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Updated November 2019
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Protein Info
Short Name:
PTCH2
Full Name:
Protein patched homolog 2
Alias:
Type:
Mass (Da):
130544
Number AA:
1203
UniProt ID:
Q9Y6C5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T2
_
_
_
_
_
_
M
T
R
S
P
P
L
R
E
Site 2
S4
_
_
_
_
M
T
R
S
P
P
L
R
E
L
P
Site 3
S13
P
L
R
E
L
P
P
S
Y
T
P
P
A
R
T
Site 4
Y14
L
R
E
L
P
P
S
Y
T
P
P
A
R
T
A
Site 5
T15
R
E
L
P
P
S
Y
T
P
P
A
R
T
A
A
Site 6
S91
Q
L
W
V
E
V
G
S
R
V
S
Q
E
L
H
Site 7
S94
V
E
V
G
S
R
V
S
Q
E
L
H
Y
T
K
Site 8
T100
V
S
Q
E
L
H
Y
T
K
E
K
L
G
E
E
Site 9
Y110
K
L
G
E
E
A
A
Y
T
S
Q
M
L
I
Q
Site 10
T111
L
G
E
E
A
A
Y
T
S
Q
M
L
I
Q
T
Site 11
T128
Q
E
G
E
N
I
L
T
P
E
A
L
G
L
H
Site 12
S148
T
A
S
K
V
Q
V
S
L
Y
G
K
S
W
D
Site 13
Y150
S
K
V
Q
V
S
L
Y
G
K
S
W
D
L
N
Site 14
S163
L
N
K
I
C
Y
K
S
G
V
P
L
I
E
N
Site 15
Y204
K
L
Q
G
G
S
A
Y
L
P
G
R
P
D
I
Site 16
S230
E
E
L
G
P
F
A
S
L
E
G
F
R
E
L
Site 17
Y247
K
A
Q
V
G
Q
A
Y
V
G
R
P
C
L
H
Site 18
S263
D
D
L
H
C
P
P
S
A
P
N
H
H
S
R
Site 19
S280
P
N
V
A
H
E
L
S
G
G
C
H
G
F
S
Site 20
T319
R
A
E
A
L
Q
S
T
F
L
L
M
S
P
R
Site 21
S324
Q
S
T
F
L
L
M
S
P
R
Q
L
Y
E
H
Site 22
Y329
L
M
S
P
R
Q
L
Y
E
H
F
R
G
D
Y
Site 23
Y336
Y
E
H
F
R
G
D
Y
Q
T
H
D
I
G
W
Site 24
T350
W
S
E
E
Q
A
S
T
V
L
Q
A
W
Q
R
Site 25
S372
E
A
L
P
E
N
A
S
Q
Q
I
H
A
F
S
Site 26
S421
L
R
W
D
C
A
Q
S
Q
G
S
V
G
L
A
Site 27
T485
F
T
E
A
L
P
G
T
P
L
Q
E
R
M
G
Site 28
T588
P
Q
E
L
G
D
G
T
V
P
V
G
I
A
H
Site 29
S628
A
H
L
V
P
P
P
S
D
P
L
G
S
E
L
Site 30
S633
P
P
S
D
P
L
G
S
E
L
F
S
P
G
G
Site 31
S637
P
L
G
S
E
L
F
S
P
G
G
S
T
R
D
Site 32
S641
E
L
F
S
P
G
G
S
T
R
D
L
L
G
Q
Site 33
T721
T
D
V
V
P
R
G
T
K
E
H
A
F
L
S
Site 34
S728
T
K
E
H
A
F
L
S
A
Q
L
R
Y
F
S
Site 35
Y749
V
T
Q
G
G
F
D
Y
A
H
S
Q
R
A
L
Site 36
S752
G
G
F
D
Y
A
H
S
Q
R
A
L
F
D
L
Site 37
S764
F
D
L
H
Q
R
F
S
S
L
K
A
V
L
P
Site 38
S765
D
L
H
Q
R
F
S
S
L
K
A
V
L
P
P
Site 39
T775
A
V
L
P
P
P
A
T
Q
A
P
R
T
W
L
Site 40
S802
A
F
D
Q
D
W
A
S
G
R
I
T
R
H
S
Site 41
S809
S
G
R
I
T
R
H
S
Y
R
N
G
S
E
D
Site 42
Y810
G
R
I
T
R
H
S
Y
R
N
G
S
E
D
G
Site 43
S814
R
H
S
Y
R
N
G
S
E
D
G
A
L
A
Y
Site 44
S837
A
Q
E
P
L
D
F
S
Q
L
T
T
R
K
L
Site 45
T840
P
L
D
F
S
Q
L
T
T
R
K
L
V
D
R
Site 46
S874
D
P
L
G
L
A
A
S
Q
A
N
F
Y
P
P
Site 47
Y879
A
A
S
Q
A
N
F
Y
P
P
P
P
E
W
L
Site 48
Y890
P
E
W
L
H
D
K
Y
D
T
T
G
E
N
L
Site 49
T893
L
H
D
K
Y
D
T
T
G
E
N
L
R
I
P
Site 50
Y945
G
Q
A
G
V
H
A
Y
P
S
G
S
P
F
L
Site 51
S949
V
H
A
Y
P
S
G
S
P
F
L
F
W
E
Q
Site 52
S1046
G
F
L
T
T
Q
G
S
R
N
L
R
A
A
H
Site 53
Y1124
P
P
E
V
I
Q
M
Y
K
E
S
P
E
I
L
Site 54
S1127
V
I
Q
M
Y
K
E
S
P
E
I
L
S
P
P
Site 55
S1132
K
E
S
P
E
I
L
S
P
P
A
P
Q
G
G
Site 56
S1146
G
G
L
R
W
G
A
S
S
S
L
P
Q
S
F
Site 57
S1147
G
L
R
W
G
A
S
S
S
L
P
Q
S
F
A
Site 58
S1148
L
R
W
G
A
S
S
S
L
P
Q
S
F
A
R
Site 59
S1152
A
S
S
S
L
P
Q
S
F
A
R
V
T
T
S
Site 60
Y1173
P
P
P
L
P
G
A
Y
I
H
P
A
P
D
E
Site 61
S1184
A
P
D
E
P
P
W
S
P
A
A
T
S
S
G
Site 62
T1188
P
P
W
S
P
A
A
T
S
S
G
N
L
S
S
Site 63
S1189
P
W
S
P
A
A
T
S
S
G
N
L
S
S
R
Site 64
S1190
W
S
P
A
A
T
S
S
G
N
L
S
S
R
G
Site 65
S1194
A
T
S
S
G
N
L
S
S
R
G
P
G
P
A
Site 66
S1195
T
S
S
G
N
L
S
S
R
G
P
G
P
A
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation