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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HEY1
Full Name:
Hairy/enhancer-of-split related with YRPW motif protein 1
Alias:
Cardiovascular helix-loop-helix factor 2;Class B basic helix-loop-helix protein 31;HES-related repressor protein 1;Hairy and enhancer of split-related protein 1;Hairy-related transcription factor 1
Type:
Mass (Da):
32613
Number AA:
304
UniProt ID:
Q9Y5J3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y8
M
K
R
A
H
P
E
Y
S
S
S
D
S
E
L
Site 2
S9
K
R
A
H
P
E
Y
S
S
S
D
S
E
L
D
Site 3
S10
R
A
H
P
E
Y
S
S
S
D
S
E
L
D
E
Site 4
S11
A
H
P
E
Y
S
S
S
D
S
E
L
D
E
T
Site 5
S13
P
E
Y
S
S
S
D
S
E
L
D
E
T
I
E
Site 6
T18
S
D
S
E
L
D
E
T
I
E
V
E
K
E
S
Site 7
S33
A
D
E
N
G
N
L
S
S
A
L
G
S
M
S
Site 8
S34
D
E
N
G
N
L
S
S
A
L
G
S
M
S
P
Site 9
S38
N
L
S
S
A
L
G
S
M
S
P
T
T
S
S
Site 10
S40
S
S
A
L
G
S
M
S
P
T
T
S
S
Q
I
Site 11
T43
L
G
S
M
S
P
T
T
S
S
Q
I
L
A
R
Site 12
S44
G
S
M
S
P
T
T
S
S
Q
I
L
A
R
K
Site 13
S45
S
M
S
P
T
T
S
S
Q
I
L
A
R
K
R
Site 14
S68
R
R
D
R
I
N
N
S
L
S
E
L
R
R
L
Site 15
S70
D
R
I
N
N
S
L
S
E
L
R
R
L
V
P
Site 16
S78
E
L
R
R
L
V
P
S
A
F
E
K
Q
G
S
Site 17
S85
S
A
F
E
K
Q
G
S
A
K
L
E
K
A
E
Site 18
T97
K
A
E
I
L
Q
M
T
V
D
H
L
K
M
L
Site 19
T106
D
H
L
K
M
L
H
T
A
G
G
K
G
Y
F
Site 20
Y112
H
T
A
G
G
K
G
Y
F
D
A
H
A
L
A
Site 21
Y122
A
H
A
L
A
M
D
Y
R
S
L
G
F
R
E
Site 22
S156
P
L
R
V
R
L
V
S
H
L
N
N
Y
A
S
Site 23
Y161
L
V
S
H
L
N
N
Y
A
S
Q
R
E
A
A
Site 24
S163
S
H
L
N
N
Y
A
S
Q
R
E
A
A
S
G
Site 25
S169
A
S
Q
R
E
A
A
S
G
A
H
A
G
L
G
Site 26
T207
G
H
G
N
A
G
T
T
A
S
P
T
E
P
H
Site 27
S209
G
N
A
G
T
T
A
S
P
T
E
P
H
H
Q
Site 28
T211
A
G
T
T
A
S
P
T
E
P
H
H
Q
G
R
Site 29
S221
H
H
Q
G
R
L
G
S
A
H
P
E
A
P
A
Site 30
S280
L
L
S
P
N
A
L
S
P
S
A
P
T
Q
A
Site 31
S282
S
P
N
A
L
S
P
S
A
P
T
Q
A
A
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation