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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EPN1
Full Name:
Epsin-1
Alias:
EH domain-binding mitotic phosphoprotein; EPS-15 interacting protein 1; EPS-15-interacting protein 1
Type:
Vesicle protein
Mass (Da):
57575
Number AA:
551
UniProt ID:
Q9Y6I3
International Prot ID:
IPI00002495
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005905
GO:0005737
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0008289
PhosphoSite+
KinaseNET
Biological Process:
GO:0006897
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y17
M
K
N
I
V
H
N
Y
S
E
A
E
I
K
V
Site 2
S18
K
N
I
V
H
N
Y
S
E
A
E
I
K
V
R
Site 3
T28
E
I
K
V
R
E
A
T
S
N
D
P
W
G
P
Site 4
S36
S
N
D
P
W
G
P
S
S
S
L
M
S
E
I
Site 5
S37
N
D
P
W
G
P
S
S
S
L
M
S
E
I
A
Site 6
S38
D
P
W
G
P
S
S
S
L
M
S
E
I
A
D
Site 7
S41
G
P
S
S
S
L
M
S
E
I
A
D
L
T
Y
Site 8
Y75
G
K
N
W
R
H
V
Y
K
A
M
T
L
M
E
Site 9
Y83
K
A
M
T
L
M
E
Y
L
I
K
T
G
S
E
Site 10
T87
L
M
E
Y
L
I
K
T
G
S
E
R
V
S
Q
Site 11
S89
E
Y
L
I
K
T
G
S
E
R
V
S
Q
Q
C
Site 12
S93
K
T
G
S
E
R
V
S
Q
Q
C
K
E
N
M
Site 13
Y101
Q
Q
C
K
E
N
M
Y
A
V
Q
T
L
K
D
Site 14
Y111
Q
T
L
K
D
F
Q
Y
V
D
R
D
G
K
D
Site 15
T157
T
K
E
K
L
A
Q
T
A
T
A
S
S
A
A
Site 16
S167
A
S
S
A
A
V
G
S
G
P
P
P
E
A
E
Site 17
S181
E
Q
A
W
P
Q
S
S
G
E
E
E
L
Q
L
Site 18
S220
L
Q
M
A
I
E
E
S
K
R
E
T
G
G
K
Site 19
T224
I
E
E
S
K
R
E
T
G
G
K
E
E
S
S
Site 20
S231
T
G
G
K
E
E
S
S
L
M
D
L
A
D
V
Site 21
T247
T
A
P
A
P
A
P
T
T
D
P
W
G
G
P
Site 22
T248
A
P
A
P
A
P
T
T
D
P
W
G
G
P
A
Site 23
T267
A
V
P
T
A
A
P
T
S
D
P
W
G
G
P
Site 24
S268
V
P
T
A
A
P
T
S
D
P
W
G
G
P
P
Site 25
T289
P
W
G
G
P
A
P
T
P
A
S
G
D
P
W
Site 26
S292
G
P
A
P
T
P
A
S
G
D
P
W
R
P
A
Site 27
S305
P
A
A
P
A
G
P
S
V
D
P
W
G
G
T
Site 28
T312
S
V
D
P
W
G
G
T
P
A
P
A
A
G
E
Site 29
T322
P
A
A
G
E
G
P
T
P
D
P
W
G
S
S
Site 30
S328
P
T
P
D
P
W
G
S
S
D
G
G
V
P
V
Site 31
S329
T
P
D
P
W
G
S
S
D
G
G
V
P
V
S
Site 32
S336
S
D
G
G
V
P
V
S
G
P
S
A
S
D
P
Site 33
S339
G
V
P
V
S
G
P
S
A
S
D
P
W
T
P
Site 34
S341
P
V
S
G
P
S
A
S
D
P
W
T
P
A
P
Site 35
T345
P
S
A
S
D
P
W
T
P
A
P
A
F
S
D
Site 36
S351
W
T
P
A
P
A
F
S
D
P
W
G
G
S
P
Site 37
S357
F
S
D
P
W
G
G
S
P
A
K
P
S
T
N
Site 38
S362
G
G
S
P
A
K
P
S
T
N
G
T
T
A
A
Site 39
T363
G
S
P
A
K
P
S
T
N
G
T
T
A
A
G
Site 40
T366
A
K
P
S
T
N
G
T
T
A
A
G
G
F
D
Site 41
T374
T
A
A
G
G
F
D
T
E
P
D
E
F
S
D
Site 42
S380
D
T
E
P
D
E
F
S
D
F
D
R
L
R
T
Site 43
T387
S
D
F
D
R
L
R
T
A
L
P
T
S
G
S
Site 44
T391
R
L
R
T
A
L
P
T
S
G
S
S
A
G
E
Site 45
S392
L
R
T
A
L
P
T
S
G
S
S
A
G
E
L
Site 46
S394
T
A
L
P
T
S
G
S
S
A
G
E
L
E
L
Site 47
S395
A
L
P
T
S
G
S
S
A
G
E
L
E
L
L
Site 48
S410
A
G
E
V
P
A
R
S
P
G
A
F
D
M
S
Site 49
S417
S
P
G
A
F
D
M
S
G
V
R
G
S
L
A
Site 50
S422
D
M
S
G
V
R
G
S
L
A
E
A
V
G
S
Site 51
S429
S
L
A
E
A
V
G
S
P
P
P
A
A
T
P
Site 52
T435
G
S
P
P
P
A
A
T
P
T
P
T
P
P
T
Site 53
T437
P
P
P
A
A
T
P
T
P
T
P
P
T
R
K
Site 54
T439
P
A
A
T
P
T
P
T
P
P
T
R
K
T
P
Site 55
T445
P
T
P
P
T
R
K
T
P
E
S
F
L
G
P
Site 56
S448
P
T
R
K
T
P
E
S
F
L
G
P
N
A
A
Site 57
S461
A
A
L
V
D
L
D
S
L
V
S
R
P
G
P
Site 58
S464
V
D
L
D
S
L
V
S
R
P
G
P
T
P
P
Site 59
T469
L
V
S
R
P
G
P
T
P
P
G
A
K
A
S
Site 60
S476
T
P
P
G
A
K
A
S
N
P
F
L
P
G
G
Site 61
T487
L
P
G
G
G
P
A
T
G
P
S
V
T
N
P
Site 62
S490
G
G
P
A
T
G
P
S
V
T
N
P
F
Q
P
Site 63
T502
F
Q
P
A
P
P
A
T
L
T
L
N
Q
L
R
Site 64
T504
P
A
P
P
A
T
L
T
L
N
Q
L
R
L
S
Site 65
S511
T
L
N
Q
L
R
L
S
P
V
P
P
V
P
G
Site 66
S525
G
A
P
P
T
Y
I
S
P
L
G
G
G
P
G
Site 67
T546
P
G
P
P
A
P
N
T
N
P
F
L
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation