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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HRH3
Full Name:
Histamine H3 receptor
Alias:
G-protein coupled receptor 97
Type:
Mass (Da):
48671
Number AA:
445
UniProt ID:
Q9Y5N1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
P
D
G
P
L
N
A
S
G
A
L
A
G
E
A
Site 2
S64
L
A
F
V
A
D
S
S
L
R
T
Q
N
N
F
Site 3
T137
Y
D
R
F
L
S
V
T
R
A
V
S
Y
R
A
Site 4
S141
L
S
V
T
R
A
V
S
Y
R
A
Q
Q
G
D
Site 5
S178
I
L
S
W
E
Y
L
S
G
G
S
S
I
P
E
Site 6
S181
W
E
Y
L
S
G
G
S
S
I
P
E
G
H
C
Site 7
S182
E
Y
L
S
G
G
S
S
I
P
E
G
H
C
Y
Site 8
Y222
T
F
F
N
L
S
I
Y
L
N
I
Q
R
R
T
Site 9
T229
Y
L
N
I
Q
R
R
T
R
L
R
L
D
G
A
Site 10
S251
P
P
P
E
A
Q
P
S
P
P
P
P
P
G
C
Site 11
S299
G
G
G
G
G
G
G
S
V
A
S
P
T
S
S
Site 12
S302
G
G
G
G
S
V
A
S
P
T
S
S
S
G
S
Site 13
T304
G
G
S
V
A
S
P
T
S
S
S
G
S
S
S
Site 14
S305
G
S
V
A
S
P
T
S
S
S
G
S
S
S
R
Site 15
S306
S
V
A
S
P
T
S
S
S
G
S
S
S
R
G
Site 16
S307
V
A
S
P
T
S
S
S
G
S
S
S
R
G
T
Site 17
S309
S
P
T
S
S
S
G
S
S
S
R
G
T
E
R
Site 18
S310
P
T
S
S
S
G
S
S
S
R
G
T
E
R
P
Site 19
S311
T
S
S
S
G
S
S
S
R
G
T
E
R
P
R
Site 20
T314
S
G
S
S
S
R
G
T
E
R
P
R
S
L
K
Site 21
S319
R
G
T
E
R
P
R
S
L
K
R
G
S
K
P
Site 22
S324
P
R
S
L
K
R
G
S
K
P
S
A
S
S
A
Site 23
S327
L
K
R
G
S
K
P
S
A
S
S
A
S
L
E
Site 24
S329
R
G
S
K
P
S
A
S
S
A
S
L
E
K
R
Site 25
S330
G
S
K
P
S
A
S
S
A
S
L
E
K
R
M
Site 26
S332
K
P
S
A
S
S
A
S
L
E
K
R
M
K
M
Site 27
S341
E
K
R
M
K
M
V
S
Q
S
F
T
Q
R
F
Site 28
S343
R
M
K
M
V
S
Q
S
F
T
Q
R
F
R
L
Site 29
T345
K
M
V
S
Q
S
F
T
Q
R
F
R
L
S
R
Site 30
S351
F
T
Q
R
F
R
L
S
R
D
R
K
V
A
K
Site 31
T424
H
S
F
R
R
A
F
T
K
L
L
C
P
Q
K
Site 32
S439
L
K
I
Q
P
H
S
S
L
E
H
C
W
K
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation