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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TACC3
Full Name:
Transforming acidic coiled-coil-containing protein 3
Alias:
ERIC1; ERIC-1; TAC3; Transforming acidic coiled-coil-containing protein 3; Transforming, acidic coiled-coil containing protein 3
Type:
Cell cycle regulation
Mass (Da):
90360
Number AA:
838
UniProt ID:
Q9Y6A5
International Prot ID:
IPI00002135
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005813
GO:0005815
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0006950
GO:0030097
GO:0032386
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
E
N
C
D
F
L
F
S
P
P
E
V
T
G
R
Site 2
T30
L
F
S
P
P
E
V
T
G
R
S
S
V
L
R
Site 3
S34
P
E
V
T
G
R
S
S
V
L
R
V
S
Q
K
Site 4
S39
R
S
S
V
L
R
V
S
Q
K
E
N
V
P
P
Site 5
T56
L
A
K
A
M
K
V
T
F
Q
T
P
L
R
D
Site 6
T59
A
M
K
V
T
F
Q
T
P
L
R
D
P
Q
T
Site 7
T66
T
P
L
R
D
P
Q
T
H
R
I
L
S
P
S
Site 8
S71
P
Q
T
H
R
I
L
S
P
S
M
A
S
K
L
Site 9
S73
T
H
R
I
L
S
P
S
M
A
S
K
L
E
A
Site 10
T83
S
K
L
E
A
P
F
T
Q
D
D
T
L
G
L
Site 11
T87
A
P
F
T
Q
D
D
T
L
G
L
E
N
S
H
Site 12
S93
D
T
L
G
L
E
N
S
H
P
V
W
T
Q
K
Site 13
T113
I
K
E
V
D
A
K
T
T
H
G
I
L
Q
K
Site 14
S133
T
D
L
L
G
D
A
S
P
A
F
G
S
G
S
Site 15
S138
D
A
S
P
A
F
G
S
G
S
S
S
E
S
G
Site 16
S140
S
P
A
F
G
S
G
S
S
S
E
S
G
P
G
Site 17
S141
P
A
F
G
S
G
S
S
S
E
S
G
P
G
A
Site 18
S142
A
F
G
S
G
S
S
S
E
S
G
P
G
A
L
Site 19
S144
G
S
G
S
S
S
E
S
G
P
G
A
L
A
D
Site 20
S155
A
L
A
D
L
D
C
S
S
S
S
Q
S
P
G
Site 21
S156
L
A
D
L
D
C
S
S
S
S
Q
S
P
G
S
Site 22
S157
A
D
L
D
C
S
S
S
S
Q
S
P
G
S
S
Site 23
S158
D
L
D
C
S
S
S
S
Q
S
P
G
S
S
E
Site 24
S160
D
C
S
S
S
S
Q
S
P
G
S
S
E
N
Q
Site 25
S163
S
S
S
Q
S
P
G
S
S
E
N
Q
M
V
S
Site 26
S164
S
S
Q
S
P
G
S
S
E
N
Q
M
V
S
P
Site 27
S170
S
S
E
N
Q
M
V
S
P
G
K
V
S
G
S
Site 28
S175
M
V
S
P
G
K
V
S
G
S
P
E
Q
A
V
Site 29
S177
S
P
G
K
V
S
G
S
P
E
Q
A
V
E
E
Site 30
S187
Q
A
V
E
E
N
L
S
S
Y
S
L
D
R
R
Site 31
S188
A
V
E
E
N
L
S
S
Y
S
L
D
R
R
V
Site 32
S190
E
E
N
L
S
S
Y
S
L
D
R
R
V
T
P
Site 33
T196
Y
S
L
D
R
R
V
T
P
A
S
E
T
L
E
Site 34
S199
D
R
R
V
T
P
A
S
E
T
L
E
D
P
C
Site 35
S210
E
D
P
C
R
T
E
S
Q
H
K
A
E
T
P
Site 36
T216
E
S
Q
H
K
A
E
T
P
H
G
A
E
E
E
Site 37
T228
E
E
E
C
K
A
E
T
P
H
G
A
E
E
E
Site 38
T249
C
A
P
A
A
V
A
T
S
P
P
G
A
I
P
Site 39
S250
A
P
A
A
V
A
T
S
P
P
G
A
I
P
K
Site 40
T288
T
P
V
P
A
D
G
T
Q
T
L
T
C
A
H
Site 41
T292
A
D
G
T
Q
T
L
T
C
A
H
T
S
A
P
Site 42
T296
Q
T
L
T
C
A
H
T
S
A
P
E
S
T
A
Site 43
S297
T
L
T
C
A
H
T
S
A
P
E
S
T
A
P
Site 44
S301
A
H
T
S
A
P
E
S
T
A
P
T
N
H
L
Site 45
T305
A
P
E
S
T
A
P
T
N
H
L
V
A
G
R
Site 46
T315
L
V
A
G
R
A
M
T
L
S
P
Q
E
E
V
Site 47
S317
A
G
R
A
M
T
L
S
P
Q
E
E
V
A
A
Site 48
S329
V
A
A
G
Q
M
A
S
S
S
R
S
G
P
V
Site 49
S330
A
A
G
Q
M
A
S
S
S
R
S
G
P
V
K
Site 50
S331
A
G
Q
M
A
S
S
S
R
S
G
P
V
K
L
Site 51
S333
Q
M
A
S
S
S
R
S
G
P
V
K
L
E
F
Site 52
S343
V
K
L
E
F
D
V
S
D
G
A
T
S
K
R
Site 53
T347
F
D
V
S
D
G
A
T
S
K
R
A
P
P
P
Site 54
S348
D
V
S
D
G
A
T
S
K
R
A
P
P
P
R
Site 55
S361
P
R
R
L
G
E
R
S
G
L
K
P
P
L
R
Site 56
S399
E
D
P
P
M
P
A
S
R
G
S
Y
H
L
D
Site 57
S402
P
M
P
A
S
R
G
S
Y
H
L
D
W
D
K
Site 58
Y403
M
P
A
S
R
G
S
Y
H
L
D
W
D
K
M
Site 59
T422
F
I
P
F
G
G
D
T
K
S
G
C
S
E
A
Site 60
S424
P
F
G
G
D
T
K
S
G
C
S
E
A
Q
P
Site 61
S434
S
E
A
Q
P
P
E
S
P
E
T
R
L
G
Q
Site 62
T437
Q
P
P
E
S
P
E
T
R
L
G
Q
P
A
A
Site 63
T453
Q
L
H
A
G
P
A
T
E
E
P
G
P
C
L
Site 64
S461
E
E
P
G
P
C
L
S
Q
Q
L
H
S
A
S
Site 65
S468
S
Q
Q
L
H
S
A
S
A
E
D
T
P
V
V
Site 66
T472
H
S
A
S
A
E
D
T
P
V
V
Q
L
A
A
Site 67
T481
V
V
Q
L
A
A
E
T
P
T
A
E
S
K
E
Site 68
S493
S
K
E
R
A
L
N
S
A
S
T
S
L
P
T
Site 69
S495
E
R
A
L
N
S
A
S
T
S
L
P
T
S
C
Site 70
T496
R
A
L
N
S
A
S
T
S
L
P
T
S
C
P
Site 71
S497
A
L
N
S
A
S
T
S
L
P
T
S
C
P
G
Site 72
T500
S
A
S
T
S
L
P
T
S
C
P
G
S
E
P
Site 73
S501
A
S
T
S
L
P
T
S
C
P
G
S
E
P
V
Site 74
S505
L
P
T
S
C
P
G
S
E
P
V
P
T
H
Q
Site 75
T510
P
G
S
E
P
V
P
T
H
Q
Q
G
Q
P
A
Site 76
S524
A
L
E
L
K
E
E
S
F
R
D
P
A
E
V
Site 77
T534
D
P
A
E
V
L
G
T
G
A
E
V
D
Y
L
Site 78
Y540
G
T
G
A
E
V
D
Y
L
E
Q
F
G
T
S
Site 79
T546
D
Y
L
E
Q
F
G
T
S
S
F
K
E
S
A
Site 80
S548
L
E
Q
F
G
T
S
S
F
K
E
S
A
L
R
Site 81
S552
G
T
S
S
F
K
E
S
A
L
R
K
Q
S
L
Site 82
S558
E
S
A
L
R
K
Q
S
L
Y
L
K
F
D
P
Site 83
Y560
A
L
R
K
Q
S
L
Y
L
K
F
D
P
L
L
Site 84
S570
F
D
P
L
L
R
D
S
P
G
R
P
V
P
V
Site 85
T579
G
R
P
V
P
V
A
T
E
T
S
S
M
H
G
Site 86
S583
P
V
A
T
E
T
S
S
M
H
G
A
N
E
T
Site 87
T590
S
M
H
G
A
N
E
T
P
S
G
R
P
R
E
Site 88
S592
H
G
A
N
E
T
P
S
G
R
P
R
E
A
K
Site 89
S660
E
E
N
R
E
L
R
S
R
C
E
E
L
H
G
Site 90
Y684
D
R
F
E
E
V
V
Y
Q
A
M
E
E
V
Q
Site 91
T712
L
K
E
K
D
Q
L
T
T
D
L
N
S
M
E
Site 92
S717
Q
L
T
T
D
L
N
S
M
E
K
S
F
S
D
Site 93
S721
D
L
N
S
M
E
K
S
F
S
D
L
F
K
R
Site 94
S723
N
S
M
E
K
S
F
S
D
L
F
K
R
F
E
Site 95
Y739
Q
K
E
V
I
E
G
Y
R
K
N
E
E
S
L
Site 96
S745
G
Y
R
K
N
E
E
S
L
K
K
C
V
E
D
Site 97
Y753
L
K
K
C
V
E
D
Y
L
A
R
I
T
Q
E
Site 98
T758
E
D
Y
L
A
R
I
T
Q
E
G
Q
R
Y
Q
Site 99
Y764
I
T
Q
E
G
Q
R
Y
Q
A
L
K
A
H
A
Site 100
S799
E
A
L
A
L
Q
A
S
L
R
K
E
Q
M
R
Site 101
S809
K
E
Q
M
R
I
Q
S
L
E
K
T
V
E
Q
Site 102
T813
R
I
Q
S
L
E
K
T
V
E
Q
K
T
K
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation