KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
LRRFIP2
Full Name:
Leucine-rich repeat flightless-interacting protein 2
Alias:
HUFI-2; Leucine rich repeat (in FLII) interacting protein 2; Leucine rich repeat interacting protein 2; LRR FLII-interacting protein 2; LRRF2
Type:
Unknown function
Mass (Da):
82171
Number AA:
721
UniProt ID:
Q9Y608
International Prot ID:
IPI00007277
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005515
GO:0019904
PhosphoSite+
KinaseNET
Biological Process:
GO:0007154
GO:0007165
GO:0007166
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
G
T
P
A
S
G
R
K
R
T
P
V
Site 2
T11
P
A
S
G
R
K
R
T
P
V
K
D
R
F
S
Site 3
S18
T
P
V
K
D
R
F
S
A
E
D
E
A
L
S
Site 4
S25
S
A
E
D
E
A
L
S
N
I
A
R
E
A
E
Site 5
Y60
L
E
R
Q
Q
K
E
Y
S
L
H
S
F
D
R
Site 6
S61
E
R
Q
Q
K
E
Y
S
L
H
S
F
D
R
K
Site 7
S64
Q
K
E
Y
S
L
H
S
F
D
R
K
W
G
Q
Site 8
S79
I
Q
K
W
L
E
D
S
E
R
A
R
Y
S
H
Site 9
Y84
E
D
S
E
R
A
R
Y
S
H
R
S
S
H
H
Site 10
S85
D
S
E
R
A
R
Y
S
H
R
S
S
H
H
R
Site 11
S88
R
A
R
Y
S
H
R
S
S
H
H
R
P
Y
L
Site 12
S89
A
R
Y
S
H
R
S
S
H
H
R
P
Y
L
G
Site 13
Y94
R
S
S
H
H
R
P
Y
L
G
V
E
D
A
L
Site 14
S108
L
S
I
R
S
V
G
S
H
R
Y
D
M
F
K
Site 15
Y111
R
S
V
G
S
H
R
Y
D
M
F
K
D
R
S
Site 16
S118
Y
D
M
F
K
D
R
S
S
R
L
S
S
L
N
Site 17
S119
D
M
F
K
D
R
S
S
R
L
S
S
L
N
H
Site 18
S122
K
D
R
S
S
R
L
S
S
L
N
H
S
Y
S
Site 19
S123
D
R
S
S
R
L
S
S
L
N
H
S
Y
S
H
Site 20
S127
R
L
S
S
L
N
H
S
Y
S
H
S
H
G
M
Site 21
Y128
L
S
S
L
N
H
S
Y
S
H
S
H
G
M
K
Site 22
S129
S
S
L
N
H
S
Y
S
H
S
H
G
M
K
K
Site 23
S131
L
N
H
S
Y
S
H
S
H
G
M
K
K
R
S
Site 24
S139
H
G
M
K
K
R
S
S
D
S
H
K
D
L
L
Site 25
S141
M
K
K
R
S
S
D
S
H
K
D
L
L
S
G
Site 26
S147
D
S
H
K
D
L
L
S
G
L
Y
F
D
Q
R
Site 27
Y150
K
D
L
L
S
G
L
Y
F
D
Q
R
N
Y
S
Site 28
Y156
L
Y
F
D
Q
R
N
Y
S
S
L
R
H
S
K
Site 29
S157
Y
F
D
Q
R
N
Y
S
S
L
R
H
S
K
P
Site 30
S158
F
D
Q
R
N
Y
S
S
L
R
H
S
K
P
T
Site 31
S162
N
Y
S
S
L
R
H
S
K
P
T
S
A
Y
Y
Site 32
S166
L
R
H
S
K
P
T
S
A
Y
Y
T
R
Q
S
Site 33
Y168
H
S
K
P
T
S
A
Y
Y
T
R
Q
S
S
S
Site 34
Y169
S
K
P
T
S
A
Y
Y
T
R
Q
S
S
S
L
Site 35
T170
K
P
T
S
A
Y
Y
T
R
Q
S
S
S
L
Y
Site 36
S173
S
A
Y
Y
T
R
Q
S
S
S
L
Y
S
D
P
Site 37
S174
A
Y
Y
T
R
Q
S
S
S
L
Y
S
D
P
L
Site 38
S175
Y
Y
T
R
Q
S
S
S
L
Y
S
D
P
L
A
Site 39
Y177
T
R
Q
S
S
S
L
Y
S
D
P
L
A
T
Y
Site 40
S178
R
Q
S
S
S
L
Y
S
D
P
L
A
T
Y
K
Site 41
Y184
Y
S
D
P
L
A
T
Y
K
S
D
R
A
S
P
Site 42
S186
D
P
L
A
T
Y
K
S
D
R
A
S
P
T
A
Site 43
S190
T
Y
K
S
D
R
A
S
P
T
A
N
S
G
L
Site 44
T192
K
S
D
R
A
S
P
T
A
N
S
G
L
L
R
Site 45
S195
R
A
S
P
T
A
N
S
G
L
L
R
S
A
S
Site 46
S200
A
N
S
G
L
L
R
S
A
S
L
A
S
L
Y
Site 47
S202
S
G
L
L
R
S
A
S
L
A
S
L
Y
N
G
Site 48
S205
L
R
S
A
S
L
A
S
L
Y
N
G
G
L
Y
Site 49
Y207
S
A
S
L
A
S
L
Y
N
G
G
L
Y
N
P
Site 50
Y212
S
L
Y
N
G
G
L
Y
N
P
Y
G
P
R
T
Site 51
Y215
N
G
G
L
Y
N
P
Y
G
P
R
T
P
S
E
Site 52
T219
Y
N
P
Y
G
P
R
T
P
S
E
C
S
Y
Y
Site 53
S221
P
Y
G
P
R
T
P
S
E
C
S
Y
Y
S
S
Site 54
S224
P
R
T
P
S
E
C
S
Y
Y
S
S
R
I
S
Site 55
Y225
R
T
P
S
E
C
S
Y
Y
S
S
R
I
S
S
Site 56
Y226
T
P
S
E
C
S
Y
Y
S
S
R
I
S
S
A
Site 57
S227
P
S
E
C
S
Y
Y
S
S
R
I
S
S
A
R
Site 58
S228
S
E
C
S
Y
Y
S
S
R
I
S
S
A
R
S
Site 59
S231
S
Y
Y
S
S
R
I
S
S
A
R
S
S
P
G
Site 60
S232
Y
Y
S
S
R
I
S
S
A
R
S
S
P
G
F
Site 61
S235
S
R
I
S
S
A
R
S
S
P
G
F
T
N
D
Site 62
S236
R
I
S
S
A
R
S
S
P
G
F
T
N
D
D
Site 63
T240
A
R
S
S
P
G
F
T
N
D
D
T
A
S
I
Site 64
T244
P
G
F
T
N
D
D
T
A
S
I
V
S
S
D
Site 65
S246
F
T
N
D
D
T
A
S
I
V
S
S
D
R
A
Site 66
S250
D
T
A
S
I
V
S
S
D
R
A
S
R
G
R
Site 67
S254
I
V
S
S
D
R
A
S
R
G
R
R
E
S
V
Site 68
S260
A
S
R
G
R
R
E
S
V
V
S
A
A
D
Y
Site 69
S263
G
R
R
E
S
V
V
S
A
A
D
Y
F
S
R
Site 70
Y267
S
V
V
S
A
A
D
Y
F
S
R
S
N
R
R
Site 71
S269
V
S
A
A
D
Y
F
S
R
S
N
R
R
G
S
Site 72
S271
A
A
D
Y
F
S
R
S
N
R
R
G
S
V
V
Site 73
S276
S
R
S
N
R
R
G
S
V
V
S
E
V
D
D
Site 74
S279
N
R
R
G
S
V
V
S
E
V
D
D
I
S
I
Site 75
S290
D
I
S
I
P
D
L
S
S
L
D
E
K
S
D
Site 76
S291
I
S
I
P
D
L
S
S
L
D
E
K
S
D
K
Site 77
S296
L
S
S
L
D
E
K
S
D
K
Q
Y
A
E
N
Site 78
Y300
D
E
K
S
D
K
Q
Y
A
E
N
Y
T
R
P
Site 79
Y304
D
K
Q
Y
A
E
N
Y
T
R
P
S
S
R
N
Site 80
T305
K
Q
Y
A
E
N
Y
T
R
P
S
S
R
N
S
Site 81
S308
A
E
N
Y
T
R
P
S
S
R
N
S
A
S
A
Site 82
S309
E
N
Y
T
R
P
S
S
R
N
S
A
S
A
T
Site 83
S312
T
R
P
S
S
R
N
S
A
S
A
T
T
P
L
Site 84
S314
P
S
S
R
N
S
A
S
A
T
T
P
L
S
G
Site 85
T316
S
R
N
S
A
S
A
T
T
P
L
S
G
N
S
Site 86
T317
R
N
S
A
S
A
T
T
P
L
S
G
N
S
S
Site 87
S320
A
S
A
T
T
P
L
S
G
N
S
S
R
R
G
Site 88
S323
T
T
P
L
S
G
N
S
S
R
R
G
S
G
D
Site 89
S324
T
P
L
S
G
N
S
S
R
R
G
S
G
D
T
Site 90
S328
G
N
S
S
R
R
G
S
G
D
T
S
S
L
I
Site 91
T331
S
R
R
G
S
G
D
T
S
S
L
I
D
P
D
Site 92
S332
R
R
G
S
G
D
T
S
S
L
I
D
P
D
T
Site 93
S333
R
G
S
G
D
T
S
S
L
I
D
P
D
T
S
Site 94
T339
S
S
L
I
D
P
D
T
S
L
S
E
L
R
D
Site 95
S340
S
L
I
D
P
D
T
S
L
S
E
L
R
D
I
Site 96
S342
I
D
P
D
T
S
L
S
E
L
R
D
I
Y
D
Site 97
Y348
L
S
E
L
R
D
I
Y
D
L
K
D
Q
I
Q
Site 98
S371
G
L
K
E
L
K
E
S
L
S
E
V
E
E
K
Site 99
S373
K
E
L
K
E
S
L
S
E
V
E
E
K
Y
K
Site 100
Y398
N
E
K
N
N
L
I
Y
Q
V
D
T
L
K
D
Site 101
S425
Y
R
E
N
E
E
K
S
K
E
L
E
R
Q
K
Site 102
T468
R
M
Q
Q
K
I
D
T
M
T
K
E
V
F
D
Site 103
T470
Q
Q
K
I
D
T
M
T
K
E
V
F
D
L
Q
Site 104
T517
E
L
A
D
L
Q
E
T
V
K
T
G
E
K
H
Site 105
T520
D
L
Q
E
T
V
K
T
G
E
K
H
G
L
V
Site 106
S539
G
T
P
N
G
D
V
S
H
E
P
V
A
G
A
Site 107
S582
G
E
K
E
E
L
L
S
Q
I
R
K
L
K
L
Site 108
T604
K
C
S
R
N
D
G
T
V
G
D
L
A
G
L
Site 109
S631
R
D
A
N
R
Q
I
S
E
Y
K
F
K
L
S
Site 110
Y633
A
N
R
Q
I
S
E
Y
K
F
K
L
S
K
A
Site 111
T645
S
K
A
E
Q
D
I
T
T
L
E
Q
S
I
S
Site 112
T646
K
A
E
Q
D
I
T
T
L
E
Q
S
I
S
R
Site 113
S652
T
T
L
E
Q
S
I
S
R
L
E
G
Q
V
L
Site 114
T663
G
Q
V
L
R
Y
K
T
A
A
E
N
A
E
K
Site 115
T699
K
I
E
E
M
E
M
T
N
S
H
L
A
K
R
Site 116
S701
E
E
M
E
M
T
N
S
H
L
A
K
R
L
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation