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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PUS1
Full Name:
tRNA pseudouridine synthase A, mitochondrial
Alias:
EC 5.4.99.12; MLASA; Pseudouridine synthase 1; Pseudouridylate synthase 1; TRNA pseudouridine synthase A; TRNA pseudouridine synthase A: tRNA-uridine isomerase I: tRNA pseudouridylate synthase I: tRNA pseudouridine synthase A: tRNA-uridine isomerase I: tRNA pseudouridylate synthase I; TRNA pseudouridylate synthase I; TRNA-uridine isomerase I; TRUA
Type:
Nucleus protein
Mass (Da):
47470
Number AA:
427
UniProt ID:
Q9Y606
International Prot ID:
IPI00619930
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0009982
GO:0004730
PhosphoSite+
KinaseNET
Biological Process:
GO:0001522
GO:0008033
GO:0006396
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T16
L
G
A
F
G
R
W
T
L
R
L
G
P
R
P
Site 2
S24
L
R
L
G
P
R
P
S
C
S
P
R
M
A
G
Site 3
S26
L
G
P
R
P
S
C
S
P
R
M
A
G
N
A
Site 4
S48
A
C
P
Q
D
R
R
S
C
S
G
R
A
G
G
Site 5
S50
P
Q
D
R
R
S
C
S
G
R
A
G
G
D
R
Site 6
S71
H
P
A
K
K
L
K
S
G
G
D
E
E
R
R
Site 7
Y97
M
A
Y
S
G
K
G
Y
H
G
M
Q
R
N
V
Site 8
S106
G
M
Q
R
N
V
G
S
S
Q
F
K
T
I
E
Site 9
S107
M
Q
R
N
V
G
S
S
Q
F
K
T
I
E
D
Site 10
T111
V
G
S
S
Q
F
K
T
I
E
D
D
L
V
S
Site 11
S138
G
E
D
M
R
K
M
S
F
Q
R
C
A
R
T
Site 12
T145
S
F
Q
R
C
A
R
T
D
K
G
V
S
A
A
Site 13
S150
A
R
T
D
K
G
V
S
A
A
G
Q
V
V
S
Site 14
S172
D
I
L
E
K
I
N
S
H
L
P
S
H
I
R
Site 15
S176
K
I
N
S
H
L
P
S
H
I
R
I
L
G
L
Site 16
T187
I
L
G
L
K
R
V
T
G
G
F
N
S
K
N
Site 17
S192
R
V
T
G
G
F
N
S
K
N
R
C
D
A
R
Site 18
T200
K
N
R
C
D
A
R
T
Y
C
Y
L
L
P
T
Site 19
Y201
N
R
C
D
A
R
T
Y
C
Y
L
L
P
T
F
Site 20
T221
D
R
D
V
Q
D
E
T
Y
R
L
S
A
E
T
Site 21
Y222
R
D
V
Q
D
E
T
Y
R
L
S
A
E
T
L
Site 22
S225
Q
D
E
T
Y
R
L
S
A
E
T
L
Q
Q
V
Site 23
T228
T
Y
R
L
S
A
E
T
L
Q
Q
V
N
R
L
Site 24
Y239
V
N
R
L
L
A
C
Y
K
G
T
H
N
F
H
Site 25
S258
Q
K
G
P
Q
D
P
S
A
C
R
Y
I
L
E
Site 26
S312
V
K
G
Y
A
P
E
S
V
L
E
R
S
W
G
Site 27
Y343
E
R
V
H
F
E
K
Y
N
Q
R
F
G
N
D
Site 28
Y374
A
F
K
E
E
H
I
Y
P
T
I
I
G
T
E
Site 29
T380
I
Y
P
T
I
I
G
T
E
R
D
E
R
S
M
Site 30
S386
G
T
E
R
D
E
R
S
M
A
Q
W
L
S
T
Site 31
T393
S
M
A
Q
W
L
S
T
L
P
I
H
N
F
S
Site 32
S415
G
T
G
A
K
V
P
S
P
L
E
G
S
E
G
Site 33
S420
V
P
S
P
L
E
G
S
E
G
D
G
D
T
D
Site 34
T426
G
S
E
G
D
G
D
T
D
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation