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Updated November 2019
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Protein Info
Short Name:
SHANK1
Full Name:
SH3 and multiple ankyrin repeat domains protein 1
Alias:
SH3 and multiple ankyrin repeat domains 1; SHAN1; Somatostatin receptor interacting; Somatostatin receptor-interacting protein; SPANK-1; SSTR interacting; SSTRIP; Synamon
Type:
Adaptor/scaffold
Mass (Da):
224959
Number AA:
2161
UniProt ID:
Q9Y566
International Prot ID:
IPI00007695
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0005737
GO:0030425
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007016
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
T
H
S
P
A
T
S
E
D
E
E
R
H
S
Site 2
S15
S
E
D
E
E
R
H
S
A
S
E
C
P
E
G
Site 3
S17
D
E
E
R
H
S
A
S
E
C
P
E
G
G
S
Site 4
S24
S
E
C
P
E
G
G
S
E
S
D
S
S
P
D
Site 5
S26
C
P
E
G
G
S
E
S
D
S
S
P
D
G
P
Site 6
S28
E
G
G
S
E
S
D
S
S
P
D
G
P
G
R
Site 7
S29
G
G
S
E
S
D
S
S
P
D
G
P
G
R
G
Site 8
T40
P
G
R
G
P
R
G
T
R
G
Q
G
S
G
A
Site 9
S45
R
G
T
R
G
Q
G
S
G
A
P
G
S
L
A
Site 10
S50
Q
G
S
G
A
P
G
S
L
A
S
V
R
G
L
Site 11
S53
G
A
P
G
S
L
A
S
V
R
G
L
Q
G
R
Site 12
S61
V
R
G
L
Q
G
R
S
M
S
V
P
D
D
A
Site 13
S63
G
L
Q
G
R
S
M
S
V
P
D
D
A
H
F
Site 14
T124
Y
G
L
F
Q
P
A
T
S
G
R
D
A
N
F
Site 15
S125
G
L
F
Q
P
A
T
S
G
R
D
A
N
F
L
Site 16
Y141
E
E
R
L
L
R
E
Y
P
Q
S
F
E
K
G
Site 17
S144
L
L
R
E
Y
P
Q
S
F
E
K
G
V
P
Y
Site 18
Y151
S
F
E
K
G
V
P
Y
L
E
F
R
Y
K
T
Site 19
T158
Y
L
E
F
R
Y
K
T
R
V
Y
K
Q
T
N
Site 20
Y161
F
R
Y
K
T
R
V
Y
K
Q
T
N
L
D
E
Site 21
T164
K
T
R
V
Y
K
Q
T
N
L
D
E
K
Q
L
Site 22
Y186
G
L
K
K
F
L
E
Y
V
Q
L
G
T
S
D
Site 23
T191
L
E
Y
V
Q
L
G
T
S
D
K
V
A
R
L
Site 24
S192
E
Y
V
Q
L
G
T
S
D
K
V
A
R
L
L
Site 25
Y207
D
K
G
L
D
P
N
Y
H
D
S
D
S
G
E
Site 26
S210
L
D
P
N
Y
H
D
S
D
S
G
E
T
P
L
Site 27
S212
P
N
Y
H
D
S
D
S
G
E
T
P
L
T
L
Site 28
T215
H
D
S
D
S
G
E
T
P
L
T
L
A
A
Q
Site 29
T218
D
S
G
E
T
P
L
T
L
A
A
Q
T
E
G
Site 30
S272
A
L
L
D
L
G
G
S
P
N
Y
K
D
R
R
Site 31
Y275
D
L
G
G
S
P
N
Y
K
D
R
R
G
L
T
Site 32
T282
Y
K
D
R
R
G
L
T
P
L
F
H
T
A
M
Site 33
T287
G
L
T
P
L
F
H
T
A
M
V
G
G
D
P
Site 34
S327
Q
A
C
Q
R
G
H
S
Q
H
L
E
H
L
L
Site 35
Y336
H
L
E
H
L
L
F
Y
G
A
E
P
G
A
Q
Site 36
T382
V
K
N
N
N
G
Q
T
P
F
Q
V
A
V
I
Site 37
S413
D
V
V
P
F
Q
E
S
P
K
Y
A
A
R
R
Site 38
Y416
P
F
Q
E
S
P
K
Y
A
A
R
R
R
G
P
Site 39
T426
R
R
R
G
P
P
G
T
G
L
T
V
P
P
A
Site 40
S439
P
A
L
L
R
A
N
S
D
T
S
M
A
L
P
Site 41
T441
L
L
R
A
N
S
D
T
S
M
A
L
P
D
W
Site 42
S459
S
A
P
G
A
A
S
S
G
A
P
G
P
T
S
Site 43
S466
S
G
A
P
G
P
T
S
G
S
Q
G
Q
S
Q
Site 44
S468
A
P
G
P
T
S
G
S
Q
G
Q
S
Q
P
S
Site 45
S472
T
S
G
S
Q
G
Q
S
Q
P
S
A
P
T
T
Site 46
S475
S
Q
G
Q
S
Q
P
S
A
P
T
T
K
L
S
Site 47
T479
S
Q
P
S
A
P
T
T
K
L
S
S
G
T
L
Site 48
S482
S
A
P
T
T
K
L
S
S
G
T
L
R
S
A
Site 49
S483
A
P
T
T
K
L
S
S
G
T
L
R
S
A
S
Site 50
T485
T
T
K
L
S
S
G
T
L
R
S
A
S
S
P
Site 51
S488
L
S
S
G
T
L
R
S
A
S
S
P
R
G
A
Site 52
S490
S
G
T
L
R
S
A
S
S
P
R
G
A
R
A
Site 53
S491
G
T
L
R
S
A
S
S
P
R
G
A
R
A
R
Site 54
S499
P
R
G
A
R
A
R
S
P
S
R
G
R
H
P
Site 55
S501
G
A
R
A
R
S
P
S
R
G
R
H
P
E
D
Site 56
S518
R
Q
P
R
G
R
P
S
S
S
G
T
P
R
E
Site 57
S519
Q
P
R
G
R
P
S
S
S
G
T
P
R
E
G
Site 58
S520
P
R
G
R
P
S
S
S
G
T
P
R
E
G
P
Site 59
T522
G
R
P
S
S
S
G
T
P
R
E
G
P
A
G
Site 60
S534
P
A
G
G
T
G
G
S
G
G
P
G
G
S
L
Site 61
S540
G
S
G
G
P
G
G
S
L
G
S
R
G
R
R
Site 62
S543
G
P
G
G
S
L
G
S
R
G
R
R
R
K
L
Site 63
Y551
R
G
R
R
R
K
L
Y
S
A
V
P
G
R
S
Site 64
S552
G
R
R
R
K
L
Y
S
A
V
P
G
R
S
F
Site 65
S558
Y
S
A
V
P
G
R
S
F
M
A
V
K
S
Y
Site 66
S564
R
S
F
M
A
V
K
S
Y
Q
A
Q
A
E
G
Site 67
S574
A
Q
A
E
G
E
I
S
L
S
K
G
E
K
I
Site 68
S576
A
E
G
E
I
S
L
S
K
G
E
K
I
K
V
Site 69
S605
G
R
V
G
W
F
P
S
D
C
L
E
E
V
A
Site 70
S615
L
E
E
V
A
N
R
S
Q
E
S
K
Q
E
S
Site 71
S622
S
Q
E
S
K
Q
E
S
R
S
D
K
A
K
R
Site 72
Y634
A
K
R
L
F
R
H
Y
T
V
G
S
Y
D
S
Site 73
T635
K
R
L
F
R
H
Y
T
V
G
S
Y
D
S
F
Site 74
Y639
R
H
Y
T
V
G
S
Y
D
S
F
D
A
P
S
Site 75
S641
Y
T
V
G
S
Y
D
S
F
D
A
P
S
L
M
Site 76
S646
Y
D
S
F
D
A
P
S
L
M
D
G
I
G
P
Site 77
S655
M
D
G
I
G
P
G
S
D
Y
I
I
K
E
K
Site 78
Y657
G
I
G
P
G
S
D
Y
I
I
K
E
K
T
V
Site 79
T663
D
Y
I
I
K
E
K
T
V
L
L
Q
K
K
D
Site 80
T685
L
R
G
A
K
A
Q
T
P
I
E
E
F
T
P
Site 81
T691
Q
T
P
I
E
E
F
T
P
T
P
A
F
P
A
Site 82
T693
P
I
E
E
F
T
P
T
P
A
F
P
A
L
Q
Site 83
Y701
P
A
F
P
A
L
Q
Y
L
E
S
V
D
E
G
Site 84
S704
P
A
L
Q
Y
L
E
S
V
D
E
G
G
V
A
Site 85
T781
A
K
R
L
P
P
P
T
I
S
L
R
S
K
S
Site 86
S783
R
L
P
P
P
T
I
S
L
R
S
K
S
M
T
Site 87
S788
T
I
S
L
R
S
K
S
M
T
S
E
L
E
E
Site 88
T790
S
L
R
S
K
S
M
T
S
E
L
E
E
M
E
Site 89
S791
L
R
S
K
S
M
T
S
E
L
E
E
M
E
Y
Site 90
Y798
S
E
L
E
E
M
E
Y
E
Q
Q
P
A
P
V
Site 91
S807
Q
Q
P
A
P
V
P
S
M
E
K
K
R
T
V
Site 92
T813
P
S
M
E
K
K
R
T
V
Y
Q
M
A
L
N
Site 93
Y815
M
E
K
K
R
T
V
Y
Q
M
A
L
N
K
L
Site 94
S834
A
A
A
Q
Q
T
I
S
A
S
E
S
P
G
P
Site 95
S836
A
Q
Q
T
I
S
A
S
E
S
P
G
P
G
G
Site 96
S838
Q
T
I
S
A
S
E
S
P
G
P
G
G
L
A
Site 97
S846
P
G
P
G
G
L
A
S
L
G
K
H
R
P
K
Site 98
T858
R
P
K
G
F
F
A
T
E
S
S
F
D
P
H
Site 99
S860
K
G
F
F
A
T
E
S
S
F
D
P
H
H
R
Site 100
S861
G
F
F
A
T
E
S
S
F
D
P
H
H
R
A
Site 101
S871
P
H
H
R
A
Q
P
S
Y
E
R
P
S
F
L
Site 102
Y872
H
H
R
A
Q
P
S
Y
E
R
P
S
F
L
P
Site 103
S876
Q
P
S
Y
E
R
P
S
F
L
P
P
G
P
G
Site 104
S890
G
L
M
L
R
Q
K
S
I
G
A
A
E
D
D
Site 105
Y900
A
A
E
D
D
R
P
Y
L
A
P
P
A
M
K
Site 106
S909
A
P
P
A
M
K
F
S
R
S
L
S
V
P
G
Site 107
S911
P
A
M
K
F
S
R
S
L
S
V
P
G
S
E
Site 108
S913
M
K
F
S
R
S
L
S
V
P
G
S
E
D
I
Site 109
S917
R
S
L
S
V
P
G
S
E
D
I
P
P
P
P
Site 110
T925
E
D
I
P
P
P
P
T
T
S
P
P
E
P
P
Site 111
T926
D
I
P
P
P
P
T
T
S
P
P
E
P
P
Y
Site 112
S927
I
P
P
P
P
T
T
S
P
P
E
P
P
Y
S
Site 113
Y933
T
S
P
P
E
P
P
Y
S
T
P
P
V
P
S
Site 114
S934
S
P
P
E
P
P
Y
S
T
P
P
V
P
S
S
Site 115
T935
P
P
E
P
P
Y
S
T
P
P
V
P
S
S
S
Site 116
S940
Y
S
T
P
P
V
P
S
S
S
G
R
L
T
P
Site 117
S941
S
T
P
P
V
P
S
S
S
G
R
L
T
P
S
Site 118
S942
T
P
P
V
P
S
S
S
G
R
L
T
P
S
P
Site 119
T946
P
S
S
S
G
R
L
T
P
S
P
R
G
G
P
Site 120
S948
S
S
G
R
L
T
P
S
P
R
G
G
P
F
N
Site 121
S958
G
G
P
F
N
P
G
S
G
G
P
L
P
A
S
Site 122
S965
S
G
G
P
L
P
A
S
S
P
A
S
F
D
G
Site 123
S966
G
G
P
L
P
A
S
S
P
A
S
F
D
G
P
Site 124
S969
L
P
A
S
S
P
A
S
F
D
G
P
S
P
P
Site 125
S974
P
A
S
F
D
G
P
S
P
P
D
T
R
V
G
Site 126
T978
D
G
P
S
P
P
D
T
R
V
G
S
R
E
K
Site 127
S982
P
P
D
T
R
V
G
S
R
E
K
S
L
Y
H
Site 128
S986
R
V
G
S
R
E
K
S
L
Y
H
S
G
P
L
Site 129
Y988
G
S
R
E
K
S
L
Y
H
S
G
P
L
P
P
Site 130
S990
R
E
K
S
L
Y
H
S
G
P
L
P
P
A
H
Site 131
S1031
P
E
M
E
T
G
G
S
P
D
D
P
P
P
R
Site 132
S1046
L
A
L
G
P
Q
P
S
L
R
G
W
R
G
G
Site 133
S1056
G
W
R
G
G
G
P
S
P
T
P
G
A
P
S
Site 134
T1058
R
G
G
G
P
S
P
T
P
G
A
P
S
P
S
Site 135
S1063
S
P
T
P
G
A
P
S
P
S
H
H
G
S
A
Site 136
S1065
T
P
G
A
P
S
P
S
H
H
G
S
A
G
G
Site 137
S1069
P
S
P
S
H
H
G
S
A
G
G
G
G
G
S
Site 138
S1077
A
G
G
G
G
G
S
S
Q
G
P
A
L
R
Y
Site 139
Y1084
S
Q
G
P
A
L
R
Y
F
Q
L
P
P
R
A
Site 140
Y1097
R
A
A
S
A
A
M
Y
V
P
A
R
S
G
R
Site 141
S1102
A
M
Y
V
P
A
R
S
G
R
G
R
K
G
P
Site 142
S1131
G
G
L
P
P
A
P
S
P
T
S
P
A
S
P
Site 143
T1133
L
P
P
A
P
S
P
T
S
P
A
S
P
Q
P
Site 144
S1134
P
P
A
P
S
P
T
S
P
A
S
P
Q
P
P
Site 145
S1137
P
S
P
T
S
P
A
S
P
Q
P
P
P
A
V
Site 146
S1148
P
P
A
V
A
A
P
S
E
K
N
S
I
P
I
Site 147
S1164
T
I
I
I
K
A
P
S
T
S
S
S
G
R
S
Site 148
T1165
I
I
I
K
A
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T
S
S
S
G
R
S
S
Site 149
S1166
I
I
K
A
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S
G
R
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S
Q
Site 150
S1167
I
K
A
P
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T
S
S
S
G
R
S
S
Q
G
Site 151
S1168
K
A
P
S
T
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S
S
G
R
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S
Q
G
S
Site 152
S1171
S
T
S
S
S
G
R
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G
S
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T
E
Site 153
S1172
T
S
S
S
G
R
S
S
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G
S
S
T
E
A
Site 154
S1175
S
G
R
S
S
Q
G
S
S
T
E
A
E
P
P
Site 155
S1176
G
R
S
S
Q
G
S
S
T
E
A
E
P
P
T
Site 156
T1177
R
S
S
Q
G
S
S
T
E
A
E
P
P
T
Q
Site 157
T1183
S
T
E
A
E
P
P
T
Q
P
E
P
T
G
G
Site 158
S1196
G
G
G
G
G
G
G
S
S
P
S
P
A
P
A
Site 159
S1197
G
G
G
G
G
G
S
S
P
S
P
A
P
A
M
Site 160
S1199
G
G
G
G
S
S
P
S
P
A
P
A
M
S
P
Site 161
S1205
P
S
P
A
P
A
M
S
P
V
P
P
S
P
S
Site 162
S1210
A
M
S
P
V
P
P
S
P
S
P
V
P
T
P
Site 163
S1212
S
P
V
P
P
S
P
S
P
V
P
T
P
A
S
Site 164
T1216
P
S
P
S
P
V
P
T
P
A
S
P
S
G
P
Site 165
S1219
S
P
V
P
T
P
A
S
P
S
G
P
A
T
L
Site 166
S1221
V
P
T
P
A
S
P
S
G
P
A
T
L
D
F
Site 167
T1225
A
S
P
S
G
P
A
T
L
D
F
T
S
Q
F
Site 168
S1254
Q
N
E
A
R
R
R
S
T
L
F
L
S
T
D
Site 169
T1255
N
E
A
R
R
R
S
T
L
F
L
S
T
D
A
Site 170
S1259
R
R
S
T
L
F
L
S
T
D
A
G
D
E
D
Site 171
T1274
G
G
D
G
G
L
G
T
G
A
A
P
G
P
R
Site 172
S1285
P
G
P
R
L
R
H
S
K
S
I
D
E
G
M
Site 173
S1287
P
R
L
R
H
S
K
S
I
D
E
G
M
F
S
Site 174
S1294
S
I
D
E
G
M
F
S
A
E
P
Y
L
R
L
Site 175
Y1298
G
M
F
S
A
E
P
Y
L
R
L
E
S
A
G
Site 176
S1303
E
P
Y
L
R
L
E
S
A
G
S
G
A
G
Y
Site 177
S1306
L
R
L
E
S
A
G
S
G
A
G
Y
G
G
Y
Site 178
Y1310
S
A
G
S
G
A
G
Y
G
G
Y
G
A
G
S
Site 179
Y1313
S
G
A
G
Y
G
G
Y
G
A
G
S
R
A
Y
Site 180
S1317
Y
G
G
Y
G
A
G
S
R
A
Y
G
G
G
G
Site 181
Y1320
Y
G
A
G
S
R
A
Y
G
G
G
G
G
S
S
Site 182
T1330
G
G
G
S
S
A
F
T
S
F
L
P
P
R
P
Site 183
S1331
G
G
S
S
A
F
T
S
F
L
P
P
R
P
L
Site 184
T1343
R
P
L
V
H
P
L
T
G
K
A
L
D
P
A
Site 185
S1367
R
E
R
A
L
K
E
S
S
E
G
G
G
A
P
Site 186
S1382
Q
P
P
P
R
P
P
S
P
R
Y
E
A
P
P
Site 187
Y1385
P
R
P
P
S
P
R
Y
E
A
P
P
P
T
P
Site 188
T1391
R
Y
E
A
P
P
P
T
P
H
H
H
S
P
H
Site 189
S1396
P
P
T
P
H
H
H
S
P
H
A
H
H
E
P
Site 190
S1411
V
L
R
L
W
G
A
S
P
P
D
P
A
R
R
Site 191
Y1422
P
A
R
R
E
L
G
Y
R
A
G
L
G
S
Q
Site 192
S1428
G
Y
R
A
G
L
G
S
Q
E
K
S
L
P
A
Site 193
S1432
G
L
G
S
Q
E
K
S
L
P
A
S
P
P
A
Site 194
S1436
Q
E
K
S
L
P
A
S
P
P
A
A
R
R
S
Site 195
S1443
S
P
P
A
A
R
R
S
L
L
H
R
L
P
P
Site 196
T1464
P
L
L
L
Q
L
G
T
E
P
P
A
P
H
P
Site 197
S1474
P
A
P
H
P
G
V
S
K
P
W
R
S
A
A
Site 198
S1479
G
V
S
K
P
W
R
S
A
A
P
E
E
P
E
Site 199
T1505
C
Q
P
R
A
P
V
T
S
G
R
G
P
P
S
Site 200
S1506
Q
P
R
A
P
V
T
S
G
R
G
P
P
S
E
Site 201
S1512
T
S
G
R
G
P
P
S
E
D
G
P
G
V
P
Site 202
S1522
G
P
G
V
P
P
P
S
P
R
R
S
V
P
P
Site 203
S1526
P
P
P
S
P
R
R
S
V
P
P
S
P
T
S
Site 204
S1530
P
R
R
S
V
P
P
S
P
T
S
P
R
A
S
Site 205
T1532
R
S
V
P
P
S
P
T
S
P
R
A
S
E
E
Site 206
S1533
S
V
P
P
S
P
T
S
P
R
A
S
E
E
N
Site 207
S1537
S
P
T
S
P
R
A
S
E
E
N
G
L
P
L
Site 208
S1553
V
L
P
P
P
A
P
S
V
D
V
E
D
G
E
Site 209
S1574
L
P
P
P
L
E
F
S
N
S
F
E
K
P
E
Site 210
S1576
P
P
L
E
F
S
N
S
F
E
K
P
E
S
P
Site 211
S1582
N
S
F
E
K
P
E
S
P
L
T
P
G
P
P
Site 212
T1585
E
K
P
E
S
P
L
T
P
G
P
P
H
P
L
Site 213
T1595
P
P
H
P
L
P
D
T
P
A
P
A
T
P
L
Site 214
T1600
P
D
T
P
A
P
A
T
P
L
P
P
V
P
P
Site 215
S1619
A
A
P
P
T
L
D
S
T
A
S
S
L
T
S
Site 216
T1620
A
P
P
T
L
D
S
T
A
S
S
L
T
S
Y
Site 217
S1622
P
T
L
D
S
T
A
S
S
L
T
S
Y
D
S
Site 218
S1623
T
L
D
S
T
A
S
S
L
T
S
Y
D
S
E
Site 219
S1626
S
T
A
S
S
L
T
S
Y
D
S
E
V
A
T
Site 220
Y1627
T
A
S
S
L
T
S
Y
D
S
E
V
A
T
L
Site 221
S1629
S
S
L
T
S
Y
D
S
E
V
A
T
L
T
Q
Site 222
T1633
S
Y
D
S
E
V
A
T
L
T
Q
G
A
S
A
Site 223
T1635
D
S
E
V
A
T
L
T
Q
G
A
S
A
A
P
Site 224
S1639
A
T
L
T
Q
G
A
S
A
A
P
G
D
P
H
Site 225
T1671
G
P
D
P
P
P
G
T
D
S
G
I
E
E
V
Site 226
S1673
D
P
P
P
G
T
D
S
G
I
E
E
V
D
S
Site 227
S1680
S
G
I
E
E
V
D
S
R
S
S
S
D
H
P
Site 228
S1682
I
E
E
V
D
S
R
S
S
S
D
H
P
L
E
Site 229
S1683
E
E
V
D
S
R
S
S
S
D
H
P
L
E
T
Site 230
S1684
E
V
D
S
R
S
S
S
D
H
P
L
E
T
I
Site 231
T1690
S
S
D
H
P
L
E
T
I
S
S
A
S
T
L
Site 232
S1692
D
H
P
L
E
T
I
S
S
A
S
T
L
S
S
Site 233
S1693
H
P
L
E
T
I
S
S
A
S
T
L
S
S
L
Site 234
T1696
E
T
I
S
S
A
S
T
L
S
S
L
S
A
E
Site 235
S1699
S
S
A
S
T
L
S
S
L
S
A
E
G
G
G
Site 236
S1701
A
S
T
L
S
S
L
S
A
E
G
G
G
S
A
Site 237
S1707
L
S
A
E
G
G
G
S
A
G
G
G
G
G
A
Site 238
T1727
S
G
P
E
L
L
D
T
Y
V
A
Y
L
D
G
Site 239
Y1728
G
P
E
L
L
D
T
Y
V
A
Y
L
D
G
Q
Site 240
S1740
D
G
Q
A
F
G
G
S
S
T
P
G
P
P
Y
Site 241
S1741
G
Q
A
F
G
G
S
S
T
P
G
P
P
Y
P
Site 242
T1742
Q
A
F
G
G
S
S
T
P
G
P
P
Y
P
P
Site 243
Y1747
S
S
T
P
G
P
P
Y
P
P
Q
L
M
T
P
Site 244
T1753
P
Y
P
P
Q
L
M
T
P
S
K
L
R
G
R
Site 245
S1755
P
P
Q
L
M
T
P
S
K
L
R
G
R
A
L
Site 246
S1765
R
G
R
A
L
G
A
S
G
G
L
R
P
G
P
Site 247
S1773
G
G
L
R
P
G
P
S
G
G
L
R
D
P
V
Site 248
T1781
G
G
L
R
D
P
V
T
P
T
S
P
T
V
S
Site 249
S1784
R
D
P
V
T
P
T
S
P
T
V
S
V
T
G
Site 250
S1788
T
P
T
S
P
T
V
S
V
T
G
A
G
T
D
Site 251
T1808
R
A
C
S
G
P
P
T
A
G
V
A
G
G
P
Site 252
T1829
V
P
P
V
P
L
P
T
A
S
S
L
P
R
K
Site 253
S1875
A
S
I
I
S
E
L
S
S
K
L
Q
Q
F
G
Site 254
S1876
S
I
I
S
E
L
S
S
K
L
Q
Q
F
G
G
Site 255
S1898
L
P
W
A
R
G
G
S
G
G
G
G
D
S
H
Site 256
S1904
G
S
G
G
G
G
D
S
H
H
G
G
A
S
Y
Site 257
Y1911
S
H
H
G
G
A
S
Y
V
P
E
R
T
S
S
Site 258
S1917
S
Y
V
P
E
R
T
S
S
L
Q
R
Q
R
L
Site 259
S1918
Y
V
P
E
R
T
S
S
L
Q
R
Q
R
L
S
Site 260
S1925
S
L
Q
R
Q
R
L
S
D
D
S
Q
S
S
L
Site 261
S1928
R
Q
R
L
S
D
D
S
Q
S
S
L
L
S
K
Site 262
S1930
R
L
S
D
D
S
Q
S
S
L
L
S
K
P
V
Site 263
S1931
L
S
D
D
S
Q
S
S
L
L
S
K
P
V
S
Site 264
S1934
D
S
Q
S
S
L
L
S
K
P
V
S
S
L
F
Site 265
S1938
S
L
L
S
K
P
V
S
S
L
F
Q
N
W
P
Site 266
S1939
L
L
S
K
P
V
S
S
L
F
Q
N
W
P
K
Site 267
T1954
P
P
L
P
P
L
P
T
G
T
G
V
S
P
T
Site 268
S1970
A
A
A
P
G
A
T
S
P
S
A
S
S
S
S
Site 269
S1972
A
P
G
A
T
S
P
S
A
S
S
S
S
T
S
Site 270
S1974
G
A
T
S
P
S
A
S
S
S
S
T
S
T
R
Site 271
S1975
A
T
S
P
S
A
S
S
S
S
T
S
T
R
H
Site 272
S1976
T
S
P
S
A
S
S
S
S
T
S
T
R
H
L
Site 273
S1977
S
P
S
A
S
S
S
S
T
S
T
R
H
L
Q
Site 274
T1978
P
S
A
S
S
S
S
T
S
T
R
H
L
Q
G
Site 275
S1979
S
A
S
S
S
S
T
S
T
R
H
L
Q
G
V
Site 276
T1980
A
S
S
S
S
T
S
T
R
H
L
Q
G
V
E
Site 277
S2000
P
L
L
R
R
A
P
S
P
S
L
L
P
A
S
Site 278
S2002
L
R
R
A
P
S
P
S
L
L
P
A
S
E
H
Site 279
S2007
S
P
S
L
L
P
A
S
E
H
K
V
S
P
A
Site 280
S2012
P
A
S
E
H
K
V
S
P
A
P
R
P
S
S
Site 281
S2018
V
S
P
A
P
R
P
S
S
L
P
I
L
P
S
Site 282
S2019
S
P
A
P
R
P
S
S
L
P
I
L
P
S
G
Site 283
S2038
G
L
F
D
I
R
G
S
P
T
G
G
A
G
G
Site 284
S2046
P
T
G
G
A
G
G
S
A
D
P
F
A
P
V
Site 285
S2073
G
G
A
L
S
G
A
S
R
S
L
S
P
T
R
Site 286
S2077
S
G
A
S
R
S
L
S
P
T
R
L
L
S
L
Site 287
T2079
A
S
R
S
L
S
P
T
R
L
L
S
L
P
P
Site 288
S2083
L
S
P
T
R
L
L
S
L
P
P
D
K
P
F
Site 289
S2127
L
D
H
E
I
D
G
S
H
L
P
A
L
T
K
Site 290
Y2137
P
A
L
T
K
E
D
Y
V
D
L
G
V
T
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation