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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TRAF6
Full Name:
TNF receptor-associated factor 6
Alias:
Interleukin 1 signal transducer; RING finger protein 85; RNF85
Type:
Mass (Da):
59570
Number AA:
UniProt ID:
Q9Y4K3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004842
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0050852
GO:0007250
GO:0006916
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
S
L
L
N
C
E
N
S
C
G
S
S
Q
S
E
Site 2
S12
N
C
E
N
S
C
G
S
S
Q
S
E
S
D
C
Site 3
S13
C
E
N
S
C
G
S
S
Q
S
E
S
D
C
C
Site 4
S15
N
S
C
G
S
S
Q
S
E
S
D
C
C
V
A
Site 5
S17
C
G
S
S
Q
S
E
S
D
C
C
V
A
M
A
Site 6
S35
S
A
V
T
K
D
D
S
V
G
G
T
A
S
T
Site 7
T39
K
D
D
S
V
G
G
T
A
S
T
G
N
L
S
Site 8
S41
D
S
V
G
G
T
A
S
T
G
N
L
S
S
S
Site 9
T42
S
V
G
G
T
A
S
T
G
N
L
S
S
S
F
Site 10
S46
T
A
S
T
G
N
L
S
S
S
F
M
E
E
I
Site 11
S48
S
T
G
N
L
S
S
S
F
M
E
E
I
Q
G
Site 12
Y56
F
M
E
E
I
Q
G
Y
D
V
E
F
D
P
P
Site 13
Y68
D
P
P
L
E
S
K
Y
E
C
P
I
C
L
M
Site 14
T83
A
L
R
E
A
V
Q
T
P
C
G
H
R
F
C
Site 15
S188
D
C
P
R
R
Q
V
S
C
D
N
C
A
A
S
Site 16
Y231
R
E
Q
M
P
N
H
Y
D
L
D
C
P
T
A
Site 17
S286
S
L
S
V
I
P
D
S
G
Y
I
S
E
V
R
Site 18
Y288
S
V
I
P
D
S
G
Y
I
S
E
V
R
N
F
Site 19
S290
I
P
D
S
G
Y
I
S
E
V
R
N
F
Q
E
Site 20
T298
E
V
R
N
F
Q
E
T
I
H
Q
L
E
G
R
Site 21
T317
D
H
Q
I
R
E
L
T
A
K
M
E
T
Q
S
Site 22
S324
T
A
K
M
E
T
Q
S
M
Y
V
S
E
L
K
Site 23
Y326
K
M
E
T
Q
S
M
Y
V
S
E
L
K
R
T
Site 24
S328
E
T
Q
S
M
Y
V
S
E
L
K
R
T
I
R
Site 25
T333
Y
V
S
E
L
K
R
T
I
R
T
L
E
D
K
Site 26
Y353
A
Q
Q
C
N
G
I
Y
I
W
K
I
G
N
F
Site 27
S377
E
K
P
V
V
I
H
S
P
G
F
Y
T
G
K
Site 28
Y381
V
I
H
S
P
G
F
Y
T
G
K
P
G
Y
K
Site 29
T382
I
H
S
P
G
F
Y
T
G
K
P
G
Y
K
L
Site 30
Y418
V
H
T
M
Q
G
E
Y
D
S
H
L
P
W
P
Site 31
T433
F
Q
G
T
I
R
L
T
I
L
D
Q
S
E
A
Site 32
S438
R
L
T
I
L
D
Q
S
E
A
P
V
R
Q
N
Site 33
T463
L
L
A
F
Q
R
P
T
I
P
R
N
P
K
G
Site 34
Y473
R
N
P
K
G
F
G
Y
V
T
F
M
H
L
E
Site 35
T486
L
E
A
L
R
Q
R
T
F
I
K
D
D
T
L
Site 36
S507
S
T
R
F
D
M
G
S
L
R
R
E
G
F
Q
Site 37
S517
R
E
G
F
Q
P
R
S
T
D
A
G
V
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation