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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GJA3
Full Name:
Gap junction alpha-3 protein
Alias:
Connexin 46; Connexin-46; Cx46; CXA3; CZP3; Gap junction alpha-3; Gap junction protein, alpha 3, 46kDa
Type:
Plasma membrane, Connexon complex, Cell junction, Integral membrane protein
Mass (Da):
47428
Number AA:
435
UniProt ID:
Q9Y6H8
International Prot ID:
IPI00221385
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005922
GO:0016021
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0007267
GO:0006810
GO:0007601
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T19
E
N
A
Q
E
H
S
T
V
I
G
K
V
W
L
Site 2
T53
G
D
E
Q
S
D
F
T
C
N
T
Q
Q
P
G
Site 3
Y66
P
G
C
E
N
V
C
Y
D
R
A
F
P
I
S
Site 4
S119
E
E
Q
L
K
R
E
S
P
S
P
K
E
P
P
Site 5
S121
Q
L
K
R
E
S
P
S
P
K
E
P
P
Q
D
Site 6
S131
E
P
P
Q
D
N
P
S
S
R
D
D
R
G
R
Site 7
S132
P
P
Q
D
N
P
S
S
R
D
D
R
G
R
V
Site 8
Y179
G
F
E
L
K
P
L
Y
R
C
D
R
W
P
C
Site 9
T235
K
K
L
K
Q
G
V
T
S
R
L
G
P
D
A
Site 10
S243
S
R
L
G
P
D
A
S
E
A
P
L
G
T
A
Site 11
T249
A
S
E
A
P
L
G
T
A
D
P
P
P
L
P
Site 12
S258
D
P
P
P
L
P
P
S
S
R
P
P
A
V
A
Site 13
S259
P
P
P
L
P
P
S
S
R
P
P
A
V
A
I
Site 14
Y287
G
Q
A
R
A
V
G
Y
P
G
A
P
P
P
A
Site 15
T303
D
F
K
M
L
A
L
T
E
A
R
G
K
G
Q
Site 16
S311
E
A
R
G
K
G
Q
S
A
K
L
Y
N
G
H
Site 17
Y315
K
G
Q
S
A
K
L
Y
N
G
H
H
H
L
L
Site 18
Y343
Q
P
P
A
L
K
A
Y
P
A
A
S
T
P
A
Site 19
S347
L
K
A
Y
P
A
A
S
T
P
A
A
P
S
P
Site 20
T348
K
A
Y
P
A
A
S
T
P
A
A
P
S
P
V
Site 21
S353
A
S
T
P
A
A
P
S
P
V
G
S
S
S
P
Site 22
S357
A
A
P
S
P
V
G
S
S
S
P
P
L
A
H
Site 23
S358
A
P
S
P
V
G
S
S
S
P
P
L
A
H
E
Site 24
S359
P
S
P
V
G
S
S
S
P
P
L
A
H
E
A
Site 25
S378
A
P
L
L
L
D
G
S
G
S
S
L
E
G
S
Site 26
S381
L
L
D
G
S
G
S
S
L
E
G
S
A
L
A
Site 27
S385
S
G
S
S
L
E
G
S
A
L
A
G
T
P
E
Site 28
T390
E
G
S
A
L
A
G
T
P
E
E
E
E
Q
A
Site 29
T399
E
E
E
E
Q
A
V
T
T
A
A
Q
M
H
Q
Site 30
S418
L
G
D
P
G
R
A
S
K
A
S
R
A
S
S
Site 31
S421
P
G
R
A
S
K
A
S
R
A
S
S
G
R
A
Site 32
S424
A
S
K
A
S
R
A
S
S
G
R
A
R
P
E
Site 33
S425
S
K
A
S
R
A
S
S
G
R
A
R
P
E
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation