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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
USP16
Full Name:
Ubiquitin carboxyl-terminal hydrolase 16
Alias:
Deubiquitinating enzyme 16; Ubiquitin processing protease UBP-M; Ubiquitin thioesterase 16; Ubiquitin thiolesterase 16; Ubiquitin-specific processing protease 16; UBP16; UBPG; UBP-M
Type:
Ubiquitin conjugating system; EC 3.1.2.15; Protease
Mass (Da):
93570
Number AA:
823
UniProt ID:
Q9Y5T5
International Prot ID:
IPI00001780
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0004197
GO:0042393
GO:0003713
PhosphoSite+
KinaseNET
Biological Process:
GO:0051301
GO:0016578
GO:0007067
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
K
K
R
T
K
G
K
T
V
P
I
D
D
S
S
Site 2
S16
K
T
V
P
I
D
D
S
S
E
T
L
E
P
V
Site 3
S17
T
V
P
I
D
D
S
S
E
T
L
E
P
V
C
Site 4
T19
P
I
D
D
S
S
E
T
L
E
P
V
C
R
H
Site 5
T53
N
I
C
Q
D
C
K
T
D
N
K
V
K
D
K
Site 6
S86
H
Q
G
C
G
R
N
S
Q
E
Q
H
A
L
K
Site 7
Y95
E
Q
H
A
L
K
H
Y
L
T
P
R
S
E
P
Site 8
T97
H
A
L
K
H
Y
L
T
P
R
S
E
P
H
C
Site 9
S100
K
H
Y
L
T
P
R
S
E
P
H
C
L
V
L
Site 10
Y125
V
C
D
N
E
V
Q
Y
C
S
S
N
Q
L
G
Site 11
Y137
Q
L
G
Q
V
V
D
Y
V
R
K
Q
A
S
I
Site 12
T146
R
K
Q
A
S
I
T
T
P
K
P
A
E
K
D
Site 13
S189
K
E
N
P
P
M
N
S
P
C
Q
I
T
V
K
Site 14
T194
M
N
S
P
C
Q
I
T
V
K
G
L
S
N
L
Site 15
S199
Q
I
T
V
K
G
L
S
N
L
G
N
T
C
F
Site 16
S215
N
A
V
M
Q
N
L
S
Q
T
P
V
L
R
E
Site 17
S230
L
L
K
E
V
K
M
S
G
T
I
V
K
I
E
Site 18
T277
E
T
K
K
G
V
V
T
P
K
E
L
F
S
Q
Site 19
S300
K
G
Y
Q
Q
Q
D
S
Q
E
L
L
R
Y
L
Site 20
Y306
D
S
Q
E
L
L
R
Y
L
L
D
G
M
R
A
Site 21
S320
A
E
E
H
Q
R
V
S
K
G
I
L
K
A
F
Site 22
Y345
L
K
N
K
V
K
D
Y
E
K
K
K
S
M
P
Site 23
S350
K
D
Y
E
K
K
K
S
M
P
S
F
V
D
R
Site 24
S353
E
K
K
K
S
M
P
S
F
V
D
R
I
F
G
Site 25
S386
H
E
S
F
L
D
L
S
L
P
V
L
D
D
Q
Site 26
S394
L
P
V
L
D
D
Q
S
G
K
K
S
V
N
D
Site 27
S398
D
D
Q
S
G
K
K
S
V
N
D
K
N
L
K
Site 28
T407
N
D
K
N
L
K
K
T
V
E
D
E
D
Q
D
Site 29
S415
V
E
D
E
D
Q
D
S
E
E
E
K
D
N
D
Site 30
S423
E
E
E
K
D
N
D
S
Y
I
K
E
R
S
D
Site 31
Y424
E
E
K
D
N
D
S
Y
I
K
E
R
S
D
I
Site 32
S429
D
S
Y
I
K
E
R
S
D
I
P
S
G
T
S
Site 33
S433
K
E
R
S
D
I
P
S
G
T
S
K
H
L
Q
Site 34
T472
L
H
L
N
D
I
C
T
I
D
H
P
E
D
S
Site 35
S479
T
I
D
H
P
E
D
S
E
Y
E
A
E
M
S
Site 36
Y481
D
H
P
E
D
S
E
Y
E
A
E
M
S
L
Q
Site 37
S486
S
E
Y
E
A
E
M
S
L
Q
G
E
V
N
I
Site 38
S495
Q
G
E
V
N
I
K
S
N
H
I
S
Q
E
G
Site 39
S499
N
I
K
S
N
H
I
S
Q
E
G
V
M
H
K
Site 40
Y508
E
G
V
M
H
K
E
Y
C
V
N
Q
K
D
L
Site 41
S524
G
Q
A
K
M
I
E
S
V
T
D
N
Q
K
S
Site 42
S531
S
V
T
D
N
Q
K
S
T
E
E
V
D
M
K
Site 43
T550
D
N
D
L
E
V
L
T
S
S
P
T
R
N
L
Site 44
S551
N
D
L
E
V
L
T
S
S
P
T
R
N
L
N
Site 45
S552
D
L
E
V
L
T
S
S
P
T
R
N
L
N
G
Site 46
T554
E
V
L
T
S
S
P
T
R
N
L
N
G
A
Y
Site 47
Y561
T
R
N
L
N
G
A
Y
L
T
E
G
S
N
G
Site 48
S573
S
N
G
E
V
D
I
S
N
G
F
K
N
L
N
Site 49
S598
N
I
E
I
L
N
D
S
H
T
P
G
T
K
V
Site 50
T600
E
I
L
N
D
S
H
T
P
G
T
K
V
Y
E
Site 51
Y606
H
T
P
G
T
K
V
Y
E
V
V
N
E
D
P
Site 52
T628
A
N
R
E
V
F
N
T
D
E
C
S
I
Q
H
Site 53
Y638
C
S
I
Q
H
C
L
Y
Q
F
T
R
N
E
K
Site 54
Y677
K
G
E
R
K
H
V
Y
T
N
A
K
K
Q
M
Site 55
T678
G
E
R
K
H
V
Y
T
N
A
K
K
Q
M
L
Site 56
Y742
E
E
N
T
R
V
L
Y
S
L
Y
G
V
V
E
Site 57
T753
G
V
V
E
H
S
G
T
M
R
S
G
H
Y
T
Site 58
S756
E
H
S
G
T
M
R
S
G
H
Y
T
A
Y
A
Site 59
T760
T
M
R
S
G
H
Y
T
A
Y
A
K
A
R
T
Site 60
Y762
R
S
G
H
Y
T
A
Y
A
K
A
R
T
A
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation