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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CTDP1
Full Name:
RNA polymerase II subunit A C-terminal domain phosphatase
Alias:
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1; TFIIF-associating CTD phosphatase; TFIIF-associating CTD phosphatase 1
Type:
Transcription initiation complex; Protein phosphatase, Ser/Thr (non-receptor); EC 3.1.3.16
Mass (Da):
104297
Number AA:
961
UniProt ID:
Q9Y5B0
International Prot ID:
IPI00410256
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0008420
GO:0003899
PhosphoSite+
KinaseNET
Biological Process:
GO:0006470
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S60
E
A
A
A
S
A
Q
S
A
G
A
S
Q
S
R
Site 2
S64
S
A
Q
S
A
G
A
S
Q
S
R
V
A
S
G
Site 3
S66
Q
S
A
G
A
S
Q
S
R
V
A
S
G
G
C
Site 4
S70
A
S
Q
S
R
V
A
S
G
G
C
V
R
P
A
Site 5
S85
R
P
E
R
R
L
R
S
E
R
A
G
V
V
R
Site 6
T132
A
E
C
G
Q
D
L
T
Q
L
Q
S
K
N
G
Site 7
S136
Q
D
L
T
Q
L
Q
S
K
N
G
K
Q
Q
V
Site 8
T147
K
Q
Q
V
P
L
S
T
A
T
V
S
M
V
H
Site 9
S162
S
V
P
E
L
M
V
S
S
E
Q
A
E
Q
L
Site 10
T192
L
M
V
D
L
D
Q
T
L
I
H
T
T
E
Q
Site 11
S268
D
P
E
K
K
L
F
S
H
R
I
L
S
R
D
Site 12
S273
L
F
S
H
R
I
L
S
R
D
E
C
I
D
P
Site 13
S282
D
E
C
I
D
P
F
S
K
T
G
N
L
R
N
Site 14
Y320
N
L
I
T
V
K
K
Y
V
Y
F
Q
G
T
G
Site 15
Y322
I
T
V
K
K
Y
V
Y
F
Q
G
T
G
D
M
Site 16
S335
D
M
N
A
P
P
G
S
R
E
S
Q
T
R
K
Site 17
S338
A
P
P
G
S
R
E
S
Q
T
R
K
K
V
N
Site 18
T350
K
V
N
H
S
R
G
T
E
V
S
E
P
S
P
Site 19
S353
H
S
R
G
T
E
V
S
E
P
S
P
P
V
R
Site 20
S356
G
T
E
V
S
E
P
S
P
P
V
R
D
P
E
Site 21
T366
V
R
D
P
E
G
V
T
Q
A
P
G
V
E
P
Site 22
S387
P
A
R
E
L
N
G
S
E
A
A
T
P
R
D
Site 23
T391
L
N
G
S
E
A
A
T
P
R
D
S
P
R
P
Site 24
S395
E
A
A
T
P
R
D
S
P
R
P
G
K
P
D
Site 25
S415
P
P
A
Q
A
P
T
S
S
Q
E
L
A
G
A
Site 26
S416
P
A
Q
A
P
T
S
S
Q
E
L
A
G
A
P
Site 27
S428
G
A
P
E
P
Q
G
S
C
A
Q
G
G
R
V
Site 28
S455
T
D
L
D
F
D
L
S
S
D
S
E
S
S
S
Site 29
S456
D
L
D
F
D
L
S
S
D
S
E
S
S
S
E
Site 30
S458
D
F
D
L
S
S
D
S
E
S
S
S
E
S
E
Site 31
S460
D
L
S
S
D
S
E
S
S
S
E
S
E
G
T
Site 32
S462
S
S
D
S
E
S
S
S
E
S
E
G
T
K
S
Site 33
S464
D
S
E
S
S
S
E
S
E
G
T
K
S
S
S
Site 34
T467
S
S
S
E
S
E
G
T
K
S
S
S
S
A
S
Site 35
S469
S
E
S
E
G
T
K
S
S
S
S
A
S
D
G
Site 36
S470
E
S
E
G
T
K
S
S
S
S
A
S
D
G
E
Site 37
S471
S
E
G
T
K
S
S
S
S
A
S
D
G
E
S
Site 38
S472
E
G
T
K
S
S
S
S
A
S
D
G
E
S
E
Site 39
S474
T
K
S
S
S
S
A
S
D
G
E
S
E
G
K
Site 40
S478
S
S
A
S
D
G
E
S
E
G
K
R
G
R
Q
Site 41
S502
G
A
L
A
Q
G
S
S
L
E
P
G
R
P
A
Site 42
S512
P
G
R
P
A
A
P
S
L
P
G
E
A
E
P
Site 43
T556
A
D
R
K
E
A
E
T
E
S
Q
N
S
E
L
Site 44
S558
R
K
E
A
E
T
E
S
Q
N
S
E
L
S
G
Site 45
S561
A
E
T
E
S
Q
N
S
E
L
S
G
V
T
A
Site 46
S564
E
S
Q
N
S
E
L
S
G
V
T
A
G
E
S
Site 47
S571
S
G
V
T
A
G
E
S
L
D
Q
S
M
E
E
Site 48
S575
A
G
E
S
L
D
Q
S
M
E
E
E
E
E
E
Site 49
T584
E
E
E
E
E
E
D
T
D
E
D
D
H
L
I
Site 50
Y592
D
E
D
D
H
L
I
Y
L
E
E
I
L
V
R
Site 51
T602
E
I
L
V
R
V
H
T
D
Y
Y
A
K
Y
D
Site 52
Y604
L
V
R
V
H
T
D
Y
Y
A
K
Y
D
R
Y
Site 53
Y605
V
R
V
H
T
D
Y
Y
A
K
Y
D
R
Y
L
Site 54
Y608
H
T
D
Y
Y
A
K
Y
D
R
Y
L
N
K
E
Site 55
Y611
Y
Y
A
K
Y
D
R
Y
L
N
K
E
I
E
E
Site 56
Y658
I
E
K
T
R
E
H
Y
H
A
T
A
L
G
A
Site 57
S674
I
L
T
R
L
V
L
S
P
D
A
P
D
R
A
Site 58
T682
P
D
A
P
D
R
A
T
H
L
I
A
A
R
A
Site 59
T733
F
P
L
R
D
D
H
T
K
A
Q
R
E
N
S
Site 60
S740
T
K
A
Q
R
E
N
S
P
A
A
F
P
D
R
Site 61
T753
D
R
E
G
V
P
P
T
A
L
F
H
P
M
P
Site 62
Y774
P
G
P
E
V
R
I
Y
D
S
N
T
G
K
L
Site 63
S776
P
E
V
R
I
Y
D
S
N
T
G
K
L
I
R
Site 64
T784
N
T
G
K
L
I
R
T
G
A
R
G
P
P
A
Site 65
S793
A
R
G
P
P
A
P
S
S
S
L
P
I
R
Q
Site 66
S794
R
G
P
P
A
P
S
S
S
L
P
I
R
Q
E
Site 67
S795
G
P
P
A
P
S
S
S
L
P
I
R
Q
E
P
Site 68
S804
P
I
R
Q
E
P
S
S
F
R
A
V
P
P
P
Site 69
S832
D
G
E
Q
P
G
P
S
R
R
K
R
Q
P
S
Site 70
S839
S
R
R
K
R
Q
P
S
M
S
E
T
M
P
L
Site 71
S841
R
K
R
Q
P
S
M
S
E
T
M
P
L
Y
T
Site 72
T843
R
Q
P
S
M
S
E
T
M
P
L
Y
T
L
C
Site 73
Y847
M
S
E
T
M
P
L
Y
T
L
C
K
E
D
L
Site 74
T848
S
E
T
M
P
L
Y
T
L
C
K
E
D
L
E
Site 75
S856
L
C
K
E
D
L
E
S
M
D
K
E
V
D
D
Site 76
S869
D
D
I
L
G
E
G
S
D
D
S
D
S
E
K
Site 77
S872
L
G
E
G
S
D
D
S
D
S
E
K
R
R
P
Site 78
S874
E
G
S
D
D
S
D
S
E
K
R
R
P
E
E
Site 79
T893
P
Q
P
R
K
P
G
T
R
R
G
A
D
A
R
Site 80
S904
A
D
A
R
A
P
A
S
S
E
R
S
A
A
G
Site 81
S905
D
A
R
A
P
A
S
S
E
R
S
A
A
G
G
Site 82
S908
A
P
A
S
S
E
R
S
A
A
G
G
R
G
P
Site 83
S929
L
N
E
E
D
A
A
S
E
S
S
R
E
S
S
Site 84
S931
E
E
D
A
A
S
E
S
S
R
E
S
S
N
E
Site 85
S932
E
D
A
A
S
E
S
S
R
E
S
S
N
E
D
Site 86
S935
A
S
E
S
S
R
E
S
S
N
E
D
E
G
S
Site 87
S936
S
E
S
S
R
E
S
S
N
E
D
E
G
S
S
Site 88
S942
S
S
N
E
D
E
G
S
S
S
E
A
D
E
M
Site 89
S943
S
N
E
D
E
G
S
S
S
E
A
D
E
M
A
Site 90
S944
N
E
D
E
G
S
S
S
E
A
D
E
M
A
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation