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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MRVI1
Full Name:
Protein MRVI1
Alias:
Inositol 1,4,5-triphosphate-associated cGMP kinase substrate; IP3R-associated cGMP kinase substrate; IRAG; JAW1L; JAW1-related protein; Murine retrovirus integration site 1; Retrovirus integration site 1 homolog
Type:
Adapter/scaffold protein
Mass (Da):
96145
Number AA:
885
UniProt ID:
Q9Y6F6
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005789
GO:0016021
GO:0048471
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T34
D
A
A
E
V
P
G
T
R
G
H
S
Q
Q
E
Site 2
S38
V
P
G
T
R
G
H
S
Q
Q
E
A
A
M
P
Site 3
S62
G
E
P
Q
A
A
Q
S
P
A
G
Q
G
P
P
Site 4
T84
P
T
P
T
I
V
L
T
G
D
A
T
S
P
E
Site 5
T88
I
V
L
T
G
D
A
T
S
P
E
G
E
T
D
Site 6
S89
V
L
T
G
D
A
T
S
P
E
G
E
T
D
K
Site 7
S104
N
L
A
N
R
V
H
S
P
H
K
R
L
S
H
Site 8
S110
H
S
P
H
K
R
L
S
H
R
H
L
K
V
S
Site 9
S117
S
H
R
H
L
K
V
S
T
A
S
L
T
S
V
Site 10
S142
N
D
Q
L
P
D
I
S
I
S
E
E
D
K
K
Site 11
S162
L
E
E
A
K
L
V
S
E
R
F
L
T
R
R
Site 12
T167
L
V
S
E
R
F
L
T
R
R
G
R
K
S
R
Site 13
S173
L
T
R
R
G
R
K
S
R
S
S
P
G
D
S
Site 14
S175
R
R
G
R
K
S
R
S
S
P
G
D
S
P
S
Site 15
S176
R
G
R
K
S
R
S
S
P
G
D
S
P
S
A
Site 16
S180
S
R
S
S
P
G
D
S
P
S
A
V
S
P
N
Site 17
S182
S
S
P
G
D
S
P
S
A
V
S
P
N
L
S
Site 18
S185
G
D
S
P
S
A
V
S
P
N
L
S
P
S
A
Site 19
S189
S
A
V
S
P
N
L
S
P
S
A
S
P
T
S
Site 20
S191
V
S
P
N
L
S
P
S
A
S
P
T
S
S
R
Site 21
S193
P
N
L
S
P
S
A
S
P
T
S
S
R
S
N
Site 22
T195
L
S
P
S
A
S
P
T
S
S
R
S
N
S
L
Site 23
S196
S
P
S
A
S
P
T
S
S
R
S
N
S
L
T
Site 24
S197
P
S
A
S
P
T
S
S
R
S
N
S
L
T
V
Site 25
S199
A
S
P
T
S
S
R
S
N
S
L
T
V
P
T
Site 26
S201
P
T
S
S
R
S
N
S
L
T
V
P
T
P
P
Site 27
T203
S
S
R
S
N
S
L
T
V
P
T
P
P
D
G
Site 28
T206
S
N
S
L
T
V
P
T
P
P
D
G
D
E
A
Site 29
S216
D
G
D
E
A
D
V
S
S
P
H
P
G
E
P
Site 30
S217
G
D
E
A
D
V
S
S
P
H
P
G
E
P
N
Site 31
S241
Q
N
D
Q
R
K
V
S
Q
G
R
L
A
P
R
Site 32
Y271
E
N
F
D
P
L
Q
Y
P
E
T
T
P
K
G
Site 33
T274
D
P
L
Q
Y
P
E
T
T
P
K
G
L
A
P
Site 34
T275
P
L
Q
Y
P
E
T
T
P
K
G
L
A
P
V
Site 35
T283
P
K
G
L
A
P
V
T
N
S
S
G
K
M
A
Site 36
S286
L
A
P
V
T
N
S
S
G
K
M
A
L
N
S
Site 37
S293
S
G
K
M
A
L
N
S
P
Q
P
G
P
V
E
Site 38
S301
P
Q
P
G
P
V
E
S
E
L
G
K
Q
L
L
Site 39
T310
L
G
K
Q
L
L
K
T
G
W
E
G
S
P
L
Site 40
S315
L
K
T
G
W
E
G
S
P
L
P
R
S
P
T
Site 41
S320
E
G
S
P
L
P
R
S
P
T
Q
D
A
A
G
Site 42
T322
S
P
L
P
R
S
P
T
Q
D
A
A
G
V
G
Site 43
S333
A
G
V
G
P
P
A
S
Q
G
R
G
P
A
G
Site 44
T356
S
K
A
E
L
P
P
T
V
S
R
P
P
L
L
Site 45
S358
A
E
L
P
P
T
V
S
R
P
P
L
L
R
G
Site 46
S367
P
P
L
L
R
G
L
S
W
D
S
G
P
E
E
Site 47
S370
L
R
G
L
S
W
D
S
G
P
E
E
P
G
P
Site 48
T425
P
V
R
M
Q
K
L
T
K
L
R
E
E
H
I
Site 49
S448
G
L
K
L
P
D
L
S
E
A
A
E
Q
E
K
Site 50
S459
E
Q
E
K
G
L
P
S
E
L
S
P
A
I
E
Site 51
S462
K
G
L
P
S
E
L
S
P
A
I
E
E
E
E
Site 52
S470
P
A
I
E
E
E
E
S
K
S
G
L
D
V
M
Site 53
S472
I
E
E
E
E
S
K
S
G
L
D
V
M
P
N
Site 54
S493
R
K
L
R
V
H
R
S
L
P
G
S
A
P
P
Site 55
S497
V
H
R
S
L
P
G
S
A
P
P
L
T
E
K
Site 56
T502
P
G
S
A
P
P
L
T
E
K
E
V
E
N
V
Site 57
S514
E
N
V
F
V
Q
L
S
L
A
F
R
N
D
S
Site 58
S521
S
L
A
F
R
N
D
S
Y
T
L
E
S
R
I
Site 59
Y522
L
A
F
R
N
D
S
Y
T
L
E
S
R
I
N
Site 60
T523
A
F
R
N
D
S
Y
T
L
E
S
R
I
N
Q
Site 61
T538
A
E
R
E
R
N
L
T
E
E
N
T
E
K
E
Site 62
S552
E
L
E
N
F
K
A
S
I
T
S
S
A
S
L
Site 63
T554
E
N
F
K
A
S
I
T
S
S
A
S
L
W
H
Site 64
S555
N
F
K
A
S
I
T
S
S
A
S
L
W
H
H
Site 65
T568
H
H
C
E
H
R
E
T
Y
Q
K
L
L
E
D
Site 66
Y569
H
C
E
H
R
E
T
Y
Q
K
L
L
E
D
I
Site 67
S587
H
R
L
A
A
R
L
S
S
R
A
E
V
V
G
Site 68
S603
V
R
Q
E
K
R
M
S
K
A
T
E
V
M
M
Site 69
T606
E
K
R
M
S
K
A
T
E
V
M
M
Q
Y
V
Site 70
Y612
A
T
E
V
M
M
Q
Y
V
E
N
L
K
R
T
Site 71
Y620
V
E
N
L
K
R
T
Y
E
K
D
H
A
E
L
Site 72
S638
K
K
L
A
N
Q
N
S
S
R
S
C
G
P
S
Site 73
S639
K
L
A
N
Q
N
S
S
R
S
C
G
P
S
E
Site 74
S641
A
N
Q
N
S
S
R
S
C
G
P
S
E
D
G
Site 75
S645
S
S
R
S
C
G
P
S
E
D
G
V
P
R
T
Site 76
T652
S
E
D
G
V
P
R
T
A
R
S
M
S
L
T
Site 77
S655
G
V
P
R
T
A
R
S
M
S
L
T
L
G
K
Site 78
S657
P
R
T
A
R
S
M
S
L
T
L
G
K
N
M
Site 79
T659
T
A
R
S
M
S
L
T
L
G
K
N
M
P
R
Site 80
S670
N
M
P
R
R
R
V
S
V
A
V
V
P
K
F
Site 81
T686
A
L
N
L
P
G
Q
T
P
S
S
S
S
I
P
Site 82
S688
N
L
P
G
Q
T
P
S
S
S
S
I
P
S
L
Site 83
S689
L
P
G
Q
T
P
S
S
S
S
I
P
S
L
P
Site 84
S690
P
G
Q
T
P
S
S
S
S
I
P
S
L
P
A
Site 85
S691
G
Q
T
P
S
S
S
S
I
P
S
L
P
A
L
Site 86
S694
L
P
G
Q
T
P
S
S
S
S
I
P
S
L
P
Site 87
S699
I
P
S
L
P
A
L
S
E
S
P
N
G
K
G
Site 88
S701
S
L
P
A
L
S
E
S
P
N
G
K
G
S
L
Site 89
S707
E
S
P
N
G
K
G
S
L
P
V
T
S
A
L
Site 90
T723
A
L
L
E
N
G
K
T
N
G
D
P
D
C
E
Site 91
S745
L
S
C
L
E
E
L
S
Q
E
T
K
A
R
M
Site 92
T748
L
E
E
L
S
Q
E
T
K
A
R
M
E
E
E
Site 93
Y757
A
R
M
E
E
E
A
Y
S
K
G
F
Q
E
G
Site 94
S758
R
M
E
E
E
A
Y
S
K
G
F
Q
E
G
L
Site 95
S783
E
E
E
E
E
Q
K
S
E
S
P
E
E
P
E
Site 96
S785
E
E
E
Q
K
S
E
S
P
E
E
P
E
E
V
Site 97
T795
E
P
E
E
V
E
E
T
E
E
E
E
K
G
P
Site 98
S804
E
E
E
K
G
P
R
S
S
K
L
E
E
L
V
Site 99
S805
E
E
K
G
P
R
S
S
K
L
E
E
L
V
H
Site 100
S847
V
V
L
G
L
Y
N
S
Y
N
S
C
A
E
Q
Site 101
S862
A
D
G
P
L
G
R
S
T
C
S
A
A
Q
R
Site 102
T863
D
G
P
L
G
R
S
T
C
S
A
A
Q
R
D
Site 103
S865
P
L
G
R
S
T
C
S
A
A
Q
R
D
S
W
Site 104
S871
C
S
A
A
Q
R
D
S
W
W
S
S
G
L
Q
Site 105
S874
A
Q
R
D
S
W
W
S
S
G
L
Q
H
E
Q
Site 106
S875
Q
R
D
S
W
W
S
S
G
L
Q
H
E
Q
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation