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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PPME1
Full Name:
Protein phosphatase methylesterase 1
Alias:
EC 3.1.1.-; PME1; PME-1; Protein phosphatase methylesterase-1
Type:
Protein phosphatase, regulatory subunit, Carbohydrate Metabolism group, Butanoate metabolism family
Mass (Da):
42315
Number AA:
386
UniProt ID:
Q9Y570
International Prot ID:
IPI00007694
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0004864
GO:0051722
GO:0051721
PhosphoSite+
KinaseNET
Biological Process:
GO:0006482
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
S
A
L
E
K
S
M
H
L
G
R
L
P
Site 2
S15
M
H
L
G
R
L
P
S
R
P
P
L
P
G
S
Site 3
S22
S
R
P
P
L
P
G
S
G
G
S
Q
S
G
A
Site 4
S25
P
L
P
G
S
G
G
S
Q
S
G
A
K
M
R
Site 5
S27
P
G
S
G
G
S
Q
S
G
A
K
M
R
M
G
Site 6
S42
P
G
R
K
R
D
F
S
P
V
P
W
S
Q
Y
Site 7
Y49
S
P
V
P
W
S
Q
Y
F
E
S
M
E
D
V
Site 8
S52
P
W
S
Q
Y
F
E
S
M
E
D
V
E
V
E
Site 9
T66
E
N
E
T
G
K
D
T
F
R
V
Y
K
S
G
Site 10
Y70
G
K
D
T
F
R
V
Y
K
S
G
S
E
G
P
Site 11
S72
D
T
F
R
V
Y
K
S
G
S
E
G
P
V
L
Site 12
T118
D
L
R
S
H
G
E
T
K
V
K
N
P
E
D
Site 13
S193
T
A
M
D
A
L
N
S
M
Q
N
F
L
R
G
Site 14
T204
F
L
R
G
R
P
K
T
F
K
S
L
E
N
A
Site 15
S207
G
R
P
K
T
F
K
S
L
E
N
A
I
E
W
Site 16
S226
G
Q
I
R
N
L
E
S
A
R
V
S
M
V
G
Site 17
S230
N
L
E
S
A
R
V
S
M
V
G
Q
V
K
Q
Site 18
T242
V
K
Q
C
E
G
I
T
S
P
E
G
S
K
S
Site 19
S243
K
Q
C
E
G
I
T
S
P
E
G
S
K
S
I
Site 20
S247
G
I
T
S
P
E
G
S
K
S
I
V
E
G
I
Site 21
S249
T
S
P
E
G
S
K
S
I
V
E
G
I
I
E
Site 22
S267
E
D
E
E
G
S
E
S
I
S
K
R
K
K
E
Site 23
S269
E
E
G
S
E
S
I
S
K
R
K
K
E
D
D
Site 24
T279
K
K
E
D
D
M
E
T
K
K
D
H
P
Y
T
Site 25
Y285
E
T
K
K
D
H
P
Y
T
W
R
I
E
L
A
Site 26
T286
T
K
K
D
H
P
Y
T
W
R
I
E
L
A
K
Site 27
Y297
E
L
A
K
T
E
K
Y
W
D
G
W
F
R
G
Site 28
S306
D
G
W
F
R
G
L
S
N
L
F
L
S
C
P
Site 29
T331
D
R
L
D
K
D
L
T
I
G
Q
M
Q
G
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation