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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HYOU1
Full Name:
Hypoxia up-regulated protein 1
Alias:
150 kDa oxygen-regulated protein; Glucose-regulated protein 170; Grp170; HSP12A; Hypoxia up-regulated 1; Orp150; ORP150; Oxygen regulated protein
Type:
Chaperone
Mass (Da):
111317
Number AA:
999
UniProt ID:
Q9Y4L1
International Prot ID:
IPI00000877
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005788
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Hypoxia up-regulated protein 1 pan-specific antibody AB-NN265-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN265-1#Hypoxia up-regulated protein 1 pan-specific antibody AB-NN265-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN265-2
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S64
E
I
V
L
N
K
E
S
R
R
K
T
P
V
I
Site 2
T68
N
K
E
S
R
R
K
T
P
V
I
V
T
L
K
Site 3
S84
N
E
R
F
F
G
D
S
A
A
S
M
A
I
K
Site 4
T96
A
I
K
N
P
K
A
T
L
R
Y
F
Q
H
L
Site 5
Y99
N
P
K
A
T
L
R
Y
F
Q
H
L
L
G
K
Site 6
Y116
D
N
P
H
V
A
L
Y
Q
A
R
F
P
E
H
Site 7
T126
R
F
P
E
H
E
L
T
F
D
P
Q
R
Q
T
Site 8
T133
T
F
D
P
Q
R
Q
T
V
H
F
Q
I
S
S
Site 9
S140
T
V
H
F
Q
I
S
S
Q
L
Q
F
S
P
E
Site 10
S145
I
S
S
Q
L
Q
F
S
P
E
E
V
L
G
M
Site 11
S159
M
V
L
N
Y
S
R
S
L
A
E
D
F
A
E
Site 12
T223
F
R
R
K
D
I
N
T
T
A
Q
N
I
M
F
Site 13
Y231
T
A
Q
N
I
M
F
Y
D
M
G
S
G
S
T
Site 14
T238
Y
D
M
G
S
G
S
T
V
C
T
I
V
T
Y
Site 15
T269
R
G
V
G
F
D
R
T
L
G
G
L
E
M
E
Site 16
T318
R
E
A
N
R
L
K
T
V
L
S
A
N
A
D
Site 17
S321
N
R
L
K
T
V
L
S
A
N
A
D
H
M
A
Site 18
S369
P
V
Q
Q
A
L
Q
S
A
E
M
S
L
D
E
Site 19
S373
A
L
Q
S
A
E
M
S
L
D
E
I
E
Q
V
Site 20
Y476
L
F
S
R
M
G
P
Y
P
Q
R
K
V
I
T
Site 21
S513
E
D
L
R
V
F
G
S
Q
N
L
T
T
V
K
Site 22
T518
F
G
S
Q
N
L
T
T
V
K
L
K
G
V
G
Site 23
S527
K
L
K
G
V
G
D
S
F
K
K
Y
P
D
Y
Site 24
Y531
V
G
D
S
F
K
K
Y
P
D
Y
E
S
K
G
Site 25
Y534
S
F
K
K
Y
P
D
Y
E
S
K
G
I
K
A
Site 26
S536
K
K
Y
P
D
Y
E
S
K
G
I
K
A
H
F
Site 27
S548
A
H
F
N
L
D
E
S
G
V
L
S
L
D
R
Site 28
S552
L
D
E
S
G
V
L
S
L
D
R
V
E
S
V
Site 29
T562
R
V
E
S
V
F
E
T
L
V
E
D
S
A
E
Site 30
S567
F
E
T
L
V
E
D
S
A
E
E
E
S
T
L
Site 31
S572
E
D
S
A
E
E
E
S
T
L
T
K
L
G
N
Site 32
T573
D
S
A
E
E
E
S
T
L
T
K
L
G
N
T
Site 33
T575
A
E
E
E
S
T
L
T
K
L
G
N
T
I
S
Site 34
T590
S
L
F
G
G
G
T
T
P
D
A
K
E
N
G
Site 35
T600
A
K
E
N
G
T
D
T
V
Q
E
E
E
E
S
Site 36
S607
T
V
Q
E
E
E
E
S
P
A
E
G
S
K
D
Site 37
S634
E
A
P
V
E
D
G
S
Q
P
P
P
P
E
P
Site 38
T646
P
E
P
K
G
D
A
T
P
E
G
E
K
A
T
Site 39
S661
E
K
E
N
G
D
K
S
E
A
Q
K
P
S
E
Site 40
T727
V
Q
K
L
Q
D
L
T
L
R
D
L
E
K
Q
Site 41
S742
E
R
E
K
A
A
N
S
L
E
A
F
I
F
E
Site 42
Y755
F
E
T
Q
D
K
L
Y
Q
P
E
Y
Q
E
V
Site 43
Y759
D
K
L
Y
Q
P
E
Y
Q
E
V
S
T
E
E
Site 44
S772
E
E
Q
R
E
E
I
S
G
K
L
S
A
A
S
Site 45
S776
E
E
I
S
G
K
L
S
A
A
S
T
W
L
E
Site 46
S779
S
G
K
L
S
A
A
S
T
W
L
E
D
E
G
Site 47
T780
G
K
L
S
A
A
S
T
W
L
E
D
E
G
V
Site 48
S823
K
K
W
P
E
R
L
S
A
L
D
N
L
L
N
Site 49
S833
D
N
L
L
N
H
S
S
M
F
L
K
G
A
R
Site 50
T881
E
Q
A
K
L
P
A
T
E
K
P
V
L
L
S
Site 51
S933
A
E
P
P
L
N
A
S
A
S
D
Q
G
E
K
Site 52
S935
P
P
L
N
A
S
A
S
D
Q
G
E
K
V
I
Site 53
S955
T
E
D
A
E
P
I
S
E
P
E
K
V
E
T
Site 54
T962
S
E
P
E
K
V
E
T
G
S
E
P
G
D
T
Site 55
S964
P
E
K
V
E
T
G
S
E
P
G
D
T
E
P
Site 56
T969
T
G
S
E
P
G
D
T
E
P
L
E
L
G
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation