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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GTF3C5
Full Name:
General transcription factor 3C polypeptide 5
Alias:
CDABP0017; General transcription factor IIIC; General transcription factor IIIC, polypeptide 5 (63kD); General transcription factor IIIC, polypeptide 5, 63kDa; TF3C5; TF3C-epsilon; TFIIIC 63 kDa subunit; TFiiiC2-63; TFIIIC63; TFIIICepsilon; Transcription factor IIIC subunit epsilon; Transcription factor IIIC, 63 kD; Transcription factor IIIC-epsilon subunit
Type:
Transcription initiation complex
Mass (Da):
59571
Number AA:
519
UniProt ID:
Q9Y5Q8
International Prot ID:
IPI00411531
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000127
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0042791
GO:0042797
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S50
L
G
G
E
E
G
V
S
R
I
Y
A
D
P
T
Site 2
Y53
E
E
G
V
S
R
I
Y
A
D
P
T
K
R
L
Site 3
T57
S
R
I
Y
A
D
P
T
K
R
L
E
L
Y
F
Site 4
Y63
P
T
K
R
L
E
L
Y
F
R
P
K
D
P
Y
Site 5
Y70
Y
F
R
P
K
D
P
Y
C
H
P
V
C
A
N
Site 6
S83
A
N
R
F
S
T
S
S
L
L
L
R
I
R
K
Site 7
T92
L
L
R
I
R
K
R
T
R
R
Q
K
G
V
L
Site 8
Y131
Q
G
M
S
D
F
Q
Y
L
A
V
H
T
E
A
Site 9
S144
E
A
G
G
K
H
T
S
M
Y
D
K
V
L
M
Site 10
Y146
G
G
K
H
T
S
M
Y
D
K
V
L
M
L
R
Site 11
Y167
F
H
Q
E
L
P
L
Y
I
P
P
P
I
F
S
Site 12
Y182
R
L
D
A
P
V
D
Y
F
Y
R
P
E
T
Q
Site 13
Y184
D
A
P
V
D
Y
F
Y
R
P
E
T
Q
H
R
Site 14
T188
D
Y
F
Y
R
P
E
T
Q
H
R
E
G
Y
N
Site 15
Y194
E
T
Q
H
R
E
G
Y
N
N
P
P
I
S
G
Site 16
S200
G
Y
N
N
P
P
I
S
G
E
N
L
I
G
L
Site 17
S208
G
E
N
L
I
G
L
S
R
A
R
R
P
H
N
Site 18
T237
P
L
E
A
A
A
Q
T
W
R
R
V
C
T
N
Site 19
T243
Q
T
W
R
R
V
C
T
N
P
V
D
R
K
V
Site 20
S274
N
A
V
K
A
N
I
S
V
H
P
D
K
L
K
Site 21
Y290
L
L
P
F
I
A
Y
Y
M
I
T
G
P
W
R
Site 22
Y305
S
L
W
I
R
F
G
Y
D
P
R
K
N
P
D
Site 23
Y316
K
N
P
D
A
K
I
Y
Q
V
L
D
F
R
I
Site 24
Y331
R
C
G
M
K
H
G
Y
A
P
S
D
L
P
V
Site 25
S334
M
K
H
G
Y
A
P
S
D
L
P
V
K
A
K
Site 26
T344
P
V
K
A
K
R
S
T
Y
N
Y
S
L
P
I
Site 27
Y345
V
K
A
K
R
S
T
Y
N
Y
S
L
P
I
T
Site 28
Y347
A
K
R
S
T
Y
N
Y
S
L
P
I
T
V
K
Site 29
S348
K
R
S
T
Y
N
Y
S
L
P
I
T
V
K
K
Site 30
T352
Y
N
Y
S
L
P
I
T
V
K
K
T
S
S
Q
Site 31
S358
I
T
V
K
K
T
S
S
Q
L
V
T
M
H
D
Site 32
T362
K
T
S
S
Q
L
V
T
M
H
D
L
K
Q
G
Site 33
S376
G
L
G
P
S
G
T
S
G
A
R
K
P
A
S
Site 34
S383
S
G
A
R
K
P
A
S
S
K
Y
K
L
K
D
Site 35
S384
G
A
R
K
P
A
S
S
K
Y
K
L
K
D
S
Site 36
Y386
R
K
P
A
S
S
K
Y
K
L
K
D
S
V
Y
Site 37
S391
S
K
Y
K
L
K
D
S
V
Y
I
F
R
E
G
Site 38
Y393
Y
K
L
K
D
S
V
Y
I
F
R
E
G
A
L
Site 39
Y403
R
E
G
A
L
P
P
Y
R
Q
M
F
Y
Q
L
Site 40
Y408
P
P
Y
R
Q
M
F
Y
Q
L
C
D
L
N
V
Site 41
S431
R
N
D
G
A
E
N
S
C
T
E
R
D
G
W
Site 42
T443
D
G
W
C
L
P
K
T
S
D
E
L
R
D
T
Site 43
S444
G
W
C
L
P
K
T
S
D
E
L
R
D
T
M
Site 44
T450
T
S
D
E
L
R
D
T
M
S
L
M
I
R
Q
Site 45
S452
D
E
L
R
D
T
M
S
L
M
I
R
Q
T
I
Site 46
T458
M
S
L
M
I
R
Q
T
I
R
S
K
R
P
A
Site 47
S461
M
I
R
Q
T
I
R
S
K
R
P
A
L
F
S
Site 48
S468
S
K
R
P
A
L
F
S
S
S
A
K
A
D
G
Site 49
S470
R
P
A
L
F
S
S
S
A
K
A
D
G
G
K
Site 50
T481
D
G
G
K
E
Q
L
T
Y
E
S
G
E
D
E
Site 51
Y482
G
G
K
E
Q
L
T
Y
E
S
G
E
D
E
E
Site 52
S507
D
F
K
P
S
D
G
S
E
N
E
M
E
T
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation