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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TMEM184B
Full Name:
Transmembrane protein 184B
Alias:
C22orf5; DKFZP586A1024; FM08; HS5O6A; MAP kinase-activating protein C22orf5; Putative MAPK-activating protein FM08; T184B
Type:
Membrane protein, integral
Mass (Da):
45562
Number AA:
407
UniProt ID:
Q9Y519
International Prot ID:
IPI00016853
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016020
GO:0016021
GO:0031224
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T17
P
D
P
A
S
P
T
T
A
A
A
S
P
S
V
Site 2
S23
T
T
A
A
A
S
P
S
V
S
V
I
P
E
G
Site 3
S31
V
S
V
I
P
E
G
S
P
T
A
M
E
Q
P
Site 4
Y72
I
Y
M
H
L
R
C
Y
S
C
P
N
E
Q
R
Site 5
Y108
F
F
T
N
D
Q
Y
Y
V
Y
F
G
T
V
R
Site 6
Y110
T
N
D
Q
Y
Y
V
Y
F
G
T
V
R
D
C
Site 7
Y131
Y
N
F
L
S
L
C
Y
E
Y
L
G
G
E
S
Site 8
S139
E
Y
L
G
G
E
S
S
I
M
S
E
I
R
G
Site 9
S142
G
G
E
S
S
I
M
S
E
I
R
G
K
P
I
Site 10
T208
R
D
G
D
F
D
V
T
S
G
Y
L
Y
V
T
Site 11
S241
F
A
T
R
E
L
L
S
P
Y
S
P
V
L
K
Site 12
Y243
T
R
E
L
L
S
P
Y
S
P
V
L
K
F
F
Site 13
S280
G
A
I
P
K
I
H
S
A
R
V
S
V
G
E
Site 14
T289
R
V
S
V
G
E
G
T
V
A
A
G
Y
Q
D
Site 15
Y316
A
L
R
H
A
F
T
Y
K
V
Y
A
D
K
R
Site 16
S335
G
R
C
A
P
M
K
S
I
S
S
S
L
K
E
Site 17
S337
C
A
P
M
K
S
I
S
S
S
L
K
E
T
M
Site 18
S339
P
M
K
S
I
S
S
S
L
K
E
T
M
N
P
Site 19
T343
I
S
S
S
L
K
E
T
M
N
P
H
D
I
V
Site 20
Y361
I
H
N
F
S
P
A
Y
Q
Q
Y
T
Q
Q
S
Site 21
Y364
F
S
P
A
Y
Q
Q
Y
T
Q
Q
S
T
L
E
Site 22
T365
S
P
A
Y
Q
Q
Y
T
Q
Q
S
T
L
E
P
Site 23
T369
Q
Q
Y
T
Q
Q
S
T
L
E
P
G
P
T
W
Site 24
T375
S
T
L
E
P
G
P
T
W
R
G
G
A
H
G
Site 25
S384
R
G
G
A
H
G
L
S
R
S
H
S
L
S
G
Site 26
S386
G
A
H
G
L
S
R
S
H
S
L
S
G
A
R
Site 27
S388
H
G
L
S
R
S
H
S
L
S
G
A
R
D
N
Site 28
S390
L
S
R
S
H
S
L
S
G
A
R
D
N
E
K
Site 29
T398
G
A
R
D
N
E
K
T
L
L
L
S
S
D
D
Site 30
S402
N
E
K
T
L
L
L
S
S
D
D
E
F
_
_
Site 31
S403
E
K
T
L
L
L
S
S
D
D
E
F
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation