
N
L
G
Site 136
T1193
M
G
R
M
E
R
R
T
M
I
E
P
D
Q
Y
Site 137
Y1200
T
M
I
E
P
D
Q
Y
S
L
G
S
Y
A
P
Site 138
S1201
M
I
E
P
D
Q
Y
S
L
G
S
Y
A
P
M
Site 139
S1204
P
D
Q
Y
S
L
G
S
Y
A
P
M
S
E
G
Site 140
Y1205
D
Q
Y
S
L
G
S
Y
A
P
M
S
E
G
R
Site 141
S1209
L
G
S
Y
A
P
M
S
E
G
R
G
L
Y
A
Site 142
T1217
E
G
R
G
L
Y
A
T
A
T
V
I
S
S
P
Site 143
S1223
A
T
A
T
V
I
S
S
P
S
T
E
E
L
S
Site 144
S1225
A
T
V
I
S
S
P
S
T
E
E
L
S
Q
D
Site 145
T1226
T
V
I
S
S
P
S
T
E
E
L
S
Q
D
Q
Site 146
S1230
S
P
S
T
E
E
L
S
Q
D
Q
G
D
R
A
Site 147
S1238
Q
D
Q
G
D
R
A
S
L
D
A
A
D
S
G
Site 148
S1244
A
S
L
D
A
A
D
S
G
R
G
S
W
T
S
Site 149
S1248
A
A
D
S
G
R
G
S
W
T
S
C
S
S
G
Site 150
T1250
D
S
G
R
G
S
W
T
S
C
S
S
G
S
H
Site 151
S1251
S
G
R
G
S
W
T
S
C
S
S
G
S
H
D
Site 152
S1253
R
G
S
W
T
S
C
S
S
G
S
H
D
N
I
Site 153
S1254
G
S
W
T
S
C
S
S
G
S
H
D
N
I
Q
Site 154
S1268
Q
T
I
Q
H
Q
R
S
W
E
T
L
P
F
G
Site 155
Y1281
F
G
H
T
H
F
D
Y
S
G
D
P
A
G
L
Site 156
S1291
D
P
A
G
L
W
A
S
S
S
H
M
D
Q
I
Site 157
Y1307
F
S
D
H
S
T
K
Y
N
R
Q
N
Q
S
R
Site 158
S1316
R
Q
N
Q
S
R
E
S
L
E
Q
A
Q
S
R
Site 159
S1322
E
S
L
E
Q
A
Q
S
R
A
S
W
A
S
S
Site 160
S1325
E
Q
A
Q
S
R
A
S
W
A
S
S
T
G
Y
Site 161
S1328
Q
S
R
A
S
W
A
S
S
T
G
Y
W
G
E
Site 162
S1329
S
R
A
S
W
A
S
S
T
G
Y
W
G
E
D
Site 163
Y1332
S
W
A
S
S
T
G
Y
W
G
E
D
S
E
G
Site 164
S1337
T
G
Y
W
G
E
D
S
E
G
D
T
G
T
I
Site 165
T1341
G
E
D
S
E
G
D
T
G
T
I
K
R
R
G
Site 166
T1343
D
S
E
G
D
T
G
T
I
K
R
R
G
G
K
Site 167
S1353
R
R
G
G
K
D
V
S
I
E
A
E
S
S
S
Site 168
S1360
S
I
E
A
E
S
S
S
L
T
S
V
T
T
E
Site 169
T1362
E
A
E
S
S
S
L
T
S
V
T
T
E
E
T
Site 170
S1363
A
E
S
S
S
L
T
S
V
T
T
E
E
T
K
Site 171
Y1396
I
A
R
K
E
G
R
Y
R
E
P
P
P
T
P
Site 172
T1402
R
Y
R
E
P
P
P
T
P
P
G
Y
I
G
I
Site 173
Y1406
P
P
P
T
P
P
G
Y
I
G
I
P
I
T
D
Site 174
T1412
G
Y
I
G
I
P
I
T
D
F
P
E
G
H
S
Site 175
Y1428
P
A
R
K
P
P
D
Y
N
V
A
L
Q
R
S
Site 176
S1441
R
S
R
M
V
A
R
S
S
D
T
A
G
P
S
Site 177
S1442
S
R
M
V
A
R
S
S
D
T
A
G
P
S
S
Site 178
T1444
M
V
A
R
S
S
D
T
A
G
P
S
S
V
Q
Site 179
S1448
S
S
D
T
A
G
P
S
S
V
Q
Q
P
H
G
Site 180
S1449
S
D
T
A
G
P
S
S
V
Q
Q
P
H
G
H
Site 181
S1459
Q
P
H
G
H
P
T
S
S
R
P
V
N
K
P
Site 182
S1460
P
H
G
H
P
T
S
S
R
P
V
N
K
P
Q
Site 183
Y1481
S
D
P
R
L
A
P
Y
Q
S
Q
G
F
S
T
Site 184
S1483
P
R
L
A
P
Y
Q
S
Q
G
F
S
T
E
E
Site 185
S1487
P
Y
Q
S
Q
G
F
S
T
E
E
D
E
D
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation