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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AIM1
Full Name:
Absent in melanoma 1 protein
Alias:
Beta/gamma crystallin domain-containing protein 1; Beta-gamma crystallin domain containing 1; CRYBG1; ST4; Suppression of tumorigenicity 4
Type:
Calcium-binding protein
Mass (Da):
188676
Number AA:
1723
UniProt ID:
Q9Y4K1
International Prot ID:
IPI00294840
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005529
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
E
K
R
S
S
G
R
R
S
G
R
Site 2
S6
_
_
M
E
K
R
S
S
G
R
R
S
G
R
R
Site 3
S10
K
R
S
S
G
R
R
S
G
R
R
R
G
S
Q
Site 4
S16
R
S
G
R
R
R
G
S
Q
K
S
T
D
S
P
Site 5
S19
R
R
R
G
S
Q
K
S
T
D
S
P
G
A
D
Site 6
T20
R
R
G
S
Q
K
S
T
D
S
P
G
A
D
A
Site 7
S22
G
S
Q
K
S
T
D
S
P
G
A
D
A
E
L
Site 8
S32
A
D
A
E
L
P
E
S
A
A
R
D
D
A
V
Site 9
S50
E
V
A
P
N
A
A
S
D
N
A
S
A
E
K
Site 10
S54
N
A
A
S
D
N
A
S
A
E
K
K
V
K
S
Site 11
S61
S
A
E
K
K
V
K
S
P
R
A
A
L
D
G
Site 12
S72
A
L
D
G
G
V
A
S
A
A
S
P
E
S
K
Site 13
S75
G
G
V
A
S
A
A
S
P
E
S
K
P
S
P
Site 14
S78
A
S
A
A
S
P
E
S
K
P
S
P
G
T
K
Site 15
S81
A
S
P
E
S
K
P
S
P
G
T
K
G
Q
L
Site 16
S92
K
G
Q
L
R
G
E
S
D
R
S
K
Q
P
P
Site 17
S95
L
R
G
E
S
D
R
S
K
Q
P
P
P
A
S
Site 18
S102
S
K
Q
P
P
P
A
S
S
P
T
K
R
K
G
Site 19
S103
K
Q
P
P
P
A
S
S
P
T
K
R
K
G
R
Site 20
T105
P
P
P
A
S
S
P
T
K
R
K
G
R
S
R
Site 21
S111
P
T
K
R
K
G
R
S
R
A
L
E
A
V
P
Site 22
S123
A
V
P
A
P
P
A
S
G
P
R
A
P
A
K
Site 23
S132
P
R
A
P
A
K
E
S
P
P
K
R
V
P
D
Site 24
S141
P
K
R
V
P
D
P
S
P
V
T
K
G
T
A
Site 25
T147
P
S
P
V
T
K
G
T
A
A
E
S
G
E
E
Site 26
S167
P
R
E
L
P
V
K
S
S
S
L
L
P
E
I
Site 27
S169
E
L
P
V
K
S
S
S
L
L
P
E
I
K
P
Site 28
S196
G
R
A
E
G
G
R
S
R
E
L
G
R
A
A
Site 29
T229
V
G
R
S
T
V
T
T
K
V
T
L
P
A
K
Site 30
T232
S
T
V
T
T
K
V
T
L
P
A
K
P
K
H
Site 31
T246
H
V
E
L
N
L
K
T
P
K
N
L
D
S
L
Site 32
S252
K
T
P
K
N
L
D
S
L
G
N
E
H
N
P
Site 33
S261
G
N
E
H
N
P
F
S
Q
P
V
H
K
G
N
Site 34
T281
S
L
F
E
N
K
R
T
N
S
S
P
R
H
T
Site 35
S283
F
E
N
K
R
T
N
S
S
P
R
H
T
D
I
Site 36
S284
E
N
K
R
T
N
S
S
P
R
H
T
D
I
R
Site 37
T288
T
N
S
S
P
R
H
T
D
I
R
G
Q
R
N
Site 38
T296
D
I
R
G
Q
R
N
T
P
A
S
S
K
T
F
Site 39
S299
G
Q
R
N
T
P
A
S
S
K
T
F
V
G
R
Site 40
T302
N
T
P
A
S
S
K
T
F
V
G
R
A
K
L
Site 41
S329
E
K
K
V
M
P
N
S
P
Q
N
G
V
L
V
Site 42
S348
I
E
T
K
V
T
V
S
E
E
E
I
L
P
A
Site 43
S364
R
G
M
N
G
D
S
S
E
N
Q
A
L
G
P
Site 44
T383
D
D
K
A
D
V
Q
T
D
A
G
C
L
S
E
Site 45
S410
K
L
L
E
K
E
D
S
E
A
A
D
S
K
S
Site 46
S415
E
D
S
E
A
A
D
S
K
S
L
V
L
E
N
Site 47
S417
S
E
A
A
D
S
K
S
L
V
L
E
N
V
T
Site 48
T426
V
L
E
N
V
T
D
T
A
Q
D
I
P
T
T
Site 49
T433
T
A
Q
D
I
P
T
T
V
D
T
K
D
L
P
Site 50
T442
D
T
K
D
L
P
P
T
A
M
P
K
P
Q
H
Site 51
T450
A
M
P
K
P
Q
H
T
F
S
D
S
Q
S
P
Site 52
S452
P
K
P
Q
H
T
F
S
D
S
Q
S
P
A
E
Site 53
S454
P
Q
H
T
F
S
D
S
Q
S
P
A
E
S
S
Site 54
S456
H
T
F
S
D
S
Q
S
P
A
E
S
S
P
G
Site 55
S460
D
S
Q
S
P
A
E
S
S
P
G
P
S
L
S
Site 56
S461
S
Q
S
P
A
E
S
S
P
G
P
S
L
S
L
Site 57
S465
A
E
S
S
P
G
P
S
L
S
L
S
A
P
A
Site 58
S467
S
S
P
G
P
S
L
S
L
S
A
P
A
P
G
Site 59
S469
P
G
P
S
L
S
L
S
A
P
A
P
G
D
V
Site 60
T480
P
G
D
V
P
K
D
T
C
V
Q
S
P
I
S
Site 61
S484
P
K
D
T
C
V
Q
S
P
I
S
S
F
P
C
Site 62
T492
P
I
S
S
F
P
C
T
D
L
K
V
S
E
N
Site 63
S508
K
G
C
V
L
P
V
S
R
Q
N
N
E
K
M
Site 64
T525
L
E
L
G
G
E
T
T
P
P
L
S
T
E
R
Site 65
S529
G
E
T
T
P
P
L
S
T
E
R
S
P
E
A
Site 66
S533
P
P
L
S
T
E
R
S
P
E
A
V
G
S
E
Site 67
S539
R
S
P
E
A
V
G
S
E
C
P
S
R
V
L
Site 68
S558
S
F
V
L
P
V
E
S
T
Q
D
V
S
S
Q
Site 69
S563
V
E
S
T
Q
D
V
S
S
Q
V
I
P
E
S
Site 70
S564
E
S
T
Q
D
V
S
S
Q
V
I
P
E
S
S
Site 71
S570
S
S
Q
V
I
P
E
S
S
E
V
R
E
V
Q
Site 72
S571
S
Q
V
I
P
E
S
S
E
V
R
E
V
Q
L
Site 73
S583
V
Q
L
P
T
C
H
S
N
E
P
E
V
V
S
Site 74
S590
S
N
E
P
E
V
V
S
V
A
S
C
A
P
P
Site 75
S607
E
V
L
G
N
E
H
S
H
C
T
A
E
L
A
Site 76
S617
T
A
E
L
A
A
K
S
G
P
Q
V
I
P
P
Site 77
S626
P
Q
V
I
P
P
A
S
E
K
T
L
P
I
Q
Site 78
S636
T
L
P
I
Q
A
Q
S
Q
G
S
R
T
P
L
Site 79
T641
A
Q
S
Q
G
S
R
T
P
L
M
A
E
S
S
Site 80
S648
T
P
L
M
A
E
S
S
P
T
N
S
P
S
S
Site 81
T650
L
M
A
E
S
S
P
T
N
S
P
S
S
G
N
Site 82
S652
A
E
S
S
P
T
N
S
P
S
S
G
N
H
L
Site 83
S654
S
S
P
T
N
S
P
S
S
G
N
H
L
A
T
Site 84
S655
S
P
T
N
S
P
S
S
G
N
H
L
A
T
P
Site 85
T661
S
S
G
N
H
L
A
T
P
Q
R
P
D
Q
T
Site 86
T668
T
P
Q
R
P
D
Q
T
V
T
N
G
Q
D
S
Site 87
S675
T
V
T
N
G
Q
D
S
P
A
S
L
L
N
I
Site 88
S678
N
G
Q
D
S
P
A
S
L
L
N
I
S
A
G
Site 89
S689
I
S
A
G
S
D
D
S
V
F
D
S
S
S
D
Site 90
S693
S
D
D
S
V
F
D
S
S
S
D
M
E
K
F
Site 91
S695
D
S
V
F
D
S
S
S
D
M
E
K
F
T
E
Site 92
S709
E
I
I
K
Q
M
D
S
A
V
C
M
P
M
K
Site 93
S725
K
K
A
R
M
P
N
S
P
A
P
H
F
A
M
Site 94
S759
G
L
G
K
K
K
E
S
Q
P
E
M
S
P
A
Site 95
S764
K
E
S
Q
P
E
M
S
P
A
L
H
L
M
Q
Site 96
T775
H
L
M
Q
N
L
D
T
K
S
K
L
R
P
K
Site 97
S777
M
Q
N
L
D
T
K
S
K
L
R
P
K
R
A
Site 98
S785
K
L
R
P
K
R
A
S
A
E
Q
S
V
L
F
Site 99
S789
K
R
A
S
A
E
Q
S
V
L
F
K
S
L
H
Site 100
S794
E
Q
S
V
L
F
K
S
L
H
T
N
T
N
G
Site 101
T820
D
K
E
N
R
D
V
T
N
G
G
I
K
R
S
Site 102
S827
T
N
G
G
I
K
R
S
R
L
E
K
S
A
L
Site 103
S832
K
R
S
R
L
E
K
S
A
L
F
S
S
L
L
Site 104
S836
L
E
K
S
A
L
F
S
S
L
L
S
S
L
P
Site 105
S837
E
K
S
A
L
F
S
S
L
L
S
S
L
P
Q
Site 106
S840
A
L
F
S
S
L
L
S
S
L
P
Q
D
K
I
Site 107
S841
L
F
S
S
L
L
S
S
L
P
Q
D
K
I
F
Site 108
S849
L
P
Q
D
K
I
F
S
P
S
V
T
S
V
N
Site 109
S851
Q
D
K
I
F
S
P
S
V
T
S
V
N
T
M
Site 110
T859
V
T
S
V
N
T
M
T
T
A
F
S
T
S
Q
Site 111
S865
M
T
T
A
F
S
T
S
Q
N
G
S
L
S
Q
Site 112
S869
F
S
T
S
Q
N
G
S
L
S
Q
S
S
V
S
Site 113
S871
T
S
Q
N
G
S
L
S
Q
S
S
V
S
Q
P
Site 114
S873
Q
N
G
S
L
S
Q
S
S
V
S
Q
P
T
T
Site 115
S874
N
G
S
L
S
Q
S
S
V
S
Q
P
T
T
E
Site 116
S876
S
L
S
Q
S
S
V
S
Q
P
T
T
E
G
A
Site 117
T880
S
S
V
S
Q
P
T
T
E
G
A
P
P
C
G
Site 118
S893
C
G
L
N
K
E
Q
S
N
L
L
P
D
N
S
Site 119
S900
S
N
L
L
P
D
N
S
L
K
V
F
N
F
N
Site 120
S908
L
K
V
F
N
F
N
S
S
S
T
S
H
S
S
Site 121
S909
K
V
F
N
F
N
S
S
S
T
S
H
S
S
L
Site 122
S910
V
F
N
F
N
S
S
S
T
S
H
S
S
L
K
Site 123
T911
F
N
F
N
S
S
S
T
S
H
S
S
L
K
S
Site 124
S912
N
F
N
S
S
S
T
S
H
S
S
L
K
S
P
Site 125
S914
N
S
S
S
T
S
H
S
S
L
K
S
P
S
H
Site 126
S915
S
S
S
T
S
H
S
S
L
K
S
P
S
H
M
Site 127
S918
T
S
H
S
S
L
K
S
P
S
H
M
E
K
Y
Site 128
S920
H
S
S
L
K
S
P
S
H
M
E
K
Y
P
Q
Site 129
Y925
S
P
S
H
M
E
K
Y
P
Q
K
E
K
T
K
Site 130
S937
K
T
K
E
D
L
D
S
R
S
N
L
H
L
P
Site 131
S939
K
E
D
L
D
S
R
S
N
L
H
L
P
E
T
Site 132
T946
S
N
L
H
L
P
E
T
K
F
S
E
L
S
K
Site 133
S949
H
L
P
E
T
K
F
S
E
L
S
K
L
K
N
Site 134
S967
E
K
A
N
H
I
E
S
V
I
K
S
N
L
P
Site 135
S971
H
I
E
S
V
I
K
S
N
L
P
N
C
A
N
Site 136
S979
N
L
P
N
C
A
N
S
D
T
D
F
M
G
L
Site 137
S989
D
F
M
G
L
F
K
S
S
R
Y
D
P
S
I
Site 138
Y992
G
L
F
K
S
S
R
Y
D
P
S
I
S
F
S
Site 139
S995
K
S
S
R
Y
D
P
S
I
S
F
S
G
M
S
Site 140
S997
S
R
Y
D
P
S
I
S
F
S
G
M
S
L
S
Site 141
S999
Y
D
P
S
I
S
F
S
G
M
S
L
S
D
T
Site 142
S1004
S
F
S
G
M
S
L
S
D
T
M
T
L
R
G
Site 143
T1006
S
G
M
S
L
S
D
T
M
T
L
R
G
S
V
Site 144
T1008
M
S
L
S
D
T
M
T
L
R
G
S
V
Q
N
Site 145
S1012
D
T
M
T
L
R
G
S
V
Q
N
K
L
N
P
Site 146
Y1027
R
P
G
K
V
V
I
Y
S
E
P
D
V
S
E
Site 147
S1028
P
G
K
V
V
I
Y
S
E
P
D
V
S
E
K
Site 148
S1033
I
Y
S
E
P
D
V
S
E
K
C
I
E
V
F
Site 149
S1041
E
K
C
I
E
V
F
S
D
I
Q
D
C
S
S
Site 150
S1047
F
S
D
I
Q
D
C
S
S
W
S
L
S
P
V
Site 151
S1048
S
D
I
Q
D
C
S
S
W
S
L
S
P
V
I
Site 152
Y1067
V
R
G
C
W
I
L
Y
E
Q
P
N
F
E
G
Site 153
S1087
E
E
G
E
L
E
L
S
G
L
W
G
I
E
D
Site 154
S1104
E
R
H
E
E
A
E
S
D
K
P
V
V
I
G
Site 155
S1112
D
K
P
V
V
I
G
S
I
R
H
V
V
Q
D
Site 156
Y1120
I
R
H
V
V
Q
D
Y
R
V
S
H
I
D
L
Site 157
S1123
V
V
Q
D
Y
R
V
S
H
I
D
L
F
T
E
Site 158
S1138
P
E
G
L
G
I
L
S
S
Y
F
D
D
T
E
Site 159
S1139
E
G
L
G
I
L
S
S
Y
F
D
D
T
E
E
Site 160
Y1140
G
L
G
I
L
S
S
Y
F
D
D
T
E
E
M
Site 161
T1144
L
S
S
Y
F
D
D
T
E
E
M
Q
G
F
G
Site 162
Y1186
F
I
L
E
P
G
E
Y
P
D
L
S
F
W
D
Site 163
S1190
P
G
E
Y
P
D
L
S
F
W
D
T
E
E
A
Site 164
T1194
P
D
L
S
F
W
D
T
E
E
A
Y
I
G
S
Site 165
S1201
T
E
E
A
Y
I
G
S
M
R
P
L
K
M
G
Site 166
Y1223
T
D
P
K
V
V
V
Y
E
K
P
F
F
E
G
Site 167
S1241
E
L
E
T
G
M
C
S
F
V
M
E
G
G
E
Site 168
T1249
F
V
M
E
G
G
E
T
E
E
A
T
G
D
D
Site 169
T1261
G
D
D
H
L
P
F
T
S
V
G
S
M
K
V
Site 170
Y1276
L
R
G
I
W
V
A
Y
E
K
P
G
F
T
G
Site 171
Y1286
P
G
F
T
G
H
Q
Y
L
L
E
E
G
E
Y
Site 172
Y1293
Y
L
L
E
E
G
E
Y
R
D
W
K
A
W
G
Site 173
S1308
G
Y
N
G
E
L
Q
S
L
R
P
I
L
G
D
Site 174
Y1324
S
N
A
H
M
I
M
Y
S
E
K
N
F
G
S
Site 175
S1331
Y
S
E
K
N
F
G
S
K
G
S
S
I
D
V
Site 176
Y1350
A
N
L
K
E
T
G
Y
G
V
K
T
Q
S
I
Site 177
T1354
E
T
G
Y
G
V
K
T
Q
S
I
N
V
L
S
Site 178
Y1367
L
S
G
V
W
V
A
Y
E
N
P
D
F
T
G
Site 179
T1373
A
Y
E
N
P
D
F
T
G
E
Q
Y
I
L
D
Site 180
Y1377
P
D
F
T
G
E
Q
Y
I
L
D
K
G
F
Y
Site 181
Y1384
Y
I
L
D
K
G
F
Y
T
S
F
E
D
W
G
Site 182
S1386
L
D
K
G
F
Y
T
S
F
E
D
W
G
G
K
Site 183
S1399
G
K
N
C
K
I
S
S
V
Q
P
I
C
L
D
Site 184
S1407
V
Q
P
I
C
L
D
S
F
T
G
P
R
R
R
Site 185
T1409
P
I
C
L
D
S
F
T
G
P
R
R
R
N
Q
Site 186
S1429
E
P
Q
F
Q
G
H
S
Q
S
F
E
E
T
T
Site 187
S1431
Q
F
Q
G
H
S
Q
S
F
E
E
T
T
S
Q
Site 188
T1435
H
S
Q
S
F
E
E
T
T
S
Q
I
D
D
S
Site 189
S1437
Q
S
F
E
E
T
T
S
Q
I
D
D
S
F
S
Site 190
S1442
T
T
S
Q
I
D
D
S
F
S
T
K
S
C
R
Site 191
S1444
S
Q
I
D
D
S
F
S
T
K
S
C
R
V
S
Site 192
S1447
D
D
S
F
S
T
K
S
C
R
V
S
G
G
S
Site 193
S1451
S
T
K
S
C
R
V
S
G
G
S
W
V
V
Y
Site 194
S1454
S
C
R
V
S
G
G
S
W
V
V
Y
D
G
E
Site 195
Y1458
S
G
G
S
W
V
V
Y
D
G
E
N
F
T
G
Site 196
Y1468
E
N
F
T
G
N
Q
Y
V
L
E
E
G
H
Y
Site 197
S1491
P
P
G
A
T
F
K
S
L
R
F
I
D
V
E
Site 198
T1523
K
I
E
L
N
A
E
T
V
N
L
R
S
L
G
Site 199
T1533
L
R
S
L
G
F
N
T
Q
I
R
S
V
Q
V
Site 200
Y1548
I
G
G
I
W
V
T
Y
E
Y
G
S
Y
R
G
Site 201
Y1550
G
I
W
V
T
Y
E
Y
G
S
Y
R
G
R
Q
Site 202
Y1553
V
T
Y
E
Y
G
S
Y
R
G
R
Q
F
L
L
Site 203
S1561
R
G
R
Q
F
L
L
S
P
A
E
V
P
N
W
Site 204
Y1569
P
A
E
V
P
N
W
Y
E
F
S
G
C
R
Q
Site 205
S1579
S
G
C
R
Q
I
G
S
L
R
P
F
V
Q
K
Site 206
Y1589
P
F
V
Q
K
R
I
Y
F
R
L
R
N
K
A
Site 207
S1602
K
A
T
G
L
F
M
S
T
N
G
N
L
E
D
Site 208
S1668
A
L
D
Q
N
A
D
S
Q
F
W
S
L
K
S
Site 209
S1672
N
A
D
S
Q
F
W
S
L
K
S
D
G
R
I
Site 210
S1675
S
Q
F
W
S
L
K
S
D
G
R
I
Y
S
K
Site 211
Y1680
L
K
S
D
G
R
I
Y
S
K
L
K
P
N
L
Site 212
S1681
K
S
D
G
R
I
Y
S
K
L
K
P
N
L
V
Site 213
Y1697
D
I
K
G
G
T
Q
Y
D
Q
N
H
I
I
L
Site 214
S1708
H
I
I
L
N
T
V
S
K
E
K
F
T
Q
V
Site 215
Y1722
V
W
E
A
M
V
L
Y
T
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation