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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PARP3
Full Name:
Poly [ADP-ribose] polymerase 3
Alias:
ADP-ribosyltransferase 3; ADPRT3; ADPRTL2; ADPRTL3; IRT1; NAD+ ADP-ribosyltransferase 3; pADPRT-3; PARP-3; poly (ADP-ribose) polymerase family, member 3; poly(ADP-ribose) polymerase 3; poly(ADP-ribose) synthetase-3
Type:
EC 2.4.2.30; DNA repair; Transferase
Mass (Da):
60089
Number AA:
533
UniProt ID:
Q9Y6F1
International Prot ID:
IPI00023184
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005814
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003950
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006281
GO:0006471
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T32
E
E
D
P
F
R
S
T
A
E
A
L
K
A
I
Site 2
T51
R
I
I
R
V
D
P
T
C
P
L
S
S
N
P
Site 3
S55
V
D
P
T
C
P
L
S
S
N
P
G
T
Q
V
Site 4
S56
D
P
T
C
P
L
S
S
N
P
G
T
Q
V
Y
Site 5
T60
P
L
S
S
N
P
G
T
Q
V
Y
E
D
Y
N
Site 6
Y63
S
N
P
G
T
Q
V
Y
E
D
Y
N
C
T
L
Site 7
Y66
G
T
Q
V
Y
E
D
Y
N
C
T
L
N
Q
T
Site 8
S110
R
V
G
E
V
G
Q
S
K
I
N
H
F
T
R
Site 9
T133
E
K
K
F
R
E
K
T
K
N
N
W
A
E
R
Site 10
S145
A
E
R
D
H
F
V
S
H
P
G
K
Y
T
L
Site 11
T175
V
D
R
G
P
V
R
T
V
T
K
R
V
Q
P
Site 12
T177
R
G
P
V
R
T
V
T
K
R
V
Q
P
C
S
Site 13
S184
T
K
R
V
Q
P
C
S
L
D
P
A
T
Q
K
Site 14
T189
P
C
S
L
D
P
A
T
Q
K
L
I
T
N
I
Site 15
T194
P
A
T
Q
K
L
I
T
N
I
F
S
K
E
M
Site 16
T205
S
K
E
M
F
K
N
T
M
A
L
M
D
L
D
Site 17
S249
G
P
T
D
G
G
Q
S
L
E
E
L
S
S
H
Site 18
S255
Q
S
L
E
E
L
S
S
H
F
Y
T
V
I
P
Site 19
Y258
E
E
L
S
S
H
F
Y
T
V
I
P
H
N
F
Site 20
T259
E
L
S
S
H
F
Y
T
V
I
P
H
N
F
G
Site 21
S268
I
P
H
N
F
G
H
S
Q
P
P
P
I
N
S
Site 22
S275
S
Q
P
P
P
I
N
S
P
E
L
L
Q
A
K
Site 23
T307
A
V
S
E
Q
E
K
T
V
E
E
V
P
H
P
Site 24
Y319
P
H
P
L
D
R
D
Y
Q
L
L
K
C
Q
L
Site 25
S331
C
Q
L
Q
L
L
D
S
G
A
P
E
Y
K
V
Site 26
Y336
L
D
S
G
A
P
E
Y
K
V
I
Q
T
Y
L
Site 27
Y342
E
Y
K
V
I
Q
T
Y
L
E
Q
T
G
S
N
Site 28
S348
T
Y
L
E
Q
T
G
S
N
H
R
C
P
T
L
Site 29
S374
E
D
R
F
Q
A
H
S
K
L
G
N
R
K
L
Site 30
S405
G
L
R
I
M
P
H
S
G
G
R
V
G
K
G
Site 31
Y414
G
R
V
G
K
G
I
Y
F
A
S
E
N
S
K
Site 32
S417
G
K
G
I
Y
F
A
S
E
N
S
K
S
A
G
Site 33
S422
F
A
S
E
N
S
K
S
A
G
Y
V
I
G
M
Site 34
Y425
E
N
S
K
S
A
G
Y
V
I
G
M
K
C
G
Site 35
T454
G
R
E
H
H
I
N
T
D
N
P
S
L
K
S
Site 36
S458
H
I
N
T
D
N
P
S
L
K
S
P
P
P
G
Site 37
S461
T
D
N
P
S
L
K
S
P
P
P
G
F
D
S
Site 38
S468
S
P
P
P
G
F
D
S
V
I
A
R
G
H
T
Site 39
T475
S
V
I
A
R
G
H
T
E
P
D
P
T
Q
D
Site 40
T480
G
H
T
E
P
D
P
T
Q
D
T
E
L
E
L
Site 41
S506
P
V
P
C
P
E
F
S
S
S
T
F
S
Q
S
Site 42
S507
V
P
C
P
E
F
S
S
S
T
F
S
Q
S
E
Site 43
S508
P
C
P
E
F
S
S
S
T
F
S
Q
S
E
Y
Site 44
T509
C
P
E
F
S
S
S
T
F
S
Q
S
E
Y
L
Site 45
S511
E
F
S
S
S
T
F
S
Q
S
E
Y
L
I
Y
Site 46
S513
S
S
S
T
F
S
Q
S
E
Y
L
I
Y
Q
E
Site 47
Y515
S
T
F
S
Q
S
E
Y
L
I
Y
Q
E
S
Q
Site 48
Y518
S
Q
S
E
Y
L
I
Y
Q
E
S
Q
C
R
L
Site 49
Y527
E
S
Q
C
R
L
R
Y
L
L
E
V
H
L
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation