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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AFG3L2
Full Name:
AFG3-like protein 2
Alias:
AFG3 ATPase family gene 3-like 2; AFG32; EC 3.4.24.-; Paraplegin-like; Paraplegin-like protein
Type:
Chaperone, Protease, Mitochondrial, Cell development/differentiation
Mass (Da):
88584
Number AA:
797
UniProt ID:
Q9Y4W6
International Prot ID:
IPI00001091
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005739
GO:0005743
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0003824
GO:0004175
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
GO:0008152
GO:0009056
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y40
Q
P
C
L
R
T
L
Y
R
F
V
T
T
Q
A
Site 2
T44
R
T
L
Y
R
F
V
T
T
Q
A
R
A
S
R
Site 3
S50
V
T
T
Q
A
R
A
S
R
N
S
L
L
T
D
Site 4
S53
Q
A
R
A
S
R
N
S
L
L
T
D
I
I
A
Site 5
Y62
L
T
D
I
I
A
A
Y
Q
R
F
C
S
R
P
Site 6
S67
A
A
Y
Q
R
F
C
S
R
P
P
K
G
F
E
Site 7
Y76
P
P
K
G
F
E
K
Y
F
P
N
G
K
N
G
Site 8
S87
G
K
N
G
K
K
A
S
E
P
K
E
V
M
G
Site 9
S99
V
M
G
E
K
K
E
S
K
P
A
A
T
T
R
Site 10
T104
K
E
S
K
P
A
A
T
T
R
S
S
G
G
G
Site 11
S107
K
P
A
A
T
T
R
S
S
G
G
G
G
G
G
Site 12
S108
P
A
A
T
T
R
S
S
G
G
G
G
G
G
G
Site 13
S166
F
Y
L
L
L
K
R
S
G
R
E
I
T
W
K
Site 14
T171
K
R
S
G
R
E
I
T
W
K
D
F
V
N
N
Site 15
Y179
W
K
D
F
V
N
N
Y
L
S
K
G
V
V
D
Site 16
T199
N
K
R
F
V
R
V
T
F
T
P
G
K
T
P
Site 17
T201
R
F
V
R
V
T
F
T
P
G
K
T
P
V
D
Site 18
T205
V
T
F
T
P
G
K
T
P
V
D
G
Q
Y
V
Site 19
Y211
K
T
P
V
D
G
Q
Y
V
W
F
N
I
G
S
Site 20
T221
F
N
I
G
S
V
D
T
F
E
R
N
L
E
T
Site 21
Y245
E
N
R
V
P
V
V
Y
I
A
E
S
D
G
S
Site 22
T281
G
P
A
G
I
G
R
T
G
R
G
M
G
G
L
Site 23
S290
R
G
M
G
G
L
F
S
V
G
E
T
T
A
K
Site 24
T347
I
P
K
G
A
I
L
T
G
P
P
G
T
G
K
Site 25
T430
G
Q
S
E
Q
E
N
T
L
N
Q
L
L
V
E
Site 26
S485
P
D
I
K
G
R
A
S
I
F
K
V
H
L
R
Site 27
T499
R
P
L
K
L
D
S
T
L
E
K
D
K
L
A
Site 28
S511
K
L
A
R
K
L
A
S
L
T
P
G
F
S
G
Site 29
T513
A
R
K
L
A
S
L
T
P
G
F
S
G
A
D
Site 30
S537
L
I
A
A
R
H
L
S
D
S
I
N
Q
K
H
Site 31
S539
A
A
R
H
L
S
D
S
I
N
Q
K
H
F
E
Site 32
T560
I
G
G
L
E
K
K
T
Q
V
L
Q
P
E
E
Site 33
T570
L
Q
P
E
E
K
K
T
V
A
Y
H
E
A
G
Site 34
Y573
E
E
K
K
T
V
A
Y
H
E
A
G
H
A
V
Site 35
Y605
P
R
G
K
G
L
G
Y
A
Q
Y
L
P
K
E
Site 36
Y608
K
G
L
G
Y
A
Q
Y
L
P
K
E
Q
Y
L
Site 37
Y614
Q
Y
L
P
K
E
Q
Y
L
Y
T
K
E
Q
L
Site 38
Y616
L
P
K
E
Q
Y
L
Y
T
K
E
Q
L
L
D
Site 39
S634
M
T
L
G
G
R
V
S
E
E
I
F
F
G
R
Site 40
T643
E
I
F
F
G
R
I
T
T
G
A
Q
D
D
L
Site 41
T644
I
F
F
G
R
I
T
T
G
A
Q
D
D
L
R
Site 42
T654
Q
D
D
L
R
K
V
T
Q
S
A
Y
A
Q
I
Site 43
S656
D
L
R
K
V
T
Q
S
A
Y
A
Q
I
V
Q
Site 44
S674
N
E
K
V
G
Q
I
S
F
D
L
P
R
Q
G
Site 45
Y689
D
M
V
L
E
K
P
Y
S
E
A
T
A
R
L
Site 46
S754
P
R
P
F
A
E
K
S
T
Y
E
E
F
V
E
Site 47
Y756
P
F
A
E
K
S
T
Y
E
E
F
V
E
G
T
Site 48
S765
E
F
V
E
G
T
G
S
L
D
E
D
T
S
L
Site 49
T770
T
G
S
L
D
E
D
T
S
L
P
E
G
L
K
Site 50
S771
G
S
L
D
E
D
T
S
L
P
E
G
L
K
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation