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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SUPT16H
Full Name:
FACT complex subunit SPT16
Alias:
CDC68; Chromatin-specific transcription elongation factor 140 kDa subunit; Facilitates chromatin remodeling 140 kDa subunit; Facilitates chromatin transcription complex subunit SPT16; FACT; FACT140; FACTP140; FLJ10857; FLJ14010; SP16H; SPT16/CDC68; Suppressor of Ty 16
Type:
Transcription initiation complex
Mass (Da):
119914
Number AA:
1047
UniProt ID:
Q9Y5B9
International Prot ID:
IPI00026970
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005694
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0008159
PhosphoSite+
KinaseNET
Biological Process:
GO:0006281
GO:0006260
GO:0006337
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y10
V
T
L
D
K
D
A
Y
Y
R
R
V
K
R
L
Site 2
Y11
T
L
D
K
D
A
Y
Y
R
R
V
K
R
L
Y
Site 3
Y18
Y
R
R
V
K
R
L
Y
S
N
W
R
K
G
E
Site 4
S19
R
R
V
K
R
L
Y
S
N
W
R
K
G
E
D
Site 5
Y28
W
R
K
G
E
D
E
Y
A
N
V
D
A
I
V
Site 6
Y46
G
V
D
E
E
I
V
Y
A
K
S
T
A
L
Q
Site 7
S49
E
E
I
V
Y
A
K
S
T
A
L
Q
T
W
L
Site 8
S113
L
I
R
E
K
N
E
S
N
K
S
S
F
D
K
Site 9
S116
E
K
N
E
S
N
K
S
S
F
D
K
M
I
E
Site 10
S117
K
N
E
S
N
K
S
S
F
D
K
M
I
E
A
Site 11
S138
G
K
K
I
G
V
F
S
K
D
K
F
P
G
E
Site 12
S188
N
L
M
K
K
A
A
S
I
T
S
E
V
F
N
Site 13
S215
A
D
E
K
V
R
H
S
K
L
A
E
S
V
E
Site 14
Y230
K
A
I
E
E
K
K
Y
L
A
G
A
D
P
S
Site 15
T238
L
A
G
A
D
P
S
T
V
E
M
C
Y
P
P
Site 16
Y243
P
S
T
V
E
M
C
Y
P
P
I
I
Q
S
G
Site 17
S258
G
N
Y
N
L
K
F
S
V
V
S
D
K
N
H
Site 18
S281
A
M
G
I
R
F
K
S
Y
C
S
N
L
V
R
Site 19
Y282
M
G
I
R
F
K
S
Y
C
S
N
L
V
R
T
Site 20
T289
Y
C
S
N
L
V
R
T
L
M
V
D
P
S
Q
Site 21
S295
R
T
L
M
V
D
P
S
Q
E
V
Q
E
N
Y
Site 22
S360
G
I
E
F
R
E
G
S
L
V
I
N
S
K
N
Site 23
Y369
V
I
N
S
K
N
Q
Y
K
L
K
K
G
M
V
Site 24
T387
N
L
G
F
S
D
L
T
N
K
E
G
K
K
P
Site 25
T398
G
K
K
P
E
E
K
T
Y
A
L
F
I
G
D
Site 26
Y399
K
K
P
E
E
K
T
Y
A
L
F
I
G
D
T
Site 27
T416
V
D
E
D
G
P
A
T
V
L
T
S
V
K
K
Site 28
S455
E
D
L
L
G
R
G
S
R
A
A
L
L
T
E
Site 29
T461
G
S
R
A
A
L
L
T
E
R
T
R
N
E
M
Site 30
T494
E
E
A
K
R
R
L
T
E
Q
K
G
E
Q
Q
Site 31
S508
Q
I
Q
K
A
R
K
S
N
V
S
Y
K
N
P
Site 32
S511
K
A
R
K
S
N
V
S
Y
K
N
P
S
L
M
Site 33
Y512
A
R
K
S
N
V
S
Y
K
N
P
S
L
M
P
Site 34
S516
N
V
S
Y
K
N
P
S
L
M
P
K
E
P
H
Site 35
Y530
H
I
R
E
M
K
I
Y
I
D
K
K
Y
E
T
Site 36
Y535
K
I
Y
I
D
K
K
Y
E
T
V
I
M
P
V
Site 37
S558
I
A
T
I
K
N
I
S
M
S
V
E
G
D
Y
Site 38
S560
T
I
K
N
I
S
M
S
V
E
G
D
Y
T
Y
Site 39
Y565
S
M
S
V
E
G
D
Y
T
Y
L
R
I
N
F
Site 40
Y567
S
V
E
G
D
Y
T
Y
L
R
I
N
F
Y
C
Site 41
S577
I
N
F
Y
C
P
G
S
A
L
G
R
N
E
G
Site 42
T593
I
F
P
N
P
E
A
T
F
V
K
E
I
T
Y
Site 43
T599
A
T
F
V
K
E
I
T
Y
R
A
S
N
I
K
Site 44
Y600
T
F
V
K
E
I
T
Y
R
A
S
N
I
K
A
Site 45
S603
K
E
I
T
Y
R
A
S
N
I
K
A
P
G
E
Site 46
Y632
I
K
E
V
Q
K
R
Y
K
T
R
E
A
E
E
Site 47
T634
E
V
Q
K
R
Y
K
T
R
E
A
E
E
K
E
Site 48
S650
E
G
I
V
K
Q
D
S
L
V
I
N
L
N
R
Site 49
S658
L
V
I
N
L
N
R
S
N
P
K
L
K
D
L
Site 50
Y666
N
P
K
L
K
D
L
Y
I
R
P
N
I
A
Q
Site 51
S679
A
Q
K
R
M
Q
G
S
L
E
A
H
V
N
G
Site 52
T690
H
V
N
G
F
R
F
T
S
V
R
G
D
K
V
Site 53
S691
V
N
G
F
R
F
T
S
V
R
G
D
K
V
D
Site 54
Y701
G
D
K
V
D
I
L
Y
N
N
I
K
H
A
L
Site 55
T736
M
F
G
K
K
R
H
T
D
V
Q
F
Y
T
E
Site 56
Y741
R
H
T
D
V
Q
F
Y
T
E
V
G
E
I
T
Site 57
Y764
M
H
D
R
D
D
L
Y
A
E
Q
M
E
R
E
Site 58
T778
E
M
R
H
K
L
K
T
A
F
K
N
F
I
E
Site 59
T814
N
G
A
P
Y
R
S
T
C
L
L
Q
P
T
S
Site 60
Y861
N
F
D
M
V
I
V
Y
K
D
Y
S
K
K
V
Site 61
T869
K
D
Y
S
K
K
V
T
M
I
N
A
I
P
V
Site 62
Y893
L
N
S
C
D
L
K
Y
T
E
G
V
Q
S
L
Site 63
T903
G
V
Q
S
L
N
W
T
K
I
M
K
T
I
V
Site 64
T908
N
W
T
K
I
M
K
T
I
V
D
D
P
E
G
Site 65
S923
F
F
E
Q
G
G
W
S
F
L
E
P
E
G
E
Site 66
S932
L
E
P
E
G
E
G
S
D
A
E
E
G
D
S
Site 67
S939
S
D
A
E
E
G
D
S
E
S
E
I
E
D
E
Site 68
S941
A
E
E
G
D
S
E
S
E
I
E
D
E
T
F
Site 69
T947
E
S
E
I
E
D
E
T
F
N
P
S
E
D
D
Site 70
Y955
F
N
P
S
E
D
D
Y
E
E
E
E
E
D
S
Site 71
S962
Y
E
E
E
E
E
D
S
D
E
D
Y
S
S
E
Site 72
Y966
E
E
D
S
D
E
D
Y
S
S
E
A
E
E
S
Site 73
S967
E
D
S
D
E
D
Y
S
S
E
A
E
E
S
D
Site 74
S968
D
S
D
E
D
Y
S
S
E
A
E
E
S
D
Y
Site 75
S973
Y
S
S
E
A
E
E
S
D
Y
S
K
E
S
L
Site 76
Y975
S
E
A
E
E
S
D
Y
S
K
E
S
L
G
S
Site 77
S976
E
A
E
E
S
D
Y
S
K
E
S
L
G
S
E
Site 78
S979
E
S
D
Y
S
K
E
S
L
G
S
E
E
E
S
Site 79
S982
Y
S
K
E
S
L
G
S
E
E
E
S
G
K
D
Site 80
S986
S
L
G
S
E
E
E
S
G
K
D
W
D
E
L
Site 81
S1004
A
R
K
A
D
R
E
S
R
Y
E
E
E
E
E
Site 82
Y1006
K
A
D
R
E
S
R
Y
E
E
E
E
E
Q
S
Site 83
S1013
Y
E
E
E
E
E
Q
S
R
S
M
S
R
K
R
Site 84
S1015
E
E
E
E
Q
S
R
S
M
S
R
K
R
K
A
Site 85
S1017
E
E
Q
S
R
S
M
S
R
K
R
K
A
S
V
Site 86
S1023
M
S
R
K
R
K
A
S
V
H
S
S
G
R
G
Site 87
S1026
K
R
K
A
S
V
H
S
S
G
R
G
S
N
R
Site 88
S1027
R
K
A
S
V
H
S
S
G
R
G
S
N
R
G
Site 89
S1031
V
H
S
S
G
R
G
S
N
R
G
S
R
H
S
Site 90
S1035
G
R
G
S
N
R
G
S
R
H
S
S
A
P
P
Site 91
S1038
S
N
R
G
S
R
H
S
S
A
P
P
K
K
K
Site 92
S1039
N
R
G
S
R
H
S
S
A
P
P
K
K
K
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation