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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FHOD1
Full Name:
FH1/FH2 domain-containing protein 1
Alias:
FH1/FH2 domains-containing protein; FHOS; Formin homolog overexpressed in spleen; Formin homology 2 domain containing 1; forminy 2 domain containing 1
Type:
Actin binding protein
Mass (Da):
126551
Number AA:
1164
UniProt ID:
Q9Y613
International Prot ID:
IPI00001730
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003779
PhosphoSite+
KinaseNET
Biological Process:
GO:0030036
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
R
G
D
G
E
P
V
S
V
V
T
V
R
V
Q
Site 2
T26
R
V
Q
Y
L
E
D
T
D
P
F
A
C
A
N
Site 3
T42
P
E
P
R
R
A
P
T
C
S
L
D
G
A
L
Site 4
S44
P
R
R
A
P
T
C
S
L
D
G
A
L
P
L
Site 5
S76
E
D
C
A
L
Q
V
S
P
S
G
Y
Y
L
D
Site 6
S78
C
A
L
Q
V
S
P
S
G
Y
Y
L
D
T
E
Site 7
T84
P
S
G
Y
Y
L
D
T
E
L
S
L
E
E
Q
Site 8
S87
Y
Y
L
D
T
E
L
S
L
E
E
Q
R
E
M
Site 9
Y99
R
E
M
L
E
G
F
Y
E
E
I
S
K
G
R
Site 10
S103
E
G
F
Y
E
E
I
S
K
G
R
K
P
T
L
Site 11
T109
I
S
K
G
R
K
P
T
L
I
L
R
T
Q
L
Site 12
Y128
N
A
I
L
E
K
L
Y
S
S
S
G
P
E
L
Site 13
S129
A
I
L
E
K
L
Y
S
S
S
G
P
E
L
R
Site 14
S131
L
E
K
L
Y
S
S
S
G
P
E
L
R
R
S
Site 15
S138
S
G
P
E
L
R
R
S
L
F
S
L
K
Q
I
Site 16
S141
E
L
R
R
S
L
F
S
L
K
Q
I
F
Q
E
Site 17
Y176
G
A
A
A
D
H
N
Y
Q
S
Y
I
L
R
A
Site 18
Y179
A
D
H
N
Y
Q
S
Y
I
L
R
A
L
G
Q
Site 19
S293
A
A
L
P
D
Q
D
S
F
Y
D
V
T
D
A
Site 20
Y295
L
P
D
Q
D
S
F
Y
D
V
T
D
A
L
E
Site 21
T298
Q
D
S
F
Y
D
V
T
D
A
L
E
Q
Q
G
Site 22
T325
G
T
D
V
D
L
R
T
Q
L
V
L
Y
E
N
Site 23
S357
R
R
E
R
R
K
P
S
S
E
E
G
K
R
S
Site 24
S358
R
E
R
R
K
P
S
S
E
E
G
K
R
S
R
Site 25
S364
S
S
E
E
G
K
R
S
R
R
S
L
E
G
G
Site 26
S367
E
G
K
R
S
R
R
S
L
E
G
G
G
C
P
Site 27
T383
R
A
P
E
P
G
P
T
G
P
A
S
P
V
G
Site 28
S387
P
G
P
T
G
P
A
S
P
V
G
P
T
S
S
Site 29
S406
L
L
T
G
P
A
S
S
P
V
G
P
P
S
G
Site 30
S412
S
S
P
V
G
P
P
S
G
L
Q
A
S
V
N
Site 31
S429
P
T
I
S
V
A
P
S
A
D
T
S
S
E
R
Site 32
T432
S
V
A
P
S
A
D
T
S
S
E
R
S
I
Y
Site 33
S433
V
A
P
S
A
D
T
S
S
E
R
S
I
Y
K
Site 34
S434
A
P
S
A
D
T
S
S
E
R
S
I
Y
K
A
Site 35
S437
A
D
T
S
S
E
R
S
I
Y
K
A
R
F
L
Site 36
Y439
T
S
S
E
R
S
I
Y
K
A
R
F
L
E
N
Site 37
T465
L
A
Q
G
R
A
E
T
L
A
G
A
M
P
N
Site 38
S486
D
A
R
Q
L
W
D
S
P
E
T
A
P
A
A
Site 39
T495
E
T
A
P
A
A
R
T
P
Q
S
P
A
P
C
Site 40
S498
P
A
A
R
T
P
Q
S
P
A
P
C
V
L
L
Site 41
S510
V
L
L
R
A
Q
R
S
L
A
P
E
P
K
E
Site 42
S523
K
E
P
L
I
P
A
S
P
K
A
E
P
I
W
Site 43
T534
E
P
I
W
E
L
P
T
R
A
P
R
L
S
I
Site 44
S540
P
T
R
A
P
R
L
S
I
G
D
L
D
F
S
Site 45
S547
S
I
G
D
L
D
F
S
D
L
G
E
D
E
D
Site 46
S573
G
K
D
I
P
A
P
S
P
P
L
P
L
L
S
Site 47
S580
S
P
P
L
P
L
L
S
G
V
P
P
P
P
P
Site 48
S617
L
P
H
S
V
P
D
S
S
A
L
P
T
K
R
Site 49
S618
P
H
S
V
P
D
S
S
A
L
P
T
K
R
K
Site 50
T622
P
D
S
S
A
L
P
T
K
R
K
T
V
K
L
Site 51
T626
A
L
P
T
K
R
K
T
V
K
L
F
W
R
E
Site 52
S645
G
G
H
G
V
S
A
S
R
F
G
P
C
A
T
Site 53
T652
S
R
F
G
P
C
A
T
L
W
A
S
L
D
P
Site 54
S661
W
A
S
L
D
P
V
S
V
D
T
A
R
L
E
Site 55
S673
R
L
E
H
L
F
E
S
R
A
K
E
V
L
P
Site 56
S681
R
A
K
E
V
L
P
S
K
K
A
G
E
G
R
Site 57
T690
K
A
G
E
G
R
R
T
M
T
T
V
L
D
P
Site 58
T692
G
E
G
R
R
T
M
T
T
V
L
D
P
K
R
Site 59
T693
E
G
R
R
T
M
T
T
V
L
D
P
K
R
S
Site 60
S700
T
V
L
D
P
K
R
S
N
A
I
N
I
G
L
Site 61
T708
N
A
I
N
I
G
L
T
T
L
P
P
V
H
V
Site 62
S729
N
F
D
E
F
A
V
S
K
D
G
I
E
K
L
Site 63
T738
D
G
I
E
K
L
L
T
M
M
P
T
E
E
E
Site 64
Y790
L
W
A
F
K
L
D
Y
D
S
M
E
R
E
I
Site 65
S792
A
F
K
L
D
Y
D
S
M
E
R
E
I
A
E
Site 66
T816
E
Q
L
V
Q
N
A
T
F
R
C
I
L
A
T
Site 67
S834
V
G
N
F
L
N
G
S
Q
S
S
G
F
E
L
Site 68
S836
N
F
L
N
G
S
Q
S
S
G
F
E
L
S
Y
Site 69
S842
Q
S
S
G
F
E
L
S
Y
L
E
K
V
S
E
Site 70
Y843
S
S
G
F
E
L
S
Y
L
E
K
V
S
E
V
Site 71
T853
K
V
S
E
V
K
D
T
V
R
R
Q
S
L
L
Site 72
S858
K
D
T
V
R
R
Q
S
L
L
H
H
L
C
S
Site 73
T870
L
C
S
L
V
L
Q
T
R
P
E
S
S
D
L
Site 74
S874
V
L
Q
T
R
P
E
S
S
D
L
Y
S
E
I
Site 75
S875
L
Q
T
R
P
E
S
S
D
L
Y
S
E
I
P
Site 76
Y878
R
P
E
S
S
D
L
Y
S
E
I
P
A
L
T
Site 77
S879
P
E
S
S
D
L
Y
S
E
I
P
A
L
T
R
Site 78
S906
L
G
Q
L
E
R
R
S
R
A
A
E
E
S
L
Site 79
S912
R
S
R
A
A
E
E
S
L
R
S
L
A
K
H
Site 80
S915
A
A
E
E
S
L
R
S
L
A
K
H
E
L
A
Site 81
Y960
R
F
H
A
F
L
L
Y
L
G
Y
T
P
Q
A
Site 82
Y963
A
F
L
L
Y
L
G
Y
T
P
Q
A
A
R
E
Site 83
T979
R
I
M
Q
F
C
H
T
L
R
E
F
A
L
E
Site 84
T1010
T
Y
R
E
R
N
K
T
R
G
R
M
I
T
E
Site 85
T1016
K
T
R
G
R
M
I
T
E
T
E
K
F
S
G
Site 86
T1018
R
G
R
M
I
T
E
T
E
K
F
S
G
V
A
Site 87
S1033
G
E
A
P
S
N
P
S
V
P
V
A
V
S
S
Site 88
S1039
P
S
V
P
V
A
V
S
S
G
P
G
R
G
D
Site 89
S1040
S
V
P
V
A
V
S
S
G
P
G
R
G
D
A
Site 90
S1049
P
G
R
G
D
A
D
S
H
A
S
M
K
S
L
Site 91
S1052
G
D
A
D
S
H
A
S
M
K
S
L
L
T
S
Site 92
S1055
D
S
H
A
S
M
K
S
L
L
T
S
R
P
E
Site 93
T1058
A
S
M
K
S
L
L
T
S
R
P
E
D
T
T
Site 94
S1059
S
M
K
S
L
L
T
S
R
P
E
D
T
T
H
Site 95
T1065
T
S
R
P
E
D
T
T
H
N
R
R
S
R
G
Site 96
S1070
D
T
T
H
N
R
R
S
R
G
M
V
Q
S
S
Site 97
S1076
R
S
R
G
M
V
Q
S
S
S
P
I
M
P
T
Site 98
S1077
S
R
G
M
V
Q
S
S
S
P
I
M
P
T
V
Site 99
S1078
R
G
M
V
Q
S
S
S
P
I
M
P
T
V
G
Site 100
T1083
S
S
S
P
I
M
P
T
V
G
P
S
T
A
S
Site 101
T1088
M
P
T
V
G
P
S
T
A
S
P
E
E
P
P
Site 102
S1090
T
V
G
P
S
T
A
S
P
E
E
P
P
G
S
Site 103
S1097
S
P
E
E
P
P
G
S
S
L
P
S
D
T
S
Site 104
S1098
P
E
E
P
P
G
S
S
L
P
S
D
T
S
D
Site 105
S1101
P
P
G
S
S
L
P
S
D
T
S
D
E
I
M
Site 106
T1103
G
S
S
L
P
S
D
T
S
D
E
I
M
D
L
Site 107
S1104
S
S
L
P
S
D
T
S
D
E
I
M
D
L
L
Site 108
S1114
I
M
D
L
L
V
Q
S
V
T
K
S
S
P
R
Site 109
S1119
V
Q
S
V
T
K
S
S
P
R
A
L
A
A
R
Site 110
S1131
A
A
R
E
R
K
R
S
R
G
N
R
K
S
L
Site 111
S1137
R
S
R
G
N
R
K
S
L
R
R
T
L
K
S
Site 112
T1141
N
R
K
S
L
R
R
T
L
K
S
G
L
G
D
Site 113
S1144
S
L
R
R
T
L
K
S
G
L
G
D
D
L
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation