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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CD2AP
Full Name:
CD2-associated protein
Alias:
Adapter protein CMS; C2AP; Cas ligand with multiple SH3 domains; CD2AP/CMS; CD2-associated protein; CMS; Mesenchym-to-epithelium transition protein with SH3 domains 1; METS1; METS-1
Type:
Motility/polarity/chemotaxis; Adaptor/scaffold
Mass (Da):
71451
Number AA:
639
UniProt ID:
Q9Y5K6
International Prot ID:
IPI00412771
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031941
GO:0005730
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0017124
GO:0005200
PhosphoSite+
KinaseNET
Biological Process:
GO:0051301
GO:0007067
GO:0006461
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y8
M
V
D
Y
I
V
E
Y
D
Y
D
A
V
H
D
Site 2
Y10
D
Y
I
V
E
Y
D
Y
D
A
V
H
D
D
E
Site 3
T61
V
K
E
I
K
R
E
T
E
F
K
D
D
S
L
Site 4
S67
E
T
E
F
K
D
D
S
L
P
I
K
R
E
R
Site 5
S80
E
R
H
G
N
V
A
S
L
V
Q
R
I
S
T
Site 6
S86
A
S
L
V
Q
R
I
S
T
Y
G
L
P
A
G
Site 7
T87
S
L
V
Q
R
I
S
T
Y
G
L
P
A
G
G
Site 8
Y88
L
V
Q
R
I
S
T
Y
G
L
P
A
G
G
I
Site 9
T149
E
E
G
W
W
S
G
T
L
N
N
K
L
G
L
Site 10
S159
N
K
L
G
L
F
P
S
N
F
V
K
E
L
E
Site 11
T168
F
V
K
E
L
E
V
T
D
D
G
E
T
H
E
Site 12
S180
T
H
E
A
Q
D
D
S
E
T
V
L
A
G
P
Site 13
T182
E
A
Q
D
D
S
E
T
V
L
A
G
P
T
S
Site 14
S193
G
P
T
S
P
I
P
S
L
G
N
V
S
E
T
Site 15
T200
S
L
G
N
V
S
E
T
A
S
G
S
V
T
Q
Site 16
S202
G
N
V
S
E
T
A
S
G
S
V
T
Q
P
K
Site 17
T206
E
T
A
S
G
S
V
T
Q
P
K
K
I
R
G
Site 18
S224
G
D
I
F
K
E
G
S
V
K
L
R
T
R
T
Site 19
T229
E
G
S
V
K
L
R
T
R
T
S
S
S
E
T
Site 20
T231
S
V
K
L
R
T
R
T
S
S
S
E
T
E
E
Site 21
S232
V
K
L
R
T
R
T
S
S
S
E
T
E
E
K
Site 22
S233
K
L
R
T
R
T
S
S
S
E
T
E
E
K
K
Site 23
S234
L
R
T
R
T
S
S
S
E
T
E
E
K
K
P
Site 24
T236
T
R
T
S
S
S
E
T
E
E
K
K
P
E
K
Site 25
S249
E
K
P
L
I
L
Q
S
L
G
P
K
T
Q
S
Site 26
T254
L
Q
S
L
G
P
K
T
Q
S
V
E
I
T
K
Site 27
S256
S
L
G
P
K
T
Q
S
V
E
I
T
K
T
D
Site 28
T260
K
T
Q
S
V
E
I
T
K
T
D
T
E
G
K
Site 29
T262
Q
S
V
E
I
T
K
T
D
T
E
G
K
I
K
Site 30
Y273
G
K
I
K
A
K
E
Y
C
R
T
L
F
A
Y
Site 31
T276
K
A
K
E
Y
C
R
T
L
F
A
Y
E
G
T
Site 32
Y280
Y
C
R
T
L
F
A
Y
E
G
T
N
E
D
E
Site 33
T289
G
T
N
E
D
E
L
T
F
K
E
G
E
I
I
Site 34
S300
G
E
I
I
H
L
I
S
K
E
T
G
E
A
G
Site 35
Y361
L
I
A
A
E
K
K
Y
F
S
L
K
P
E
E
Site 36
S363
A
A
E
K
K
Y
F
S
L
K
P
E
E
K
D
Site 37
S373
P
E
E
K
D
E
K
S
T
L
E
Q
K
P
S
Site 38
S380
S
T
L
E
Q
K
P
S
K
P
A
A
P
Q
V
Site 39
T393
Q
V
P
P
K
K
P
T
P
P
T
K
A
S
N
Site 40
T396
P
K
K
P
T
P
P
T
K
A
S
N
L
L
R
Site 41
S399
P
T
P
P
T
K
A
S
N
L
L
R
S
S
G
Site 42
S404
K
A
S
N
L
L
R
S
S
G
T
V
Y
P
K
Site 43
S405
A
S
N
L
L
R
S
S
G
T
V
Y
P
K
R
Site 44
T407
N
L
L
R
S
S
G
T
V
Y
P
K
R
P
E
Site 45
Y409
L
R
S
S
G
T
V
Y
P
K
R
P
E
K
P
Site 46
S432
K
I
N
G
E
V
S
S
I
S
S
K
F
E
T
Site 47
S435
G
E
V
S
S
I
S
S
K
F
E
T
E
P
V
Site 48
T439
S
I
S
S
K
F
E
T
E
P
V
S
K
L
K
Site 49
S443
K
F
E
T
E
P
V
S
K
L
K
L
D
S
E
Site 50
S449
V
S
K
L
K
L
D
S
E
Q
L
P
L
R
P
Site 51
S458
Q
L
P
L
R
P
K
S
V
D
F
D
S
L
T
Site 52
S463
P
K
S
V
D
F
D
S
L
T
V
R
T
S
K
Site 53
T465
S
V
D
F
D
S
L
T
V
R
T
S
K
E
T
Site 54
S469
D
S
L
T
V
R
T
S
K
E
T
D
V
V
N
Site 55
T490
S
E
N
L
L
H
L
T
A
N
R
P
K
M
P
Site 56
S510
G
R
F
N
G
G
H
S
P
T
H
S
P
E
K
Site 57
T512
F
N
G
G
H
S
P
T
H
S
P
E
K
I
L
Site 58
S514
G
G
H
S
P
T
H
S
P
E
K
I
L
K
L
Site 59
S527
K
L
P
K
E
E
D
S
A
N
L
K
P
S
E
Site 60
S533
D
S
A
N
L
K
P
S
E
L
K
K
D
T
C
Site 61
T539
P
S
E
L
K
K
D
T
C
Y
S
P
K
P
S
Site 62
Y541
E
L
K
K
D
T
C
Y
S
P
K
P
S
V
Y
Site 63
S542
L
K
K
D
T
C
Y
S
P
K
P
S
V
Y
L
Site 64
S546
T
C
Y
S
P
K
P
S
V
Y
L
S
T
P
S
Site 65
Y548
Y
S
P
K
P
S
V
Y
L
S
T
P
S
S
A
Site 66
S550
P
K
P
S
V
Y
L
S
T
P
S
S
A
S
K
Site 67
T551
K
P
S
V
Y
L
S
T
P
S
S
A
S
K
A
Site 68
S553
S
V
Y
L
S
T
P
S
S
A
S
K
A
N
T
Site 69
S554
V
Y
L
S
T
P
S
S
A
S
K
A
N
T
T
Site 70
S556
L
S
T
P
S
S
A
S
K
A
N
T
T
A
F
Site 71
T560
S
S
A
S
K
A
N
T
T
A
F
L
T
P
L
Site 72
T565
A
N
T
T
A
F
L
T
P
L
E
I
K
A
K
Site 73
S582
T
D
D
V
K
K
N
S
L
D
E
L
R
A
Q
Site 74
T620
K
D
L
E
E
E
K
T
M
R
S
N
L
E
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation