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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ANGPTL3
Full Name:
Angiopoietin-related protein 3
Alias:
Angiopoietin-5;Angiopoietin-like protein 3
Type:
Mass (Da):
53637
Number AA:
460
UniProt ID:
Q9Y5C1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S24
S
R
I
D
Q
D
N
S
S
F
D
S
L
S
P
Site 2
S25
R
I
D
Q
D
N
S
S
F
D
S
L
S
P
E
Site 3
S28
Q
D
N
S
S
F
D
S
L
S
P
E
P
K
S
Site 4
S30
N
S
S
F
D
S
L
S
P
E
P
K
S
R
F
Site 5
S35
S
L
S
P
E
P
K
S
R
F
A
M
L
D
D
Site 6
S81
K
L
N
I
F
D
Q
S
F
Y
D
L
S
L
Q
Site 7
S86
D
Q
S
F
Y
D
L
S
L
Q
T
S
E
I
K
Site 8
S90
Y
D
L
S
L
Q
T
S
E
I
K
E
E
E
K
Site 9
T102
E
E
K
E
L
R
R
T
T
Y
K
L
Q
V
K
Site 10
T103
E
K
E
L
R
R
T
T
Y
K
L
Q
V
K
N
Site 11
Y104
K
E
L
R
R
T
T
Y
K
L
Q
V
K
N
E
Site 12
S117
N
E
E
V
K
N
M
S
L
E
L
N
S
K
L
Site 13
S122
N
M
S
L
E
L
N
S
K
L
E
S
L
L
E
Site 14
S126
E
L
N
S
K
L
E
S
L
L
E
E
K
I
L
Site 15
Y140
L
L
Q
Q
K
V
K
Y
L
E
E
Q
L
T
N
Site 16
T146
K
Y
L
E
E
Q
L
T
N
L
I
Q
N
Q
P
Site 17
T155
L
I
Q
N
Q
P
E
T
P
E
H
P
E
V
T
Site 18
T166
P
E
V
T
S
L
K
T
F
V
E
K
Q
D
N
Site 19
S174
F
V
E
K
Q
D
N
S
I
K
D
L
L
Q
T
Site 20
T181
S
I
K
D
L
L
Q
T
V
E
D
Q
Y
K
Q
Site 21
Y186
L
Q
T
V
E
D
Q
Y
K
Q
L
N
Q
Q
H
Site 22
S194
K
Q
L
N
Q
Q
H
S
Q
I
K
E
I
E
N
Site 23
T206
I
E
N
Q
L
R
R
T
S
I
Q
E
P
T
E
Site 24
S207
E
N
Q
L
R
R
T
S
I
Q
E
P
T
E
I
Site 25
T212
R
T
S
I
Q
E
P
T
E
I
S
L
S
S
K
Site 26
S215
I
Q
E
P
T
E
I
S
L
S
S
K
P
R
A
Site 27
S217
E
P
T
E
I
S
L
S
S
K
P
R
A
P
R
Site 28
S218
P
T
E
I
S
L
S
S
K
P
R
A
P
R
T
Site 29
T225
S
K
P
R
A
P
R
T
T
P
F
L
Q
L
N
Site 30
T226
K
P
R
A
P
R
T
T
P
F
L
Q
L
N
E
Site 31
Y250
P
A
E
C
T
T
I
Y
N
R
G
E
H
T
S
Site 32
T283
V
I
S
G
S
P
W
T
L
I
Q
H
R
I
D
Site 33
Y302
F
N
E
T
W
E
N
Y
K
Y
G
F
G
R
L
Site 34
Y304
E
T
W
E
N
Y
K
Y
G
F
G
R
L
D
G
Site 35
S322
L
G
L
E
K
I
Y
S
I
V
K
Q
S
N
Y
Site 36
Y329
S
I
V
K
Q
S
N
Y
V
L
R
I
E
L
E
Site 37
Y344
D
W
K
D
N
K
H
Y
I
E
Y
S
F
Y
L
Site 38
Y347
D
N
K
H
Y
I
E
Y
S
F
Y
L
G
N
H
Site 39
Y350
H
Y
I
E
Y
S
F
Y
L
G
N
H
E
T
N
Site 40
T359
G
N
H
E
T
N
Y
T
L
H
L
V
A
I
T
Site 41
Y417
E
N
N
L
N
G
K
Y
N
K
P
R
A
K
S
Site 42
S424
Y
N
K
P
R
A
K
S
K
P
E
R
R
R
G
Site 43
S433
P
E
R
R
R
G
L
S
W
K
S
Q
N
G
R
Site 44
S436
R
R
G
L
S
W
K
S
Q
N
G
R
L
Y
S
Site 45
Y442
K
S
Q
N
G
R
L
Y
S
I
K
S
T
K
M
Site 46
S443
S
Q
N
G
R
L
Y
S
I
K
S
T
K
M
L
Site 47
S446
G
R
L
Y
S
I
K
S
T
K
M
L
I
H
P
Site 48
T447
R
L
Y
S
I
K
S
T
K
M
L
I
H
P
T
Site 49
T454
T
K
M
L
I
H
P
T
D
S
E
S
F
E
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation