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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ATG4B
Full Name:
Cysteine protease ATG4B
Alias:
APG4 autophagy 4 homolog B; Apg4B; APG4B; ATG4 autophagy related 4 B; AUTL1; DKFZp586D1822; KIAA0943
Type:
Protease; EC 3.4.22.-; Autophagy; Ubiquitin conjugating system
Mass (Da):
44310
Number AA:
UniProt ID:
Q9Y4P1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005875
Uniprot
OncoNet
Molecular Function:
GO:0008234
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006914
GO:0019941
GO:0015031
Phosida
TranscriptoNet
STRING
Kinexus Products
Autophagy-related cysteine endopeptidase 1 pan-specific antibody AB-NN374-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN374-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
D
A
A
T
L
T
Y
D
T
L
R
F
A
Site 2
Y8
M
D
A
A
T
L
T
Y
D
T
L
R
F
A
E
Site 3
T10
A
A
T
L
T
Y
D
T
L
R
F
A
E
F
E
Site 4
T22
E
F
E
D
F
P
E
T
S
E
P
V
W
I
L
Site 5
Y33
V
W
I
L
G
R
K
Y
S
I
F
T
E
K
D
Site 6
S34
W
I
L
G
R
K
Y
S
I
F
T
E
K
D
E
Site 7
S44
T
E
K
D
E
I
L
S
D
V
A
S
R
L
W
Site 8
S48
E
I
L
S
D
V
A
S
R
L
W
F
T
Y
R
Site 9
T53
V
A
S
R
L
W
F
T
Y
R
K
N
F
P
A
Site 10
Y54
A
S
R
L
W
F
T
Y
R
K
N
F
P
A
I
Site 11
T70
G
T
G
P
T
S
D
T
G
W
G
C
M
L
R
Site 12
T99
L
G
R
D
W
R
W
T
Q
R
K
R
Q
P
D
Site 13
S107
Q
R
K
R
Q
P
D
S
Y
F
S
V
L
N
A
Site 14
Y108
R
K
R
Q
P
D
S
Y
F
S
V
L
N
A
F
Site 15
Y122
F
I
D
R
K
D
S
Y
Y
S
I
H
Q
I
A
Site 16
Y123
I
D
R
K
D
S
Y
Y
S
I
H
Q
I
A
Q
Site 17
T147
G
Q
W
Y
G
P
N
T
V
A
Q
V
L
K
K
Site 18
T185
E
I
R
R
L
C
R
T
S
V
P
C
A
G
A
Site 19
S199
A
T
A
F
P
A
D
S
D
R
H
C
N
G
F
Site 20
T213
F
P
A
G
A
E
V
T
N
R
P
S
P
W
R
Site 21
S217
A
E
V
T
N
R
P
S
P
W
R
P
L
V
L
Site 22
Y239
L
T
D
I
N
E
A
Y
V
E
T
L
K
H
C
Site 23
Y265
G
K
P
N
S
A
H
Y
F
I
G
Y
V
G
E
Site 24
Y276
Y
V
G
E
E
L
I
Y
L
D
P
H
T
T
Q
Site 25
T281
L
I
Y
L
D
P
H
T
T
Q
P
A
V
E
P
Site 26
S309
Q
H
P
P
C
R
M
S
I
A
E
L
D
P
S
Site 27
S316
S
I
A
E
L
D
P
S
I
A
V
G
F
F
C
Site 28
S357
E
L
V
E
Q
Q
P
S
H
L
A
C
P
D
V
Site 29
S368
C
P
D
V
L
N
L
S
L
D
S
S
D
V
E
Site 30
S372
L
N
L
S
L
D
S
S
D
V
E
R
L
E
R
Site 31
S383
R
L
E
R
F
F
D
S
E
D
E
D
F
E
I
Site 32
S392
D
E
D
F
E
I
L
S
L
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation