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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MAD1L1
Full Name:
Mitotic spindle assembly checkpoint protein MAD1
Alias:
HMAD1; HsMAD1; MAD1; MAD1 mitotic arrest deficient-like 1; MAD1-like 1; MD11; MD1L1; Mitotic arrest deficient-like protein 1; Mitotic checkpoint MAD1 protein-homolog; PIG9; Tax binding protein-181; TP53I9; TXBP181
Type:
Cell cycle regulation; Cytoskeletal protein
Mass (Da):
83067
Number AA:
718
UniProt ID:
Q9Y6D9
International Prot ID:
IPI00470518
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005813
GO:0000777
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0051301
GO:0000090
GO:0007093
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
E
D
L
G
E
N
T
M
V
L
S
T
L
R
Site 2
S12
G
E
N
T
M
V
L
S
T
L
R
S
L
N
N
Site 3
T13
E
N
T
M
V
L
S
T
L
R
S
L
N
N
F
Site 4
S16
M
V
L
S
T
L
R
S
L
N
N
F
I
S
Q
Site 5
S22
R
S
L
N
N
F
I
S
Q
R
V
E
G
G
S
Site 6
S29
S
Q
R
V
E
G
G
S
G
L
D
I
S
T
S
Site 7
S34
G
G
S
G
L
D
I
S
T
S
A
P
G
S
L
Site 8
T35
G
S
G
L
D
I
S
T
S
A
P
G
S
L
Q
Site 9
S36
S
G
L
D
I
S
T
S
A
P
G
S
L
Q
M
Site 10
S40
I
S
T
S
A
P
G
S
L
Q
M
Q
Y
Q
Q
Site 11
Y45
P
G
S
L
Q
M
Q
Y
Q
Q
S
M
Q
L
E
Site 12
S62
A
E
Q
I
R
S
K
S
H
L
I
Q
V
E
R
Site 13
S77
E
K
M
Q
M
E
L
S
H
K
R
A
R
V
E
Site 14
S90
V
E
L
E
R
A
A
S
T
S
A
R
N
Y
E
Site 15
S92
L
E
R
A
A
S
T
S
A
R
N
Y
E
R
E
Site 16
Y96
A
S
T
S
A
R
N
Y
E
R
E
V
D
R
N
Site 17
S142
Q
Q
N
L
D
A
A
S
K
R
L
R
E
K
E
Site 18
S151
R
L
R
E
K
E
D
S
L
A
Q
A
G
E
T
Site 19
S167
N
A
L
K
G
R
I
S
E
L
Q
W
S
V
M
Site 20
S185
M
R
V
K
R
L
E
S
E
K
Q
E
L
Q
E
Site 21
S214
K
I
Q
E
L
Q
A
S
Q
E
A
R
A
D
H
Site 22
S233
K
D
L
E
Q
K
L
S
L
Q
E
Q
D
A
A
Site 23
S247
A
I
V
K
N
M
K
S
E
L
V
R
L
P
R
Site 24
S266
L
K
Q
L
R
E
E
S
A
H
L
R
E
M
R
Site 25
T275
H
L
R
E
M
R
E
T
N
G
L
L
Q
E
E
Site 26
S316
R
L
L
A
K
L
Q
S
W
E
R
L
D
Q
T
Site 27
T323
S
W
E
R
L
D
Q
T
M
G
L
S
I
R
T
Site 28
S327
L
D
Q
T
M
G
L
S
I
R
T
P
E
D
L
Site 29
T330
T
M
G
L
S
I
R
T
P
E
D
L
S
R
F
Site 30
S353
L
A
L
K
D
K
N
S
A
V
T
S
S
A
R
Site 31
S357
D
K
N
S
A
V
T
S
S
A
R
G
L
E
K
Site 32
S358
K
N
S
A
V
T
S
S
A
R
G
L
E
K
A
Site 33
S377
Q
E
E
L
R
Q
V
S
G
Q
L
L
E
E
R
Site 34
T389
E
E
R
K
K
R
E
T
H
E
A
L
A
R
R
Site 35
T405
Q
K
R
V
L
L
L
T
K
E
R
D
G
M
R
Site 36
S417
G
M
R
A
I
L
G
S
Y
D
S
E
L
T
P
Site 37
S420
A
I
L
G
S
Y
D
S
E
L
T
P
A
E
Y
Site 38
T423
G
S
Y
D
S
E
L
T
P
A
E
Y
S
P
Q
Site 39
Y427
S
E
L
T
P
A
E
Y
S
P
Q
L
T
R
R
Site 40
S428
E
L
T
P
A
E
Y
S
P
Q
L
T
R
R
M
Site 41
T432
A
E
Y
S
P
Q
L
T
R
R
M
R
E
A
E
Site 42
S457
A
E
M
E
A
Q
L
S
Q
A
L
E
E
L
G
Site 43
S482
M
E
L
K
M
L
K
S
Q
S
S
S
A
E
Q
Site 44
S484
L
K
M
L
K
S
Q
S
S
S
A
E
Q
S
F
Site 45
S485
K
M
L
K
S
Q
S
S
S
A
E
Q
S
F
L
Site 46
S486
M
L
K
S
Q
S
S
S
A
E
Q
S
F
L
F
Site 47
S490
Q
S
S
S
A
E
Q
S
F
L
F
S
R
E
E
Site 48
S494
A
E
Q
S
F
L
F
S
R
E
E
A
D
T
L
Site 49
T500
F
S
R
E
E
A
D
T
L
R
L
K
V
E
E
Site 50
S513
E
E
L
E
G
E
R
S
R
L
E
E
E
K
R
Site 51
Y535
R
R
A
L
Q
G
D
Y
D
Q
S
R
T
K
V
Site 52
S538
L
Q
G
D
Y
D
Q
S
R
T
K
V
L
H
M
Site 53
S546
R
T
K
V
L
H
M
S
L
N
P
T
S
V
A
Site 54
T550
L
H
M
S
L
N
P
T
S
V
A
R
Q
R
L
Site 55
S551
H
M
S
L
N
P
T
S
V
A
R
Q
R
L
R
Site 56
S562
Q
R
L
R
E
D
H
S
Q
L
Q
A
E
C
E
Site 57
T583
R
A
M
E
R
G
G
T
V
P
A
D
L
E
A
Site 58
S594
D
L
E
A
A
A
A
S
L
P
S
S
K
E
V
Site 59
S597
A
A
A
A
S
L
P
S
S
K
E
V
A
E
L
Site 60
S598
A
A
A
S
L
P
S
S
K
E
V
A
E
L
K
Site 61
T624
R
L
K
E
V
F
Q
T
K
I
Q
E
F
R
K
Site 62
Y634
Q
E
F
R
K
A
C
Y
T
L
T
G
Y
Q
I
Site 63
T635
E
F
R
K
A
C
Y
T
L
T
G
Y
Q
I
D
Site 64
T644
T
G
Y
Q
I
D
I
T
T
E
N
Q
Y
R
L
Site 65
Y649
D
I
T
T
E
N
Q
Y
R
L
T
S
L
Y
A
Site 66
T652
T
E
N
Q
Y
R
L
T
S
L
Y
A
E
H
P
Site 67
S653
E
N
Q
Y
R
L
T
S
L
Y
A
E
H
P
G
Site 68
Y655
Q
Y
R
L
T
S
L
Y
A
E
H
P
G
D
C
Site 69
T668
D
C
L
I
F
K
A
T
S
P
S
G
S
K
M
Site 70
S669
C
L
I
F
K
A
T
S
P
S
G
S
K
M
Q
Site 71
S671
I
F
K
A
T
S
P
S
G
S
K
M
Q
L
L
Site 72
S673
K
A
T
S
P
S
G
S
K
M
Q
L
L
E
T
Site 73
T680
S
K
M
Q
L
L
E
T
E
F
S
H
T
V
G
Site 74
S699
V
H
L
R
R
Q
D
S
I
P
A
F
L
S
S
Site 75
T708
P
A
F
L
S
S
L
T
L
E
L
F
S
R
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation