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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NCOR2
Full Name:
Nuclear receptor corepressor 2
Alias:
CTG repeat protein 26; CTG26; N-CoR2; NCR2; Nuclear receptor co-repressor 2; Nuclear receptor corepressor 2: Silencing mediator of retinoic acid and thyroid hormone receptor: Thyroid-, retinoic-acid-receptor-associated corepressor: T3 receptor-associating factor: CTG repeat protein 26: SMAP270: Putative uncharacterized protein: Nuclear receptor corepressor 2: Silencing mediator of retinoic acid and thyroid hormone receptor: Thyroid-, retinoic-acid-receptor-associated corepressor: T3 receptor-associating factor: CTG repeat protein 26: SMAP270; Silencing mediator of retinoic acid and thyroid hormone receptor; SMAP270; SMRT; SMRTe; T3 receptor- associating factor; Thyroid-, retinoic-acid-receptor-associated corepressor; TNRC14; TRAC; TRAC-1
Type:
Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Mass (Da):
274804
Number AA:
2525
UniProt ID:
Q9Y618
International Prot ID:
IPI00001735
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016604
GO:0017053
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0005112
GO:0047485
PhosphoSite+
KinaseNET
Biological Process:
GO:0010553
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T15
V
A
Q
T
W
R
A
T
E
P
R
Y
P
P
H
Site 2
Y19
W
R
A
T
E
P
R
Y
P
P
H
S
L
S
Y
Site 3
S23
E
P
R
Y
P
P
H
S
L
S
Y
P
V
Q
I
Site 4
S25
R
Y
P
P
H
S
L
S
Y
P
V
Q
I
A
R
Site 5
T33
Y
P
V
Q
I
A
R
T
H
T
D
V
G
L
L
Site 6
T35
V
Q
I
A
R
T
H
T
D
V
G
L
L
E
Y
Site 7
Y42
T
D
V
G
L
L
E
Y
Q
H
H
S
R
D
Y
Site 8
S46
L
L
E
Y
Q
H
H
S
R
D
Y
A
S
H
L
Site 9
Y49
Y
Q
H
H
S
R
D
Y
A
S
H
L
S
P
G
Site 10
S51
H
H
S
R
D
Y
A
S
H
L
S
P
G
S
I
Site 11
S54
R
D
Y
A
S
H
L
S
P
G
S
I
I
Q
P
Site 12
S57
A
S
H
L
S
P
G
S
I
I
Q
P
Q
R
R
Site 13
S67
Q
P
Q
R
R
R
P
S
L
L
S
E
F
Q
P
Site 14
S70
R
R
R
P
S
L
L
S
E
F
Q
P
G
N
E
Site 15
S79
F
Q
P
G
N
E
R
S
Q
E
L
H
L
R
P
Site 16
S88
E
L
H
L
R
P
E
S
H
S
Y
L
P
E
L
Site 17
S90
H
L
R
P
E
S
H
S
Y
L
P
E
L
G
K
Site 18
Y91
L
R
P
E
S
H
S
Y
L
P
E
L
G
K
S
Site 19
S98
Y
L
P
E
L
G
K
S
E
M
E
F
I
E
S
Site 20
S105
S
E
M
E
F
I
E
S
K
R
P
R
L
E
L
Site 21
S121
P
D
P
L
L
R
P
S
P
L
L
A
T
G
Q
Site 22
T126
R
P
S
P
L
L
A
T
G
Q
P
A
G
S
E
Site 23
T136
P
A
G
S
E
D
L
T
K
D
R
S
L
T
G
Site 24
S140
E
D
L
T
K
D
R
S
L
T
G
K
L
E
P
Site 25
T142
L
T
K
D
R
S
L
T
G
K
L
E
P
V
S
Site 26
S149
T
G
K
L
E
P
V
S
P
P
S
P
P
H
T
Site 27
S152
L
E
P
V
S
P
P
S
P
P
H
T
D
P
E
Site 28
T156
S
P
P
S
P
P
H
T
D
P
E
L
E
L
V
Site 29
S168
E
L
V
P
P
R
L
S
K
E
E
L
I
Q
N
Site 30
T184
D
R
V
D
R
E
I
T
M
V
E
Q
Q
I
S
Site 31
S191
T
M
V
E
Q
Q
I
S
K
L
K
K
K
Q
Q
Site 32
S215
P
E
P
E
K
P
V
S
P
P
P
I
E
S
K
Site 33
S221
V
S
P
P
P
I
E
S
K
H
R
S
L
V
Q
Site 34
S225
P
I
E
S
K
H
R
S
L
V
Q
I
I
Y
D
Site 35
Y231
R
S
L
V
Q
I
I
Y
D
E
N
R
K
K
A
Site 36
Y257
P
Q
V
E
L
P
L
Y
N
Q
P
S
D
T
R
Site 37
S261
L
P
L
Y
N
Q
P
S
D
T
R
Q
Y
H
E
Site 38
Y266
Q
P
S
D
T
R
Q
Y
H
E
N
I
K
I
N
Site 39
Y283
M
R
K
K
L
I
L
Y
F
K
R
R
N
H
A
Site 40
Y302
E
Q
K
F
C
Q
R
Y
D
Q
L
M
E
A
W
Site 41
S327
P
R
R
R
A
K
E
S
K
V
R
E
Y
Y
E
Site 42
Y332
K
E
S
K
V
R
E
Y
Y
E
K
Q
F
P
E
Site 43
Y333
E
S
K
V
R
E
Y
Y
E
K
Q
F
P
E
I
Site 44
S352
E
L
Q
E
R
M
Q
S
R
V
G
Q
R
G
S
Site 45
S359
S
R
V
G
Q
R
G
S
G
L
S
M
S
A
A
Site 46
S362
G
Q
R
G
S
G
L
S
M
S
A
A
R
S
E
Site 47
S364
R
G
S
G
L
S
M
S
A
A
R
S
E
H
E
Site 48
S368
L
S
M
S
A
A
R
S
E
H
E
V
S
E
I
Site 49
S373
A
R
S
E
H
E
V
S
E
I
I
D
G
L
S
Site 50
S380
S
E
I
I
D
G
L
S
E
Q
E
N
L
E
K
Site 51
Y400
A
V
I
P
P
M
L
Y
D
A
D
Q
Q
R
I
Site 52
T439
W
S
E
Q
E
K
E
T
F
R
E
K
F
M
Q
Site 53
Y469
T
V
A
E
C
V
L
Y
Y
Y
L
T
K
K
N
Site 54
Y471
A
E
C
V
L
Y
Y
Y
L
T
K
K
N
E
N
Site 55
S481
K
K
N
E
N
Y
K
S
L
V
R
R
S
Y
R
Site 56
S486
Y
K
S
L
V
R
R
S
Y
R
R
R
G
K
S
Site 57
Y487
K
S
L
V
R
R
S
Y
R
R
R
G
K
S
Q
Site 58
S493
S
Y
R
R
R
G
K
S
Q
Q
Q
Q
Q
Q
Q
Site 59
S516
Q
Q
P
M
P
R
S
S
Q
E
E
K
D
E
K
Site 60
T550
E
D
L
L
K
E
K
T
D
D
T
S
G
E
D
Site 61
T553
L
K
E
K
T
D
D
T
S
G
E
D
N
D
E
Site 62
S554
K
E
K
T
D
D
T
S
G
E
D
N
D
E
K
Site 63
S566
D
E
K
E
A
V
A
S
K
G
R
K
T
A
N
Site 64
T571
V
A
S
K
G
R
K
T
A
N
S
Q
G
R
R
Site 65
S574
K
G
R
K
T
A
N
S
Q
G
R
R
K
G
R
Site 66
T583
G
R
R
K
G
R
I
T
R
S
M
A
N
E
A
Site 67
S585
R
K
G
R
I
T
R
S
M
A
N
E
A
N
S
Site 68
T597
A
N
S
E
E
A
I
T
P
Q
Q
S
A
E
L
Site 69
S612
A
S
M
E
L
N
E
S
S
R
W
T
E
E
E
Site 70
T616
L
N
E
S
S
R
W
T
E
E
E
M
E
T
A
Site 71
T622
W
T
E
E
E
M
E
T
A
K
K
G
L
L
E
Site 72
S635
L
E
H
G
R
N
W
S
A
I
A
R
M
V
G
Site 73
T645
A
R
M
V
G
S
K
T
V
S
Q
C
K
N
F
Site 74
Y653
V
S
Q
C
K
N
F
Y
F
N
Y
K
K
R
Q
Site 75
Y656
C
K
N
F
Y
F
N
Y
K
K
R
Q
N
L
D
Site 76
S708
E
D
E
E
M
E
A
S
G
V
S
G
N
E
E
Site 77
T741
G
E
C
S
G
P
A
T
V
N
N
S
S
D
T
Site 78
S745
G
P
A
T
V
N
N
S
S
D
T
E
S
I
P
Site 79
S746
P
A
T
V
N
N
S
S
D
T
E
S
I
P
S
Site 80
T748
T
V
N
N
S
S
D
T
E
S
I
P
S
P
H
Site 81
S750
N
N
S
S
D
T
E
S
I
P
S
P
H
T
E
Site 82
S753
S
D
T
E
S
I
P
S
P
H
T
E
A
A
K
Site 83
T756
E
S
I
P
S
P
H
T
E
A
A
K
D
T
G
Site 84
T772
N
G
P
K
P
P
A
T
L
G
A
D
G
P
P
Site 85
T784
G
P
P
P
G
P
P
T
P
P
P
E
D
I
P
Site 86
T797
I
P
A
P
T
E
P
T
P
A
S
E
A
T
G
Site 87
S800
P
T
E
P
T
P
A
S
E
A
T
G
A
P
T
Site 88
T803
P
T
P
A
S
E
A
T
G
A
P
T
P
P
P
Site 89
T807
S
E
A
T
G
A
P
T
P
P
P
A
P
P
S
Site 90
S814
T
P
P
P
A
P
P
S
P
S
A
P
P
P
V
Site 91
S816
P
P
A
P
P
S
P
S
A
P
P
P
V
V
P
Site 92
S864
K
A
E
E
P
V
K
S
E
C
T
E
E
A
E
Site 93
S900
A
E
K
K
E
G
G
S
G
R
A
T
T
A
K
Site 94
T904
E
G
G
S
G
R
A
T
T
A
K
S
S
G
A
Site 95
T905
G
G
S
G
R
A
T
T
A
K
S
S
G
A
P
Site 96
S915
S
S
G
A
P
Q
D
S
D
S
S
A
T
C
S
Site 97
S917
G
A
P
Q
D
S
D
S
S
A
T
C
S
A
D
Site 98
S918
A
P
Q
D
S
D
S
S
A
T
C
S
A
D
E
Site 99
S922
S
D
S
S
A
T
C
S
A
D
E
V
D
E
A
Site 100
S939
G
D
K
N
R
L
L
S
P
R
P
S
L
L
T
Site 101
S943
R
L
L
S
P
R
P
S
L
L
T
P
T
G
D
Site 102
T946
S
P
R
P
S
L
L
T
P
T
G
D
P
R
A
Site 103
T948
R
P
S
L
L
T
P
T
G
D
P
R
A
N
A
Site 104
S956
G
D
P
R
A
N
A
S
P
Q
K
P
L
D
L
Site 105
T992
P
R
E
D
A
A
P
T
K
P
A
P
P
A
P
Site 106
S1009
P
Q
N
L
Q
P
E
S
D
A
P
Q
Q
P
G
Site 107
S1017
D
A
P
Q
Q
P
G
S
S
P
R
G
K
S
R
Site 108
S1018
A
P
Q
Q
P
G
S
S
P
R
G
K
S
R
S
Site 109
S1023
G
S
S
P
R
G
K
S
R
S
P
A
P
P
A
Site 110
S1025
S
P
R
G
K
S
R
S
P
A
P
P
A
D
K
Site 111
S1059
G
D
P
P
C
W
T
S
G
L
P
F
P
V
P
Site 112
S1074
P
R
E
V
I
K
A
S
P
H
A
P
D
P
S
Site 113
S1081
S
P
H
A
P
D
P
S
A
F
S
Y
A
P
P
Site 114
S1084
A
P
D
P
S
A
F
S
Y
A
P
P
G
H
P
Site 115
Y1085
P
D
P
S
A
F
S
Y
A
P
P
G
H
P
L
Site 116
T1099
L
P
L
G
L
H
D
T
A
R
P
V
L
P
R
Site 117
T1109
P
V
L
P
R
P
P
T
I
S
N
P
P
P
L
Site 118
S1111
L
P
R
P
P
T
I
S
N
P
P
P
L
I
S
Site 119
S1118
S
N
P
P
P
L
I
S
S
A
K
H
P
S
V
Site 120
S1119
N
P
P
P
L
I
S
S
A
K
H
P
S
V
L
Site 121
S1124
I
S
S
A
K
H
P
S
V
L
E
R
Q
I
G
Site 122
S1134
E
R
Q
I
G
A
I
S
Q
G
M
S
V
Q
L
Site 123
S1146
V
Q
L
H
V
P
Y
S
E
H
A
K
A
P
V
Site 124
S1173
P
K
K
L
A
P
F
S
G
V
K
Q
E
Q
L
Site 125
S1181
G
V
K
Q
E
Q
L
S
P
R
G
Q
A
G
P
Site 126
S1191
G
Q
A
G
P
P
E
S
L
G
V
P
T
A
Q
Site 127
T1206
E
A
S
V
L
R
G
T
A
L
G
S
V
P
G
Site 128
S1210
L
R
G
T
A
L
G
S
V
P
G
G
S
I
T
Site 129
S1215
L
G
S
V
P
G
G
S
I
T
K
G
I
P
S
Site 130
T1217
S
V
P
G
G
S
I
T
K
G
I
P
S
T
R
Site 131
S1222
S
I
T
K
G
I
P
S
T
R
V
P
S
D
S
Site 132
T1223
I
T
K
G
I
P
S
T
R
V
P
S
D
S
A
Site 133
S1227
I
P
S
T
R
V
P
S
D
S
A
I
T
Y
R
Site 134
S1229
S
T
R
V
P
S
D
S
A
I
T
Y
R
G
S
Site 135
T1232
V
P
S
D
S
A
I
T
Y
R
G
S
I
T
H
Site 136
Y1233
P
S
D
S
A
I
T
Y
R
G
S
I
T
H
G
Site 137
S1236
S
A
I
T
Y
R
G
S
I
T
H
G
T
P
A
Site 138
T1241
R
G
S
I
T
H
G
T
P
A
D
V
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D
L
Y
L
P
P
P
D
H
G
Site 291
S2205
H
G
A
P
A
R
G
S
P
H
S
E
G
G
K
Site 292
S2208
P
A
R
G
S
P
H
S
E
G
G
K
R
S
P
Site 293
S2214
H
S
E
G
G
K
R
S
P
E
P
N
K
T
S
Site 294
T2220
R
S
P
E
P
N
K
T
S
V
L
G
G
G
E
Site 295
S2221
S
P
E
P
N
K
T
S
V
L
G
G
G
E
D
Site 296
S2234
E
D
G
I
E
P
V
S
P
P
E
G
M
T
E
Site 297
T2240
V
S
P
P
E
G
M
T
E
P
G
H
S
R
S
Site 298
S2245
G
M
T
E
P
G
H
S
R
S
A
V
Y
P
L
Site 299
S2247
T
E
P
G
H
S
R
S
A
V
Y
P
L
L
Y
Site 300
Y2250
G
H
S
R
S
A
V
Y
P
L
L
Y
R
D
G
Site 301
Y2254
S
A
V
Y
P
L
L
Y
R
D
G
E
Q
T
E
Site 302
T2260
L
Y
R
D
G
E
Q
T
E
P
S
R
M
G
S
Site 303
S2263
D
G
E
Q
T
E
P
S
R
M
G
S
K
S
P
Site 304
S2267
T
E
P
S
R
M
G
S
K
S
P
G
N
T
S
Site 305
S2269
P
S
R
M
G
S
K
S
P
G
N
T
S
Q
P
Site 306
T2273
G
S
K
S
P
G
N
T
S
Q
P
P
A
F
F
Site 307
S2274
S
K
S
P
G
N
T
S
Q
P
P
A
F
F
S
Site 308
S2281
S
Q
P
P
A
F
F
S
K
L
T
E
S
N
S
Site 309
S2286
F
F
S
K
L
T
E
S
N
S
A
M
V
K
S
Site 310
S2288
S
K
L
T
E
S
N
S
A
M
V
K
S
K
K
Site 311
S2293
S
N
S
A
M
V
K
S
K
K
Q
E
I
N
K
Site 312
T2304
E
I
N
K
K
L
N
T
H
N
R
N
E
P
E
Site 313
Y2312
H
N
R
N
E
P
E
Y
N
I
S
Q
P
G
T
Site 314
S2315
N
E
P
E
Y
N
I
S
Q
P
G
T
E
I
F
Site 315
T2319
Y
N
I
S
Q
P
G
T
E
I
F
N
M
P
A
Site 316
T2334
I
T
G
T
G
L
M
T
Y
R
S
Q
A
V
Q
Site 317
Y2335
T
G
T
G
L
M
T
Y
R
S
Q
A
V
Q
E
Site 318
S2337
T
G
L
M
T
Y
R
S
Q
A
V
Q
E
H
A
Site 319
T2346
A
V
Q
E
H
A
S
T
N
M
G
L
E
A
I
Site 320
Y2362
R
K
A
L
M
G
K
Y
D
Q
W
E
E
S
P
Site 321
S2368
K
Y
D
Q
W
E
E
S
P
P
L
S
A
N
A
Site 322
S2372
W
E
E
S
P
P
L
S
A
N
A
F
N
P
L
Site 323
T2392
L
P
A
A
M
P
I
T
A
A
D
G
R
S
D
Site 324
T2401
A
D
G
R
S
D
H
T
L
T
S
P
G
G
G
Site 325
T2403
G
R
S
D
H
T
L
T
S
P
G
G
G
G
K
Site 326
S2404
R
S
D
H
T
L
T
S
P
G
G
G
G
K
A
Site 327
S2414
G
G
G
K
A
K
V
S
G
R
P
S
S
R
K
Site 328
S2418
A
K
V
S
G
R
P
S
S
R
K
A
K
S
P
Site 329
S2419
K
V
S
G
R
P
S
S
R
K
A
K
S
P
A
Site 330
S2424
P
S
S
R
K
A
K
S
P
A
P
G
L
A
S
Site 331
S2431
S
P
A
P
G
L
A
S
G
D
R
P
P
S
V
Site 332
S2437
A
S
G
D
R
P
P
S
V
S
S
V
H
S
E
Site 333
S2439
G
D
R
P
P
S
V
S
S
V
H
S
E
G
D
Site 334
S2440
D
R
P
P
S
V
S
S
V
H
S
E
G
D
C
Site 335
S2443
P
S
V
S
S
V
H
S
E
G
D
C
N
R
R
Site 336
T2451
E
G
D
C
N
R
R
T
P
L
T
N
R
V
W
Site 337
T2454
C
N
R
R
T
P
L
T
N
R
V
W
E
D
R
Site 338
S2463
R
V
W
E
D
R
P
S
S
A
G
S
T
P
F
Site 339
S2464
V
W
E
D
R
P
S
S
A
G
S
T
P
F
P
Site 340
S2467
D
R
P
S
S
A
G
S
T
P
F
P
Y
N
P
Site 341
T2468
R
P
S
S
A
G
S
T
P
F
P
Y
N
P
L
Site 342
S2496
P
P
G
L
P
A
G
S
G
P
L
A
G
P
H
Site 343
S2516
E
P
K
P
L
L
C
S
Q
Y
E
T
L
S
D
Site 344
Y2518
K
P
L
L
C
S
Q
Y
E
T
L
S
D
S
E
Site 345
T2520
L
L
C
S
Q
Y
E
T
L
S
D
S
E
_
_
Site 346
S2522
C
S
Q
Y
E
T
L
S
D
S
E
_
_
_
_
Site 347
S2524
Q
Y
E
T
L
S
D
S
E
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation